KEGG   ENZYME: 1.14.11.68Help
Entry
EC 1.14.11.68               Enzyme                                 

Name
[histone H3]-trimethyl-L-lysine27 demethylase;
KDM6A (gene name);
KDM6C (gene name);
UTX (gene name);
UTY (gene name);
JMJD3 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
Sysname
[histone H3]-N6,N6,N6-trimethyl-L-lysine27,2-oxoglutarate:oxygen oxidoreductase
Reaction(IUBMB)
a [histone H3]-N6,N6,N6-trimethyl-L-lysine27 + 2 2-oxoglutarate + 2 O2 = a [histone H3]-N6-methyl-L-lysine27 + 2 succinate + 2 formaldehyde + 2 CO2 (overall reaction) [RN:R12459];
(1a) a [histone H3]-N6,N6,N6-trimethyl-L-lysine27 + 2-oxoglutarate + O2 = a [histone H3]-N6,N6-dimethyl-L-lysine27 + succinate + formaldehyde + CO2 [RN:R12460];
(1b) a [histone H3]-N6,N6-dimethyl-L-lysine27 + 2-oxoglutarate + O2 = a [histone H3]-N6-methyl-L-lysine27 + succinate + formaldehyde + CO2 [RN:R09510]
Reaction(KEGG)
Substrate
[histone H3]-N6,N6,N6-trimethyl-L-lysine27;
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007];
[histone H3]-N6,N6-dimethyl-L-lysine27
Product
[histone H3]-N6-methyl-L-lysine27;
succinate [CPD:C00042];
formaldehyde [CPD:C00067];
CO2 [CPD:C00011];
[histone H3]-N6,N6-dimethyl-L-lysine27
Comment
Requires iron(II). This entry describes a group of enzymes that demethylate N-methylated L-lysine residues at position 27 of histone H3 (H3K27). The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde. They can act on tri- and di-methylated forms, but have no activity with the mono-methylated form.
History
EC 1.14.11.68 created 2019
Orthology
K11447  lysine-specific demethylase 6A
K11448  lysine-specific demethylase 6B
K23742  lysine-specific demethylase 6C
Genes
HSA: 23135(KDM6B) 7403(KDM6A) 7404(UTY)
PTR: 112204057 449579(UTY) 465593(KDM6A) 468438(KDM6B)
PPS: 100971965(KDM6B) 100981353(KDM6A)
GGO: 101145831(KDM6A) 101146851(KDM6B)
PON: 100440779(KDM6B) 100455632(KDM6A)
NLE: 100581756(KDM6B) 100592229(KDM6A)
MCC: 100270704(UTY) 100427119(KDM6A) 716348(KDM6B)
MCF: 102122893(KDM6A) 102138681(KDM6B)
CSAB: 103231851(KDM6A) 103242325(KDM6B) 103246976(UTY)
RRO: 104657060(UTY) 104661704(KDM6B) 104681961(KDM6A)
RBB: 108514285(KDM6B) 108523779
CJC: 100405718(KDM6A) 100414637(KDM6B)
SBQ: 101030793(KDM6A) 101031578(KDM6B)
MMU: 216850(Kdm6b) 22289(Kdm6a) 22290(Uty)
MCAL: 110286985(Kdm6a) 110304445(Kdm6b)
MPAH: 110313380(Kdm6a) 110331384(Kdm6b)
RNO: 100310845(Kdm6a) 103689969(NEWGENE_1565481) 363630(Kdm6b)
CGE: 100756212(Kdm6b) 100758834(Kdm6a)
NGI: 103731790(Kdm6a) 103740770 103752113(Kdm6b)
HGL: 101703654(Kdm6b) 101706268(Kdm6a)
CCAN: 109680035 109683662(Kdm6a) 109693893(Kdm6b)
OCU: 100343083(KDM6B) 100347603(KDM6A)
TUP: 102482383(KDM6B) 102487244(KDM6A) 102494740
CFA: 489481(KDM6B) 491845(KDM6A)
VVP: 112911969 112924857(KDM6B) 112930002(KDM6A)
AML: 100476598(KDM6A) 100477084(KDM6B)
UMR: 103660480(KDM6B) 103666195(KDM6A) 103680203
UAH: 113248376 113265907(KDM6A) 113271139(KDM6B)
FCA: 101088307(KDM6A) 101100010(KDM6B)
PTG: 102955246 102962926(KDM6A)
PPAD: 109246086(KDM6B) 109248052(KDM6A)
AJU: 106972505(KDM6B) 106972538(KDM6A) 106985056
BTA: 100140276(KDM6B) 280952(KDM6A)
BOM: 102273800(KDM6B) 102274742(KDM6A)
BIU: 109555184(KDM6A) 109555600 109573750(KDM6B)
BBUB: 102395023(KDM6B) 102400345(KDM6A)
CHX: 102168575(KDM6B) 102191597(KDM6A) 108634619
OAS: 101103543(KDM6A) 101119656(KDM6B)
SSC: 100154376(KDM6A) 100512495(KDM6B)
CDK: 105085270(KDM6A) 105100394 105103070(KDM6B)
BACU: 103003878(KDM6A) 103016921(KDM6B)
LVE: 103073128(KDM6A) 103083949(KDM6B)
OOR: 101269349(KDM6A) 101284645(KDM6B)
DLE: 111165558(KDM6A) 111185695(KDM6B)
PCAD: 102976704(KDM6B) 102983773(KDM6A)
ECB: 100059800(KDM6A) 100073033(KDM6B)
MYB: 102241356(KDM6A) 102242922(KDM6B) 102260650
MYD: 102756321(KDM6A) 102761382 102767919(UTY) 102775429(KDM6B)
MNA: 107533023 107541456(KDM6A) 107544494(KDM6B)
HAI: 109386479(KDM6A) 109395116(KDM6B)
DRO: 112306833 112308749(KDM6B) 112322497(KDM6A)
PALE: 102882574(KDM6A) 102891492(KDM6B) 102897701
MJV: 108383384(KDM6B) 108391267(KDM6A)
LAV: 100669039(KDM6A) 100669880(KDM6B)
MDO: 100016846(KDM6A)
SHR: 100914132(KDM6B) 100921077 100931212(KDM6A)
PCW: 110194281(KDM6B) 110214916(KDM6A)
OAA: 100081798(KDM6A) 103167751(KDM6B)
GGA: 418556(KDM6A)
MGP: 100539898(KDM6A)
CJO: 107324231(KDM6A)
NMEL: 110403634(KDM6A)
APLA: 101792422(KDM6A)
ACYG: 106036049(KDM6A) 106049694
TGU: 100231869(KDM6A)
LSR: 110474877(KDM6A) 110481217(KDM6B)
SCAN: 103815764(KDM6A)
GFR: 102034141(KDM6A)
FAB: 101811628(KDM6B) 101814502(KDM6A) 107604578
PHI: 102100209(KDM6B) 102104710(KDM6A)
PMAJ: 107202288(KDM6A)
CCAE: 111927175(KDM6A)
CCW: 104686240(KDM6A)
ETL: 114055736(KDM6A)
FPG: 101910985(KDM6A) 101916863(KDM6B)
FCH: 102055770(KDM6A)
CLV: 102086584(KDM6A)
EGZ: 104133576(KDM6A)
NNI: 104020856(KDM6A)
ACUN: 113483873(KDM6A)
PADL: 103912591(KDM6A)
AAM: 106483639 106483685(KDM6A)
ASN: 102367730 102375331(KDM6A) 102378019(KDM6B)
AMJ: 102565918(KDM6B) 102573879(KDM6A)
PSS: 102452800(KDM6B) 102457422(KDM6A)
CMY: 102935096(KDM6A) 102947171(KDM6B)
CPIC: 101934912(KDM6A) 101935571(KDM6B)
ACS: 100561474(kdm6b) 100564779(kdm6a)
PVT: 110074058(KDM6A) 110087745(KDM6B)
PMUR: 107286489 107299463(KDM6B)
TSR: 106548216 106551474(KDM6A) 106552123(KDM6B)
PMUA: 114582422(KDM6B) 114596145(KDM6A)
GJA: 107109235(KDM6A) 107119809(KDM6B)
XLA: 108703539(kdm6b.S) 108708200 108708201 108711772(kdm6b.L) 446609(kdm6a.S)
XTR: 100170558(kdm6a) 779446(kdm6b)
NPR: 108794712(KDM6A) 108794738(KDM6B)
DRE: 556678(kdm6ba) 563644(kdm6bb) 569207(kdm6al) 569277(kdm6a)
PHYP: 113524185 113524844(kdm6a) 113540439(kdm6b) 113545870
AMEX: 103021707 103025477(kdm6a) 103028490 103028970(kdm6b)
NCC: 104942379 104954641(kdm6a) 104964153(kdm6b)
PRET: 103475798 103475867 103480559(kdm6b) 103481677(kdm6a)
NFU: 107376882(kdm6b) 107381076(kdm6a) 107386615
AOCE: 111563862(kdm6a) 111571569(kdm6b) 111571985 111575440
CSEM: 103389705 103391115(kdm6b) 103391558(kdm6a) 103394748
LCM: 102350275(KDM6A) 102354908(KDM6B)
CMK: 103183921(kdm6a)
RTP: 109919147(kdm6a) 109924747(kdm6b) 109924822
CIN: 100185843
SPU: 587845
APLC: 110981656
SKO: 100366814
DME: Dmel_CG5640(Utx)
DER: 6541075
DSI: Dsimw501_GD22282(Dsim_GD22282)
DSR: 110183393
DPE: 6588710
DMN: 108161316
DWI: 6653350
DAZ: 108611753
DNV: 108649669
DHE: 111594733
AAG: 5577734
AME: 412863
BIM: 100740862
BTER: 100646833
CCAL: 108626073
OBB: 114874915
SOC: 105208158
HST: 105185449
DQU: 106740982
LHU: 105672366
PGC: 109856462
OBO: 105279865
PCF: 106787937
NVI: 100120693
CSOL: 105368386
MDL: 103569314
TCA: 657074
DPA: 109532897
ATD: 109602948
NVL: 108562582
BMOR: 101738100
PMAC: 106714422
PRAP: 110994772
HAW: 110383759
TNL: 113496932
PXY: 105391295
API: 100166299
DNX: 107169491
AGS: 114120407
RMD: 113550707
BTAB: 109043968
CLEC: 106672663
ZNE: 110832815
PVM: 113825233
TUT: 107366987
DPTE: 113791121
CSCU: 111629923
PTEP: 107452612
CEL: CELE_C29F7.6(jmjd-3.3) CELE_D2021.1(utx-1) CELE_F18E9.5(jmjd-3.1) CELE_F23D12.5(jmjd-3.2)
BMY: Bm1_21195
TSP: Tsp_03329
PCAN: 112554796
CRG: 105317220
MYI: 110466209
OBI: 106880021
EGL: EGR_04225
EPA: 110246134
ADF: 107353322
AMIL: 114966211
PDAM: 113675503
SPIS: 111334851
DGT: 114524716
HMG: 100197335
 » show all
Taxonomy
Reference
1  [PMID:17825402]
  Authors
De Santa F, Totaro MG, Prosperini E, Notarbartolo S, Testa G, Natoli G
  Title
The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing.
  Journal
Cell 130:1083-94 (2007)
DOI:10.1016/j.cell.2007.08.019
  Sequence
[hsa:23135]
Reference
2  [PMID:18003914]
  Authors
Hong S, Cho YW, Yu LR, Yu H, Veenstra TD, Ge K
  Title
Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases.
  Journal
Proc Natl Acad Sci U S A 104:18439-44 (2007)
  Sequence
[hsa:7403 23135]
Reference
3  [PMID:17851529]
  Authors
Lan F, Bayliss PE, Rinn JL, Whetstine JR, Wang JK, Chen S, Iwase S, Alpatov R, Issaeva I, Canaani E, Roberts TM, Chang HY, Shi Y
  Title
A histone H3 lysine 27 demethylase regulates animal posterior development.
  Journal
Nature 449:689-94 (2007)
  Sequence
[hsa:7403 23135]
Reference
4  [PMID:17761849]
  Authors
Lee MG, Villa R, Trojer P, Norman J, Yan KP, Reinberg D, Di Croce L, Shiekhattar R
  Title
Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.
  Journal
Science 318:447-50 (2007)
DOI:10.1126/science.1149042
  Sequence
[hsa:7403]
Reference
5  [PMID:17923864]
  Authors
Xiang Y, Zhu Z, Han G, Lin H, Xu L, Chen CD
  Title
JMJD3 is a histone H3K27 demethylase.
  Journal
Cell Res 17:850-7 (2007)
  Sequence
[hsa:23135]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.68
IUBMB Enzyme Nomenclature: 1.14.11.68
ExPASy - ENZYME nomenclature database: 1.14.11.68
BRENDA, the Enzyme Database: 1.14.11.68

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