KEGG   ENZYME: 1.14.11.76
Entry
EC 1.14.11.76               Enzyme                                 

Name
L-glutamate 3(R)-hydroxylase;
iboH (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
Sysname
L-glutamate,2-oxoglutarate:oxygen oxidoreductase (3R-hydroxylating)
Reaction(IUBMB)
L-glutamate + 2-oxoglutarate + O2 = (3R)-3-hydroxy-L-glutamate + succinate + CO2 [RN:R12663]
Reaction(KEGG)
R12663
Substrate
L-glutamate [CPD:C00025];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
(3R)-3-hydroxy-L-glutamate [CPD:C22314];
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Requires Fe2+ and L-ascorbate. The enzyme, characterized from the basidiomycete mushroom Amanita muscaria, participates in the biosynthesis of the psychoactive compounds ibotenate and muscimol.
History
EC 1.14.11.76 created 2020
Orthology
K24701  L-glutamate 3(R)-hydroxylase
Reference
1  [PMID:32233056]
  Authors
Obermaier S, Muller M.
  Title
Ibotenic Acid Biosynthesis in the Fly Agaric Is Initiated by Glutamate Hydroxylation.
  Journal
Angew Chem Int Ed Engl 59:12432-12435 (2020)
DOI:10.1002/anie.202001870
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.76
IUBMB Enzyme Nomenclature: 1.14.11.76
ExPASy - ENZYME nomenclature database: 1.14.11.76
BRENDA, the Enzyme Database: 1.14.11.76

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