EC               Enzyme                                 

[histone H3]-trimethyl-L-lysine27 demethylase;
KDM6A (gene name);
KDM6C (gene name);
UTX (gene name);
UTY (gene name);
JMJD3 (gene name)
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
[histone H3]-N6,N6,N6-trimethyl-L-lysine27,2-oxoglutarate:oxygen oxidoreductase
a [histone H3]-N6,N6,N6-trimethyl-L-lysine27 + 2 2-oxoglutarate + 2 O2 = a [histone H3]-N6-methyl-L-lysine27 + 2 succinate + 2 formaldehyde + 2 CO2 (overall reaction) [RN:R12459];
(1a) a [histone H3]-N6,N6,N6-trimethyl-L-lysine27 + 2-oxoglutarate + O2 = a [histone H3]-N6,N6-dimethyl-L-lysine27 + succinate + formaldehyde + CO2 [RN:R12460];
(1b) a [histone H3]-N6,N6-dimethyl-L-lysine27 + 2-oxoglutarate + O2 = a [histone H3]-N6-methyl-L-lysine27 + succinate + formaldehyde + CO2 [RN:R09510]
[histone H3]-N6,N6,N6-trimethyl-L-lysine27;
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007];
[histone H3]-N6,N6-dimethyl-L-lysine27
[histone H3]-N6-methyl-L-lysine27;
succinate [CPD:C00042];
formaldehyde [CPD:C00067];
CO2 [CPD:C00011];
[histone H3]-N6,N6-dimethyl-L-lysine27
Requires iron(II). This entry describes a group of enzymes that demethylate N-methylated L-lysine residues at position 27 of histone H3 (H3K27). The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde. They can act on tri- and di-methylated forms, but have no activity with the mono-methylated form.
EC created 2019
K11447  lysine-specific demethylase 6A
K11448  lysine-specific demethylase 6B
K23742  lysine-specific demethylase 6C
HSA: 23135(KDM6B) 7403(KDM6A) 7404(UTY)
PTR: 112204057 449579(UTY) 465593(KDM6A) 468438(KDM6B)
PPS: 100971965(KDM6B) 100981353(KDM6A)
GGO: 101145831(KDM6A) 101146851(KDM6B)
PON: 100440779(KDM6B) 100455632(KDM6A)
NLE: 100581756(KDM6B) 100592229(KDM6A)
MCC: 100270704(UTY) 100427119(KDM6A) 716348(KDM6B)
MCF: 102122893(KDM6A) 102138681(KDM6B)
CSAB: 103231851(KDM6A) 103242325(KDM6B) 103246976(UTY)
RRO: 104657060(UTY) 104661704(KDM6B) 104681961(KDM6A)
RBB: 108514285(KDM6B)
CJC: 100405718(KDM6A) 100414637(KDM6B)
SBQ: 101030793(KDM6A) 101031578(KDM6B)
MMU: 216850(Kdm6b) 22289(Kdm6a) 22290(Uty)
MCAL: 110286985(Kdm6a) 110304445(Kdm6b)
MPAH: 110313380(Kdm6a) 110331384(Kdm6b)
RNO: 100310845(Uty) 103689969(Kdm6a) 363630(Kdm6b)
MUN: 110542546 110555144(Kdm6b)
CGE: 100758834(Kdm6a)
NGI: 103731790(Kdm6a) 103752113(Kdm6b)
HGL: 101703654(Kdm6b) 101706268(Kdm6a)
CCAN: 109680035 109683662(Kdm6a) 109693893(Kdm6b)
OCU: 100343083(KDM6B) 100347603(KDM6A)
TUP: 102482383(KDM6B) 102487244(KDM6A) 102494740
CFA: 489481(KDM6B) 491845(KDM6A)
VVP: 112911969 112924857(KDM6B) 112930002(KDM6A)
AML: 100476598(KDM6A) 100477084(KDM6B)
UMR: 103660480(KDM6B) 103666195(KDM6A) 103680203
UAH: 113248376 113265907(KDM6A) 113271139(KDM6B)
FCA: 101088307(KDM6A) 101100010(KDM6B)
PTG: 102955246 102962926(KDM6A)
PPAD: 109246086(KDM6B) 109248052(KDM6A)
AJU: 106972505(KDM6B) 106972538(KDM6A) 106985056
BTA: 100140276(KDM6B) 280952(KDM6A)
BOM: 102273800(KDM6B) 102274742(KDM6A)
BIU: 109555184(KDM6A) 109555600 109573750(KDM6B)
BBUB: 102395023(KDM6B) 102400345(KDM6A)
CHX: 102168575(KDM6B) 102191597(KDM6A) 108634619
OAS: 101103543(KDM6A) 101119656(KDM6B)
SSC: 100154376(KDM6A) 100512495(KDM6B) 110255320
CFR: 102523561(KDM6B) 102523633(KDM6A)
CDK: 105085270(KDM6A) 105103070(KDM6B)
BACU: 103003878(KDM6A) 103016921(KDM6B)
LVE: 103073128(KDM6A) 103083949(KDM6B)
OOR: 101269349(KDM6A) 101284645(KDM6B)
DLE: 111165558(KDM6A) 111185695(KDM6B)
PCAD: 102976704(KDM6B) 102983773(KDM6A)
ECB: 100059800(KDM6A) 100073033(KDM6B)
EAI: 106825057 106827448(KDM6A) 106844144(KDM6B)
MYB: 102241356(KDM6A) 102242922(KDM6B) 102260650
MYD: 102756321(KDM6A) 102767919(UTY) 102775429(KDM6B)
MNA: 107533023 107541456(KDM6A) 107544494(KDM6B)
HAI: 109386479(KDM6A) 109395116(KDM6B)
DRO: 112306833 112308749(KDM6B) 112322497(KDM6A)
PALE: 102882574(KDM6A) 102891492(KDM6B) 102897701
RAY: 107502042 107515683(KDM6B) 107521705(KDM6A)
MJV: 108383384(KDM6B) 108391267(KDM6A)
LAV: 100669039(KDM6A) 100669880(KDM6B)
MDO: 100016846(KDM6A)
SHR: 100914132(KDM6B) 100931212(KDM6A)
PCW: 110194281(KDM6B) 110214916(KDM6A)
OAA: 100081798(KDM6A) 103167751(KDM6B)
GGA: 418556(KDM6A)
CJO: 107324231(KDM6A)
NMEL: 110403634(KDM6A)
APLA: 101792422(KDM6A)
ACYG: 106036049(KDM6A)
TGU: 100231869(KDM6A) 115492722
LSR: 110474877(KDM6A) 110481217(KDM6B)
SCAN: 103815764(KDM6A)
GFR: 102034141(KDM6A)
FAB: 101814502(KDM6A)
PHI: 102100209(KDM6B) 102104710(KDM6A)
PMAJ: 107202288(KDM6A)
CCAE: 111927175(KDM6A)
CCW: 104686240(KDM6A)
ETL: 114055736(KDM6A)
FPG: 101910985(KDM6A)
FCH: 102055770(KDM6A)
CLV: 102086584(KDM6A)
EGZ: 104133576(KDM6A)
NNI: 104020856(KDM6A)
ACUN: 113483873(KDM6A)
PADL: 103912591(KDM6A)
AAM: 106483685(KDM6A)
ASN: 102375331(KDM6A) 102378019(KDM6B)
AMJ: 102565918(KDM6B) 102573879(KDM6A)
PSS: 102452800(KDM6B) 102457422(KDM6A)
CMY: 102935096(KDM6A) 102947171(KDM6B)
CPIC: 101934912(KDM6A) 101935571(KDM6B)
ACS: 100561474(kdm6b) 100564779(kdm6a)
PVT: 110074058(KDM6A) 110087745(KDM6B)
PMUR: 107286489 107299463(KDM6B)
TSR: 106548216 106551474(KDM6A) 106552123(KDM6B)
PMUA: 114582422(KDM6B) 114596145(KDM6A)
GJA: 107109235(KDM6A) 107119809(KDM6B)
XLA: 108703539(kdm6b.S) 108708200 108711772(kdm6b.L) 446609(kdm6a.S)
XTR: 100170558(kdm6a) 779446(kdm6b)
NPR: 108794712(KDM6A) 108794738(KDM6B)
DRE: 556678(kdm6ba) 563644(kdm6bb) 569207(kdm6al) 569277(kdm6a)
PHYP: 113524185 113524844(kdm6a) 113540439(kdm6b) 113545870
AMEX: 103021707 103025477(kdm6a) 103028490 103028970(kdm6b)
NCC: 104942379 104954641(kdm6a) 104964153(kdm6b)
PRET: 103475798 103475867 103480559(kdm6b) 103481677(kdm6a)
NFU: 107376882(kdm6b) 107381076(kdm6a) 107386615
KMR: 108233868(kdm6bb) 108242869(kdm6ba) 108243541(kdm6a) 108249342
AOCE: 111563862(kdm6a) 111571569(kdm6b) 111571985 111575440
CSEM: 103389705 103391115(kdm6b) 103391558(kdm6a) 103394748
MALB: 109952094(kdm6a) 109960405 109971923(kdm6b) 109973222
LCM: 102350275(KDM6A) 102354908(KDM6B)
CMK: 103183921(kdm6a)
RTP: 109919147(kdm6a) 109924747(kdm6b)
BFO: 118426912
CIN: 100185843
SPU: 587845
APLC: 110981656
SKO: 100366814
DME: Dmel_CG5640(Utx)
DER: 6541075
DSE: 6611949
DSI: Dsimw501_GD22282(Dsim_GD22282)
DAN: 6496950
DSR: 110183393
DPE: 6588710
DMN: 108161316
DWI: 6653350
DNV: 108649669
DHE: 111594733
DVI: 6627378
MDE: 101888100
LCQ: 111684696
AAG: 5577734
AME: 412863
BIM: 100740862
BTER: 100646833
CCAL: 108626073
OBB: 114874915
SOC: 105208158
MPHA: 105831887
AEC: 105145441
ACEP: 105621895
PBAR: 105425233
VEM: 105566126
HST: 105185449
DQU: 106740982
LHU: 105672366
PGC: 109856462
OBO: 105279865
PCF: 106787937
NVI: 100120693
CSOL: 105368386
MDL: 103569314
TCA: 657074
DPA: 109532897
ATD: 109602948
NVL: 108562582
BMOR: 101738100
BMAN: 114244907
PMAC: 106714422
PRAP: 110994772
HAW: 110383759
TNL: 113496932
PXY: 105391295
API: 100166299
DNX: 107169491
AGS: 114120407
RMD: 113550707
BTAB: 109043968
CLEC: 106672663
ZNE: 110832815
FCD: 110842825
PVM: 113825233
TUT: 107366987
DPTE: 113791121
CSCU: 111629923
PTEP: 107452612
CEL: CELE_C29F7.6(jmjd-3.3) CELE_D2021.1(utx-1) CELE_F18E9.5(jmjd-3.1) CELE_F23D12.5(jmjd-3.2)
BMY: Bm1_21195
TSP: Tsp_03329
PCAN: 112554796
CRG: 105317220
MYI: 110466209
OBI: 106880021
LAK: 106181631
EGL: EGR_04225
NVE: 5510983
EPA: 110246134
ADF: 107353322
AMIL: 114966211
PDAM: 113675503
SPIS: 111334851
DGT: 114524716
HMG: 100197335
AQU: 100637155
 » show all
1  [PMID:17825402]
De Santa F, Totaro MG, Prosperini E, Notarbartolo S, Testa G, Natoli G
The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing.
Cell 130:1083-94 (2007)
2  [PMID:18003914]
Hong S, Cho YW, Yu LR, Yu H, Veenstra TD, Ge K
Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases.
Proc Natl Acad Sci U S A 104:18439-44 (2007)
[hsa:7403 23135]
3  [PMID:17851529]
Lan F, Bayliss PE, Rinn JL, Whetstine JR, Wang JK, Chen S, Iwase S, Alpatov R, Issaeva I, Canaani E, Roberts TM, Chang HY, Shi Y
A histone H3 lysine 27 demethylase regulates animal posterior development.
Nature 449:689-94 (2007)
[hsa:7403 23135]
4  [PMID:17761849]
Lee MG, Villa R, Trojer P, Norman J, Yan KP, Reinberg D, Di Croce L, Shiekhattar R
Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.
Science 318:447-50 (2007)
5  [PMID:17923864]
Xiang Y, Zhu Z, Han G, Lin H, Xu L, Chen CD
JMJD3 is a histone H3K27 demethylase.
Cell Res 17:850-7 (2007)
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