KEGG   ENZYME: 1.14.11.63
Entry
EC 1.14.11.63               Enzyme                                 
Name
peptidyl-lysine (3S)-dioxygenase;
JMJD7 (gene name);
Jumonji domain-containing protein 7;
JmjC domain-containing protein 7
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
Sysname
[protein]-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3S-hydroxylating)
Reaction(IUBMB)
a [protein]-L-lysine + 2-oxoglutarate + O2 = a [protein]-(3S)-3-hydroxy-L-lysine + succinate + CO2 [RN:R12315]
Reaction(KEGG)
R12315
Substrate
[protein]-L-lysine [CPD:C02188];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
[protein]-(3S)-3-hydroxy-L-lysine [CPD:C22076];
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Requires iron(II). The enzyme acts on specific lysine residues in its substrates, and is stereo-specific. The enzyme encoded by the human JMJD7 gene acts specifically on two related members of the translation factor family of GTPases, DRG1 and DRG2.
History
EC 1.14.11.63 created 2019
Orthology
K19219  peptidyl-lysine (3S)-dioxygenase / protease
Genes
HSA100137047(JMJD7)
PTR107972857 107973006 748548 749464
PPS117975335 117976332 117977851 117978085 117978191 117979216 117979218
GGO101130728 115932637
PON100533112(JMJD7)
NLE115835479(JMJD7)
MCC707262(JMJD7)
MCF102140936(JMJD7)
CSAB103245779(JMJD7)
CATY105574208(JMJD7)
PANU103885782(JMJD7)
TGE112627985(JMJD7)
RRO104666908(JMJD7)
RBB108544336(JMJD7)
TFN117070844(JMJD7)
PTEH111531142(JMJD7)
CJC100533114(JMJD7)
SBQ104652609(JMJD7)
CSYR103249828(JMJD7)
MMUR105872490(JMJD7)
LCAT123629662(JMJD7)
OGA100962881
MMU433466(Jmjd7)
MCAL110284590(Jmjd7)
MPAH110317836(Jmjd7)
RNO100137086(Jmjd7)
MCOC116090745(Jmjd7)
MUN110554756(Jmjd7)
CGE100760377(Jmjd7)
MAUA106020715(Jmjd7)
PLEU114681119(Jmjd7)
NGI103744941(Jmjd7)
HGL106007588(Jmjd7)
CPOC106024982
CCAN109693134
NCAR124976717
OCU100341549(JMJD7)
OPI101535165(JMJD7)
CFA100533116(JMJD7)
CLUD112675419(JMJD7)
VVP112919976(JMJD7)
UMR103673535(JMJD7)
UAH113241998
UAR123775781(JMJD7)
ELK111159662
ORO101362628(JMJD7)
EJU114201678(JMJD7)
ZCA113910558
PPAD109263117
HHV120232223(JMJD7)
BTA100137087(JMJD7)
BOM102281738(JMJD7)
BIU109564978(JMJD7)
OAS101116914(JMJD7)
ODA120853179(JMJD7)
CCAD122443433(JMJD7)
SSC100533119(JMJD7)
CFR102506621(JMJD7)
CBAI105076931(JMJD7)
CDK105096849(JMJD7)
VPC102529209(JMJD7)
BACU102998250(JMJD7)
LVE103091220(JMJD7)
DLE115801469(JMJD7)
ECB100533115(JMJD7)
EPZ103549949(JMJD7)
EAI106841349(JMJD7)
MYB102239879(JMJD7)
MMYO118650187(JMJD7)
PKL118723202(JMJD7)
HAI109384056(JMJD7)
DRO112309041 112311147
AJM119061269(JMJD7)
PDIC114492922(JMJD7)
PHAS123808058(JMJD7)
MMF118628865(JMJD7)
RFQ117023944
PALE107195254(JMJD7)
PGIG120622759(JMJD7)
PVP105288666(JMJD7)
RAY107514504(JMJD7)
MJV108385410(JMJD7)
TOD119238525(JMJD7)
SARA105943040(JMJD7)
LAV100674267(JMJD7)
TMU101354437
SHR111720048(JMJD7)
OAA100089728
GGA423221(JMJD7)
PCOC116229211(JMJD7)
MGP104911088(JMJD7)
CJO107314828(JMJD7)
NMEL110401267(JMJD7)
APLA101792985(JMJD7)
ACYG106040727(JMJD7)
AFUL116489925(JMJD7)
TGU115495506(JMJD7)
LSR110472114(JMJD7)
SCAN103826652(JMJD7)
OTC121335225(JMJD7)
PRUF121349484(JMJD7)
GFR106631784(JMJD7)
FAB101815783(JMJD7)
PHI102105670(JMJD7)
PMAJ107205987(JMJD7)
CCW104688206(JMJD7)
CBRC103620946(JMJD7)
ETL114056490(JMJD7)
ZAB106629343(JMJD7)
ACHL103805952(JMJD7)
FCH114015725(JMJD7)
CLV106145677(JMJD7)
EGZ104127569(JMJD7)
NNI104020446(JMJD7)
PLET104621276(JMJD7)
PCRI104031213(JMJD7)
ACUN113480748(JMJD7)
TALA104359792(JMJD7)
ACHC115350889(JMJD7)
HALD104318327(JMJD7)
CSTI104551098(JMJD7)
EHS104504083(JMJD7)
MUI104548610(JMJD7)
GSTE104252004(JMJD7)
LDI104341235(JMJD7)
MNB103777683(JMJD7)
OHA104328174(JMJD7)
AAM106498215(JMJD7)
AROW112964025(JMJD7)
NPD112942471(JMJD7)
DNE112980616(JMJD7)
ASN106721816(JMJD7)
AMJ106737746(JMJD7)
CPOO109321071(JMJD7)
GGN109298781(JMJD7)
PSS106732512(JMJD7)
CMY114018481(JMJD7)
CPIC101942325(JMJD7)
TST117876775(JMJD7)
CABI116832810(JMJD7)
MRV120403380(JMJD7)
PVT110079000(JMJD7)
SUND121930436(JMJD7)
PBI103052777(JMJD7)
PMUR107287418(JMJD7)
TSR106544674(JMJD7)
PGUT117665650(JMJD7)
PMUA114594240(JMJD7)
ZVI118083530(JMJD7)
STOW125426062(JMJD7)
XLA100036980(jmjd7.S)
XTR496732(jmjd7)
NPR108789918(JMJD7)
RTEM120921144(JMJD7)
BBUF120982532(JMJD7)
BGAR122921657 122921658
DRE550278(jmjd7)
SRX107729259(jmjd7)
SANH107693178(jmjd7)
SGH107586593(jmjd7) 107589668
CCAR109106803(jmjd7)
CAUA113117662(jmjd7)
PPRM120480494(jmjd7)
MAMB125268619(jmjd7)
IPU108270221(jmjd7)
PHYP113538640(jmjd7)
SMEO124390610(jmjd7)
TFD113659525(jmjd7)
AMEX103032045(jmjd7)
EEE113579350(jmjd7)
TRU101076402(jmjd7)
TNGGSTEN00003606G001
LCO104936578(jmjd7)
CGOB115027842(jmjd7)
ELY117267336(jmjd7)
EFO125900365(jmjd7)
PLEP121939951
SLUC116053567(jmjd7)
PFLV114547052(jmjd7)
GAT120832413(jmjd7)
PPUG119227565(jmjd7)
MSAM119887980 119910146
CUD121526654(jmjd7)
ALAT119005217(jmjd7)
MZE101467553(jmjd7)
ONL100700949(jmjd7)
OAU116327987(jmjd7)
OLA101158565(jmjd7)
OML112142740(jmjd7)
XMA102219182(jmjd7)
XCO114156198(jmjd7)
XHE116708793(jmjd7)
PRET103458248
PFOR103147767(jmjd7)
PLAI106934574(jmjd7)
PMEI106907269(jmjd7)
GAF122846023(jmjd7)
CVG107096046(jmjd7)
CTUL119787816(jmjd7)
GMU124884956(jmjd7)
NFU107391658(jmjd7)
KMR108230894(jmjd7)
ALIM106527310(jmjd7)
NWH119427364(jmjd7)
AOCE111571110(jmjd7)
MCEP125023143(jmjd7)
CSEM103381819(jmjd7)
POV109647337(jmjd7)
SSEN122762848(jmjd7)
HHIP117755744(jmjd7)
HSP118116220(jmjd7)
LCF108882342(jmjd7)
SDU111237120(jmjd7)
SLAL111672839(jmjd7)
XGL120795528(jmjd7)
HCQ109520428(jmjd7)
BPEC110167131(jmjd7)
MALB109951731(jmjd7) 109972496
BSPL114847990(jmjd7)
SASA100196304(jmjd7)
OTW112261586(jmjd7)
OMY110497662(jmjd7)
OGO124002073(jmjd7)
ONE115145986(jmjd7)
SALP111968486(jmjd7)
SNH120060466(jmjd7)
CCLU121539537(jmjd7)
ELS105024717(jmjd7)
SFM108941481(jmjd7)
PKI111837019(jmjd7)
AANG118221460(jmjd7)
LOC102695533(jmjd7)
PSPA121329831(jmjd7)
ARUT117416434(jmjd7)
LCM102345464
CMK103178438(jmjd7)
RTP109924370(jmjd7)
BFO118404291 118414690
BBEL109462136 109463087
CIN100181237
SCLV120332618
SPU100888222 584542
APLC110975415 110982943
SKO100376350(jmjd7)
DMEDmel_CG10133(JMJD7)
DER6544823
DSE6605588
DSIDsimw501_GD12657(Dsim_GD12657)
DYADyak_GE20060
DAN6493816
DSR110179816
DPO4812386
DPE6602207
DMN108151366
DWI6639576
DGR6558640
DMODmoj_GI13783
DAZ108613811
DNV108652556
DHE111599858
DVI6622065
CCAT101457063
BOD106616901
MDE101892917
SCAC106093578
LCQ111682743
LSQ119604307
HIS119651580
AGAAgaP_AGAP007766
ACOZ120959198
AARA120904730
ASTE118513964
AAG5571737
AALB109411251
CQUCpipJ_CPIJ000467
CPII120413607
CNS116346428
BCOO119078448
SOC105198906 105204358
MPHA105835990
AEC105148545
ACEP105620777
PBAR105431114
VEM105565233
HST105191739
DQU106745288
CFO105253337
FEX115240610
LHU105674555
OBO105282365
PCF106791148
PFUC122523587
VPS122630177
NVI100123376
CSOL105365357
TPRE106659051
MDL106693932
CGLO123265450
FAS105265545
DAM107048814
AGIF122849729
CCIN107268861
TCA663366
DPA109540363
SOY115876346
ATD109605084
CSET123311401
AGB108911750
NVL108569390
APLN108745075
PPYR116167235 116167783 116170928
OTU111424297
BANY112054685
PMAC106718650
PXY105393811
FOC113204977
TPAL117653813
ZNE110831362
CSEC111866517
DPXDAPPUDRAFT_304184
DMK116925901
PVM113804462
PJA122258765
PCHN125026208
HAME121872884
PCLA123745253
PTRU123509404
HAZT108672349
EAF111695849
LSM121114669
PPOI119090141 119090145
ISCIscW_ISCW017121
DSV119449912
RSAN119382705
RMP119170140
VJA111267926
SDM118182661
TSPTsp_11033
HROHELRODRAFT_170668
LGILOTGIDRAFT_122126 LOTGIDRAFT_152707
PCAN112560479 112560917
BGT106060932 106078327
GAE121381801 121382236
HRF124149800
HRJ124267670
CRG105317558 105317560 105320179
MYI110453150 110459948 110459949
PMAX117335654 117336406
MMER123536392
LAK106151187
NVE5505764 5517414
EPA110233111 110239529
ATEN116307344 116308577
ADF107336840
AMIL114952880 114961200
PDAM113669374 113679966
SPIS111326803 111340380
DGT114526469 114527467
XEN124442017
TADTRIADDRAFT_58435
AQU100637214
ATHAT3G45880
ALY9311824
CRB111830393
CSAT104711045 104780404 104790824
EUSEUTSA_v10002595mg
BRP103873401
BNA106347518 106406369
BOE106335067
RSZ108808899
THJ104798521
CPAP110811377
CIT102613294
CICCICLE_v10031829mg
PVY116130342
MINC123197170
TCC18590024
GRA105799340
GHI107889279 107891459
GAB108457106
DZI111285548
EGR104444179
GMX100786655 102669104
GSJ114375930 114392389
PVUPHAVU_002G120400g
VRA106777745
VAR108335755
VUN114173413
CCAJ109792294
APRC113868486
MTRMTR_5g025190 MTR_5g032230
CAM101510987
LJALj2g3v1561980.1(Lj2g3v1561980.1)
ADU107487327
AIP107639959
AHF112747610 112800215
LANG109348970
FVE101309515
RCN112168131
PPER18778913
PMUM103325845
PAVI110771483
PDUL117626690
MDM103435650
PXB103945954
ZJU107427811
MNT21410554
RCU8261736
JCU105630023
HBR110655533
MESC122722591
POP18095020 7489285
PEU105111379 105119024 105137794
PALZ118045649 118053769
JRE108986432
QSU112008203 112021373 112034575 112034640 112034921
QLO115972562
TWL119990645
VVI100261355
VRI117905053
SLY101250242
SPEN107026817
SSTN125841612
CANN107870096
NTA107772990 107829715
NSY104228240
NTO104092998
NAU109227082
INI109149407 109164459
ITR116021845
SIND105159751
OEU111398601
EGT105966980
SSPL121750745
HAN110895946
ECAD122581393
LSV111900017
CCAV112522036
DCR108197608
CSIN114267656 114294868
BVG104884810
SOE110774973
CQI110705629
NNU104610281
MING122080695
TSS122646579
PSOM113289847 113354733
NCOL116266396
OSA4347413
DOSAOs09t0483600-01(Os09g0483600)
OBR102702595
ATS109758487
TDC119302010 119310797
TAES123112378 123121902
TUA125509705
SBI8055861
ZMA100281215
SITA101786912
SVS117844691
PVIR120661051 120682844
PHAI112881401
PDA103712993
EGU105053696
MUS103973706
PEQ110035334
AOF109838975
ATR18422646
SMOSELMODRAFT_119527
PPP112295875
CRECHLRE_03g175750v5
VCNVOLCADRAFT_107592
CSLCOCSUDRAFT_66049
CVRCHLNCDRAFT_139892
APROF751_6292
OLUOSTLU_86569
OTAOT_ostta02g02900
MISMICPUN_62809
MPPMICPUCDRAFT_18858
CCPCHC_T00002734001
YLIYALI0E13343g
NCRNCU03670
NTENEUTE1DRAFT77133(NEUTE1DRAFT_77133)
SMPSMAC_02541
PANPODANSg8133
TTTTHITE_2107001
MTMMYCTH_2024024
CTHRCTHT_0065950
MGRMGG_08136
PPEIPpBr36_01564
TMNUCRPA7_1524
SSCKSPSK_04350
FGRFGSG_07451
FPUFPSE_09414
FVRFVEG_07796
FOXFOXG_01432
NHENECHADRAFT_96071
TRETRIREDRAFT_69362
TRRM419DRAFT_90428
MAWMAC_02408
MAJMAA_06832
CMTCCM_03925
PLJVFPFJ_07723
VDAVDAG_01424
CFJCFIO01_10440
CHIGCH63R_04382
SAPOSAPIO_CDS9655
ELAUCREL1_11722
PFYPFICI_07641
BFUBCIN_08g04250
MBEMBM_01929
PSCOLY89DRAFT_681493
GLZGLAREA_11308
AORAO090001000312
AFVAFLA_008656
PNOSNOG_10528
PTEPTT_17648
BZECOCCADRAFT_3249
BSCCOCSADRAFT_163801
BORCOCMIDRAFT_2272
AALTCC77DRAFT_1022837
ZTRMYCGRDRAFT_99117
PFJMYCFIDRAFT_88328
FFUCLAFUR5_03418
BCOMBAUCODRAFT_67414
CNECND04170
CNBCNBD2150
CNGCNAG_01297
CGICGB_D7180C
TMSTREMEDRAFT_69678
TASAA1Q1_01925
PPLPOSPLDRAFT_25263
TVSTRAVEDRAFT_69995
DSQDICSQDRAFT_104943
PCOPHACADRAFT_249267
SHSSTEHIDRAFT_167730
HIRHETIRDRAFT_123667
PSQPUNSTDRAFT_119544
FMEFOMMEDRAFT_135473
GTRGLOTRDRAFT_136172
LBCLACBIDRAFT_311796
CCICC1G_14629
ABPAGABI1DRAFT38104(AGABI1DRAFT_38104)
ABVAGABI2DRAFT117066(AGABI2DRAFT_117066)
MPRMPER_13636
MRRMoror_7348
MOREE1B28_004352
CPUTCONPUDRAFT_110803
SLASERLADRAFT_461114
WSEWALSEDRAFT_70012
WICJ056_001387
UMAUMAG_00499
PFPPFL1_06150
PGRPGTG_13074 PGTG_20498
MLRMELLADRAFT_63253
MBRMONBRDRAFT_12766 MONBRDRAFT_14782
SREPTSG_00643 PTSG_03275
DDIDDB_G0292770(jcdE)
DPPDICPUDRAFT_157443
DFADFA_01100(jcdE)
ACANACA1_181660
TETTTHERM_00460680
SMINv1.2.010877.t1(symbB.v1.2.010877.t1) v1.2.039078.t1(symbB.v1.2.039078.t1)
PTIPHATRDRAFT_35781
FCYFRACYDRAFT_246102
AAFAURANDRAFT_62159
PIFPITG_15677
PSOJPHYSODRAFT_500996
SPARSPRG_11273 SPRG_11948
EHXEMIHUDRAFT_435100 EMIHUDRAFT_435104 EMIHUDRAFT_456556
GTTGUITHDRAFT_104417
NGRNAEGRDRAFT_2255
ANBANA_C13066
 » show all
Reference
1  [PMID:29915238]
  Authors
Markolovic S, Zhuang Q, Wilkins SE, Eaton CD, Abboud MI, Katz MJ, McNeil HE, Lesniak RK, Hall C, Struwe WB, Konietzny R, Davis S, Yang M, Ge W, Benesch JLP, Kessler BM, Ratcliffe PJ, Cockman ME, Fischer R, Wappner P, Chowdhury R, Coleman ML, Schofield CJ
  Title
The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases.
  Journal
Nat Chem Biol 14:688-695 (2018)
DOI:10.1038/s41589-018-0071-y
  Sequence
[hsa:100137047]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.63
IUBMB Enzyme Nomenclature: 1.14.11.63
ExPASy - ENZYME nomenclature database: 1.14.11.63
BRENDA, the Enzyme Database: 1.14.11.63

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