KEGG   ENZYME: 1.14.11.7
Entry
EC 1.14.11.7                Enzyme                                 

Name
procollagen-proline 3-dioxygenase;
proline,2-oxoglutarate 3-dioxygenase;
prolyl 3-hydroxylase;
protocollagen proline 3-hydroxylase;
prolyl-4-hydroxyprolyl-glycyl-peptide,2-oxoglutarate:oxygen oxidoreductase, 3-hydroxylating
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
Sysname
[procollagen]-L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
Reaction(IUBMB)
[procollagen]-L-proline + 2-oxoglutarate + O2 = [procollagen]-trans-3-hydroxy-L-proline + succinate + CO2 [RN:R03218]
Reaction(KEGG)
R03218
Substrate
[procollagen]-L-proline [CPD:C01078];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
[procollagen]-trans-3-hydroxy-L-proline [CPD:C04397];
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Requires Fe2+ and ascorbate. The enzyme forms a complex with protein disulfide isomerase, and is located in the endoplasmic reticulum. It modifies proline residues within the procollagen peptide of certain collagen types. The modification is essential for proper collagen triple helix formation.
History
EC 1.14.11.7 created 1981, modified 1983, modified 2017
Orthology
K08134  procollagen-proline 3-dioxygenase 1
K22459  procollagen-proline 3-dioxygenase 2
K22460  procollagen-proline 3-dioxygenase 3
Genes
HSA: 10536(P3H3) 55214(P3H2) 64175(P3H1)
PTR: 100612169(P3H3) 456811(P3H1) 740124(P3H2)
PPS: 100967913(P3H3) 100988847(P3H2) 100995838(P3H1)
GGO: 101124810(P3H2) 101134181(P3H3) 101141437(P3H1)
PON: 100445803(P3H2) 100452759(P3H3) 100454619(P3H1)
NLE: 100579995(P3H2) 100580431(P3H1) 100592815(P3H3)
MCC: 697917(P3H1) 704118(P3H2) 713865(P3H3)
MCF: 102115049(P3H1) 102125709(P3H3) 102137302(P3H2)
CSAB: 103218477(P3H3) 103224997(P3H1) 103241897(P3H2)
RRO: 104669007(P3H1) 104680052(P3H2) 104680134(P3H3)
RBB: 108530367(P3H1) 108530476(P3H2) 108542032(P3H3)
CJC: 100385724(P3H3) 100388266(P3H2) 100402370(P3H1)
SBQ: 101029883 101038436(LEPREL1) 101052278(LEPRE1)
MMU: 14789(P3h3) 210530(P3h2) 56401(P3h1)
MCAL: 110292274(P3h1) 110295793(P3h3) 110311568(P3h2)
MPAH: 110316244(P3h3) 110322804(P3h1) 110329669(P3h2)
RNO: 114200(P3h1) 288016(P3h2) 297595(P3h3)
CGE: 100752370(P3h2) 100767056(P3h3) 100769529(P3h1)
NGI: 103727504(P3h3) 103739336(P3h2) 103741906(P3h1)
HGL: 101709763(P3h2) 101719240(P3h3) 101725544(P3h1)
CCAN: 109678351(P3h2) 109682771(P3h3) 109691192(P3h1)
OCU: 100344567(P3H3) 100356128(P3H2) 100357143(P3H1)
TUP: 102468745(P3H1) 102489939(P3H3) 102490664(P3H2)
CFA: 100686626(P3H3) 478674(P3H2) 606980(P3H1)
VVP: 112908251(P3H1) 112917513(P3H3) 112926308(P3H2)
AML: 100477435(P3H1) 100482440(P3H3) 100484169(P3H2)
UMR: 103656188(P3H3) 103670920(P3H1) 103676024(P3H2)
UAH: 113253554(P3H2) 113254805(P3H1) 113257960(P3H3)
ORO: 101366397(P3H1) 101370866(P3H3) 101373687(P3H2)
FCA: 101093365(P3H3) 101094278(P3H1) 101094873(P3H2)
PTG: 102950281(P3H2) 102955345(P3H3) 102958232(P3H1)
PPAD: 109254903(P3H1) 109275310(P3H2) 109276105(P3H3)
AJU: 106965441(P3H3) 106968016(P3H2) 106970202(P3H1)
BTA: 511799(P3H2) 539976(P3H1)
BOM: 102280597(P3H1) 102284601(P3H2) 102287577(P3H3)
BIU: 109556425(P3H1) 109556764(P3H2) 109558918(P3H3)
BBUB: 102394493(P3H3) 102395789(P3H1) 102400880(P3H2)
CHX: 102176848(P3H1) 102188119(P3H3) 102189992(P3H2)
OAS: 101105862(P3H1) 101108618(P3H2) 101108826(P3H3)
SSC: 100156539(P3H3) 100520219(P3H2) 100620503(P3H1)
CFR: 102510969(P3H3) 102516638(P3H2) 102516978(P3H1)
CDK: 105097544(P3H2) 105098205(P3H3) 105103354(P3H1)
BACU: 103005242(P3H2) 103015069(P3H3) 103015131(P3H1)
LVE: 103076723(P3H2) 103081402(P3H1) 103090013(P3H3)
OOR: 101273511(P3H1) 101285801(P3H3) 101289013(P3H2)
DLE: 111172711(P3H2) 111175681(P3H1) 111176688(P3H3) 111176693
PCAD: 102977913(P3H1) 102981742(P3H3) 102993003(P3H2)
ECB: 100059777(P3H2) 100060032(P3H3) 100067315(P3H1)
EPZ: 103547016(P3H3) 103557310(P3H1) 103564888(P3H2)
EAI: 106832556(P3H2) 106847326(P3H3) 106847794(P3H1)
MYB: 102239815(P3H1) 102245885(P3H2) 102248956(P3H3)
MYD: 102755248(P3H3) 102759591(P3H2) 102764443(P3H1)
MNA: 107527300(P3H2) 107531174(P3H1) 107543975(P3H3)
HAI: 109371222(P3H2) 109373668(P3H3) 109383352(P3H1)
DRO: 112299410(P3H1) 112300959(P3H2) 112321730(P3H3)
PALE: 102884197(P3H1) 102890385(P3H2) 102893257(P3H3)
RAY: 107505908(P3H2) 107508292(P3H1) 107519795(P3H3)
MJV: 108384714(P3H2) 108403547(P3H3) 108410378(P3H1)
LAV: 100658405(P3H2) 100665625(P3H1) 100675290(P3H3)
MDO: 100016121(P3H3) 100032694(P3H1) 100618320(P3H2)
SHR: 100914814(P3H1) 100923448(P3H3) 100933913(P3H2)
PCW: 110193120(P3H2) 110206219(P3H1) 110213786(P3H3)
OAA: 100081783(P3H2) 100085351(P3H1) 103168172(P3H3)
GGA: 414142(P3H1) 414143(P3H2) 418289(P3H3)
MGP: 100546471(P3H1) 100548323(P3H3) 100549834(P3H2)
CJO: 107318275(P3H2) 107318675(P3H3) 107323389(P3H1)
NMEL: 110398259(P3H2) 110398399(P3H3) 110408525(P3H1)
APLA: 101793572(P3H1) 101794735(P3H3) 101795167(P3H2)
ACYG: 106044830(P3H2) 106047855(P3H3) 106049155(P3H1)
TGU: 100221140(P3H3) 100221254(P3H1) 100224069(P3H2)
LSR: 110472240(P3H1) 110473861(P3H2) 110480812(P3H3)
SCAN: 103812452(P3H3) 103815383(P3H2) 103824173
GFR: 102036321(P3H1) 102040203(P3H3) 102040654(P3H2)
FAB: 101810645(P3H3) 101821011(P3H2) 101821087(P3H1)
PHI: 102099220(P3H2) 102106882(P3H1) 102112679(P3H3)
PMAJ: 107208918(P3H2) 107213395(P3H3) 107213791(P3H1)
CCAE: 111933453(P3H2) 111938269(P3H3) 111938574(P3H1)
CCW: 104687224(P3H3) 104687928(P3H2) 104697539(P3H1)
ETL: 114057609(P3H2) 114058157(P3H3) 114066843(P3H1)
FPG: 101917584(P3H2) 101919025(P3H3) 101923126(P3H1)
FCH: 102048595(P3H1) 102050123(P3H2) 102055974(P3H3)
CLV: 102084407(P3H3) 102094017(P3H1) 102097675(P3H2)
EGZ: 104123376(LEPREL1) 104126599(LEPREL2) 104131732(LEPRE1)
NNI: 104011258(LEPRE1) 104015666(LEPREL1) 104022495(LEPREL2)
ACUN: 113476602(P3H3) 113483556(P3H2) 113487825(P3H1)
PADL: 103921957(LEPREL2) 103925387(LEPREL1) 103925411(LEPRE1)
AAM: 106497271(P3H3) 106498214(P3H2) 106498600(P3H1)
AMJ: 102562134(P3H3) 102572352(P3H2) 106737225(P3H1)
PSS: 102444832(P3H2) 102450598(P3H1) 102461480(P3H3)
CMY: 102929854(P3H3) 102932162(P3H1) 102939997(P3H2)
CPIC: 101931004(LEPREL2) 101931818(P3H2) 101935857(P3H1)
ACS: 100562772(p3h2) 100567613(p3h3)
PVT: 110084656(P3H3) 110085947(P3H2) 110086810(P3H1)
PBI: 103048096(P3H2) 103049535(P3H3) 103066967(P3H1)
TSR: 106545546
PMUA: 114587602(P3H3) 114598127(P3H2) 114602593(P3H1)
GJA: 107116689(P3H1) 107116803(P3H3) 107123825(P3H2)
XLA: 108697338(p3h3.S) 108716969 108718050 414447(p3h1.L)
NPR: 108783932(P3H1) 108795998(P3H3) 108804588(P3H2)
DRE: 553311(p3h3) 553321(p3h1) 566697(p3h2)
IPU: 108270766(p3h2) 108274273(p3h3) 108281059(p3h1)
PHYP: 113537803(p3h1) 113542320(p3h3) 113547067(p3h2)
AMEX: 103024133(p3h1) 103026715(p3h3) 103045377(p3h2)
EEE: 113570617(p3h3) 113582372(p3h2) 113586117(p3h1)
TRU: 101075372(p3h3) 101075489(p3h1) 101076075(p3h2)
LCO: 104920250(p3h2) 104922230(p3h3) 104939521(p3h1)
MZE: 101465294(p3h1) 101479402(p3h2) 101486114(p3h3)
ONL: 100699187(p3h2) 100708165(p3h1) 100708642(p3h3)
OLA: 101170663(p3h2) 101171860(p3h3) 101172073(p3h1)
XMA: 102223713(p3h2) 102234680(p3h3) 102238287(p3h1)
XCO: 114136016(p3h1) 114142259(p3h3) 114150787(p3h2)
PRET: 103464183(p3h2) 103465445(p3h1) 103477971(p3h3)
CVG: 107082187(p3h3) 107101026(p3h2) 107104181(p3h1)
NFU: 107373178 107379477(p3h3) 107392670(p3h2)
KMR: 108230631 108235396(p3h3) 108250443(p3h1)
ALIM: 106521056(p3h3) 106527403(p3h1) 106537303(p3h2)
AOCE: 111571080(p3h3) 111574099(p3h1) 111578231 111585771(p3h2)
CSEM: 103386606(p3h1) 103387968(p3h3) 103392998(p3h2)
POV: 109625858(p3h2) 109629287(p3h1) 109633247(p3h3)
LCF: 108877527(p3h1) 108880725(p3h3) 108881307(p3h2)
SDU: 111217020(p3h2) 111221750(p3h1) 111230047(p3h3)
SLAL: 111650235(p3h2) 111668691(p3h1) 111669862(p3h3)
HCQ: 109515135(p3h1) 109515281(p3h3) 109522012(p3h2)
BPEC: 110160074(p3h2) 110163193(p3h3) 110171175(p3h1)
ELS: 105007738(p3h2) 105028240(p3h3) 105030006(p3h1)
SFM: 108922091(p3h3) 108937368(p3h2) 108938176(p3h1)
LCM: 102348936(P3H3) 102353193(P3H2) 102356877(P3H1)
CMK: 103181352(p3h1) 103191590(p3h2)
RTP: 109915299(p3h1)
CIN: 445606(leprecan)
APLC: 110983136
SKO: 100313646
AME: 725819
BIM: 100740426
BTER: 100650141
CCAL: 108630344
OBB: 114873602
SOC: 105199999
MPHA: 105840059
AEC: 105148061
ACEP: 105624115
PBAR: 105427498
VEM: 105568238
HST: 105190225
DQU: 106747649
CFO: 105259052
LHU: 105679345
PGC: 109859021
OBO: 105282343
PCF: 106788117
NVI: 100123941
CSOL: 105366801
MDL: 103575387
TCA: 657387
NVL: 108566762
ZNE: 110827209
PVM: 113810720
PTEP: 107455616
PCAN: 112559825
CRG: 105325684
LAK: 106160773
NVE: 5517048
EPA: 110243698
ADF: 107344196
AMIL: 114949534
PDAM: 113667901
DGT: 114523086
HMG: 100203735
AQU: 100638799
GMX: 100788718
GSJ: 114421545
VRA: 106768895
VAR: 108347895
VUN: 114178277
LJA: Lj4g3v2406420.1(Lj4g3v2406420.1)
LANG: 109359831
CSV: 101218213
CMO: 103496668
CMAX: 111487019
 » show all
Reference
1  [PMID:191255]
  Authors
Risteli J, Tryggvason K, Kivirikko KI.
  Title
Prolyl 3-hydroxylase: partial characterization of the enzyme from rat kidney cortex.
  Journal
Eur J Biochem 73:485-92 (1977)
DOI:10.1111/j.1432-1033.1977.tb11341.x
Reference
2  [PMID:204218]
  Authors
Risteli J, Tryggvason K, Kivirikko KI.
  Title
A rapid assay for prolyl 3-hydroxylase activity.
  Journal
Anal Biochem 84:423-31 (1978)
DOI:10.1016/0003-2697(78)90060-X
Reference
3  [PMID:15044469]
  Authors
Vranka JA, Sakai LY, Bachinger HP
  Title
Prolyl 3-hydroxylase 1, enzyme characterization and identification of a novel family of enzymes.
  Journal
J Biol Chem 279:23615-21 (2004)
DOI:10.1074/jbc.M312807200
  Sequence
[gga:414142]
Reference
4  [PMID:18487197]
  Authors
Tiainen P, Pasanen A, Sormunen R, Myllyharju J
  Title
Characterization of recombinant human prolyl 3-hydroxylase isoenzyme 2, an enzyme modifying the basement membrane collagen IV.
  Journal
J Biol Chem 283:19432-9 (2008)
DOI:10.1074/jbc.M802973200
  Sequence
[hsa:55214]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.7
IUBMB Enzyme Nomenclature: 1.14.11.7
ExPASy - ENZYME nomenclature database: 1.14.11.7
BRENDA, the Enzyme Database: 1.14.11.7
CAS: 63551-75-7

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