KEGG   ENZYME: 1.14.12.1
Entry
EC 1.14.12.1                Enzyme                                 
Name
anthranilate 1,2-dioxygenase (deaminating, decarboxylating);
anthranilate hydroxylase;
anthranilic hydroxylase;
anthranilic acid hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
Sysname
anthranilate,NAD(P)H:oxygen oxidoreductase (1,2-hydroxylating, deaminating, decarboxylating)
Reaction(IUBMB)
anthranilate + NAD(P)H + 2 H+ + O2 = catechol + CO2 + NAD(P)+ + NH3 [RN:R00823 R00825]
Reaction(KEGG)
R00823 R00825
Substrate
anthranilate [CPD:C00108];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
catechol [CPD:C00090];
CO2 [CPD:C00011];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
NH3 [CPD:C00014]
Comment
Requires Fe2+.
History
EC 1.14.12.1 created 1972
Pathway
ec00627  Aminobenzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K05599  anthranilate 1,2-dioxygenase (deaminating, decarboxylating) large subunit
K05600  anthranilate 1,2-dioxygenase (deaminating, decarboxylating) small subunit
K16319  anthranilate 1,2-dioxygenase large subunit
K16320  anthranilate 1,2-dioxygenase small subunit
Genes
EBTEBL_c12070 EBL_c12080
SFOZ042_01300 Z042_01305
PSDDSC_14475 DSC_14480 DSC_14600 DSC_14605 DSC_14835 DSC_14840
RBDALSL_0883 ALSL_0884
PAEPA2512(antA) PA2513(antB)
PAEVN297_2583(antA) N297_2584(antB)
PAEIN296_2583(antA) N296_2584(antB)
PAUPA14_32150(antB) PA14_32160(antA)
PAPPSPA7_2724(antB) PSPA7_2725(antA)
PAGPLES_27821(antB) PLES_27831(antA)
PAFPAM18_2526(antB) PAM18_2527(antA)
PNCNCGM2_3517(antA) NCGM2_3518(antB)
PAEBNCGM1900_4014(antB) NCGM1900_4015(antA)
PDKPADK2_12680 PADK2_12685
PSGG655_12460 G655_12465
PRPM062_13060 M062_13065
PAEPPA1S_13080 PA1S_13085
PAERPA1R_gp0306 PA1R_gp0307
PAEMU769_12660 U769_12665
PAELT223_14280 T223_14285
PAESSCV20265_2796 SCV20265_2797
PAEUBN889_02736(antA) BN889_02737(antB)
PAEGAI22_20835 AI22_20840
PAECM802_2580(antA) M802_2581(antB)
PAEOM801_2448(antA) M801_2449(antB)
PREPCA10_14970(antB) PCA10_14980(antA) PCA10_p0060(antB) PCA10_p0070(antA)
PFUWKF707C_41350 KF707C_41360
PCQPcP3B5_23610(antB) PcP3B5_23620(antA_1) PcP3B5_30230(antA_3)
PSAVPSA3335_12300 PSA3335_12305
PAMGBKM19_019770(antB) BKM19_019775(antA)
PAVLBKM03_11110(antA) BKM03_11115(antB)
PFLPFL_0758(antB) PFL_0759(antA)
PPRCPFLCHA0_c07680(xylY1) PFLCHA0_c07690(xylX1)
PPROPPC_0771(antB) PPC_0772(antA)
PFSPFLU_5194 PFLU_5195
PFCPflA506_4487(antA) PflA506_4488(antB)
PFBVO64_2036 VO64_2037
PMANOU5_1638(tpaAa) OU5_1639
PTVAA957_19020 AA957_19025
PVRPverR02_26480 PverR02_26485
PAZOAYR47_01860 AYR47_01865
POIBOP93_21890 BOP93_21895
PFWPF1751_v1c46450 PF1751_v1c46460
PFFPFLUOLIPICF712785 PFLUOLIPICF712790
PFXA7318_21355 A7318_21360
PKCPKB_2111(antB) PKB_2112(antA) PKB_2665 PKB_3279(andac1) PKB_3280 PKB_3628(andac3) PKB_3629
PCHEY04_03160 EY04_03165
PCZPCL1606_53350 PCL1606_53360
PCPJM49_26515 JM49_26520
PSESPSCI_5126 PSCI_5127(antB)
PSEMTO66_03640 TO66_03645
PSOSPOS17_0747(antB) POS17_0748(antA)
PANRA7J50_4940 A7J50_4941
PPSLBJP27_01010 BJP27_01015
PSETTHL1_1549 THL1_1550
PYMAK972_2159 AK972_5215 AK972_5216
PALLUYA_06915 UYA_06920
PUMHGP31_03825(antB) HGP31_03830(antA)
POJPtoMrB4_24610(antB) PtoMrB4_24620(antA)
PLALFXN65_06800(antB) FXN65_06805(antA)
PSEPC4K39_0747 C4K39_0748
PTRTHU722_0014910(antA) HU722_0014915(antB) HU722_0024745(antA) HU722_0024750(antB)
PSAMHU731_011160(antA) HU731_011165(antB)
PSHHHU773_004235(antB) HU773_004240(antA)
PASGKSS96_24060(antA) KSS96_24065(antB)
PTWTUM18999_29390(antB) TUM18999_29400(antA)
ABMABSDF1970(antB) ABSDF1971(antA)
ABYABAYE1896(antA) ABAYE1897(antB)
ABCACICU_01784 ACICU_01785
ABNAB57_1977 AB57_1978
ABBABBFA_01721(antA_2) ABBFA_01722(antB)
ABXABK1_2243 ABK1_2244
ABZABZJ_01953(antB) ABZJ_01954(antA)
ABRABTJ_01921 ABTJ_01922
ABDABTW07_1997 ABTW07_1998
ABHM3Q_2137 M3Q_2138
ABADABD1_17400(antB) ABD1_17410(antA)
ABJBJAB07104_01964 BJAB07104_01965
ABABBJAB0715_01969 BJAB0715_01970
ABAJBJAB0868_01911 BJAB0868_01912
ABAZP795_8450 P795_8455
ABKLX00_08895 LX00_08900
ABAUIX87_19665 IX87_19670
ABAAIX88_10705 IX88_10710
ABWBL01_01855 BL01_01860
ABALABLAC_25960 ABLAC_25970
ACCBDGL_001117(antB) BDGL_001118(antA)
ANORR32_09230 RR32_09235
ALCOTEC02_09510 OTEC02_09515
ACALBUM88_09470 BUM88_09475
ASEII8T81_09920(antA) I8T81_09925(antB)
ACDAOLE_09970 AOLE_09975
ACIACIAD2669(antA) ACIAD2670(antB)
ATTAMQ28_12690 AMQ28_12695
ACWA0J50_08815 A0J50_08820
ASOLBEN76_01210 BEN76_01215
ADVDJ533_09325(antB) DJ533_09330(antA)
ARJDOM24_08235(antA) DOM24_08240(antB)
AGUAS4_15280(antB) AS4_15290(antA)
ADSFPL17_09680(antB) FPL17_09685(antA)
ATNFM020_06725(antB) FM020_06730(antA)
ACHICDG60_11300(antA) CDG60_11305(antB)
PSAZPA25_36660
KIMG3T16_00430 G3T16_00435 G3T16_00475 G3T16_00480
CYQQ91_0875 Q91_0964(andAc) Q91_0966 Q91_1468 Q91_1469 Q91_2196 Q91_2230 Q91_2231 Q91_2233
CZACYCME_0225 CYCME_0995 CYCME_0996 CYCME_1638 CYCME_1640 CYCME_2548 CYCME_2549 CYCME_2551
CYYCPC19_01635 CPC19_01645 CPC19_01650 CPC19_01665 CPC19_01820 CPC19_05460 CPC19_05465 CPC19_07900 CPC19_07910
HCSFF32_05700 FF32_05705
HBEBEI_0566(antA) BEI_0567
HALKCUU95_06380(antA) CUU95_06385(antB)
HVNEI420_19835(antB) EI420_19840(antA)
MARSA8C75_04805 A8C75_04810
MGEOCFI10_05005(antA) CFI10_05010(antB)
MSECLN244_11245(antB) LN244_11250(antA)
ASIMFE240_03450(antA) FE240_03455(antB)
ZDFAN401_14630 AN401_14635
GBIPG2T_01270 PG2T_01305 PG2T_02205 PG2T_04125 PG2T_08575 PG2T_08580 PG2T_08595 PG2T_09520 PG2T_09595 PG2T_09810 PG2T_11110 PG2T_11115 PG2T_11295 PG2T_11320 PG2T_11400 PG2T_11405 PG2T_12540 PG2T_13085 PG2T_13165 PG2T_13530 PG2T_14465 PG2T_14530 PG2T_14880
IGNMMG00_00665(antA) MMG00_00670(antB)
VITADP71_19020 ADP71_19030
CRZD1345_11065(antA) D1345_11070(antB)
CHAECH06BL_22710(antA) CH06BL_22720(antB)
PSENH8B_0399(antB) NH8B_0400(antA)
RPJN234_24825 N234_24830
REHH16_B0800(h16_B0800) H16_B0801(h16_B0801)
CNCCNE_2c07480 CNE_2c07490(bphA) CNE_BB1p12630(hcaE) CNE_BB1p12640
CUHBJN34_18170 BJN34_18175 BJN34_29480 BJN34_29485
REUReut_B3775 Reut_B3776
CTIRALTA_B0634
CBWRR42_s1159 RR42_s1160
COXE0W60_08895 E0W60_08900
BMABMAA0203 BMAA0204
BMVBMASAVP1_1378 BMASAVP1_1379
BMLBMA10229_1574 BMA10229_1575
BMNBMA10247_A0234 BMA10247_A0235
BMALDM55_3513 DM55_3514
BMAEDM78_4643 DM78_4644
BMAQDM76_4210 DM76_4211
BMAIDM57_14360 DM57_14365
BMAFDM51_3955 DM51_3956
BMAZBM44_3475 BM44_3476
BMABBM45_4311 BM45_4312
BPSBPSS1887 BPSS1888
BPMBURPS1710b_A0982 BURPS1710b_A0983
BPLBURPS1106A_A2562 BURPS1106A_A2563
BPDBURPS668_A2706 BURPS668_A2707
BPRGBP346_A0961 GBP346_A0962
BPSEBDL_5292 BDL_5293
BPSMBBQ_4243 BBQ_4244
BPSUBBN_5351 BBN_5352
BPSDBBX_4457 BBX_4458
BPZBP1026B_II2026 BP1026B_II2027
BPQBPC006_II2524 BPC006_II2525
BPKBBK_4625 BBK_4626
BPSHDR55_5847 DR55_5848
BPSABBU_4122 BBU_4123
BPSOX996_5645 X996_5646
BUTX994_5208 X994_5209
BTEBTH_II0488 BTH_II0489
BTQBTQ_3780 BTQ_3781
BTJBTJ_4811 BTJ_4812
BTZBTL_5597 BTL_5598
BTDBTI_5102 BTI_5103
BTVBTHA_4603 BTHA_4604
BTHEBTN_5268 BTN_5269
BTHMBTRA_5538 BTRA_5539
BTHADR62_5397 DR62_5398
BTHLBG87_5613 BG87_5614
BOKDM82_6176 DM82_6177
BOCBG90_4487 BG90_4488
BUUWS70_26915 WS70_26920
BSAVWS86_28585 WS86_28590
BVIBcep1808_4162 Bcep1808_4163
BVEAK36_4532 AK36_4533
BURBcep18194_B2324 Bcep18194_B2325
BCNBcen_4587 Bcen_4588
BCHBcen2424_3775 Bcen2424_3776
BCMBcenmc03_3747 Bcenmc03_3748
BCJBCAM0810 BCAM0811
BCENDM39_4370 DM39_4371 DM39_6335 DM39_6336
BCEWDM40_3782 DM40_3783
BCEOI35_4708 I35_4709
BAMBamb_5502 Bamb_5503
BACBamMC406_3667 BamMC406_3668
BMJBMULJ_03557(andAc) BMULJ_03558(andAd)
BMUBmul_4956 Bmul_4957
BMKDM80_4128 DM80_4129
BMULNP80_3763 NP80_3764
BCTGEM_4989 GEM_4990
BCEDDM42_4275 DM42_4276
BCEPAPZ15_20375 APZ15_20380
BDLAK34_4633 AK34_4634
BPYRABD05_17735 ABD05_17740
BCONNL30_21755 NL30_21760
BUBBW23_4531 BW23_4532
BDFWI26_17655 WI26_17660
BLATWK25_21490 WK25_21495
BTEIWS51_02340 WS51_02345
BSEMWJ12_24045 WJ12_24050
BPSLWS57_10005 WS57_10010
BMECWJ16_23025 WJ16_23030
BSTGWT74_23090 WT74_23095
BSTLBBJ41_31700 BBJ41_31705
BANNJFN94_21560 JFN94_21565 JFN94_25210 JFN94_25215
BGLbglu_2g21220 bglu_2g21230
BGUKS03_3803(antA) KS03_3804(antB)
BUGBC1001_2081 BC1001_2082
BGDbgla_2g22320 bgla_2g22330
BGOBM43_5906 BM43_5907 BM43_6961 BM43_6962
BYIBYI23_D006350 BYI23_D006360 BYI23_D010460(tphA) BYI23_D010470
BUKMYA_3862
BUEBRPE67_DCDS08170 BRPE67_DCDS08180 BRPE67_DCDS12550(tphA) BRPE67_DCDS12560
BULBW21_4639 BW21_4640
BUQAC233_11100 AC233_11105 AC233_11150 AC233_11155
BUDAQ610_29895 AQ610_29900
BUMAXG89_32055 AXG89_32060
BURKDM992_29670 DM992_29675
BXEBxe_A1101 Bxe_A1102 Bxe_A1107(ohbB) Bxe_A1108(ohbA) Bxe_B1108 Bxe_B1109 Bxe_B2347 Bxe_B2348 Bxe_B2751 Bxe_B2752 Bxe_C0941 Bxe_C0942 Bxe_C1120(andAd) Bxe_C1121(andAc)
BXBDR64_3265 DR64_3266 DR64_3271 DR64_3272 DR64_4679 DR64_4680 DR64_5084 DR64_5085 DR64_6426 DR64_6427 DR64_7508 DR64_7509 DR64_8679 DR64_8680
BGEBC1002_0157 BC1002_7006 BC1002_7007
PARABTO02_23405 BTO02_23410
PARBCJU94_37820 CJU94_37825 CJU94_37845 CJU94_37850 CJU94_37915
PHSC2L64_23745 C2L64_23750 C2L64_41770 C2L64_41775
PTERC2L65_26820 C2L65_26825 C2L65_38785 C2L65_38790
PACPFAZ97_21615(antB) FAZ97_21620(antA)
PACSFAZ98_30600 FAZ98_30605
PEWKZJ38_24835 KZJ38_24840
PDIOPDMSB3_0305.1(tphA2I) PDMSB3_0306.1(tphA3I) PDMSB3_0743.1(tphA2I) PDMSB3_0744.1
PSPUNA29_13015 NA29_13020
CABASBC2_53600(andAd) SBC2_53610(nagG)
BUOBRPE64_DCDS05860 BRPE64_DCDS05870 BRPE64_DCDS11800 BRPE64_DCDS11810
BPEBP0583 BP0584
BPCBPTD_0592 BPTD_0593
BPERBN118_3483 BN118_3484
BPETB1917_3470 B1917_3471
BPEUQ425_35650 Q425_35660
BPARBN117_0271 BN117_0272 BN117_1352
BPABPP0273 BPP0274 BPP2193
BBHBN112_1865 BN112_1866 BN112_3140 BN112_3141
BBRBB0276 BB0277 BB1590 BB1591
BBMBN115_0261 BN115_0262 BN115_1544 BN115_1545
BBXBBS798_0271 BBS798_0272 BBS798_1549 BBS798_1550
BPTBpet1540 Bpet1541 Bpet3743
BAVBAV0657 BAV0658 BAV1583 BAV1584
BBROBAU06_12305 BAU06_12310
BFZBAU07_14170 BAU07_14175
BPDZBBN53_17795 BBN53_17800
BOHAKI39_11525 AKI39_11530 AKI39_17210 AKI39_17215
BGMCAL15_12565 CAL15_12570
AXYAXYL_02468 AXYL_02469 AXYL_03917 AXYL_03918 AXYL_06586 AXYL_06587
AXNAX27061_2910 AX27061_2911
AXXERS451415_02888(andAd_2) ERS451415_02889(andAc_2)
ADTAPT56_13985 APT56_13990
AISBUW96_02620 BUW96_02625 BUW96_09070 BUW96_09075
ASWCVS48_18685 CVS48_18690
ACHRC2U31_20010 C2U31_20015 C2U31_23355 C2U31_23360
ACHBDVB37_13595 DVB37_13600
PUSCKA81_17050 CKA81_17055
PUDG9Q38_04190 G9Q38_04195 G9Q38_04440 G9Q38_04445 G9Q38_04455
AKATKWG_00625 TKWG_00630
AFAUZ73_14575 UZ73_14580
AFQAFA_15120(picB3) AFA_15125(picB4)
AAQUD3M96_16055 D3M96_16060
AAMMFE795_13985 FE795_13990
PIGEGT29_02425 EGT29_02430 EGT29_02760 EGT29_02765 EGT29_04660 EGT29_04665 EGT29_12115 EGT29_12120 EGT29_26485 EGT29_26490 EGT29_27770 EGT29_27775
PARKLSG25_10225 LSG25_10230 LSG25_11510
RHFEUB48_07875 EUB48_07880
ACIOEAG14_07270 EAG14_07275
VEIVeis_4604 Veis_4605
VAPVapar_4290 Vapar_4291
VAMC4F17_28010 C4F17_28015
HYRBSY239_2678 BSY239_2679
HYBQ5W_07045 Q5W_07050
HYNF9K07_01510 F9K07_01515 F9K07_07620
HTNKI616_03580
HSEHsero_3663(nagH) Hsero_3664(nagG)
HSZACP92_18260 ACP92_18265
HEEhmeg3_01305 hmeg3_01310
HHFE2K99_18540 E2K99_18545
HFRG5S34_19770 G5S34_19775 G5S34_23585 G5S34_23590
CARELT85_0141(ohbA) LT85_0142(ohbB)
CPRACPter91_0139 CPter91_0140
XYKGT347_17935 GT347_17940
RBUPG1C_04550 PG1C_04560 PG1C_04565 PG1C_06425 PG1C_06435 PG1C_06440 PG1C_11565 PG1C_11570
AZRCJ010_02320 CJ010_02325
THKCCZ27_09675(antB) CCZ27_09680(antA)
AGEAA314_01015 AA314_01016
MBDMEBOL_002895
HOEIMCC20628_03529
BVZBRAD3257_1703(tphA2I) BRAD3257_1704 BRAD3257_1795(tphA2I) BRAD3257_1796
BQBJ4P68_0007770
XDIEZH22_23460
MSLMsil_1468 Msil_1469
RHZRHPLAN_45720 RHPLAN_45730 RHPLAN_48820 RHPLAN_48830
NTDEGO55_05295 EGO55_05300
PHLKKY_2640 KKY_2641
PSINCAK95_02100 CAK95_02105 CAK95_25460
OAROA238_c08210
LVSLOKVESSMR4R_03228(andAd)
CMAGCBW24_16340 CBW24_16345
NARSaro_3835 Saro_3860 Saro_3867 Saro_3868
NPPPP1Y_AT15578 PP1Y_AT15588 PP1Y_AT15646 PP1Y_AT15854 PP1Y_AT31241 PP1Y_AT31639 PP1Y_AT31645 PP1Y_AT31702 PP1Y_AT31705
NPNJI59_24560 JI59_24565 JI59_24595 JI59_24600 JI59_24695
NOGGKE62_05030 GKE62_05125 GKE62_05130 GKE62_05160 GKE62_05265
SWISwit_0896
SPHDHY78_22210
SECHB18_24635 B18_24640
SJPSJA_C1-25220(andAc) SJA_C1-25230(andAd)
SBARH5V43_22260 H5V43_22265 H5V43_22295 H5V43_22300 H5V43_22425
SPHYCHN51_06895 CHN51_06900 CHN51_06930 CHN51_06935 CHN51_07060
SPHJBSL82_10945 BSL82_17600 BSL82_17605
CNAAB433_10435 AB433_18065 AB433_18160 AB433_18165 AB433_18195 AB433_18200
ERYCP97_14150 CP97_14185 CP97_14190 CP97_14270
KREGWK63_07840 GWK63_07845
AZLAZL_a06710 AZL_a06720
ALIAZOLI_p11024 AZOLI_p11025
PNPIJ22_13890 IJ22_13900
MMCMmcs_1646 Mmcs_1647
MKMMkms_1672 Mkms_1673 Mkms_5630 Mkms_5631
MJLMjls_1621 Mjls_1622 Mjls_2232 Mjls_2233
MYEAB431_15595 AB431_15600
MGAUMGALJ_00150 MGALJ_00160
MPAEK0O64_27520 K0O64_27525
MVAMvan_0492 Mvan_0493
MGIMflv_0562 Mflv_0563 Mflv_0657 Mflv_0658
MSPMspyr1_01660 Mspyr1_01670
MRHMycrhN_3163 MycrhN_3164
MTHN4412656_02480(andAd) 4412656_02481(andAc)
MGADMGAD_32100 MGAD_32110
NFRERS450000_00309(andAc)
NWLNWFMUON74_26060
RHARHA1_ro08176(tpaAa) RHA1_ro08177(tpaAb) RHA1_ro10198(tpaAb) RHA1_ro10199(tpaAa)
SPLULK06_026350
STUIGCM10017668_58050 GCM10017668_58060
ACRYAC20117_22180 AC20117_22185
AAUAAur_pTC10252 AAur_pTC10253
AGRAAGRA3207_001976 AGRA3207_003634 AGRA3207_003635
AOIAORI_4214
AJAAJAP_17840
AACDLWP59_20415 LWP59_20420
PDXPsed_0075
ACTIUA75_12805
ACADUA74_12725
AHGAHOG_12000(andAd)
SPIBG8759_19780
 » show all
Reference
1
  Authors
Kobayashi, S. and Hayaishi, O.
  Title
Anthranilic acid conversion to catechol (Pseudomonas).
  Journal
Methods Enzymol 17A:505-510 (1970)
Reference
2  [PMID:14209949]
  Authors
TANIUCHI H, HATANAKA M, KUNO S, HAYAISHI O, NAKAJIMA M, KURIHARA N.
  Title
ENZYMATIC FORMATION OF CATECHOL FROM ANTHRANILIC ACID.
  Journal
J Biol Chem 239:2204-11 (1964)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.12.1
IUBMB Enzyme Nomenclature: 1.14.12.1
ExPASy - ENZYME nomenclature database: 1.14.12.1
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.12.1
BRENDA, the Enzyme Database: 1.14.12.1
CAS: 9059-17-0

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