Entry |
|
Name |
thymine dioxygenase;
thymine 7-hydroxylase;
5-hydroxy-methyluracil dioxygenase;
5-hydroxymethyluracil oxygenase
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Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
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Sysname |
thymine,2-oxoglutarate:oxygen oxidoreductase (7-hydroxylating)
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Reaction(IUBMB) |
thymine + 2-oxoglutarate + O2 = 5-hydroxymethyluracil + succinate + CO2 [RN: R01412]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
Requires Fe2+ and ascorbate. Also acts on 5-hydroxymethyluracil to oxidize its -CH2OH group first to -CHO and then to -COOH.
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History |
EC 1.14.11.6 created 1972, modified 1976 (EC 1.14.11.5 created 1972, incorporated 1976)
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Orthology |
K22407 | thymine dioxygenase / DNA helicase |
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Genes |
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Reference |
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Authors |
Bankel L, Holme E, Lindstedt G, Lindstedt S. |
Title |
Oxygenases involved in thymine and thymidine metabolism in Neurospora crassa. |
Journal |
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Reference |
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Authors |
Liu CK, Hsu CA, Abbott MT. |
Title |
Catalysis of three sequential dioxygenase reactions by thymine 7-hydroxylase. |
Journal |
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Reference |
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Authors |
Warn-Cramer BJ, Macrander LA, Abbott MT. |
Title |
Markedly different ascorbate dependencies of the sequential alpha-ketoglutarate dioxygenase reactions catalyzed by an essentially homogeneous thymine 7-hydroxylase from Rhodotorula glutinis. |
Journal |
J Biol Chem 258:10551-7 (1983) |
Other DBs |
ExPASy - ENZYME nomenclature database: | 1.14.11.6 |
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