KEGG   ENZYME: 1.14.11.80
Entry
EC 1.14.11.80               Enzyme                                 
Name
methylcytosine dioxygenase;
TET1 (gene name);
TET2 (gene name);
TET3 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
Sysname
5-methylcytosine in DNA,2-oxoglutarate:oxygen oxidoreductase
Reaction(IUBMB)
(1) 5-methylcytosine in DNA + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine in DNA + succinate + CO2 [RN:R11030];
(2) 5-hydroxymethylcytosine in DNA + 2-oxoglutarate + O2 = 5-formylcytosine in DNA + succinate + CO2 + H2O [RN:R13108];
(3) 5-formylcytosine in DNA + 2-oxoglutarate + O2 = 5-carboxycytosine in DNA + succinate + CO2 [RN:R13109]
Reaction(KEGG)
Substrate
5-methylcytosine in DNA [CPD:C02967];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007];
5-hydroxymethylcytosine in DNA [CPD:C21031];
5-formylcytosine in DNA [CPD:C22620]
Product
5-hydroxymethylcytosine in DNA [CPD:C21031];
succinate [CPD:C00042];
CO2 [CPD:C00011];
5-formylcytosine in DNA [CPD:C22620];
H2O [CPD:C00001];
5-carboxycytosine in DNA [CPD:C22621]
Comment
The TET proteins mediate iterative oxidation of 5-methylcytosine in DNA (5mc) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). 5fC and 5caC are recognized by EC 3.2.2.29, thymine-DNA glycosylase (TDG), which excises them, leaving an apyrimidinic site. Coupled with the base excision repair (BER) pathway, these activities result in a cytosine demethylation pathway.
History
EC 1.14.11.80 created 2022
Orthology
K13097  methylcytosine dioxygenase
K24309  methylcytosine dioxygenase TET2/3
Genes
HSA200424(TET3) 54790(TET2) 80312(TET1)
PTR450497(TET1) 459329(TET3) 471263(TET2)
PPS100967275(TET3) 100985863(TET2) 100994141(TET1)
GGO101128074(TET2) 101140089(TET3) 101154365(TET1)
PON100437556(TET1) 100438711(TET2) 100442848(TET3)
NLE100582842(TET3) 100600438(TET1) 100604843(TET2)
HMH116458720(TET1) 116481641(TET2) 116482961(TET3)
MCC693707(TET1) 694137(TET2) 707759(TET3)
MCF102122605(TET1) 102122788(TET2) 102146434(TET3)
MTHB126934006 126955177 126963154
MNI105465279(TET3) 105466117(TET1) 105486308(TET2)
CSAB103216093(TET1) 103220042(TET3) 103236067(TET2)
CATY105571392(TET2) 105596851(TET3) 105597454(TET1)
PANU101000648(TET1) 101007292(TET2) 101013148(TET3)
TGE112604691(TET3) 112625297(TET2) 112631203(TET1)
MLEU105529230(TET2) 105540181(TET3) 105549509(TET1)
RRO104668766(TET2) 104671664(TET1) 104676849(TET3)
RBB108514903(TET1) 108521863(TET3) 108529613(TET2)
TFN117062039(TET3) 117082205(TET1) 117085734(TET2)
PTEH111523395(TET3) 111537923(TET1) 111547985(TET2)
CANG105501199(TET1) 105512694(TET2) 105514584(TET3)
CJC100391032(TET1) 100403244(TET3) 100407516(TET2)
SBQ101028390(TET2) 101028776(TET3) 101044521(TET1)
CIMI108289292(TET3) 108294843(TET2) 108318148
CSYR103259604(TET2) 103266741(TET3) 103277271(TET1)
MMUR105870223(TET1) 105879045(TET2) 105884598(TET3)
LCAT123627712(TET2) 123637065(TET3) 123650420(TET1)
PCOQ105818946(TET2) 105821504(TET3) 105821749(TET1)
OGA100945378(TET3) 100948153(TET1) 100954211(TET2)
MMU194388(Tet3) 214133(Tet2) 52463(Tet1)
MCAL110291600(Tet2) 110296048(Tet3) 110303891(Tet1)
MPAH110316501(Tet3) 110320561(Tet2) 110326536(Tet1)
RNO309902(Tet1) 310859(Tet2) 680576(Tet3)
MCOC116074342(Tet1) 116093808(Tet2) 116099138(Tet3)
ANU117707642(Tet2) 117714753(Tet3) 117724126(Tet1)
MUN110557208(Tet1) 110562569(Tet2) 110566855(Tet3)
CGE100769509(Tet3) 100769811(Tet2) 100771765(Tet1)
MAUA101835496(Tet3) 101839115(Tet1) 101841649(Tet2)
PROB127222986(Tet2) 127224046(Tet1) 127235602(Tet3)
PLEU114683043(Tet2) 114694408(Tet3) 114701137(Tet1)
MORG121440502(Tet3) 121447231(Tet2) 121450916(Tet1)
MFOT126499762 126501692 126515313
AAMP119800883(Tet2) 119806520(Tet3) 119823886(Tet1)
NGI103733758(Tet1) 103740608(Tet2) 103749944(Tet3)
HGL101703231(Tet1) 101710771(Tet3) 101722412(Tet2)
CPOC100715975(Tet3) 100718966(Tet1) 100733403(Tet2)
CCAN109688138(Tet3) 109695221(Tet1) 109698496(Tet2)
DORD105986303(Tet1) 105991234(Tet2) 105999582(Tet3)
DSP122122308(Tet1) 122125142(Tet3) 122127115(Tet2)
PLOP125341376(Tet2) 125346385(Tet1) 125356353(Tet3)
NCAR124963059 124985301 124994426
MMMA107141363(Tet2) 107154210(Tet3) 107154838(Tet1)
OCU100339579 100347430 100350148
OPI101528499(TET2) 101532955(TET3) 101536242(TET1)
TUP102476879(TET2) 102477884(TET3) 102498328(TET1)
GVR103585990(TET1) 103596287(TET3) 103606341
CFA478499(TET2) 479229(TET1) 483109(TET3)
CLUD112644428(TET2) 112651253(TET1) 112664232(TET3)
VVP112916731(TET3) 112923783(TET1) 112934197(TET2)
VLG121488027(TET1) 121491681(TET3) 121493169(TET2)
NPO129501279(TET3) 129509780(TET1) 129521186(TET2)
AML100469957(TET2) 100477952(TET1) 100480248(TET3)
UMR103661712(TET2) 103667771(TET1) 103671399(TET3)
UAH113243822(TET3) 113255522(TET2) 113259114(TET1)
UAR123782899(TET1) 123786066(TET3) 123793396(TET2)
ELK111144966 111148027 111153570
LLV125084934 125093241 125108351
MPUF101670989(TET3) 101674304(TET2) 106003357
MNP132001876(TET2) 132016327(TET1) 132021442(TET3)
MLK131828896(TET1) 131829689(TET2) 131840313(TET3)
NVS122889310(TET2) 122900734(TET1) 122914996(TET3)
ORO101374488(TET3) 101378267(TET2) 101378605(TET1)
EJU114214182(TET1) 114218880(TET3) 114222638(TET2)
ZCA113919689(TET1) 113924553(TET2) 113937742(TET3)
MLX118007964(TET3) 118018005 118018781 118027062(TET2)
NSU110572149(TET2) 110588865(TET3) 110589453(TET1)
LWW102725807(TET3) 102732816(TET2) 102734137(TET1)
FCA101083580(TET3) 101091562(TET1) 101092848(TET2)
PYU121019242(TET3) 121031695(TET2) 121036709(TET1)
PCOO112854753(TET1) 112858890(TET2) 112869209(TET3)
PBG122477856(TET2) 122492821(TET1) 122497026(TET3)
LRUF124503768 124506854 124520143
PTG102959541(TET1) 102960254(TET3) 102960342(TET2)
PPAD109247616(TET2) 109262972(TET3) 109264335(TET1)
PUC125922984 125932682 125937119
AJU106966496 106967141 106967737
HHV120232488(TET1) 120236995(TET3) 120247616(TET2)
BTA101904937(TET3) 513640(TET1) 538481(TET2)
BOM102272998(TET1) 102276920(TET3) 102287204(TET2)
BIU109553624(TET1) 109560281(TET2) 109565923(TET3)
BBUB102396328(TET1) 102398208(TET3) 102405717(TET2)
BBIS104980993(TET3) 104994622(TET2) 104997447(TET1)
CHX102184732(TET3) 102186373(TET1) 102191595(TET2)
OAS101103534(TET1) 101104996(TET2) 101105649(TET3)
BTAX128047853(TET1) 128049838(TET2) 128056499(TET3)
ODA120851232(TET3) 120861760(TET2) 120865194(TET1)
CCAD122422368(TET2) 122441496(TET3) 122446483(TET1)
MBEZ129539962(TET3) 129555778(TET1) 129561884(TET2)
SSC100520484(TET3) 100521465(TET2) 100625859(TET1)
CFR102506052(TET2) 102506860(TET3) 102511955(TET1)
CBAI105066365(TET1) 105066986(TET3) 105067925(TET2)
CDK105089572(TET2) 105093883(TET1) 105096566(TET3)
VPC102538207(TET2) 102542409(TET1) 102543706(TET3)
BACU102998384(TET3) 103004922(TET1) 103014051(TET2)
LVE103076185 103079040(TET3) 103090176(TET2)
OOR101270552(TET3) 101272595(TET2) 101275716(TET1)
DLE111169121(TET3) 111171470(TET2) 111183443(TET1)
PCAD102978846(TET3) 102982309(TET2) 102988205(TET1)
PSIU116742008(TET1) 116753870(TET2) 116764561(TET3)
NASI112404073(TET2) 112413578(TET1) 112413633(TET3)
ECB100057820(TET3) 100072632(TET1) 100073065(TET2)
EPZ103557579(TET1) 103558398(TET2) 103559864(TET3)
EAI106823862(TET3) 106842085(TET2) 106845001(TET1)
MYB102255490(TET3) 102261023(TET1) 102261093(TET2)
MYD102756019(TET3) 102761585(TET1) 102773712(TET2)
MMYO118668842(TET3) 118670330 118673465(TET2)
MLF102419990(TET1) 102424636(TET3) 102427377(TET2)
MNA107526041(TET1) 107529266(TET3) 107545507(TET2)
PKL118703232(TET2) 118717550(TET3) 118719003(TET1)
EFUS103289600(TET1) 103291411(TET3) 103293858(TET2)
HAI109371211(TET3) 109372700(TET1) 109377031(TET2)
DRO112302954(TET3) 112305623(TET1) 112317846(TET2)
SHON118975370(TET1) 118977172(TET2) 119000079(TET3)
AJM119038161(TET1) 119038419(TET3) 119056127(TET2)
PDIC114491415(TET2) 114497399(TET1) 114499427(TET3)
PHAS123806764(TET2) 123812017(TET3) 123821067(TET1)
MMF118624783(TET2) 118630919(TET3) 118632499(TET1)
RFQ117022137(TET2) 117032773(TET3) 117036040(TET1)
PPAM129069789(TET1) 129085313(TET2) 129086836(TET3)
PALE102883587(TET2) 102884458(TET3) 102897200(TET1)
PGIG120591192(TET2) 120594545(TET3) 120609448(TET1)
PVP105290748(TET3) 105293020(TET2) 105300099(TET1)
RAY107501310(TET1) 107502894(TET3) 107512419(TET2)
MJV108386480(TET3) 108396733(TET1) 108397333(TET2)
TOD119234554(TET1) 119243663(TET2) 119259081(TET3)
SARA101544370(TET1) 101545360(TET3) 101557265(TET2)
LAV100671009(TET3) 100674717(TET2) 100675001(TET1)
TMU101350164 101361786 101362070
ETF101640209(TET3) 101642759(TET2) 101657294(TET1)
DNM101417608(TET3) 101433103(TET1) 101443359(TET2)
MDO100013110(TET2) 100014701(TET1) 100617359(TET3)
GAS123233032(TET1) 123233070(TET3) 123252900(TET2)
SHR100914493(TET2) 100916608(TET3) 100919541(TET1)
AFZ127542016 127547320 127552102
PCW110199787(TET2) 110200064(TET1) 110222636(TET3)
OAA100079592(TET2) 100091768(TET1) 103167955(TET3)
GGA422540(TET2) 423690(TET1) 425829(TET3)
PCOC116234497(TET3) 116235004(TET1) 116238103(TET2)
MGP100539143(TET3) 100541560(TET1) 100544333(TET2)
CJO107313300(TET2) 107315707(TET1) 107323691(TET3)
TPAI128071867(TET3) 128078097(TET1) 128079861(TET2)
LMUT125685231(TET3) 125692092(TET2) 125692863(TET1)
NMEL110387222(TET3) 110397478(TET2) 110399228(TET1)
APLA101797266(TET2) 101797987(TET1) 119713564(TET3)
ACYG106030964(TET1) 106045311(TET2) 106047649(TET3)
CATA118244814(TET2) 118249363(TET1) 118259339(TET3)
AFUL116488539(TET2) 116491100(TET1) 116499295(TET3)
TGU100218736(TET1) 100228365(TET2) 115498126(TET3)
LSR110469879(TET1) 110471159(TET2) 110480184(TET3)
SCAN103821156(TET1) 103824907(TET3) 103826019(TET2)
PMOA120496107(TET1) 120499142(TET3) 120499736(TET2)
OTC121339046(TET3) 121346575(TET2) 121348061(TET1)
PRUF121355603(TET3) 121362610(TET2) 121365692(TET1)
GFR102036059(TET1) 102037031(TET2) 102044775(TET3)
FAB101813234(TET1) 101817204(TET2) 101822076(TET3)
OMA130252139(TET2) 130254837(TET1) 130261909(TET3)
PHI102105215(TET3) 102107468(TET2) 102113398(TET1)
PMAJ107199274(TET3) 107202979(TET2) 107206742(TET1)
CCAE111927752(TET2) 111931501(TET1) 111938773(TET3)
CCW104683770(TET3) 104690152(TET1) 104697108(TET2)
CBRC103617320(TET2) 103623624(TET1)
ETL114060749(TET2) 114066280(TET1) 114071512(TET3)
ZAB102065475(TET1) 102069996(TET2)
ACHL103800068 103805089(TET2)
SVG106854393(TET2) 106857302(TET1) 106862863(TET3)
MMEA130580380(TET1) 130581233(TET2) 130584217(TET3)
HRT120752764(TET2) 120755597(TET1) 120764031(TET3)
FPG101913593(TET3) 101913943(TET2) 101919711(TET1)
FCH102046196(TET3) 102047169(TET2) 102056076(TET1)
CLV102089745(TET3) 102089841(TET1) 102095484(TET2)
EGZ104124627(TET1) 104126583(TET2) 104130376(TET3)
NNI104013483(TET1) 104021176(TET2)
PCRI104025635(TET1) 104030437(TET2)
PLET104619536(TET1) 104620864(TET2)
EHS104510901(TET1)
PCAO104043512 104049477(TET2)
ACUN113479521(TET2) 113481840(TET1) 113488026
TALA104361177(TET1) 104366475(TET2) 116959725(TET3)
PADL103918484(TET1) 103919528(TET2)
AFOR103894223(TET2) 103905220(TET3) 103908202(TET1)
ACHC115343343(TET2) 115347979(TET1) 115350363(TET3)
HALD104312072(TET1) 104319322(TET2)
HLE104829018(TET3) 104839591(TET1) 104843328(TET2)
AGEN126042642 126045016 126051735
GCL127015480 127017542 127025226
CCRI104156145(TET1) 104169051(TET2)
CSTI104560235(TET1) 104564023(TET2)
CMAC104484543(TET1) 104485684(TET2)
MUI104535233 104547379(TET2)
BREG104637006(TET2) 104643006(TET1)
FGA104073526(TET1) 104074867(TET2)
GSTE104259158(TET1) 104260861(TET2)
LDI104352006(TET1) 104353898(TET2)
MNB103771187 103774983
OHA104338393(TET1) 104339124(TET2)
NNT104401976(TET1) 104404004(TET2)
SHAB115608169(TET1) 115610369(TET2) 115618360(TET3)
DPUB104301807(TET2) 104306168(TET1)
PGUU104469017(TET2) 104471706(TET1)
ACAR104523951(TET2) 104532957
CPEA104386299(TET1) 104393647(TET2)
AVIT104269294 104271454(TET2)
CVF104286857(TET2) 104294302(TET1)
RTD128903904(TET3) 128909886(TET2) 128911141(TET1)
CUCA104062873(TET2) 104065470(TET3) 104065665(TET1)
TEO104370857 104374820(TET2)
BRHI104491290(TET1) 104493639(TET2)
AAM106486962(TET1) 106492014(TET2)
AROW112963152(TET1) 112972180(TET2)
NPD112950025 112950202(TET1) 112957280(TET2)
TGT104578297(TET2) 104580165(TET1)
DNE112986863(TET1) 112988376(TET2)
SCAM104144673(TET1) 104153454(TET2)
ASN102368709(TET2) 102380670(TET3) 102387642(TET1)
AMJ102559455(TET1) 102564733(TET2) 102575499(TET3)
CPOO109309417(TET2) 109312461(TET1) 109317289(TET3)
GGN109290916(TET1) 109295505(TET3) 109301046(TET2)
PSS102453997(TET3) 102462102(TET2) 102462678(TET1)
CMY102930294(TET3) 102932494(TET1) 102946068(TET2)
CCAY125626362(TET3) 125635251(TET2)
DCC119848649(TET3) 119854395(TET2) 119858487(TET1)
CPIC101930793(TET3) 101939735(TET1) 101946912(TET2)
TST117872889(TET3) 117877611(TET2) 117881014(TET1)
CABI116821202(TET3) 116833048(TET2) 116833613(TET1)
MRV120368680(TET1) 120397188(TET3) 120406326(TET2)
ACS100552284(tet2) 100555822(tet3) 107983127
ASAO132771193(TET1) 132776950(TET2) 132782284(TET3)
PVT110072087(TET3) 110080471(TET2) 110086794(TET1)
SUND121926392(TET1) 121930501(TET2) 121932618(TET3)
PBI103048985(TET1) 103054028(TET3) 103057861(TET2)
PMUR107283256(TET3)
CTIG120299356(TET3) 120299629(TET1) 120308235(TET2)
TSR106546441(TET1) 106552164(TET3)
PGUT117673325(TET3) 117678003(TET1) 117679906(TET2)
APRI131200647(TET1) 131202940(TET2) 131204017(TET3)
PTEX113434810(TET2) 113444649(TET1) 113445766(TET3)
NSS113412812(TET2) 113415410(TET1) 113423394(TET3)
VKO123016824(TET3) 123018400(TET1) 123023180(TET2)
PMUA114597192(TET1) 114602655(TET3) 114603859(TET2)
PRAF128413914(TET1) 128420063(TET3) 128421299(TET2)
ZVI118083422(TET2) 118087968(TET3) 118096505(TET1)
HCG128326307(TET2) 128333736(TET3) 128350193(TET1)
GJA107112689(TET1) 107120329(TET3) 107125656(TET2)
STOW125437904(TET1) 125440120(TET2) 125441433(TET3)
EMC129331663(TET1) 129336874(TET2) 129341961(TET3)
XLA108706731(tet2.S) 108710731(tet2.L) 108711530(tet3.L) 108712780(tet3.S)
XTR100036628(tet3) 100380145(tet2)
NPR108785428(TET2) 108793891(TET3)
RTEM120918221(TET2) 120931049(TET3)
BBUF120986074(TET3) 120989870(TET2)
BGAR122927454(TET3) 122944354(TET2)
MUO115461156(TET2) 115469289(TET3) 115471269(TET1)
GSH117358823(TET1) 117362931(TET3) 117365856(TET2)
DRE101883702(tet1) 101887161(tet2) 103283056(tet3)
SRX107708251 107708452 107714646 107747454 107757629
SANH107654213 107678588 107690175 107695330 107697244 107700324
SGH107551814 107557386 107582512 107589523 107595052 107598249
CCAR109052757 109101144 109108305
CAUA113044437(tet2) 113057164 113071276 113071686 113108593 113112936
CGIB127950932 127957065 127969921 128013720 128026402 128028902
PTET122341477(tet2) 122345953(tet3) 122356542(tet1)
LROH127165255(tet3) 127172079(tet2) 127175164(tet1)
OMC131537146(tet2) 131540287(tet3) 131551813(tet1)
PPRM120470439(tet3) 120479303(tet1) 120494984(tet2)
RKG130083099(tet1) 130088077(tet3) 130099433(tet2)
MAMB125267359(tet3) 125272401(tet2) 125276628(tet1)
CIDE127509840 127512813
MASI127412013 127414011 127425280 127438228 127443679 127445141
TROS130551417(tet3) 130552443(tet2) 130559588(tet1)
TDW130418875(tet3) 130432057(tet1) 130433988(tet2)
MANU129415640(tet1) 129439748(tet3) 129444573(tet2)
IPU108255510 108263573 108263772
IFU128605531 128606156(tet2) 128625503(tet3)
PHYP113524609(tet2) 113536954(tet3) 113539835
SMEO124376472(tet1) 124380415(tet3) 124396260(tet2)
TFD113639797(tet1) 113657096(tet2) 113657198(tet3)
TVC132847229(tet1) 132847740(tet2) 132855401(tet3)
AMEX103033153(tet1) 103046012 103046434(tet2)
CMAO118810331(tet1) 118810755(tet2) 118826856(tet3)
EEE113585328(tet2) 113587361 113587604
CHAR105890015(tet3) 105903989(tet2) 105909953(tet1)
TRU101065346 101068038 101073625(tet2)
TFS130526305(tet3) 130527067(tet2) 130533605(tet1)
TNGGSTEN00016497G001 GSTEN00031114G001
LCO104925995(tet3) 104926967(tet2) 104930132
NCC104946267 104965096(tet2)
TBEN117481665(tet2) 117496954(tet3) 117499615(tet1)
CGOB115014035(tet3) 115015344(tet2) 115019750
PGEO117449520(tet2) 117452092(tet3) 117459736(tet1)
GACU117538195(tet1) 117553111(tet3) 117555303(tet2)
ELY117248806(tet1) 117252988(tet3) 117255249(tet2)
EFO125885386(tet2) 125889715(tet3) 125903330(tet1)
PLEP121941816(tet2) 121944609(tet3) 121954351(tet1)
SLUC116034366(tet2) 116050487(tet3) 116054055(tet1)
ECRA117937173(tet2) 117945522(tet3) 117960143(tet1)
ESP116690050 116697744(tet2) 116704931
PFLV114555176 114568827(tet2) 114572644(tet1)
GAT120820909(tet1) 120825864(tet2) 120830296(tet3)
PPUG119213985(tet1) 119217628(tet2) 119224959(tet3)
AFB129091947(tet1) 129095825(tet2) 129101347(tet3)
CLUM117735693(tet2) 117736449(tet3) 117743821(tet1)
MSAM119891294(tet3) 119898929(tet2) 119916904(tet1)
SCHU122872946(tet2) 122876524(tet3) 122884910(tet1)
CUD121508056(tet2) 121509457(tet3) 121511061(tet1)
ALAT119018507(tet2) 119019374(tet3) 119033343(tet1)
MZE101464948 101470589(tet2) 101481549
ONL102079559(tet3) 102081773 102082021(tet2)
OAU116316631(tet1) 116325381(tet3) 116330005(tet2)
OLA101165814 101169512 101170986(tet2)
OML112148024(tet3) 112157114(tet2) 112162155(tet1)
XMA102222313(tet3) 102236515(tet2) 106699700(tet1)
XCO114137933 114144979(tet2) 114154028(tet3)
XHE116712546(tet1) 116720652(tet2) 116730466(tet3)
PRET103466474(tet2) 103469756(tet3) 103476883
PFOR103146704(tet3) 103147714 103147743 103148478 103148482
PLAI106936827(tet3) 106940854 106955188(tet1) 106959448
PMEI106904236 106906237 106907602(tet1) 106908333 106925456(tet2)
GAF122828818(tet3) 122829015(tet2) 122843055(tet1)
CVG107092736 107095860(tet2) 107101442
CTUL119788573(tet1) 119791135(tet3) 119796259(tet2)
GMU124859149(tet1) 124867810(tet2) 124877530(tet3)
NFU107375277(tet2) 107375701(tet1) 107393527(tet3)
KMR108230985(tet2) 108234976(tet3) 108244348(tet1)
ALIM106517051(tet2) 106524728(tet3) 106528603(tet1)
NWH119412355(tet1) 119414114(tet3) 119430751(tet2)
AOCE111564364 111567143(tet2) 111572277
MCEP125003651(tet2) 125011670(tet3) 125018638(tet1)
CSEM103383528(tet2) 103387319(tet1) 103397059 103397467
POV109633800(tet3) 109635625 109638351(tet2)
SSEN122770130(tet3) 122771245(tet2) 122781627(tet1)
HHIP117767377(tet3) 117771572(tet2) 117775330(tet1)
HSP118114908(tet3) 118118900(tet1) 118120914(tet2)
LCF108878340 108884413 108896534
SDU111226959(tet3) 111235155(tet1) 111236619(tet2)
SLAL111647925(tet3) 111654651 111670419(tet2)
XGL120796461(tet1) 120800110(tet2) 120804943(tet3)
HCQ109509904 109511104(tet2) 109524987
SSCV125968399 125978679 125993881
SBIA133499571(tet3) 133505935 133509409(tet1)
PEE133400373(tet3) 133403541(tet2) 133409480(tet1)
PTAO133474694(tet3) 133476830(tet2) 133486016(tet1)
BPEC110163340 110164208 110165368(tet2)
MALB109954754 109961018(tet1) 109961312(tet2)
BSPL114861517(tet2) 114861909(tet3) 114870424(tet1)
SJO128365362(tet3) 128370085(tet2) 128372691(tet1)
SASA106577185 106580493 106585101 106602283 106610354 106613168
STRU115153373 115164298 115191710 115193563 115200351 115202312
OTW112241066(tet2) 112248648(tet3) 112253563 112256292(tet1) 112262693
OMY110497305(tet2) 110502641 110525859 110530841 110533203 110536245
OGO124001139(tet2) 124034168 124038367(tet1) 124041113
ONE115111770 115113089 115134959 115140236
OKI109879062 109881972 109882281 109894927 109899825 116373087
OKE118357874 118366110 118373700(tet2) 118380482 118393385
SALP111958050 111974813 111978183
SNH120017848 120035087(tet2) 120037635 120046715(tet1) 120063344(tet3)
CCLU121530650 121553401 121557063(tet2) 121567486 121585020
ELS105010609 105014352(tet3) 105021066(tet2)
SFM108920723 108924487(tet2) 108940376
PKI111837235(tet2) 111844155(tet3) 111849581
AANG118206231(tet3) 118217852(tet1) 118227299(tet2) 118231295
LOC102689575(tet3) 102689591(tet1) 102689863(tet2)
PSPA121302240 121303004(tet3) 121321870 121322046 121326180(tet1) 121327427
ARUT117397862 117408527 117415695 117418218 117421276 117966089
PSEX120532804(tet2)
LCM102346742(TET2) 102350737(TET3) 102366582(TET1)
CMK103177662 103182207(tet1) 103191015
RTP109917413 109927965
CPLA122543146(tet3) 122564906
HOC132825315 132837007(tet3)
LERI129695579 129713329
PMRN116950889
LRJ133354339
BFO118411024
BBEL109478275
CIN100181878
SCLV120347720
SPU580376
APLC110977987
SKO100366356
DMEDmel_CG43444(Tet)
DER6546372
DSE6610523
DSIDsimw501_GD13372(Dsim_GD13372)
DYADyak_GE21689
DAN6493110
DSR110185335
DPO6900088
DPE6599610
DMN108151565
DWI6639345
DGR6557193
DMODmoj_GI13905
DAZ108613259
DNV108651546
DHE111597607
DVI6623063
CCAT101460073
BOD106618212
BDR105225149
RZE108359009
TDA119667643 119680104
MDE101900516
SCAC106095028
LCQ111674877
LSQ119607850
ECOE129944122
HIS119649277
AGA5667160
ACOZ120953591
AARA120908832
AMER121592909
ASTE118510262
AFUN125770622
AALI118467261
AAG5573007
AALB109422486 115262859
CQUCpipJ_CPIJ009910
CPII120418658
CNS116350503
BCOO119079308
AME412878
ACER107995534
ALAB122712506
ADR102680417
AFLR100866593
BIM100742067
BBIF117210742
BVK117232268
BVAN117157851
BTER100642293
BAFF126921330
BPYO122573971
FVI122532787
CCAL108629950
OBB114879355
MGEN117225819
NMEA116430872
CGIG122395997
SOC105201110
MPHA105832348
AEC105145855
ACEP105618945
PBAR105434147
VEM105570560
HST105189647
DQU106750706
CFO105258876
FEX115236392
LHU105670607
PGC109855178
OBO105283671
PCF106793296
PFUC122526086
VPS122632980
VCRB124428261
NVI100114438
CSOL105362988
TPRE106660203
LHT122512715
LBD127289164
MDL103575228
CGLO123267057
FAS105266688
DAM107040167
AGIF122851822
CINS118073823
CCIN107274493
DSM124416660
NPT124210824
NFB124175539
NLO107221085
NVG124296972
TCA103312925
DPA109535782
SOY115876270
ATD109596041
CSET123310831
AGB108905769
LDC111508647
NVL108564764
APLN108734145
PPYR116170368
OTU111428051
BMOR101743969
BMAN114240805
MSEX115452729
DPLKGM_210059
BANY112047331
MJU123866945
NIQ126768610
VCD124530202
MCIX123654186
PMAC106710979
PPOT106101320
PXU106125335
PRAP110993496
PBX123714034
PNAP125060502
ZCE119831339
CCRC123692444
LSIN126973095
HAW110374536
HZE124630237
TNL113502725
SLIU111349519
OFU114358184
PXY105385720
CCRN123297879
API100159694
DNX107173867
AGS114129200
RMD113554993
BTAB109029641
DCI103505818
CLEC106665216
NLU111058182
HVI124357290
PHUPhum_PHUM059340
FOC113214477
TPAL117643904
ZNE110838460
CSEC111872603
SGRE126285408
IEL124161468
FCD110862326
DMK116917382
PVM113824054
PJA122242937
PCHN125026712
PMOO119580173
HAME121859110
PCLA123766499
PTRU123514607
ESN126995607
HAZT108667539
EAF111703686 111708890
DSV119436731
RSAN119396304
RMP119161275
CSCU111612732
PTEP107446842
SDM118188929 118200961
LPOL106458609
PCAN112563243
BGT106065605
GAE121378624
HRF124132607
HRJ124271982
CRG105322168
MYI110453899
PMAX117333895
MCAF127710228
MMER123564014
DPOL127869630
OBI106871070
OSN115213579
LAK106173631
NVE5514733
EPA110239364
ATEN116299108
ADF107350757
AMIL114946992
PDAM113671110
SPIS111344530
XEN124457572
HMG100213294
AQU100632527
 » show all
Reference
1  [PMID:20639862]
  Authors
Ito S, D'Alessio AC, Taranova OV, Hong K, Sowers LC, Zhang Y.
  Title
Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification.
  Journal
Nature 466:1129-33 (2010)
DOI:10.1038/nature09303
  Sequence
Reference
2  [PMID:21778364]
  Authors
Ito S, Shen L, Dai Q, Wu SC, Collins LB, Swenberg JA, He C, Zhang Y.
  Title
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine.
  Journal
Science 333:1300-3 (2011)
DOI:10.1126/science.1210597
Reference
3  [PMID:21817016]
  Authors
He YF, Li BZ, Li Z, Liu P, Wang Y, Tang Q, Ding J, Jia Y, Chen Z, Li L, Sun Y, Li X, Dai Q, Song CX, Zhang K, He C, Xu GL.
  Title
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA.
  Journal
Science 333:1303-7 (2011)
DOI:10.1126/science.1210944
Reference
4  [PMID:21862836]
  Authors
Maiti A, Drohat AC.
  Title
Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites.
  Journal
J Biol Chem 286:35334-35338 (2011)
DOI:10.1074/jbc.C111.284620
Reference
5  [PMID:22327402]
  Authors
Zhang L, Lu X, Lu J, Liang H, Dai Q, Xu GL, Luo C, Jiang H, He C.
  Title
Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA.
  Journal
Nat Chem Biol 8:328-30 (2012)
DOI:10.1038/nchembio.914
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.80
IUBMB Enzyme Nomenclature: 1.14.11.80
ExPASy - ENZYME nomenclature database: 1.14.11.80
BRENDA, the Enzyme Database: 1.14.11.80

DBGET integrated database retrieval system