EC               Enzyme                                 

[histone H3]-trimethyl-L-lysine4 demethylase;
KDM5A (gene name);
KDM5B (gene name);
KDM5C (gene name);
KDM5D (gene name);
JARID1A (gene name)
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
[histone H3]-N6,N6,N6-trimethyl-L-lysine4,2-oxoglutarate:oxygen oxidoreductase
a [histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 3 2-oxoglutarate + 3 O2 = a [histone H3]-L-lysine4 + 3 succinate + 3 formaldehyde + 3 CO2 (overall reaction) [RN:R12461];
(1a) a [histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2 = a [histone H3]-N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2 [RN:R12460];
(1b) a [histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2 = a [histone H3]-N6-methyl-L-lysine4 + succinate + formaldehyde + CO2 [RN:R09510];
(1c) a [histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2 = a [histone H3]-L-lysine4 + succinate + formaldehyde + CO2 [RN:R09511]
[histone H3]-N6,N6,N6-trimethyl-L-lysine4;
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007];
[histone H3]-N6,N6-dimethyl-L-lysine4;
[histone H3]-N6-methyl-L-lysine4
[histone H3]-L-lysine4;
succinate [CPD:C00042];
formaldehyde [CPD:C00067];
CO2 [CPD:C00011];
[histone H3]-N6,N6-dimethyl-L-lysine4;
[histone H3]-N6-methyl-L-lysine4
Requires iron(II). This entry describes a group of enzymes that demethylate N-methylated L-lysine residues at position 4 of histone H3 (H3K4). The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde. They can act on tri-, di-, and mono-methylated forms.
EC created 2019
K11446  [histone H3]-trimethyl-L-lysine4 demethylase
HSA: 10765(KDM5B) 5927(KDM5A) 8242(KDM5C) 8284(KDM5D)
PTR: 449032(KDM5D) 451737(KDM5A) 457630(KDM5B) 744380(KDM5C)
PPS: 100969555(KDM5B) 100970129(KDM5C) 100980071(KDM5A)
GGO: 101127412(KDM5C) 101149215(KDM5A) 101153769(KDM5B)
PON: 100172643(KDM5C) 100434572(KDM5A) 100450767(KDM5B)
NLE: 100590577(KDM5C) 100591974(KDM5B) 100593603(KDM5A)
MCC: 100270697(KDM5D) 106992262(KDM5C) 706437(KDM5B) 721599(KDM5A)
MCF: 102118086(KDM5C) 102126562(KDM5B) 102140751(KDM5A)
CSAB: 103218353(KDM5A) 103230303(KDM5B) 103232010(KDM5C) 103246987(KDM5D)
RRO: 104658712(KDM5D) 104663374(KDM5C) 104672250(KDM5A) 104674506(KDM5B)
SBQ: 101040986(KDM5C) 101053880(KDM5A) 101054224(KDM5B)
MMU: 20591(Kdm5c) 20592(Kdm5d) 214899(Kdm5a) 75605(Kdm5b)
MCAL: 110286928(Kdm5c) 110295764(Kdm5a) 110304747(Kdm5b)
MPAH: 110313472(Kdm5c) 110316599(Kdm5a) 110322297(Kdm5b)
RNO: 100312983(Kdm5d) 304809(Kdm5b) 312678(Kdm5a) 317432(Kdm5c)
MUN: 110546054(Kdm5a) 110546738(Kdm5b) 110566279(Kdm5c) 110566475
CGE: 100757111(Kdm5a) 100758549(Kdm5c) 100761435(Kdm5b)
NGI: 103731840(Kdm5b) 103739366(Kdm5a) 103747323(Kdm5c)
HGL: 101697034(Kdm5a) 101709640(Kdm5c) 101711865(Kdm5b)
OCU: 100341721(KDM5C) 100351408(KDM5A) 100356218(KDM5B)
TUP: 102477639(KDM5B) 102483934(KDM5C) 102494185(KDM5A) 102494379
CFA: 477727(KDM5A) 479999(KDM5B) 491894(KDM5C)
VVP: 112911956(KDM5C) 112911964 112917407(KDM5A) 112934568(KDM5B)
AML: 100476032(KDM5A) 100483283(KDM5B) 100484551(KDM5C)
ORO: 101370942(KDM5B) 101371710(KDM5C) 101372331(KDM5A) 101375635
FCA: 101087846(KDM5A) 101091600(KDM5C) 101101609(KDM5B)
PTG: 102953605(KDM5B) 102957240(KDM5C) 102962286(KDM5A) 102965571
PPAD: 109256462(KDM5B) 109260277(KDM5C) 109276231(KDM5A)
AJU: 106965399(KDM5A) 106974127(KDM5B) 106985380(KDM5C) 106989091
BTA: 281490(KDM5C) 507962(KDM5A) 540633(KDM5B)
BOM: 102271619(KDM5A) 102276246(KDM5B) 102285874(KDM5C)
BIU: 109555159(KDM5C) 109559764(KDM5A) 109570476(KDM5B)
BBUB: 102393119(KDM5A) 102405105(KDM5C) 102408415(KDM5B)
CHX: 102178381(KDM5B) 102183856(KDM5A) 102185641(KDM5C)
OAS: 101110351(KDM5B) 101115023(KDM5A) 101121317(KDM5C)
SSC: 100037295(KDM5C) 100294704(KDM5A) 102163404(KDM5B) 110257883
CFR: 102504875(KDM5B) 102505415(KDM5C) 102519291 102520574(KDM5A) 102523369
CDK: 105096692(KDM5C) 105102938(KDM5A) 105105928(KDM5B)
BACU: 103009652(KDM5D) 103009914(KDM5B) 103010727(KDM5A) 103011953(KDM5C)
LVE: 103072576(KDM5B) 103083652(KDM5A) 103088289(KDM5C)
OOR: 101270071(KDM5A) 101271172(KDM5C) 101288712(KDM5B)
DLE: 111168309(KDM5B) 111170781(KDM5C) 111176614(KDM5A)
PCAD: 102983382(KDM5B) 102988928(KDM5A) 102992593(KDM5C)
ECB: 100034190(KDM5C) 100056935(KDM5A) 100064707(KDM5B)
EAI: 106827754(KDM5C) 106831523(KDM5A) 106836255 106840227(KDM5B)
MYD: 102752699(KDM5A) 102762785(KDM5B) 102775396(KDM5C)
MNA: 107536012(KDM5B) 107542357(KDM5C) 107542684 107546447(KDM5A)
HAI: 109380463(KDM5B) 109388945(KDM5A) 109396384(KDM5C)
DRO: 112310318 112311208(KDM5A) 112318809(KDM5B) 112322361(KDM5C)
PALE: 102878118(KDM5A) 102882705(KDM5B) 102883012(KDM5C) 102887656
RAY: 107502986(KDM5B) 107503761(KDM5C) 107505201 107506898 107509747(KDM5A)
MJV: 108384283(KDM5C) 108396319(KDM5B) 108399069(KDM5A)
LAV: 100660048(KDM5C) 100665887(KDM5A) 100675094(KDM5B)
MDO: 100011885(KDM5B) 100020718(KDM5A) 100379644(KDM5C)
SHR: 100915015 100920680(KDM5C) 100921713(KDM5A) 100925521(KDM5B) 100931322(HNRNPU)
PCW: 110201022 110218651(KDM5A) 110219561(KDM5B)
OAA: 100075501(KDM5C) 100077577(KDM5B) 100080164(KDM5A)
GGA: 418148(KDM5A) 421168(KDM5B)
MGP: 100543349 100548982(KDM5B)
CJO: 107307756 107315373(KDM5A) 107324646(KDM5B)
NMEL: 110388134(KDM5B) 110398370(KDM5A)
APLA: 101790186 101794048(KDM5A) 101802603(KDM5B)
ACYG: 106030948(KDM5A) 106045876(KDM5B)
TGU: 100220128(KDM5B) 100226987(KDM5A) 101233075
LSR: 110469157(KDM5B) 110472936(KDM5A) 110482321
SCAN: 103820453(KDM5A) 103822358(KDM5B)
GFR: 102036569 102036946(KDM5B) 102042789(KDM5A)
FAB: 101810162(KDM5A) 101819778(KDM5B)
PHI: 102102154(KDM5B) 102104485(KDM5A) 102111304(KDM5C)
PMAJ: 107199412 107204784(KDM5A) 107214918(KDM5B)
CCAE: 111927901(KDM5A) 111939719(KDM5B)
CCW: 104692233(KDM5A) 104692454(KDM5B)
ETL: 114064760(KDM5B) 114069392(KDM5A)
FPG: 101914016(KDM5B) 101916107(KDM5A) 101921902(KDM5C)
FCH: 102046513(KDM5C) 102048054(KDM5B) 102049474(KDM5A)
CLV: 102091315(KDM5B) 102094750 102097139(KDM5A)
EGZ: 104122023(KDM5B) 104129750(KDM5A)
NNI: 104009118 104011099(KDM5B) 104020219(KDM5A)
ACUN: 113488968(KDM5B) 113491464(KDM5A)
PADL: 103913826(KDM5B) 103924376(KDM5A)
AAM: 106488690(KDM5A) 106493906 106500239(KDM5B)
AMJ: 102562466(KDM5C) 102563181(KDM5B) 106736739(KDM5A)
CMY: 102934613(KDM5B) 102937991(KDM5A)
CPIC: 101937175 101942004(KDM5B) 101948551(KDM5A) 101952359(KDM5C)
ACS: 100562154(kdm5a) 100562356(kdm5b) 100565551(kdm5c)
PVT: 110073373(KDM5B) 110076663(KDM5A) 110078625(KDM5C)
PBI: 103057421(KDM5C) 103064844(KDM5A) 103067839(KDM5B) 103067939
PMUR: 107285905(KDM5A) 107287109(KDM5B) 107289352(KDM5C)
PMUA: 114587654(KDM5C) 114599455(KDM5B) 114605015(KDM5A)
GJA: 107105528 107107867(KDM5B) 107120238(KDM5A)
XLA: 108699964(kdm5c.S) 108704489(kdm5c.L) 108704575 108708118 108709501(kdm5b.S) 108712258
XTR: 100488170(kdm5b) 100492348(kdm5a) 780176(kdm5c)
NPR: 108787373(KDM5B) 108788900(KDM5C) 108804616(KDM5A)
DRE: 100333310(kdm5a) 327168(kdm5ba) 415256(kdm5bb) 553406(kdm5c)
IPU: 108254769 108265475 108265643(kdm5bb) 108279764(kdm5a)
PRET: 103459510(kdm5a) 103465305 103467711(kdm5c) 103467750
ALIM: 106513272(kdm5b) 106519344 106521815(kdm5a) 106527724
AOCE: 111572088 111573173(kdm5a) 111579740 111580302(kdm5c)
SLAL: 111651986(kdm5a) 111654193(kdm5c) 111661918 111667789
HCQ: 109512943(kdm5c) 109522375(kdm5b) 109526864 109530074(kdm5a)
BPEC: 110164505 110164696(kdm5c) 110164872(kdm5a) 110171262
MALB: 109956240 109960867(kdm5a) 109966708(kdm5c) 109970307
LCM: 102354446 102357112(KDM5A) 102367371(KDM5B)
CMK: 103181874(kdm5a) 103190333(kdm5b)
CIN: 778759
SPU: 578457
APLC: 110974950
SKO: 100376922
DME: Dmel_CG9088(lid)
DER: 6540673
DSI: Dsimw501_GD22616(Dsim_GD22616)
DSR: 110185577
DPE: 6589743
DMN: 108162737
DWI: 6642661
DAZ: 108610621
DNV: 108649376
DHE: 111602297
MDE: 101900476
LCQ: 111679656
AAG: 5574390
AME: 410874
BIM: 100744731
BTER: 100648929
CCAL: 108623075
OBB: 114883217
SOC: 105204666
MPHA: 105837910
AEC: 105145222
ACEP: 105617083
PBAR: 105423324
VEM: 105565846
HST: 105181157
DQU: 106746492
CFO: 105258084
LHU: 105671686
PGC: 109852955
OBO: 105285592
PCF: 106787082
NVI: 100120294(KDM5A)
CSOL: 105359430
MDL: 103569442
TCA: 103314648
DPA: 109540983
ATD: 109598089
NVL: 108567195
API: 100163705
DNX: 107174064
AGS: 114123745
RMD: 113550660
BTAB: 109034748
ZNE: 110834947
PVM: 113822739
DPTE: 113795667
CSCU: 111633283
PTEP: 107441111
CEL: CELE_ZK593.4(rbr-2)
CBR: CBG05959(Cbr-rbr-2)
BMY: Bm1_31510
TSP: Tsp_06137
PCAN: 112571484
CRG: 105342266
OBI: 106868491
EPA: 110247338
AMIL: 114969044
PDAM: 113683111
SPIS: 111339408
DGT: 114521659
HMG: 100214586(kdm5a)
AQU: 100639023
ATH: AT1G08620(PKDM7D) AT1G30810(JMJ18) AT1G63490 AT2G34880(MEE27) AT2G38950 AT4G20400(JMJ14)
LJA: Lj0g3v0258129.1(Lj0g3v0258129.1) Lj0g3v0287519.1(Lj0g3v0287519.1) Lj1g3v4515430.1(Lj1g3v4515430.1) Lj2g3v2017660.2(Lj2g3v2017660.2) Lj2g3v2017660.3(Lj2g3v2017660.3) Lj5g3v1265040.1(Lj5g3v1265040.1) Lj6g3v1116100.1(Lj6g3v1116100.1)
DOSA: Os03t0151300-01(Os03g0151300) Os05t0196500-01(Os05g0196500) Os05t0302300-01(Os05g0302300) Os06t0731600-00(Os06g0731600)
ATS: 109742693(LOC109742693) 109777849(LOC109777849) 109783037(LOC109783037)
ERC: Ecym_7196
KMX: KLMA_60433(JHD2)
NCS: NCAS_0H00320(NCAS0H00320)
NDI: NDAI_0D00270(NDAI0D00270)
TPF: TPHA_0E00310(TPHA0E00310)
TBL: TBLA_0J00310(TBLA0J00310)
TDL: TDEL_0H00660(TDEL0H00660)
KAF: KAFR_0A03230(KAFR0A03230)
PIC: PICST_88926(RBP2)
CAL: CAALFM_C400260WA(CaO19.5651)
SLB: AWJ20_4593 AWJ20_4594(ECM5) AWJ20_714(JHD2)
NCR: NCU01238
MGR: MGG_04878
SSCK: SPSK_08278
MAW: MAC_04053
MAJ: MAA_01434
CMT: CCM_07966
BFU: BCIN_02g00190(Bcecm5)
MBE: MBM_08533
ANI: AN8211.2
ANG: ANI_1_734084(An09g05800)
ABE: ARB_06850
TVE: TRV_05239
PTE: PTT_07707
SPO: SPAC343.11c(msc1) SPBP19A11.06(lid2)
CNE: CND05870
LBC: LACBIDRAFT_311495(JMJ16202)
MGL: MGL_2159
MRT: MRET_0349
DDI: DDB_G0268778(rbbB)
DFA: DFA_11947(rbbB)
TGO: TGME49_307010(JMJC1)
 » show all
1  [PMID:17310255]
Seward DJ, Cubberley G, Kim S, Schonewald M, Zhang L, Tripet B, Bentley DL
Demethylation of trimethylated histone H3 Lys4 in vivo by JARID1 JmjC proteins.
Nat Struct Mol Biol 14:240-2 (2007)
[sce:YJR119C] [mmu:75605]
2  [PMID:17320163]
Klose RJ, Yan Q, Tothova Z, Yamane K, Erdjument-Bromage H, Tempst P, Gilliland DG, Zhang Y, Kaelin WG Jr
The retinoblastoma binding protein RBP2 is an H3K4 demethylase.
Cell 128:889-900 (2007)
[hsa:5927] [mmu:214899]
3  [PMID:17320160]
Iwase S, Lan F, Bayliss P, de la Torre-Ubieta L, Huarte M, Qi HH, Whetstine JR, Bonni A, Roberts TM, Shi Y
The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3  lysine 4 demethylases.
Cell 128:1077-88 (2007)
4  [PMID:17320161]
Christensen J, Agger K, Cloos PA, Pasini D, Rose S, Sennels L, Rappsilber J, Hansen KH, Salcini AE, Helin K
RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3.
Cell 128:1063-76 (2007)
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