KEGG ENZYME: 1.14.12.15

ENZYME: 1.14.12.15

Entry

EC 1.14.12.15               Enzyme

Name

terephthalate 1,2-dioxygenase;
benzene-1,4-dicarboxylate 1,2-dioxygenase;
1,4-dicarboxybenzoate 1,2-dioxygenase

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor

Sysname

benzene-1,4-dicarboxylate,NADH:oxygen oxidoreductase (1,2-hydroxylating)

Reaction(IUBMB)

terephthalate + NADH + H+ + O2 = (1R,6S)-dihydroxycyclohexa-2,4-diene-1,4-dicarboxylate + NAD+ [RN:R05148]

Reaction(KEGG)

R05148

Substrate

terephthalate [CPD:C06337];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]

Product

(1R,6S)-dihydroxycyclohexa-2,4-diene-1,4-dicarboxylate [CPD:C06318];
NAD+ [CPD:C00003]

Comment

Has been shown to contain a Rieske [2Fe-2S] cluster

History

EC 1.14.12.15 created 1999

Pathway

ec00624

Polycyclic aromatic hydrocarbon degradation

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K18074

terephthalate 1,2-dioxygenase oxygenase component alpha subunit

K18075

terephthalate 1,2-dioxygenase oxygenase component beta subunit

Genes

PARK:

LSG25_11505

RHOB:

HTY51_11710

VPD:	VAPA_2c09660 VAPA_2c09670

CTT:	CtCNB1_1493 CtCNB1_1494

CTES:

O987_22455 O987_22460

RTA:	Rta_16740 Rta_16750

HYB:	Q5W_19730 Q5W_19735

HTN:	KI616_03585

HCZ:	G9Q37_15485

HYY:	JNX00_08635 JNX00_14775 JNX00_14780

HYDR:

SOM08_05245 SOM08_05250 SOM08_12235 SOM08_12240

HYDA:

ABSY19_21630

» show all

Reference

1 [PMID:7961417]

Authors

Schlafli HR, Weiss MA, Leisinger T, Cook AM

Title

Terephthalate 1,2-dioxygenase system from Comamonas testosteroni T-2: purification and some properties of the oxygenase component.

Journal

J Bacteriol 176:6644-52 (1994)
DOI:10.1128/JB.176.21.6644-6652.1994

Sequence

[ctt:CtCNB1_1493 CtCNB1_1494]

Other DBs

ExplorEnz - The Enzyme Database:

1.14.12.15

IUBMB Enzyme Nomenclature:

1.14.12.15

ExPASy - ENZYME nomenclature database:

1.14.12.15

UM-BBD (Biocatalysis/Biodegradation Database):

1.14.12.15

BRENDA, the Enzyme Database:

1.14.12.15

CAS:	162032-76-0

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