KEGG   ENZYME: 1.14.11.66Help
Entry
EC 1.14.11.66               Enzyme                                 

Name
[histone H3]-trimethyl-L-lysine9 demethylase;
KDM4A (gene name);
KDM4B (gene name);
KDM4C (gene name);
KDM4D (gene name);
JHDM3A (gene name);
JMJD2 (gene name);
JMJD2A (gene name);
GASC1 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
Sysname
[histone H3]-N6,N6,N6-trimethyl-L-lysine9,2-oxoglutarate:oxygen oxidoreductase
Reaction(IUBMB)
a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 = a [histone H3]-N6-methyl-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2 (overall reaction) [RN:R12459];
(1a) a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 = a [histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2 [RN:R12460];
(1b) a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 = a [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2 [RN:R09510]
Reaction(KEGG)
Substrate
[histone H3]-N6,N6,N6-trimethyl-L-lysine9;
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007];
[histone H3]-N6,N6-dimethyl-L-lysine9
Product
[histone H3]-N6-methyl-L-lysine9;
succinate [CPD:C00042];
formaldehyde [CPD:C00067];
CO2 [CPD:C00011];
[histone H3]-N6,N6-dimethyl-L-lysine9
Comment
Requires iron(II). This entry describes a group of enzymes that demethylate N-methylated Lys-9 residues in the tail of the histone protein H3 (H3K9). This lysine residue can exist in three methylation states (mono-, di- and trimethylated), but this group of enzymes only act on the the tri- and di-methylated forms. The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde. cf. EC 1.14.11.65, [histone H3]-dimethyl-L-lysine9 demethylase.
History
EC 1.14.11.66 created 2019
Orthology
K06709  [histone H3]-trimethyl-L-lysine9/36 demethylase
Genes
HSA: 23030(KDM4B) 23081(KDM4C) 390245(KDM4E) 55693(KDM4D) 9682(KDM4A)
PTR: 451494 455614(KDM4B) 456829(KDM4A) 464989(KDM4C) 466754(KDM4D) 466755(KDM4E)
PPS: 100975218(KDM4B) 100979908(KDM4E) 100980259(KDM4D) 100981728(KDM4A) 100990982(KDM4C) 100992739
GGO: 101125373(KDM4A) 101132085(KDM4C) 101140323(KDM4D) 101144162(KDM4E) 101145208(KDM4B)
PON: 100172003(KDM4A) 100433788(KDM4C) 100443182(KDM4D) 100443556(KDM4E) 100449542 100457548(KDM4B)
NLE: 100582140 100586305 100587983 100589019(KDM4A) 100592056(KDM4C) 100597675(KDM4D) 100598260
MCC: 695760(KDM4B) 698455(KDM4D) 700412 700765 701272(KDM4A) 715273(KDM4C)
MCF: 101926063(KDM4A) 102125576(KDM4B) 102136790(KDM4C) 102140298 102142534(KDM4D) 102144694(KDM4E)
CSAB: 103219465(KDM4C) 103224954(KDM4A) 103233733(KDM4B) 103248265(KDM4D) 103248269 103248270
RRO: 104657671(KDM4C) 104658622 104660268(KDM4D) 104660270(KDM4E) 104665479(KDM4B) 104669036(KDM4A)
RBB: 108512104(KDM4B) 108518738(KDM4C) 108525734 108535690(KDM4A) 108535741
CJC: 100387524 100388242 100389334(KDM4E) 100391630(KDM4C) 100406442(KDM4B) 100408074(KDM4D) 100411431(KDM4A)
SBQ: 101041165(KDM4B) 101045989(KDM4D) 101046833(KDM4E) 101053425(KDM4C) 101054213(KDM4A) 104652776
MMU: 193796(Kdm4b) 230674(Kdm4a) 244694(Kdm4d) 76804(Kdm4c)
MCAL: 110291915 110292899(Kdm4c) 110292914(Kdm4a) 110301432 110302014(Kdm4d) 110312705(Kdm4b)
MPAH: 110320880 110322808(Kdm4c) 110323167(Kdm4a) 110327601 110328486(Kdm4d) 110335468(Kdm4b)
RNO: 108348070 298144(Kdm4c) 301128(Kdm4b) 313539(Kdm4a) 689582(Kdm4d)
CGE: 100753944(Kdm4d) 100756054(Kdm4a) 100767737 100770247(Kdm4b) 100771667(Kdm4c)
HGL: 101698040(Kdm4c) 101698784 101698983 101707641(Kdm4d) 101715237(Kdm4a) 101718659(Kdm4b)
TUP: 102469253 102481449(KDM4B) 102486046(KDM4A) 102488334(KDM4C) 102492936(KDM4D)
CFA: 474704(KDM4C) 476741(KDM4B) 482530(KDM4A) 485120 485121(KDM4D)
VVP: 112913043 112914824(KDM4A) 112915836(KDM4D) 112915837 112921978(KDM4C) 112935617(KDM4B)
AML: 100467443(KDM4B) 100473204(KDM4A) 100475996(KDM4C) 100476158(KDM4D)
UMR: 103660769(KDM4D) 103660770 103662205(KDM4C) 103670808(KDM4A) 103681849(KDM4B)
ORO: 101369815(KDM4A) 101369880(KDM4B) 101379678(KDM4D) 101379961 101386926(KDM4C)
PTG: 102949786(KDM4C) 102950423(KDM4B) 102957193(KDM4D) 102957475 102967856(KDM4A)
AJU: 106970219(KDM4A) 106975455(KDM4B) 106984309(KDM4C) 106987083 106987092(KDM4D)
BTA: 107133150 508141(KDM4B) 512622(KDM4A) 524768 535671(KDM4C)
BOM: 102273176(KDM4C) 102275589(KDM4D) 102282048(KDM4B) 102283294 102284243(KDM4A)
BIU: 109556399(KDM4A) 109561725(KDM4B) 109562475(KDM4C) 109568776 109568777
BBUB: 102390095 102390765 102392239(KDM4A) 102402037(KDM4C) 102406406(KDM4B)
CHX: 102169067(KDM4A) 102170507(KDM4B) 102175575(KDM4C) 102185583 102185851(KDM4D)
OAS: 101103090 101103347 101110232(KDM4B) 101111840(KDM4A) 101117992(KDM4C)
SSC: 100514356 100621904(KDM4A) 100622077(KDM4C) 100627657 100738761(KDM4B)
BACU: 103003061(KDM4C) 103003890(KDM4A) 103011189(KDM4B) 103017228
ECB: 100053154(KDM4A) 100060699(KDM4C) 100062103(KDM4B) 100067390 100067461
EAI: 106827478 106827509 106832335(KDM4B) 106837522(KDM4C) 106847916(KDM4A)
MNA: 107525662(KDM4B) 107526696(KDM4A) 107532354 107532356(KDM4D) 107538119(KDM4C)
HAI: 109383414(KDM4A) 109388603(KDM4B) 109390558(KDM4D) 109394570(KDM4C)
DRO: 112302738(KDM4C) 112312675(KDM4B) 112314479(KDM4A) 112317537 112317538
PALE: 102882553(KDM4A) 102892415 102897382(KDM4B) 102899019(KDM4C) 107196611
RAY: 107499501(KDM4A) 107510873(KDM4B) 107517665 107517666(KDM4D) 107519315(KDM4C)
MDO: 100018628(KDM4C) 100023921(KDM4B) 100025487(KDM4A)
PCW: 110197484(KDM4B) 110200215(KDM4A) 110221590(KDM4C)
OAA: 100077514(KDM4B) 100077720(KDM4A)
GGA: 424571(KDM4A) 427231(KDM4C) 428354(KDM4B)
MGP: 100541123(KDM4B) 100544296(KDM4A)
NMEL: 110389067(KDM4B) 110389566(KDM4C) 110402235(KDM4A)
APLA: 101791399(KDM4C) 101799328(KDM4B) 101803199(KDM4A)
ACYG: 106034076(KDM4A) 106044969(KDM4B) 106046383(KDM4C)
TGU: 100219686(KDM4C) 100224169(KDM4A) 100225201(KDM4B)
SCAN: 103814958(KDM4A) 103819525(KDM4C) 103822070(KDM4B)
GFR: 102032085(KDM4B) 102039020(KDM4C) 102043301(KDM4A)
FAB: 101806204(KDM4B) 101811297(KDM4C) 101813754(KDM4A)
PHI: 102104087(KDM4A) 102109112(KDM4C) 102109691(KDM4B) 106628634
PMAJ: 107208042(KDM4A) 107215441(KDM4B) 107215920(KDM4C)
CCAE: 111933144(KDM4A) 111940282(KDM4B) 111940625(KDM4C)
ETL: 114056133(KDM4C) 114066015(KDM4A) 114067900(KDM4B)
FPG: 101912991(KDM4B) 101916030(KDM4A) 101918182(KDM4C)
FCH: 102046078(KDM4B) 102047870 102048418(KDM4A)
CLV: 102091977(KDM4A) 102092770(KDM4B) 102093362(KDM4C)
EGZ: 104124361(KDM4B) 104125526(KDM4A) 104125755(KDM4C)
NNI: 104015560(KDM4A) 104018736(KDM4B) 104021360(KDM4C)
ACUN: 113482983(KDM4A) 113489346(KDM4B) 113490378(KDM4C)
PADL: 103912179(KDM4B) 103920347(KDM4C) 103924079(KDM4A)
AAM: 106484490(KDM4B) 106484929(KDM4A) 106496770(KDM4C)
ASN: 102368582(KDM4B) 102377299(KDM4A) 102383020(KDM4C)
AMJ: 102561727(KDM4B) 102571128(KDM4A) 106737064(KDM4C)
PSS: 102450770(KDM4C) 102458937(KDM4B) 102459587(KDM4A)
CMY: 102933803(KDM4C) 102937272(KDM4A) 102947631(KDM4B)
CPIC: 101943254(KDM4A) 101952792(KDM4B) 101953431(KDM4C)
ACS: 100551717(kdm4c) 100563051(kdm4b) 100566487(kdm4a)
PVT: 110073730(KDM4A) 110079264(KDM4B) 110083700 110088211(KDM4C)
PMUR: 107283446(KDM4A) 107296147(KDM4B) 107299130(KDM4C) 107300567
PMUA: 114588176(KDM4C) 114588484(KDM4B) 114599133(KDM4A)
GJA: 107109527(KDM4A) 107113915 107116117(KDM4C)
XTR: 100127653(kdm4c) 100135350(kdm4a) 394661(kdm4b)
DRE: 100003413(kdm4aa) 334347(kdm4ab) 556504(kdm4b) 570194(kdm4c)
LCM: 102348735(KDM4B) 102351941(KDM4A) 102355951(KDM4C) 102365533
CMK: 103174610(kdm4a) 103183550(kdm4b) 103185468(kdm4c)
CIN: 100180205
SPU: 579470
APLC: 110985312
SKO: 100329036(Jmjd2c)
DME: Dmel_CG15835(Kdm4A) Dmel_CG33182(Kdm4B)
DSI: Dsimw501_GD10212(Dsim_GD10212)
AME: 726918
BIM: 100748259
BTER: 100648978
CCAL: 108628463
OBB: 114871125
MPHA: 105828504
AEC: 105143816
ACEP: 105626723
PBAR: 105432945
VEM: 105564383
HST: 105181802
DQU: 106750795
CFO: 105259589
LHU: 105675397
PGC: 109853913
OBO: 105279628
PCF: 106792706
NVI: 100124275
CSOL: 105362294
MDL: 103580058
TCA: 663231
NVL: 108557278
BMOR: 100862759
PMAC: 106709641
PRAP: 110999090
HAW: 110382356
TNL: 113505720
CLEC: 106674420
ZNE: 110833525
TUT: 107361997
DPTE: 113788484
PTEP: 107442880
CEL: CELE_Y48B6A.11(jmjd-2)
CBR: CBG20662(Cbr-jmjd-2)
BMY: Bm1_43520
TSP: Tsp_10658
PCAN: 112573289
MYI: 110456629
LAK: 106150433
SHX: MS3_07846
EGL: EGR_02504
EPA: 110232595
ADF: 107335219
AMIL: 114952836
PDAM: 113674402
SPIS: 111325663
DGT: 114516485
AQU: 100631846
APRO: F751_2217
MAW: MAC_07423
MAJ: MAA_00645
SPAR: SPRG_04576
 » show all
Taxonomy
Reference
1  [PMID:16732293]
  Authors
Cloos PA, Christensen J, Agger K, Maiolica A, Rappsilber J, Antal T, Hansen KH, Helin K
  Title
The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3.
  Journal
Nature 442:307-11 (2006)
  Sequence
[hsa:23081]
Reference
2  [PMID:16738407]
  Authors
Fodor BD, Kubicek S, Yonezawa M, O'Sullivan RJ, Sengupta R, Perez-Burgos L, Opravil S, Mechtler K, Schotta G, Jenuwein T
  Title
Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells.
  Journal
Genes Dev 20:1557-62 (2006)
  Sequence
[mmu:193796]
Reference
3  [PMID:16732292]
  Authors
Klose RJ, Yamane K, Bae Y, Zhang D, Erdjument-Bromage H, Tempst P, Wong J, Zhang Y
  Title
The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36.
  Journal
Nature 442:312-6 (2006)
  Sequence
[hsa:9682]
Reference
4  [PMID:16603238]
  Authors
Whetstine JR, Nottke A, Lan F, Huarte M, Smolikov S, Chen Z, Spooner E, Li E, Zhang G, Colaiacovo M, Shi Y
  Title
Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases.
  Journal
Cell 125:467-81 (2006)
DOI:10.1016/j.cell.2006.03.028
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.66
IUBMB Enzyme Nomenclature: 1.14.11.66
ExPASy - ENZYME nomenclature database: 1.14.11.66
BRENDA, the Enzyme Database: 1.14.11.66

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