KEGG   ENZYME: 1.14.11.72
Entry
EC 1.14.11.72               Enzyme                                 
Name
[2-(trimethylamino)ethyl]phosphonate dioxygenase;
tmpA (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
Sysname
[2-(trimethylamino)ethyl]phosphonate,2-oxoglutarate:oxygen oxidoreductase (1R-hydroxylating)
Reaction(IUBMB)
[2-(trimethylamino)ethyl]phosphonate + 2-oxoglutarate + O2 = [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + succinate + CO2 [RN:R12615]
Reaction(KEGG)
R12615
Substrate
[2-(trimethylamino)ethyl]phosphonate [CPD:C22281];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate [CPD:C22271];
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Requires Fe2+ and ascorbate. The enzyme, found in bacteria, participates in a degradation pathway for [2-(trimethylamino)ethyl]phosphonate.
History
EC 1.14.11.72 created 2020
Orthology
K24291  [2-(trimethylamino)ethyl]phosphonate dioxygenase
Genes
MARJMARI_16720
MOQHWV03_17260
SHAILMH63_14695
CCAGSR908_07940
HAFC8233_04175
HASHHXW73_04270 HXW73_04280 HXW73_04785
HNPSR894_19700 SR894_19760
HPISP1P91_13960 P1P91_14455 P1P91_14530
CAMHLCW13_07215
COBBH2O77_01115 H2O77_07230 H2O77_08130 H2O77_11585
MARSA8C75_09130
MRZKDW95_08530
TSNW908_07695
THINCRN91_02445
PMEGFNZ07_29585
MLOmll1440
MLNA9174_18900
MCIMesci_3237
MCICA4R28_10585
MOPMesop_3629
MAMMesau_03502
MAMOA6B35_22570
MESWA9K65_017530
MESPC1M53_13015
MHUAMCHK_3077
MJREB229_19185
MERDEB233_16530
MOHIHQ72_17265
MMEILRP31_11945
HOEIMCC20628_01348
PHYLHB779_23160
RLSHB780_09245
LNEFZC33_24920
NOHG5V57_30915
LABRCHH27_03690
LABPFJ695_19965
SILSPO3380
SITTM1040_0333
RUAD1823_16315
RUTFIU92_15150
RCONK3740_16490
PGAPGA1_c27220
PGLPGA2_c25240
PGDGal_00705
PHPPhaeoP97_02668
PPICPhaeoP14_02470
PHQD1820_08325
OCTFTO60_03580
LMDMETH_08250
LEJETW24_09560
LAQUR2C4_08480
LEVETW23_09420
LCAEK3721_08720
SULZC1J03_21470
SULIC1J05_15870
ROMEI983_17985
RPELN7U68_11415
LALGLentiSH36_00731
TSCOR1T40_04525 R1T40_13870
SEDIEBB79_01655
PPSOQPJ95_14615
PSEBEOK75_16310
PAEDG5B38_12540
CACTHZ995_05375
ACROK3J57_14495
AMYLQBD29_06795
RHOCQTA57_03285 QTA57_08995
LVRT8T21_12360
RBXI3V23_12110
THART8K17_21070 T8K17_21105
PAQIKW060_01785
SNEANBZ79_11455 NBZ79_16040
IAMHC251_12395
NSPHBDGGKGIB_02714
 » show all
Reference
1  [PMID:30789718]
  Authors
Rajakovich LJ, Pandelia ME, Mitchell AJ, Chang WC, Zhang B, Boal AK, Krebs C, Bollinger JM Jr
  Title
A New Microbial Pathway for Organophosphonate Degradation Catalyzed by Two Previously Misannotated Non-Heme-Iron Oxygenases.
  Journal
Biochemistry 58:1627-1647 (2019)
DOI:10.1021/acs.biochem.9b00044
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.72
IUBMB Enzyme Nomenclature: 1.14.11.72
ExPASy - ENZYME nomenclature database: 1.14.11.72
BRENDA, the Enzyme Database: 1.14.11.72

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