KEGG   ENZYME: 1.14.11.59
Entry
EC 1.14.11.59               Enzyme                                 
Name
2,4-dihydroxy-1,4-benzoxazin-3-one-glucoside dioxygenase;
BX6 (gene name);
DIBOA-Glc dioxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
Sysname
(2R)-4-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside:oxygen oxidoreductase (7-hydroxylating)
Reaction(IUBMB)
(2R)-4-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside + 2-oxoglutarate + O2 = (2R)-4,7-dihydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside + succinate + CO2 + H2O [RN:R08972]
Reaction(KEGG)
R08972
Substrate
(2R)-4-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside [CPD:C15772];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
(2R)-4,7-dihydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside [CPD:C18062];
succinate [CPD:C00042];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Comment
The enzyme is involved in the biosynthesis of protective and allelophatic benzoxazinoids in some plants, most commonly from the family of Poaceae (grasses).
History
EC 1.14.11.59 created 2012 as EC 1.14.20.2, transferred 2018 to EC 1.14.11.59
Pathway
ec00402  Benzoxazinoid biosynthesis
ec00999  Biosynthesis of various plant secondary metabolites
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13229  2,4-dihydroxy-1,4-benzoxazin-3-one-glucoside dioxygenase
Genes
ATS: 109766943
TDC: 119345335 119361973
SBI: 8070754
ZMA: 541977
SITA: 101778204 101781203
PVIR: 120669653
Reference
1  [PMID:18192444]
  Authors
Jonczyk R, Schmidt H, Osterrieder A, Fiesselmann A, Schullehner K, Haslbeck M, Sicker D, Hofmann D, Yalpani N, Simmons C, Frey M, Gierl A
  Title
Elucidation of the final reactions of DIMBOA-glucoside biosynthesis in maize: characterization of Bx6 and Bx7.
  Journal
Plant Physiol 146:1053-63 (2008)
DOI:10.1104/pp.107.111237
  Sequence
[zma:541977]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.59
IUBMB Enzyme Nomenclature: 1.14.11.59
ExPASy - ENZYME nomenclature database: 1.14.11.59
BRENDA, the Enzyme Database: 1.14.11.59

  All links  
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (4)   
   InterPro (4)   
All databases (9)   

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