KEGG   ENZYME: 1.14.11.72
Entry
EC 1.14.11.72               Enzyme                                 

Name
[2-(trimethylamino)ethyl]phosphonate dioxygenase;
tmpA (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
Sysname
[2-(trimethylamino)ethyl]phosphonate,2-oxoglutarate:oxygen oxidoreductase (1R-hydroxylating)
Reaction(IUBMB)
[2-(trimethylamino)ethyl]phosphonate + 2-oxoglutarate + O2 = [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + succinate + CO2 [RN:R12615]
Reaction(KEGG)
R12615
Substrate
[2-(trimethylamino)ethyl]phosphonate [CPD:C22281];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate [CPD:C22271];
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Requires Fe2+ and ascorbate. The enzyme, found in bacteria, participates in a degradation pathway for [2-(trimethylamino)ethyl]phosphonate.
History
EC 1.14.11.72 created 2020
Orthology
K24291  [2-(trimethylamino)ethyl]phosphonate dioxygenase
Genes
MARJ: MARI_16720
THIM: KFB96_01255 KFB96_10685
HAF: C8233_04175
MARS: A8C75_09130
TSN: W908_07695
THIN: CRN91_02445
PMEG: FNZ07_29585
MLO: mll1440
MLN: A9174_18900
MCI: Mesci_3237
MHUA: MCHK_3077
SIL: SPO3380
PGD: Gal_00705
LAQU: R2C4_08480
 » show all
Reference
1  [PMID:30789718]
  Authors
Rajakovich LJ, Pandelia ME, Mitchell AJ, Chang WC, Zhang B, Boal AK, Krebs C, Bollinger JM Jr
  Title
A New Microbial Pathway for Organophosphonate Degradation Catalyzed by Two Previously Misannotated Non-Heme-Iron Oxygenases.
  Journal
Biochemistry 58:1627-1647 (2019)
DOI:10.1021/acs.biochem.9b00044
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.72
IUBMB Enzyme Nomenclature: 1.14.11.72
ExPASy - ENZYME nomenclature database: 1.14.11.72
BRENDA, the Enzyme Database: 1.14.11.72

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