KEGG   ENZYME: 1.14.11.66
Entry
EC 1.14.11.66               Enzyme                                 
Name
[histone H3]-trimethyl-L-lysine9 demethylase;
KDM4A (gene name);
KDM4B (gene name);
KDM4C (gene name);
KDM4D (gene name);
JHDM3A (gene name);
JMJD2 (gene name);
JMJD2A (gene name);
GASC1 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
Sysname
[histone H3]-N6,N6,N6-trimethyl-L-lysine9,2-oxoglutarate:oxygen oxidoreductase
Reaction(IUBMB)
a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 = a [histone H3]-N6-methyl-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2 (overall reaction) [RN:R12459];
(1a) a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 = a [histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2 [RN:R12460];
(1b) a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 = a [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2 [RN:R09510]
Reaction(KEGG)
R09510 R12459 R12460
Substrate
[histone H3]-N6,N6,N6-trimethyl-L-lysine9;
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007];
[histone H3]-N6,N6-dimethyl-L-lysine9
Product
[histone H3]-N6-methyl-L-lysine9;
succinate [CPD:C00042];
formaldehyde [CPD:C00067];
CO2 [CPD:C00011];
[histone H3]-N6,N6-dimethyl-L-lysine9
Comment
Requires iron(II). This entry describes a group of enzymes that demethylate N-methylated Lys-9 residues in the tail of the histone protein H3 (H3K9). This lysine residue can exist in three methylation states (mono-, di- and trimethylated), but this group of enzymes only act on the the tri- and di-methylated forms. The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde. cf. EC 1.14.11.65, [histone H3]-dimethyl-L-lysine9 demethylase.
History
EC 1.14.11.66 created 2019
Orthology
K06709  [histone H3]-trimethyl-L-lysine9/36 demethylase
Genes
HSA: 23030(KDM4B) 23081(KDM4C) 390245(KDM4E) 55693(KDM4D) 9682(KDM4A)
PTR: 451494 455614(KDM4B) 456829(KDM4A) 464989(KDM4C) 466754(KDM4D) 466755(KDM4E)
PPS: 100975218(KDM4B) 100979908 100980259(KDM4D) 100981728(KDM4A) 100990982(KDM4C) 100992739
GGO: 101125373(KDM4A) 101132085(KDM4C) 101140323(KDM4D) 101144162 101145208(KDM4B) 115936314(KDM4E)
PON: 100172003(KDM4A) 100433788(KDM4C) 100443182(KDM4D) 100443556(KDM4E) 100449542 100457548(KDM4B)
NLE: 100582140 100586305 100587983 100589019(KDM4A) 100592056(KDM4C) 100597675(KDM4D) 100598260 115830958(KDM4B)
MCC: 695760(KDM4B) 698455(KDM4D) 700412 700765 701272(KDM4A) 715273(KDM4C)
MCF: 101926063(KDM4A) 102125576(KDM4B) 102136790(KDM4C) 102140298 102142534 102144694(KDM4E)
CSAB: 103219465(KDM4C) 103224954(KDM4A) 103233733(KDM4B) 103248265(KDM4D) 103248269 103248270
CATY: 105584066(KDM4C) 105591372(KDM4D) 105591404 105591405(KDM4E) 105591826(KDM4B) 105594628(KDM4A)
PANU: 101010163(KDM4A) 101012323 101015068 101016547(KDM4B) 101024524(KDM4C) 103877825(KDM4E)
TGE: 112605949 112606620 112607616(KDM4C) 112612664(KDM4B) 112617249 112617415 112623689(KDM4A)
RRO: 104657671(KDM4C) 104658622 104660268(KDM4D) 104660270(KDM4E) 104665479(KDM4B) 104669036(KDM4A)
RBB: 108512104(KDM4B) 108518738(KDM4C) 108535690(KDM4A) 108535741
TFN: 117074414(KDM4B) 117079990(KDM4E) 117081234(KDM4D) 117081356 117092724(KDM4A) 117098566(KDM4C)
PTEH: 111521955(KDM4B) 111543284(KDM4C) 111548731(KDM4A) 111551605 111551608 111551624
CJC: 100387524 100388242 100389334(KDM4E) 100391630(KDM4C) 100406442(KDM4B) 100408074(KDM4D) 100411431(KDM4A)
SBQ: 101041165(KDM4B) 101045989(KDM4D) 101046833(KDM4E) 101053425(KDM4C) 101054213(KDM4A)
CSYR: 103250113(KDM4C) 103250367(KDM4B) 103252389 103257016(KDM4A)
MMUR: 105856550(KDM4C) 105869638(KDM4B) 105870628 105877425(KDM4A) 105882851 109730742
LCAT: 123634241(KDM4A) 123636669(KDM4B) 123641994 123642197(KDM4D) 123646647(KDM4C)
OGA: 100942348(KDM4C) 100953181(KDM4D) 100957805(KDM4A) 100962670(KDM4B)
MMU: 193796(Kdm4b) 230674(Kdm4a) 244694(Kdm4d) 76804(Kdm4c)
MCAL: 110291915 110292899(Kdm4c) 110292914(Kdm4a) 110301432 110302014(Kdm4d) 110312705(Kdm4b)
MPAH: 110320880 110322808(Kdm4c) 110323167(Kdm4a) 110327601 110328486(Kdm4d) 110335468(Kdm4b)
RNO: 298144(Kdm4c) 301128(Kdm4b) 313539(Kdm4a) 500944(Kdm4dl2) 689582(Kdm4d)
MCOC: 116072401(Kdm4d) 116072620 116075514(Kdm4b) 116076471 116083577 116096161(Kdm4c) 116096517(Kdm4a)
MUN: 110546245(Kdm4b) 110547533(Kdm4d) 110547551 110552915(Kdm4a) 110565242
CGE: 100753944(Kdm4d) 100756054(Kdm4a) 100767737 100770247(Kdm4b) 100771667(Kdm4c)
MAUA: 101825344(Kdm4b) 101828585(Kdm4d) 101828781 101829374(Kdm4a) 101844032 121135863 121135869
PLEU: 114685005(Kdm4d) 114685107(Kdm4b) 114696302(Kdm4c) 114709349(Kdm4a)
MORG: 121433824(Kdm4c) 121448143(Kdm4a) 121451298 121451299 121451793 121459382(Kdm4b)
AAMP: 119809265 119809266(Kdm4d) 119814865(Kdm4b) 119816352(Kdm4c) 119816789(Kdm4a)
NGI: 103725815 103725819 103725820 103729477(Kdm4c) 103737215(Kdm4b) 103743860(Kdm4a)
HGL: 101698040(Kdm4c) 101698784 101698983 101707641(Kdm4d) 101715237(Kdm4a) 101718659(Kdm4b)
CPOC: 100714222 100715051 100715897 100716465 100719501 100719778(Kdm4d) 100719980(Kdm4c) 100721657 100731064(Kdm4a) 100733163(Kdm4b)
CCAN: 109681563(Kdm4a) 109683599 109687448 109692019(Kdm4b) 109702940
DORD: 105981849 105986181(Kdm4a) 105990459(Kdm4b) 105993221(Kdm4c) 105993925 105993936
DSP: 122099351(Kdm4b) 122105877(Kdm4a) 122113602(Kdm4c) 122120065
NCAR: 124959637 124959638 124960122 124964387 124968364 124984980 124994207
OCU: 100343440(KDM4C) 100346681 100347204 100347458 100347712 100348204(KDM4D) 100353935(KDM4A)
OPI: 101516091(KDM4C) 101523282(KDM4D) 101526192(KDM4B) 101529141(KDM4A)
TUP: 102469253 102481449(KDM4B) 102486046(KDM4A) 102488334(KDM4C) 102492936(KDM4D)
CFA: 474704(KDM4C) 476741(KDM4B) 482530(KDM4A) 485120 485121
VVP: 112914824(KDM4A) 112915836(KDM4D) 112915837 112921978(KDM4C) 112935617(KDM4B)
VLG: 121476210(KDM4D) 121476211 121481112(KDM4A) 121483885 121494540(KDM4B)
AML: 100467443 100473204(KDM4A) 100475996(KDM4C) 100476158 117803347(KDM4D)
UMR: 103660769(KDM4D) 103660770 103662205(KDM4C) 103670808(KDM4A) 103681849(KDM4B)
UAH: 113242850(KDM4B) 113254782(KDM4A) 113259730 113260162(KDM4D) 113260620
UAR: 123781013(KDM4C) 123787887 123787901(KDM4D) 123793797(KDM4A) 123796793(KDM4B)
ELK: 111143010 111154365 111154510 111156570 111161727
LLV: 125079135 125079692 125083144 125087969 125098476
MPUF: 101679772(KDM4C) 101693240(KDM4A) 101693935(KDM4D) 101694210 101694583(KDM4B)
ORO: 101369815(KDM4A) 101369880(KDM4B) 101379678(KDM4D) 101379961 101386926(KDM4C)
EJU: 114212392(KDM4C) 114221556 114221570(KDM4D) 114224188(KDM4A) 114226096(KDM4B)
ZCA: 113913706(KDM4D) 113913707 113917083(KDM4B) 113933950(KDM4A) 113934426(KDM4C)
MLX: 117999076(KDM4C) 118005625 118013525 118013526(KDM4D) 118019520(KDM4A)
FCA: 101081651(KDM4A) 101085402 101091764 101100423(KDM4C) 105259981
PYU: 121020810(KDM4C) 121021328(KDM4B) 121026994(KDM4A)
PBG: 122474669(KDM4C) 122480387(KDM4A) 122483194(KDM4D) 122484222 122486747(KDM4B)
PTG: 102949786(KDM4C) 102950423(KDM4B) 102957193(KDM4D) 102957475 102967856(KDM4A)
PPAD: 109254791(KDM4A) 109255872(KDM4B) 109260118(KDM4C) 109267055 109267056 109267369(KDM4D)
AJU: 106970219(KDM4A) 106975455(KDM4B) 106984309(KDM4C) 106987083 106987092(KDM4D)
HHV: 120220115(KDM4C) 120236043(KDM4A) 120242088(KDM4B) 120247183 120247184 120247192(KDM4D)
BTA: 107133150 508141(KDM4B) 512622(KDM4A) 524768 535671(KDM4C)
BOM: 102273176(KDM4C) 102275589(KDM4D) 102282048(KDM4B) 102284243(KDM4A)
BIU: 109556399(KDM4A) 109561725(KDM4B) 109562475(KDM4C) 109568776 109568777
BBUB: 102390095 102390765(KDM4D) 102392239(KDM4A) 102402037(KDM4C) 102406406(KDM4B)
CHX: 102169067(KDM4A) 102170507(KDM4B) 102175575(KDM4C) 102185583 102185851(KDM4D)
OAS: 101103090 101103347 101110232(KDM4B) 101117992(KDM4C)
ODA: 120856274(KDM4A) 120860208 120863043 120864849(KDM4B)
CCAD: 122437080(KDM4A) 122440262(KDM4B) 122450047 122450048 122452937(KDM4C)
SSC: 100514356 100621904(KDM4A) 100622077(KDM4C) 100627657 100738761(KDM4B)
CFR: 102505483(KDM4C) 102518341(KDM4A) 102523437(KDM4B) 102523511(KDM4D) 102523759
CBAI: 105072711(KDM4A) 105073418(KDM4C) 105078236(KDM4B) 105083591 105083592
CDK: 105090903(KDM4A) 105091754(KDM4B) 105096552(KDM4D) 105098276(KDM4C) 105102910 105106725
VPC: 102526447(KDM4C) 102530022(KDM4B) 102541593(KDM4A)
BACU: 103003061(KDM4C) 103003890(KDM4A) 103011189(KDM4B) 103017228
LVE: 103073873(KDM4B) 103076969(KDM4C) 103079146 103083099(KDM4A) 103090224 103091599
OOR: 101271577 101271823 101272067 101272702(KDM4B) 101278833(KDM4C) 101279102 101282712 101287314 101289051(KDM4A)
DLE: 111166151(KDM4B) 111171036 111171322 111171367 111171369 111171386 111171388 111174667(KDM4C) 111175707(KDM4A)
PCAD: 102986762(KDM4C) 102987474 102990200 102991669(KDM4B) 102992791(KDM4A) 112062047 112062716 112062970 112063148 112066976 112066977 112066979
PSIU: 116750729(KDM4B) 116755446(KDM4C) 116756429(KDM4A) 116757349 116758199 116758301 116758302(KDM4D) 116758311 116758819
ECB: 100053154(KDM4A) 100060699(KDM4C) 100062103(KDM4B) 100067390 100067461
EPZ: 103541685(KDM4B) 103546861 103546874 103557275(KDM4C) 103557419(KDM4A)
EAI: 106827478 106827509 106832335(KDM4B) 106837522(KDM4C) 106847916(KDM4A)
MYB: 102239838 102243828(KDM4B) 102246724 102252195(KDM4A) 102257879(KDM4C) 102261864(KDM4D)
MYD: 102755754 102757566(KDM4B) 102768643(KDM4D) 102769560(KDM4C) 102773056(KDM4A)
MMYO: 118653535 118657732(KDM4B) 118664143 118664144 118664145 118664156 118664498(KDM4D) 118667538(KDM4C) 118675288(KDM4A)
MLF: 102417101 102419795(KDM4A) 102422048 102427537(KDM4D) 102428343(KDM4B) 102433762 102441248 102441553(KDM4C) 102442255 102442569 102442883 102443208
MNA: 107525662(KDM4B) 107526696(KDM4A) 107532354 107532356(KDM4D) 107538119(KDM4C)
PKL: 118712906 118713769 118713771 118716568(KDM4C) 118723805(KDM4A) 118731328(KDM4B)
HAI: 109383414(KDM4A) 109388603(KDM4B) 109390558(KDM4D) 109394570(KDM4C)
DRO: 112302738(KDM4C) 112312675(KDM4B) 112314479(KDM4A) 112317537 112317538
SHON: 118975697(KDM4D) 118984535(KDM4B) 118997639(KDM4C) 119003326(KDM4A)
AJM: 119052354(KDM4A) 119057837(KDM4C) 119062466(KDM4D) 119063818(KDM4B)
PDIC: 114492771(KDM4C) 114496275(KDM4A) 114498818(KDM4D) 114502360(KDM4B)
PHAS: 123805380(KDM4D) 123813722(KDM4B) 123819795(KDM4C) 123831665(KDM4A)
MMF: 118615412(KDM4B) 118626061(KDM4A) 118627839 118627840 118627844 118627847 118629904(KDM4C)
RFQ: 117027200(KDM4A) 117029768 117031319(KDM4D) 117032097(KDM4C) 117037757(KDM4B)
PALE: 102882553(KDM4A) 102892415 102897382(KDM4B) 102899019(KDM4C)
PGIG: 120616059(KDM4C) 120618109 120618129 120619301(KDM4A)
PVP: 105297094(KDM4A) 105297224(KDM4C) 105301061(KDM4B) 105301886(KDM4D)
RAY: 107499501(KDM4A) 107510873(KDM4B) 107517665 107517666(KDM4D) 107519315(KDM4C)
MJV: 108383425 108384259 108384365 108384817 108385055 108385199 108387600 108388388 108389174 108391385(KDM4B) 108392207 108396482 108397151 108401722(KDM4A)
TOD: 119231990(KDM4C) 119237202(KDM4A) 119240282 119240604(KDM4B)
SARA: 101538917(KDM4A) 101553031(KDM4C) 101555622(KDM4D) 101556022(KDM4B)
LAV: 100666311(KDM4B) 100668190(KDM4A) 100673362(KDM4C) 100674739(KDM4D) 100675306 100675588 100675872 100676158
TMU: 101340534 101341303 101346944 101347201 101357303
DNM: 101436329(KDM4B) 101438363(KDM4A) 101442459
MDO: 100018628(KDM4C) 100023921(KDM4B) 100025487(KDM4A)
GAS: 123242851(KDM4B) 123243614(KDM4A) 123248392(KDM4C)
SHR: 100920302(KDM4A) 100923927(KDM4B) 100930851(KDM4C)
PCW: 110197484(KDM4B) 110200215(KDM4A) 110221590(KDM4C)
OAA: 100077514(KDM4B) 100077720(KDM4A) 100681304(KDM4C)
GGA: 424571(KDM4A) 427231(KDM4C) 428354(KDM4B)
PCOC: 116233828(KDM4A) 116235672(KDM4B) 116237181(KDM4C)
MGP: 100541123(KDM4B) 100544296(KDM4A) 100550263
CJO: 107306117 107306118 107317431(KDM4A) 107325397(KDM4B)
NMEL: 110389067(KDM4B) 110389566(KDM4C) 110402235(KDM4A)
APLA: 101791399(KDM4C) 101799328(KDM4B) 101803199(KDM4A)
ACYG: 106034076(KDM4A) 106044969(KDM4B) 106046383(KDM4C)
AFUL: 116491788(KDM4A) 116499008(KDM4B) 116500894(KDM4C)
TGU: 100219686(KDM4C) 100224169(KDM4A) 100225201(KDM4B)
LSR: 110469429(KDM4A) 110471241(KDM4C) 110477880(KDM4B)
SCAN: 103814958(KDM4A) 103819525(KDM4C) 103822070(KDM4B)
PMOA: 120503198(KDM4A) 120511993(KDM4C) 120513796(KDM4B)
OTC: 121332014(KDM4C) 121345033(KDM4A) 121346874(KDM4B)
PRUF: 121349894(KDM4B) 121362157(KDM4A) 121363667(KDM4C)
GFR: 102032085(KDM4B) 102039020(KDM4C) 102043301(KDM4A)
FAB: 101806204(KDM4B) 101811297(KDM4C) 101813754(KDM4A)
PHI: 102104087(KDM4A) 102109112(KDM4C) 102109691(KDM4B)
PMAJ: 107208042(KDM4A) 107215441(KDM4B) 107215920(KDM4C)
CCAE: 111933144(KDM4A) 111940625(KDM4C)
CCW: 104685185(KDM4C) 104695543(KDM4A)
ETL: 114056133(KDM4C) 114066015(KDM4A) 114067900(KDM4B)
ZAB: 102060546(KDM4A) 102062140(KDM4B) 102073064(KDM4C)
FPG: 101912991(KDM4B) 101916030(KDM4A) 101918182(KDM4C)
FCH: 102046078(KDM4B) 102047870 102048418(KDM4A)
CLV: 102091977(KDM4A) 102092770(KDM4B) 102093362(KDM4C)
EGZ: 104124361(KDM4B) 104125526(KDM4A) 104125755(KDM4C)
NNI: 104015560(KDM4A) 104018736(KDM4B) 104021360(KDM4C)
PLET: 104626228(KDM4A)
ACUN: 113482983(KDM4A) 113489346(KDM4B) 113490378(KDM4C)
TALA: 104358325(KDM4A) 104361174(KDM4B) 104364906(KDM4C)
PADL: 103912179(KDM4B) 103920347(KDM4C) 103924079(KDM4A)
ACHC: 115336799(KDM4C) 115348973(KDM4A) 115349009(KDM4B)
AAM: 106484490(KDM4B) 106484929(KDM4A) 106496770(KDM4C)
AROW: 112966724(KDM4B) 112974541(KDM4C) 112976002(KDM4A)
NPD: 112942390(KDM4A) 112943892(KDM4B) 112947585(KDM4C)
DNE: 112981254(KDM4A) 112981665(KDM4C) 112986585(KDM4B)
ASN: 102368582(KDM4B) 102377299(KDM4A) 102383020(KDM4C)
AMJ: 102571128(KDM4A) 106737064(KDM4C)
CPOO: 109307388(KDM4A) 109320455(KDM4B) 109323501(KDM4C)
GGN: 109286753(KDM4A) 109294889(KDM4B) 109297648(KDM4C)
PSS: 102450770(KDM4C) 102458937(KDM4B) 102459587(KDM4A)
CMY: 102933803(KDM4C) 102937272(KDM4A) 102947631(KDM4B)
CPIC: 101943254(KDM4A) 101952792(KDM4B) 101953431(KDM4C)
TST: 117869062(KDM4B) 117878874(KDM4C) 117881338(KDM4A)
CABI: 116816675(KDM4A) 116823100(KDM4B) 116838317
MRV: 120370157(KDM4A) 120391881(KDM4B) 120407934(KDM4C)
ACS: 100551717(kdm4c) 100563051(kdm4b) 100566487(kdm4a)
PVT: 110073730(KDM4A) 110079264(KDM4B) 110088211(KDM4C)
SUND: 121922302(KDM4C) 121928493(KDM4A) 121936816(KDM4B)
PBI: 103049044(KDM4A) 103054441 103066528
PMUR: 107283446(KDM4A) 107299130(KDM4C)
TSR: 106540806(KDM4C) 106542258(KDM4A) 106555958
PGUT: 117661503(KDM4C) 117664095(KDM4A) 117668653(KDM4B)
VKO: 123016849(KDM4B) 123029584(KDM4A) 123031292(KDM4C)
PMUA: 114588176(KDM4C) 114588484(KDM4B) 114599133(KDM4A)
ZVI: 118086977(KDM4B) 118088512(KDM4A) 118097712(KDM4C)
GJA: 107109527(KDM4A) 107113915 107116117(KDM4C)
STOW: 125432792 125432868(KDM4A) 125436444(KDM4C)
XLA: 108706953(kdm4c.S) 108711800 108714164(kdm4c.L) 108714257 108715546
XTR: 100127653(kdm4c) 100135350(kdm4a) 394661(kdm4b)
NPR: 108789047(KDM4A) 108793106(KDM4C) 108796480
RTEM: 120911530(KDM4B) 120943954(KDM4C) 120946124(KDM4A)
BBUF: 120979224(KDM4A) 120989553(KDM4B) 120990876(KDM4C)
BGAR: 122922079(KDM4C) 122943405(KDM4A) 122946832(KDM4B)
DRE: 100003413(kdm4aa) 334347(kdm4ab) 556504(kdm4b) 570194(kdm4c)
SRX: 107709085 107709452 107717157 107742799 107743373 107746607(kdm4a) 107750465
SANH: 107655842 107660208 107672666 107679073 107684932 107686767(kdm4a) 107700543 107702398
SGH: 107548355 107549366 107551714 107554885 107561592 107564389 107570226 107582316(kdm4a)
CCAR: 109057546 109087276 109095593 109103532 109112889
CAUA: 113039306 113044246 113045633 113050981 113074103 113091117 113107063 113114707
PPRM: 120467918(kdm4aa) 120482386(kdm4ab) 120486825(kdm4b) 120494003(kdm4c)
MAMB: 125250555(kdm4ab) 125263268(kdm4b) 125272636(kdm4c) 125274096(kdm4aa)
IPU: 108260706(kdm4c) 108271011(kdm4b) 108271783(kdm4aa) 108280529(kdm4ab)
PHYP: 113532166(kdm4a) 113546355 113547365
SMEO: 124381343(kdm4c) 124384496(kdm4aa) 124384508 124390962(kdm4b) 124402876(kdm4ab)
TFD: 113635466(kdm4c) 113642795(kdm4aa) 113650124(kdm4ab) 113651005(kdm4b)
AMEX: 103024587 103028415 103030117(kdm4b) 103036954(kdm4a)
EEE: 113586630 113587659 113591480
TRU: 101062865(kdm4a) 101065945 101079555 101079781
TNG: GSTEN00006759G001 GSTEN00008260G001 GSTEN00019108G001 GSTEN00020884G001
LCO: 104920951 104927963 104935856 104940289(kdm4a)
NCC: 104954834 104957901 104961001 104968022
CGOB: 115006766(kdm4a) 115006866 115022114
ELY: 117253728 117253924(kdm4b) 117255204(kdm4c) 117271868(kdm4ab)
PLEP: 121941891(kdm4c) 121951041(kdm4ab) 121962464(kdm4aa) 121963299(kdm4b)
SLUC: 116037303 116040537(kdm4c) 116055295(kdm4b) 116058787(kdm4aa)
ECRA: 117950241(kdm4b) 117950869(kdm4aa) 117954076 117956998(kdm4c)
PFLV: 114561239(kdm4a) 114561331 114565234 114565613
GAT: 120815761(kdm4ab) 120823482(kdm4aa) 120823488(kdm4b) 120825047(kdm4c)
PPUG: 119209446(kdm4ab) 119216457(kdm4b) 119216579(kdm4aa) 119217651(kdm4c)
MSAM: 119899132(kdm4c) 119900546(kdm4b) 119901274(kdm4aa) 119902256
CUD: 121508226(kdm4c) 121512130 121512267(kdm4b) 121519968(kdm4ab)
ALAT: 119010812(kdm4ab) 119019429(kdm4c) 119028142(kdm4b) 119028462(kdm4aa)
MZE: 101464060(kdm4a) 101472369 101476674 101479851
ONL: 100694970(kdm4a) 100696578 100703178 100707211
OAU: 116314387 116325949(kdm4c) 116328455(kdm4b) 116333101
OLA: 101157850(kdm4a) 101162552 101165696 101173928
OML: 112136987 112147513(kdm4ab) 112150551(kdm4b) 112157128(kdm4c)
XMA: 102223593 102226356(kdm4a) 102228201 102235480
XCO: 114145442 114146733 114150374(kdm4a) 114151024
XHE: 116719793 116721826 116725857 116726038(kdm4a)
PRET: 103463436 103464194(kdm4a) 103468987 103479142
PFOR: 103129976 103130570 103137779 103153021
PLAI: 106937923 106941336 106954381 106965011
PMEI: 106907892 106909736 106914031 106918705
GAF: 122829486(kdm4c) 122838043 122839191(kdm4b) 122841334
CVG: 107093321 107094195(kdm4c) 107101563 107102789
CTUL: 119773122(kdm4ab) 119777557(kdm4aa) 119786768(kdm4c) 119787650(kdm4b)
GMU: 124868097(kdm4c) 124869807(kdm4ab) 124873606(kdm4aa) 124874091(kdm4b)
NFU: 107382182 107387334(kdm4a) 107392781 107396931
KMR: 108234360(kdm4b) 108241538(kdm4c) 108244846(kdm4ab) 108248745
ALIM: 106517316(kdm4a) 106519213 106531977 106532529
NWH: 119407438(kdm4aa) 119430591(kdm4b) 119430793(kdm4c)
AOCE: 111567014 111569806 111570592 111576552 111588723(kdm4a)
CSEM: 103383764 103395594 103395858 103399834
POV: 109625784(kdm4a) 109636650 109637823 109644379
SSEN: 122760331(kdm4c) 122774108(kdm4ab) 122780731(kdm4b) 122780743
HHIP: 117760217(kdm4b) 117760759(kdm4aa) 117768091(kdm4c) 117777871
HSP: 118118157 118119713(kdm4c) 118120900(kdm4aa) 118120949(kdm4b)
LCF: 108881199 108883687 108896426 108896968
SDU: 111228865 111230935 111231525 111231819
SLAL: 111664525 111670000 111671099 111671105 111671721
XGL: 120790564(kdm4b) 120790837(kdm4aa) 120798838 120800514(kdm4c)
HCQ: 109511129(kdm4c) 109518926 109519046 109524769(kdm4a)
BPEC: 110160143 110172611 110174785 110175075
MALB: 109958225 109958391 109969323 109972172(kdm4a)
BSPL: 114845168(kdm4ab) 114845475(kdm4c) 114853228(kdm4b) 114853781(kdm4aa)
SASA: 101448002(jhd3b) 106560339(kdm4a) 106568967 106574093 106584183 106593555 106598949
OTW: 112227083 112241534 112249956 112250624 112251284 112252020 112260288 121844686
OMY: 110508930 110521735 110523012 110524025(kdm4b) 110530113 110533913 110534600 110534602
OGO: 123996745 123997156 123997424 124009481 124018471 124018474 124024355 124037910 124042029
ONE: 115103267 115108071 115114195 115116421 115145198(kdm4a)
SALP: 111952686 111956820 111972383 111975437 111975683 111979262
SNH: 120020496 120036026 120052623 120053638 120054617 120055013 120055789
ELS: 105011321 105011874(kdm4a) 105020859 105024530
SFM: 108921450 108923844(kdm4a) 108925733 108940292
PKI: 111841055 111846045(kdm4a) 111853103 111860286
AANG: 118225589(kdm4aa) 118226166(kdm4b) 118227811 118229261 118229950(kdm4ab) 118231574
LOC: 102684122(kdm4c) 102684738(kdm4a) 102691840(kdm4b)
PSPA: 121300710 121301427 121322183(kdm4c) 121326722 121331029
ARUT: 117401447 117412169(kdm4ab) 117417234 117420863(kdm4c) 117962785
LCM: 102348735(KDM4B) 102351941(KDM4A) 102355951(KDM4C) 102365533
CMK: 103174610(kdm4aa) 103183550 103185468
RTP: 109931349(kdm4a) 109935489
BFO: 118431545 118431680
BBEL: 109483524
CIN: 100180205
SCLV: 120339886
SPU: 579470
APLC: 110985312
SKO: 100329036(Jmjd2c)
DME: Dmel_CG15835(Kdm4A) Dmel_CG33182(Kdm4B)
DER: 6542450 6549529
DSE: 6608077 6608952
DSI: Dsimw501_GD10212(Dsim_GD10212) Dsimw501_GD25786(Dsim_GD25786)
DYA: Dyak_GE13392 Dyak_GE23530
DAN: 6494095 6495811
DSR: 110182943 110189741
DPO: Dpse_GA13980 Dpse_GA24867
DPE: 6590467 6593251
DMN: 108158417 108159911 117192612 117193057
DWI: 6640217 6640402
DMO: Dmoj_GI18397 Dmoj_GI19732
DAZ: 108616129 108616911
DNV: 108652908 108655193
DHE: 111592178 111599885
DVI: 116649760 6635881
CCAT: 101449026
BOD: 106618308
MDE: 101897367 105261423
SCAC: 106092188
LCQ: 111682389 111682507
LSQ: 119600122
AGA: AgaP_AGAP006770 AgaP_AGAP011180
ACOZ: 120949773 120955750
AARA: 120900965
ASTE: 118503453
AAG: 5570368 5570369 5573483
AALB: 109420413 109423314 115253807
CQU: CpipJ_CPIJ011492 CpipJ_CPIJ019459
CPII: 120419771 120421676 120426404
CNS: 116340967
BCOO: 119072359
AME: 726918
ACER: 108001800
ALAB: 122716894
BIM: 100748259
BBIF: 117209016
BVK: 117233741
BVAN: 117160662
BTER: 100648978
BPYO: 122569752
CCAL: 108628463
OBB: 114871125
MGEN: 117223629
NMEA: 116424368
CGIG: 122395321
SOC: 105200259 105200531
MPHA: 105828504
AEC: 105143816
ACEP: 105626723
PBAR: 105432945
VEM: 105564383
HST: 105181802
DQU: 106750795
CFO: 105259589
FEX: 115242226
LHU: 105675397
PGC: 109853913
OBO: 105279628
PCF: 106792706
PFUC: 122513242 122524515
VPS: 122636998
NVI: 100124275
CSOL: 105362294
TPRE: 106659068
MDL: 103580058
CGLO: 123260280
FAS: 105272705
DAM: 107044997
AGIF: 122858610
CCIN: 107266333
TCA: 663231
DPA: 109537663 109537703
SOY: 115881741
ATD: 109602433
CSET: 123319837
AGB: 108903335
LDC: 111506467
NVL: 108557278
APLN: 108744991
PPYR: 116160982
OTU: 111418179
BMOR: 100862759
BMAN: 114251842
MSEX: 115449860
DPL: KGM_205374
BANY: 112051136
PMAC: 106709641
PPOT: 106103890
PXU: 106114717
PRAP: 123690325
ZCE: 119838999
HAW: 110382356
TNL: 113505720
SLIU: 111351292
OFU: 114366678
PXY: 105381747 105398781
API: 100158707 100159325 100160843 100164196 100164740 100168352 100568744 100574318 115034470
DNX: 107161984
AGS: 114123066
RMD: 113553978
BTAB: 109031137 109032431 109040681 109042941 109044412
CLEC: 106674420
HHAL: 106686277
NLU: 111062309
PHU: Phum_PHUM157200
FOC: 113201878 113204974 113211289
TPAL: 117639629 117647170 117647906 117648058 117648070 117648196 117651144 117652952 117653296 117653339 117653540
ZNE: 110833525
CSEC: 111862537
FCD: 110859986 110860980
DPX: DAPPUDRAFT_113278 DAPPUDRAFT_114527 DAPPUDRAFT_119490 DAPPUDRAFT_125559 DAPPUDRAFT_247944 DAPPUDRAFT_261496 DAPPUDRAFT_266513 DAPPUDRAFT_302100 DAPPUDRAFT_319039 DAPPUDRAFT_325610 DAPPUDRAFT_330275 DAPPUDRAFT_48413
DMK: 116924666
PVM: 113816835 113816836
PJA: 122262743
HAME: 121877084
PCLA: 123754421
PTRU: 123513473
HAZT: 108668297 108681101
EAF: 111697009 111707520
LSM: 121114587 121121739
PPOI: 119108101
ISC: IscW_ISCW019624
DSV: 119433581
RSAN: 119404698
RMP: 119180681
VDE: 111244235
VJA: 111266313
TUT: 107361997
DPTE: 113788484
DFR: 124496111
CSCU: 111630375 111630378 111636353
PTEP: 107442880
SDM: 118200983
CEL: CELE_Y48B6A.11(jmjd-2)
CBR: CBG_20662(Cbr-jmjd-2)
BMY: BM_BM6641(Bma-jmjd-2)
LOA: LOAG_16735
HRO: HELRODRAFT_111100 HELRODRAFT_132346 HELRODRAFT_80169
LGI: LOTGIDRAFT_121093
PCAN: 112573289
BGT: 106060082
GAE: 121373905
HRF: 124140527
HRJ: 124263971
MYI: 110456629
PMAX: 117325525
OBI: 106883456
LAK: 106150433
SMM: Smp_132170
OVI: T265_00193
EGL: EGR_02504
NVE: 116614163
EPA: 110232595
ATEN: 116292955
ADF: 107335219
AMIL: 114952836
PDAM: 113674402
SPIS: 111325663
DGT: 114516485
HMG: 100210028
TAD: TRIADDRAFT_27796
CRE: CHLRE_02g078700v5 CHLRE_17g709550v5
VCN: VOLCADRAFT_65316 VOLCADRAFT_91971
CSL: COCSUDRAFT_67911
CVR: CHLNCDRAFT_137990 CHLNCDRAFT_21253
APRO: F751_2217
BPG: Bathy14g02600
MIS: MICPUN_61256
MPP: MICPUCDRAFT_59528
PPEI: PpBr36_05771
TRE: TRIREDRAFT_38781
TRR: M419DRAFT_47915
MBR: MONBRDRAFT_27628
SRE: PTSG_08936
PTM: GSPATT00023881001 GSPATT00033659001 GSPATT00034535001 GSPATT00035495001
FCY: FRACYDRAFT_237169
TPS: THAPSDRAFT_22122
SPAR: SPRG_04576
EHX: EMIHUDRAFT_462882
GTT: GUITHDRAFT_65602 GUITHDRAFT_66646
NGR: NAEGRDRAFT_80626
 » show all
Reference
1  [PMID:16732293]
  Authors
Cloos PA, Christensen J, Agger K, Maiolica A, Rappsilber J, Antal T, Hansen KH, Helin K
  Title
The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3.
  Journal
Nature 442:307-11 (2006)
DOI:10.1038/nature04837
  Sequence
[hsa:23081]
Reference
2  [PMID:16738407]
  Authors
Fodor BD, Kubicek S, Yonezawa M, O'Sullivan RJ, Sengupta R, Perez-Burgos L, Opravil S, Mechtler K, Schotta G, Jenuwein T
  Title
Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells.
  Journal
Genes Dev 20:1557-62 (2006)
DOI:10.1101/gad.388206
  Sequence
[mmu:193796]
Reference
3  [PMID:16732292]
  Authors
Klose RJ, Yamane K, Bae Y, Zhang D, Erdjument-Bromage H, Tempst P, Wong J, Zhang Y
  Title
The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36.
  Journal
Nature 442:312-6 (2006)
DOI:10.1038/nature04853
  Sequence
[hsa:9682]
Reference
4  [PMID:16603238]
  Authors
Whetstine JR, Nottke A, Lan F, Huarte M, Smolikov S, Chen Z, Spooner E, Li E, Zhang G, Colaiacovo M, Shi Y
  Title
Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases.
  Journal
Cell 125:467-81 (2006)
DOI:10.1016/j.cell.2006.03.028
  Sequence
[hsa:9682 23030 23081 55693] [cel:CELE_Y48B6A.11]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.66
IUBMB Enzyme Nomenclature: 1.14.11.66
ExPASy - ENZYME nomenclature database: 1.14.11.66
BRENDA, the Enzyme Database: 1.14.11.66

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