KEGG   ENZYME: 1.14.11.66
Entry
EC 1.14.11.66               Enzyme                                 
Name
[histone H3]-trimethyl-L-lysine9 demethylase;
KDM4A (gene name);
KDM4B (gene name);
KDM4C (gene name);
KDM4D (gene name);
JHDM3A (gene name);
JMJD2 (gene name);
JMJD2A (gene name);
GASC1 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
Sysname
[histone H3]-N6,N6,N6-trimethyl-L-lysine9,2-oxoglutarate:oxygen oxidoreductase
Reaction(IUBMB)
a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 = a [histone H3]-N6-methyl-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2 (overall reaction) [RN:R12459];
(1a) a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 = a [histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2 [RN:R12460];
(1b) a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 = a [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2 [RN:R09510]
Reaction(KEGG)
Substrate
[histone H3]-N6,N6,N6-trimethyl-L-lysine9;
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007];
[histone H3]-N6,N6-dimethyl-L-lysine9
Product
[histone H3]-N6-methyl-L-lysine9;
succinate [CPD:C00042];
formaldehyde [CPD:C00067];
CO2 [CPD:C00011];
[histone H3]-N6,N6-dimethyl-L-lysine9
Comment
Requires iron(II). This entry describes a group of enzymes that demethylate N-methylated Lys-9 residues in the tail of the histone protein H3 (H3K9). This lysine residue can exist in three methylation states (mono-, di- and trimethylated), but this group of enzymes only act on the the tri- and di-methylated forms. The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde. cf. EC 1.14.11.65, [histone H3]-dimethyl-L-lysine9 demethylase.
History
EC 1.14.11.66 created 2019
Orthology
K06709  [histone H3]-trimethyl-L-lysine9/36 demethylase
Genes
HSA23030(KDM4B) 23081(KDM4C) 390245(KDM4E) 55693(KDM4D) 9682(KDM4A)
PTR451494 455614(KDM4B) 456829(KDM4A) 464989(KDM4C) 466754(KDM4D) 466755(KDM4E)
PPS100975218(KDM4B) 100979908 100980259(KDM4D) 100981728(KDM4A) 100990982(KDM4C) 100992739
GGO101125373(KDM4A) 101132085(KDM4C) 101140323(KDM4D) 101144162 101145208(KDM4B) 115936314(KDM4E)
PON100172003(KDM4A) 100433788(KDM4C) 100443182(KDM4D) 100443556(KDM4E) 100449542 100457548(KDM4B)
NLE100582140 100586305 100587983 100589019(KDM4A) 100592056(KDM4C) 100597675(KDM4D) 100598260 115830958(KDM4B)
MCC695760(KDM4B) 698455(KDM4D) 700412 700765 701272(KDM4A) 715273(KDM4C)
MCF101926063(KDM4A) 102125576(KDM4B) 102136790(KDM4C) 102140298 102142534 102144694(KDM4E)
CSAB103219465(KDM4C) 103224954(KDM4A) 103233733(KDM4B) 103248265(KDM4D) 103248269 103248270
CATY105584066(KDM4C) 105591372(KDM4D) 105591404 105591405(KDM4E) 105591826(KDM4B) 105594628(KDM4A)
PANU101010163(KDM4A) 101012323 101015068 101016547(KDM4B) 101024524(KDM4C) 103877825(KDM4E)
TGE112605949 112606620 112607616(KDM4C) 112612664(KDM4B) 112617249 112617415 112623689(KDM4A)
RRO104657671(KDM4C) 104658622 104660268(KDM4D) 104660270(KDM4E) 104665479(KDM4B) 104669036(KDM4A)
RBB108512104(KDM4B) 108518738(KDM4C) 108535690(KDM4A) 108535741
TFN117074414(KDM4B) 117079990(KDM4E) 117081234(KDM4D) 117081356 117092724(KDM4A) 117098566(KDM4C)
PTEH111521955(KDM4B) 111543284(KDM4C) 111548731(KDM4A) 111551605 111551608 111551624
CJC100387524 100388242 100389334(KDM4E) 100391630(KDM4C) 100406442(KDM4B) 100408074(KDM4D) 100411431(KDM4A)
SBQ101041165(KDM4B) 101045989(KDM4D) 101046833(KDM4E) 101053425(KDM4C) 101054213(KDM4A)
CSYR103250113(KDM4C) 103250367(KDM4B) 103252389 103257016(KDM4A)
MMUR105856550(KDM4C) 105869638(KDM4B) 105870628 105877425(KDM4A) 105882851 109730742
LCAT123634241(KDM4A) 123636669(KDM4B) 123641994 123642197(KDM4D) 123646647(KDM4C)
OGA100942348(KDM4C) 100953181(KDM4D) 100957805(KDM4A) 100962670(KDM4B)
MMU193796(Kdm4b) 230674(Kdm4a) 244694(Kdm4d) 76804(Kdm4c)
MCAL110291915 110292899(Kdm4c) 110292914(Kdm4a) 110301432 110302014(Kdm4d) 110312705(Kdm4b)
MPAH110320880 110322808(Kdm4c) 110323167(Kdm4a) 110327601 110328486(Kdm4d) 110335468(Kdm4b)
RNO298144(Kdm4c) 301128(Kdm4b) 313539(Kdm4a) 500944(Kdm4dl2) 689582(Kdm4d)
MCOC116072401(Kdm4d) 116072620 116075514(Kdm4b) 116076471 116083577 116096161(Kdm4c) 116096517(Kdm4a)
MUN110546245(Kdm4b) 110547533(Kdm4d) 110547551 110552915(Kdm4a) 110565242
CGE100753944(Kdm4d) 100756054(Kdm4a) 100767737 100770247(Kdm4b) 100771667(Kdm4c)
MAUA101825344(Kdm4b) 101828585(Kdm4d) 101828781 101829374(Kdm4a) 101844032 121135863 121135869
PLEU114685005(Kdm4d) 114685107(Kdm4b) 114696302(Kdm4c) 114709349(Kdm4a)
MORG121433824(Kdm4c) 121448143(Kdm4a) 121451298 121451299 121451793 121459382(Kdm4b)
AAMP119809265 119809266(Kdm4d) 119814865(Kdm4b) 119816352(Kdm4c) 119816789(Kdm4a)
NGI103725815 103725819 103725820 103729477(Kdm4c) 103737215(Kdm4b) 103743860(Kdm4a)
HGL101698040(Kdm4c) 101698784 101698983 101707641(Kdm4d) 101715237(Kdm4a) 101718659(Kdm4b)
CPOC100714222 100715051 100715897 100716465 100719501 100719778(Kdm4d) 100719980(Kdm4c) 100721657 100731064(Kdm4a) 100733163(Kdm4b)
CCAN109681563(Kdm4a) 109683599 109687448 109692019(Kdm4b) 109702940
DORD105981849 105986181(Kdm4a) 105990459(Kdm4b) 105993221(Kdm4c) 105993925 105993936
DSP122099351(Kdm4b) 122105877(Kdm4a) 122113602(Kdm4c) 122120065
NCAR124959637 124959638 124960122 124964387 124968364 124984980 124994207
OCU100343440(KDM4C) 100346681 100347204 100347458 100347712 100348204(KDM4D) 100353935(KDM4A)
OPI101516091(KDM4C) 101523282(KDM4D) 101526192(KDM4B) 101529141(KDM4A)
TUP102469253 102481449(KDM4B) 102486046(KDM4A) 102488334(KDM4C) 102492936(KDM4D)
CFA474704(KDM4C) 476741(KDM4B) 482530(KDM4A) 485120 485121
VVP112914824(KDM4A) 112915836(KDM4D) 112915837 112921978(KDM4C) 112935617(KDM4B)
VLG121476210(KDM4D) 121476211 121481112(KDM4A) 121483885 121494540(KDM4B)
AML100467443 100473204(KDM4A) 100475996(KDM4C) 100476158 117803347(KDM4D)
UMR103660769(KDM4D) 103660770 103662205(KDM4C) 103670808(KDM4A) 103681849(KDM4B)
UAH113242850(KDM4B) 113254782(KDM4A) 113259730 113260162(KDM4D) 113260620
UAR123781013(KDM4C) 123787887 123787901(KDM4D) 123793797(KDM4A) 123796793(KDM4B)
ELK111143010 111154365 111154510 111156570 111161727
LLV125079135 125079692 125083144 125087969 125098476
MPUF101679772(KDM4C) 101693240(KDM4A) 101693935(KDM4D) 101694210 101694583(KDM4B)
ORO101369815(KDM4A) 101369880(KDM4B) 101379678(KDM4D) 101379961 101386926(KDM4C)
EJU114212392(KDM4C) 114221556 114221570(KDM4D) 114224188(KDM4A) 114226096(KDM4B)
ZCA113913706(KDM4D) 113913707 113917083(KDM4B) 113933950(KDM4A) 113934426(KDM4C)
MLX117999076(KDM4C) 118005625 118013525 118013526(KDM4D) 118019520(KDM4A)
FCA101081651(KDM4A) 101085402 101091764 101100423(KDM4C) 105259981
PYU121020810(KDM4C) 121021328(KDM4B) 121026994(KDM4A)
PBG122474669(KDM4C) 122480387(KDM4A) 122483194(KDM4D) 122484222 122486747(KDM4B)
PTG102949786(KDM4C) 102950423(KDM4B) 102957193(KDM4D) 102957475 102967856(KDM4A)
PPAD109254791(KDM4A) 109255872(KDM4B) 109260118(KDM4C) 109267055 109267056 109267369(KDM4D)
AJU106970219(KDM4A) 106975455(KDM4B) 106984309(KDM4C) 106987083 106987092(KDM4D)
HHV120220115(KDM4C) 120236043(KDM4A) 120242088(KDM4B) 120247183 120247184 120247192(KDM4D)
BTA107133150 508141(KDM4B) 512622(KDM4A) 524768 535671(KDM4C)
BOM102273176(KDM4C) 102275589(KDM4D) 102282048(KDM4B) 102284243(KDM4A)
BIU109556399(KDM4A) 109561725(KDM4B) 109562475(KDM4C) 109568776 109568777
BBUB102390095 102390765(KDM4D) 102392239(KDM4A) 102402037(KDM4C) 102406406(KDM4B)
CHX102169067(KDM4A) 102170507(KDM4B) 102175575(KDM4C) 102185583 102185851(KDM4D)
OAS101103090 101103347 101110232(KDM4B) 101117992(KDM4C)
ODA120856274(KDM4A) 120860208 120863043 120864849(KDM4B)
CCAD122437080(KDM4A) 122440262(KDM4B) 122450047 122450048 122452937(KDM4C)
SSC100514356 100621904(KDM4A) 100622077(KDM4C) 100627657 100738761(KDM4B)
CFR102505483(KDM4C) 102518341(KDM4A) 102523437(KDM4B) 102523511(KDM4D) 102523759
CBAI105072711(KDM4A) 105073418(KDM4C) 105078236(KDM4B) 105083591 105083592
CDK105090903(KDM4A) 105091754(KDM4B) 105096552(KDM4D) 105098276(KDM4C) 105102910 105106725
VPC102526447(KDM4C) 102530022(KDM4B) 102541593(KDM4A)
BACU103003061(KDM4C) 103003890(KDM4A) 103011189(KDM4B) 103017228
LVE103073873(KDM4B) 103076969(KDM4C) 103079146 103083099(KDM4A) 103090224 103091599
OOR101271577 101271823 101272067 101272702(KDM4B) 101278833(KDM4C) 101279102 101282712 101287314 101289051(KDM4A)
DLE111166151(KDM4B) 111171036 111171322 111171367 111171369 111171386 111171388 111174667(KDM4C) 111175707(KDM4A)
PCAD102986762(KDM4C) 102987474 102990200 102991669(KDM4B) 102992791(KDM4A) 112062047 112062716 112062970 112063148 112066976 112066977 112066979
PSIU116750729(KDM4B) 116755446(KDM4C) 116756429(KDM4A) 116757349 116758199 116758301 116758302(KDM4D) 116758311 116758819
ECB100053154(KDM4A) 100060699(KDM4C) 100062103(KDM4B) 100067390 100067461
EPZ103541685(KDM4B) 103546861 103546874 103557275(KDM4C) 103557419(KDM4A)
EAI106827478 106827509 106832335(KDM4B) 106837522(KDM4C) 106847916(KDM4A)
MYB102239838 102243828(KDM4B) 102246724 102252195(KDM4A) 102257879(KDM4C) 102261864(KDM4D)
MYD102755754 102757566(KDM4B) 102768643(KDM4D) 102769560(KDM4C) 102773056(KDM4A)
MMYO118653535 118657732(KDM4B) 118664143 118664144 118664145 118664156 118664498(KDM4D) 118667538(KDM4C) 118675288(KDM4A)
MLF102417101 102419795(KDM4A) 102422048 102427537(KDM4D) 102428343(KDM4B) 102433762 102441248 102441553(KDM4C) 102442255 102442569 102442883 102443208
MNA107525662(KDM4B) 107526696(KDM4A) 107532354 107532356(KDM4D) 107538119(KDM4C)
PKL118712906 118713769 118713771 118716568(KDM4C) 118723805(KDM4A) 118731328(KDM4B)
HAI109383414(KDM4A) 109388603(KDM4B) 109390558(KDM4D) 109394570(KDM4C)
DRO112302738(KDM4C) 112312675(KDM4B) 112314479(KDM4A) 112317537 112317538
SHON118975697(KDM4D) 118984535(KDM4B) 118997639(KDM4C) 119003326(KDM4A)
AJM119052354(KDM4A) 119057837(KDM4C) 119062466(KDM4D) 119063818(KDM4B)
PDIC114492771(KDM4C) 114496275(KDM4A) 114498818(KDM4D) 114502360(KDM4B)
PHAS123805380(KDM4D) 123813722(KDM4B) 123819795(KDM4C) 123831665(KDM4A)
MMF118615412(KDM4B) 118626061(KDM4A) 118627839 118627840 118627844 118627847 118629904(KDM4C)
RFQ117027200(KDM4A) 117029768 117031319(KDM4D) 117032097(KDM4C) 117037757(KDM4B)
PALE102882553(KDM4A) 102892415 102897382(KDM4B) 102899019(KDM4C)
PGIG120616059(KDM4C) 120618109 120618129 120619301(KDM4A)
PVP105297094(KDM4A) 105297224(KDM4C) 105301061(KDM4B) 105301886(KDM4D)
RAY107499501(KDM4A) 107510873(KDM4B) 107517665 107517666(KDM4D) 107519315(KDM4C)
MJV108383425 108384259 108384365 108384817 108385055 108385199 108387600 108388388 108389174 108391385(KDM4B) 108392207 108396482 108397151 108401722(KDM4A)
TOD119231990(KDM4C) 119237202(KDM4A) 119240282 119240604(KDM4B)
SARA101538917(KDM4A) 101553031(KDM4C) 101555622(KDM4D) 101556022(KDM4B)
LAV100666311(KDM4B) 100668190(KDM4A) 100673362(KDM4C) 100674739(KDM4D) 100675306 100675588 100675872 100676158
TMU101340534 101341303 101346944 101347201 101357303
DNM101436329(KDM4B) 101438363(KDM4A) 101442459
MDO100018628(KDM4C) 100023921(KDM4B) 100025487(KDM4A)
GAS123242851(KDM4B) 123243614(KDM4A) 123248392(KDM4C)
SHR100920302(KDM4A) 100923927(KDM4B) 100930851(KDM4C)
PCW110197484(KDM4B) 110200215(KDM4A) 110221590(KDM4C)
OAA100077514(KDM4B) 100077720(KDM4A) 100681304(KDM4C)
GGA424571(KDM4A) 427231(KDM4C) 428354(KDM4B)
PCOC116233828(KDM4A) 116235672(KDM4B) 116237181(KDM4C)
MGP100541123(KDM4B) 100544296(KDM4A) 100550263
CJO107306117 107306118 107317431(KDM4A) 107325397(KDM4B)
NMEL110389067(KDM4B) 110389566(KDM4C) 110402235(KDM4A)
APLA101791399(KDM4C) 101799328(KDM4B) 101803199(KDM4A)
ACYG106034076(KDM4A) 106044969(KDM4B) 106046383(KDM4C)
AFUL116491788(KDM4A) 116499008(KDM4B) 116500894(KDM4C)
TGU100219686(KDM4C) 100224169(KDM4A) 100225201(KDM4B)
LSR110469429(KDM4A) 110471241(KDM4C) 110477880(KDM4B)
SCAN103814958(KDM4A) 103819525(KDM4C) 103822070(KDM4B)
PMOA120503198(KDM4A) 120511993(KDM4C) 120513796(KDM4B)
OTC121332014(KDM4C) 121345033(KDM4A) 121346874(KDM4B)
PRUF121349894(KDM4B) 121362157(KDM4A) 121363667(KDM4C)
GFR102032085(KDM4B) 102039020(KDM4C) 102043301(KDM4A)
FAB101806204(KDM4B) 101811297(KDM4C) 101813754(KDM4A)
PHI102104087(KDM4A) 102109112(KDM4C) 102109691(KDM4B)
PMAJ107208042(KDM4A) 107215441(KDM4B) 107215920(KDM4C)
CCAE111933144(KDM4A) 111940625(KDM4C)
CCW104685185(KDM4C) 104695543(KDM4A)
ETL114056133(KDM4C) 114066015(KDM4A) 114067900(KDM4B)
ZAB102060546(KDM4A) 102062140(KDM4B) 102073064(KDM4C)
FPG101912991(KDM4B) 101916030(KDM4A) 101918182(KDM4C)
FCH102046078(KDM4B) 102047870 102048418(KDM4A)
CLV102091977(KDM4A) 102092770(KDM4B) 102093362(KDM4C)
EGZ104124361(KDM4B) 104125526(KDM4A) 104125755(KDM4C)
NNI104015560(KDM4A) 104018736(KDM4B) 104021360(KDM4C)
PLET104626228(KDM4A)
ACUN113482983(KDM4A) 113489346(KDM4B) 113490378(KDM4C)
TALA104358325(KDM4A) 104361174(KDM4B) 104364906(KDM4C)
PADL103912179(KDM4B) 103920347(KDM4C) 103924079(KDM4A)
ACHC115336799(KDM4C) 115348973(KDM4A) 115349009(KDM4B)
AAM106484490(KDM4B) 106484929(KDM4A) 106496770(KDM4C)
AROW112966724(KDM4B) 112974541(KDM4C) 112976002(KDM4A)
NPD112942390(KDM4A) 112943892(KDM4B) 112947585(KDM4C)
DNE112981254(KDM4A) 112981665(KDM4C) 112986585(KDM4B)
ASN102368582(KDM4B) 102377299(KDM4A) 102383020(KDM4C)
AMJ102571128(KDM4A) 106737064(KDM4C)
CPOO109307388(KDM4A) 109320455(KDM4B) 109323501(KDM4C)
GGN109286753(KDM4A) 109294889(KDM4B) 109297648(KDM4C)
PSS102450770(KDM4C) 102458937(KDM4B) 102459587(KDM4A)
CMY102933803(KDM4C) 102937272(KDM4A) 102947631(KDM4B)
CPIC101943254(KDM4A) 101952792(KDM4B) 101953431(KDM4C)
TST117869062(KDM4B) 117878874(KDM4C) 117881338(KDM4A)
CABI116816675(KDM4A) 116823100(KDM4B) 116838317
MRV120370157(KDM4A) 120391881(KDM4B) 120407934(KDM4C)
ACS100551717(kdm4c) 100563051(kdm4b) 100566487(kdm4a)
PVT110073730(KDM4A) 110079264(KDM4B) 110088211(KDM4C)
SUND121922302(KDM4C) 121928493(KDM4A) 121936816(KDM4B)
PBI103049044(KDM4A) 103054441 103066528
PMUR107283446(KDM4A) 107299130(KDM4C)
TSR106540806(KDM4C) 106542258(KDM4A) 106555958
PGUT117661503(KDM4C) 117664095(KDM4A) 117668653(KDM4B)
VKO123016849(KDM4B) 123029584(KDM4A) 123031292(KDM4C)
PMUA114588176(KDM4C) 114588484(KDM4B) 114599133(KDM4A)
ZVI118086977(KDM4B) 118088512(KDM4A) 118097712(KDM4C)
GJA107109527(KDM4A) 107113915 107116117(KDM4C)
STOW125432792 125432868(KDM4A) 125436444(KDM4C)
XLA108706953(kdm4c.S) 108711800 108714164(kdm4c.L) 108714257 108715546
XTR100127653(kdm4c) 100135350(kdm4a) 394661(kdm4b)
NPR108789047(KDM4A) 108793106(KDM4C) 108796480
RTEM120911530(KDM4B) 120943954(KDM4C) 120946124(KDM4A)
BBUF120979224(KDM4A) 120989553(KDM4B) 120990876(KDM4C)
BGAR122922079(KDM4C) 122943405(KDM4A) 122946832(KDM4B)
DRE100003413(kdm4aa) 334347(kdm4ab) 556504(kdm4b) 570194(kdm4c)
SRX107709085 107709452 107717157 107742799 107743373 107746607(kdm4a) 107750465
SANH107655842 107660208 107672666 107679073 107684932 107686767(kdm4a) 107700543 107702398
SGH107548355 107549366 107551714 107554885 107561592 107564389 107570226 107582316(kdm4a)
CCAR109057546 109087276 109095593 109103532 109112889
CAUA113039306 113044246 113045633 113050981 113074103 113091117 113107063 113114707
PPRM120467918(kdm4aa) 120482386(kdm4ab) 120486825(kdm4b) 120494003(kdm4c)
MAMB125250555(kdm4ab) 125263268(kdm4b) 125272636(kdm4c) 125274096(kdm4aa)
IPU108260706(kdm4c) 108271011(kdm4b) 108271783(kdm4aa) 108280529(kdm4ab)
PHYP113532166(kdm4a) 113546355 113547365
SMEO124381343(kdm4c) 124384496(kdm4aa) 124384508 124390962(kdm4b) 124402876(kdm4ab)
TFD113635466(kdm4c) 113642795(kdm4aa) 113650124(kdm4ab) 113651005(kdm4b)
AMEX103024587 103028415 103030117(kdm4b) 103036954(kdm4a)
EEE113586630 113587659 113591480
TRU101062865(kdm4a) 101065945 101079555 101079781
TNGGSTEN00006759G001 GSTEN00008260G001 GSTEN00019108G001 GSTEN00020884G001
LCO104920951 104927963 104935856 104940289(kdm4a)
NCC104954834 104957901 104961001 104968022
CGOB115006766(kdm4a) 115006866 115022114
ELY117253728 117253924(kdm4b) 117255204(kdm4c) 117271868(kdm4ab)
PLEP121941891(kdm4c) 121951041(kdm4ab) 121962464(kdm4aa) 121963299(kdm4b)
SLUC116037303 116040537(kdm4c) 116055295(kdm4b) 116058787(kdm4aa)
ECRA117950241(kdm4b) 117950869(kdm4aa) 117954076 117956998(kdm4c)
PFLV114561239(kdm4a) 114561331 114565234 114565613
GAT120815761(kdm4ab) 120823482(kdm4aa) 120823488(kdm4b) 120825047(kdm4c)
PPUG119209446(kdm4ab) 119216457(kdm4b) 119216579(kdm4aa) 119217651(kdm4c)
MSAM119899132(kdm4c) 119900546(kdm4b) 119901274(kdm4aa) 119902256
CUD121508226(kdm4c) 121512130 121512267(kdm4b) 121519968(kdm4ab)
ALAT119010812(kdm4ab) 119019429(kdm4c) 119028142(kdm4b) 119028462(kdm4aa)
MZE101464060(kdm4a) 101472369 101476674 101479851
ONL100694970(kdm4a) 100696578 100703178 100707211
OAU116314387 116325949(kdm4c) 116328455(kdm4b) 116333101
OLA101157850(kdm4a) 101162552 101165696 101173928
OML112136987 112147513(kdm4ab) 112150551(kdm4b) 112157128(kdm4c)
XMA102223593 102226356(kdm4a) 102228201 102235480
XCO114145442 114146733 114150374(kdm4a) 114151024
XHE116719793 116721826 116725857 116726038(kdm4a)
PRET103463436 103464194(kdm4a) 103468987 103479142
PFOR103129976 103130570 103137779 103153021
PLAI106937923 106941336 106954381 106965011
PMEI106907892 106909736 106914031 106918705
GAF122829486(kdm4c) 122838043 122839191(kdm4b) 122841334
CVG107093321 107094195(kdm4c) 107101563 107102789
CTUL119773122(kdm4ab) 119777557(kdm4aa) 119786768(kdm4c) 119787650(kdm4b)
GMU124868097(kdm4c) 124869807(kdm4ab) 124873606(kdm4aa) 124874091(kdm4b)
NFU107382182 107387334(kdm4a) 107392781 107396931
KMR108234360(kdm4b) 108241538(kdm4c) 108244846(kdm4ab) 108248745
ALIM106517316(kdm4a) 106519213 106531977 106532529
NWH119407438(kdm4aa) 119430591(kdm4b) 119430793(kdm4c)
AOCE111567014 111569806 111570592 111576552 111588723(kdm4a)
CSEM103383764 103395594 103395858 103399834
POV109625784(kdm4a) 109636650 109637823 109644379
SSEN122760331(kdm4c) 122774108(kdm4ab) 122780731(kdm4b) 122780743
HHIP117760217(kdm4b) 117760759(kdm4aa) 117768091(kdm4c) 117777871
HSP118118157 118119713(kdm4c) 118120900(kdm4aa) 118120949(kdm4b)
LCF108881199 108883687 108896426 108896968
SDU111228865 111230935 111231525 111231819
SLAL111664525 111670000 111671099 111671105 111671721
XGL120790564(kdm4b) 120790837(kdm4aa) 120798838 120800514(kdm4c)
HCQ109511129(kdm4c) 109518926 109519046 109524769(kdm4a)
BPEC110160143 110172611 110174785 110175075
MALB109958225 109958391 109969323 109972172(kdm4a)
BSPL114845168(kdm4ab) 114845475(kdm4c) 114853228(kdm4b) 114853781(kdm4aa)
SASA101448002(jhd3b) 106560339(kdm4a) 106568967 106574093 106584183 106593555 106598949
OTW112227083 112241534 112249956 112250624 112251284 112252020 112260288 121844686
OMY110508930 110521735 110523012 110524025(kdm4b) 110530113 110533913 110534600 110534602
OGO123996745 123997156 123997424 124009481 124018471 124018474 124024355 124037910 124042029
ONE115103267 115108071 115114195 115116421 115145198(kdm4a)
SALP111952686 111956820 111972383 111975437 111975683 111979262
SNH120020496 120036026 120052623 120053638 120054617 120055013 120055789
ELS105011321 105011874(kdm4a) 105020859 105024530
SFM108921450 108923844(kdm4a) 108925733 108940292
PKI111841055 111846045(kdm4a) 111853103 111860286
AANG118225589(kdm4aa) 118226166(kdm4b) 118227811 118229261 118229950(kdm4ab) 118231574
LOC102684122(kdm4c) 102684738(kdm4a) 102691840(kdm4b)
PSPA121300710 121301427 121322183(kdm4c) 121326722 121331029
ARUT117401447 117412169(kdm4ab) 117417234 117420863(kdm4c) 117962785
LCM102348735(KDM4B) 102351941(KDM4A) 102355951(KDM4C) 102365533
CMK103174610(kdm4aa) 103183550 103185468
RTP109931349(kdm4a) 109935489
BFO118431545 118431680
BBEL109483524
CIN100180205
SCLV120339886
SPU579470
APLC110985312
SKO100329036(Jmjd2c)
DMEDmel_CG15835(Kdm4A) Dmel_CG33182(Kdm4B)
DER6542450 6549529
DSE6608077 6608952
DSIDsimw501_GD10212(Dsim_GD10212) Dsimw501_GD25786(Dsim_GD25786)
DYADyak_GE13392 Dyak_GE23530
DAN6494095 6495811
DSR110182943 110189741
DPODpse_GA13980 Dpse_GA24867
DPE6590467 6593251
DMN108158417 108159911 117192612 117193057
DWI6640217 6640402
DMODmoj_GI18397 Dmoj_GI19732
DAZ108616129 108616911
DNV108652908 108655193
DHE111592178 111599885
DVI116649760 6635881
CCAT101449026
BOD106618308
MDE101897367 105261423
SCAC106092188
LCQ111682389 111682507
LSQ119600122
AGAAgaP_AGAP006770 AgaP_AGAP011180
ACOZ120949773 120955750
AARA120900965
ASTE118503453
AAG5570368 5570369 5573483
AALB109420413 109423314 115253807
CQUCpipJ_CPIJ011492 CpipJ_CPIJ019459
CPII120419771 120421676 120426404
CNS116340967
BCOO119072359
AME726918
ACER108001800
ALAB122716894
BIM100748259
BBIF117209016
BVK117233741
BVAN117160662
BTER100648978
BPYO122569752
CCAL108628463
OBB114871125
MGEN117223629
NMEA116424368
CGIG122395321
SOC105200259 105200531
MPHA105828504
AEC105143816
ACEP105626723
PBAR105432945
VEM105564383
HST105181802
DQU106750795
CFO105259589
FEX115242226
LHU105675397
PGC109853913
OBO105279628
PCF106792706
PFUC122513242 122524515
VPS122636998
NVI100124275
CSOL105362294
TPRE106659068
MDL103580058
CGLO123260280
FAS105272705
DAM107044997
AGIF122858610
CCIN107266333
TCA663231
DPA109537663 109537703
SOY115881741
ATD109602433
CSET123319837
AGB108903335
LDC111506467
NVL108557278
APLN108744991
PPYR116160982
OTU111418179
BMOR100862759
BMAN114251842
MSEX115449860
DPLKGM_205374
BANY112051136
PMAC106709641
PPOT106103890
PXU106114717
PRAP123690325
ZCE119838999
HAW110382356
TNL113505720
SLIU111351292
OFU114366678
PXY105381747 105398781
API100158707 100159325 100160843 100164196 100164740 100168352 100568744 100574318 115034470
DNX107161984
AGS114123066
RMD113553978
BTAB109031137 109032431 109040681 109042941 109044412
CLEC106674420
HHAL106686277
NLU111062309
PHUPhum_PHUM157200
FOC113201878 113204974 113211289
TPAL117639629 117647170 117647906 117648058 117648070 117648196 117651144 117652952 117653296 117653339 117653540
ZNE110833525
CSEC111862537
FCD110859986 110860980
DPXDAPPUDRAFT_113278 DAPPUDRAFT_114527 DAPPUDRAFT_119490 DAPPUDRAFT_125559 DAPPUDRAFT_247944 DAPPUDRAFT_261496 DAPPUDRAFT_266513 DAPPUDRAFT_302100 DAPPUDRAFT_319039 DAPPUDRAFT_325610 DAPPUDRAFT_330275 DAPPUDRAFT_48413
DMK116924666
PVM113816835 113816836
PJA122262743
HAME121877084
PCLA123754421
PTRU123513473
HAZT108668297 108681101
EAF111697009 111707520
LSM121114587 121121739
PPOI119108101
ISCIscW_ISCW019624
DSV119433581
RSAN119404698
RMP119180681
VDE111244235
VJA111266313
TUT107361997
DPTE113788484
DFR124496111
CSCU111630375 111630378 111636353
PTEP107442880
SDM118200983
CELCELE_Y48B6A.11(jmjd-2)
CBRCBG_20662(Cbr-jmjd-2)
BMYBM_BM6641(Bma-jmjd-2)
LOALOAG_16735
HROHELRODRAFT_111100 HELRODRAFT_132346 HELRODRAFT_80169
LGILOTGIDRAFT_121093
PCAN112573289
BGT106060082
GAE121373905
HRF124140527
HRJ124263971
MYI110456629
PMAX117325525
OBI106883456
LAK106150433
SMMSmp_132170
OVIT265_00193
EGLEGR_02504
NVE116614163
EPA110232595
ATEN116292955
ADF107335219
AMIL114952836
PDAM113674402
SPIS111325663
DGT114516485
HMG100210028
TADTRIADDRAFT_27796
CRECHLRE_02g078700v5 CHLRE_17g709550v5
VCNVOLCADRAFT_65316 VOLCADRAFT_91971
CSLCOCSUDRAFT_67911
CVRCHLNCDRAFT_137990 CHLNCDRAFT_21253
APROF751_2217
BPGBathy14g02600
MISMICPUN_61256
MPPMICPUCDRAFT_59528
PPEIPpBr36_05771
TRETRIREDRAFT_38781
TRRM419DRAFT_47915
MBRMONBRDRAFT_27628
SREPTSG_08936
PTMGSPATT00023881001 GSPATT00033659001 GSPATT00034535001 GSPATT00035495001
FCYFRACYDRAFT_237169
TPSTHAPSDRAFT_22122
SPARSPRG_04576
EHXEMIHUDRAFT_462882
GTTGUITHDRAFT_65602 GUITHDRAFT_66646
NGRNAEGRDRAFT_80626
 » show all
Reference
1  [PMID:16732293]
  Authors
Cloos PA, Christensen J, Agger K, Maiolica A, Rappsilber J, Antal T, Hansen KH, Helin K
  Title
The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3.
  Journal
Nature 442:307-11 (2006)
DOI:10.1038/nature04837
  Sequence
[hsa:23081]
Reference
2  [PMID:16738407]
  Authors
Fodor BD, Kubicek S, Yonezawa M, O'Sullivan RJ, Sengupta R, Perez-Burgos L, Opravil S, Mechtler K, Schotta G, Jenuwein T
  Title
Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells.
  Journal
Genes Dev 20:1557-62 (2006)
DOI:10.1101/gad.388206
  Sequence
[mmu:193796]
Reference
3  [PMID:16732292]
  Authors
Klose RJ, Yamane K, Bae Y, Zhang D, Erdjument-Bromage H, Tempst P, Wong J, Zhang Y
  Title
The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36.
  Journal
Nature 442:312-6 (2006)
DOI:10.1038/nature04853
  Sequence
[hsa:9682]
Reference
4  [PMID:16603238]
  Authors
Whetstine JR, Nottke A, Lan F, Huarte M, Smolikov S, Chen Z, Spooner E, Li E, Zhang G, Colaiacovo M, Shi Y
  Title
Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases.
  Journal
Cell 125:467-81 (2006)
DOI:10.1016/j.cell.2006.03.028
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.66
IUBMB Enzyme Nomenclature: 1.14.11.66
ExPASy - ENZYME nomenclature database: 1.14.11.66
BRENDA, the Enzyme Database: 1.14.11.66

DBGET integrated database retrieval system