KEGG ENZYME: 1.14.11.56

ENZYME: 1.14.11.56

Entry

EC 1.14.11.56               Enzyme

Name

L-proline cis-4-hydroxylase

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

Sysname

L-proline,2-oxoglutarate:oxygen oxidoreductase (cis-4-hydroxylating)

Reaction(IUBMB)

L-proline + 2-oxoglutarate + O2 = cis-4-hydroxy-L-proline + succinate + CO2 [RN:R11594]

Reaction(KEGG)

R11594

Substrate

L-proline [CPD:C00148];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]

Product

cis-4-hydroxy-L-proline [CPD:C01015];
succinate [CPD:C00042];
CO2 [CPD:C00011]

Comment

Requires Fe2+ and ascorbate. The enzyme, isolated from Rhizobium species, only produces cis-4-hydroxy-L-proline (cf. EC 1.14.11.57, L-proline trans-4-hydroxylase).

History

EC 1.14.11.56 created 2017

Orthology

K21614

L-proline cis-4-hydroxylase

Genes

AGYL:

FPL18_03170

MLO:

mlr6283

SME:

SMc03253