Entry |
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Name |
benzene 1,2-dioxygenase;
benzene hydroxylase;
benzene dioxygenase
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Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
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Sysname |
benzene,NADH:oxygen oxidoreductase (1,2-hydroxylating)
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Reaction(IUBMB) |
benzene + NADH + H+ + O2 = cis-cyclohexa-3,5-diene-1,2-diol + NAD+ [RN: R03543]
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Reaction(KEGG) |
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Substrate |
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Product |
cis-cyclohexa-3,5-diene-1,2-diol [CPD: C04091];
NAD+ [CPD: C00003]
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Comment |
A system, containing a reductase which is an iron-sulfur flavoprotein (FAD), an iron-sulfur oxygenase and ferredoxin. Requires Fe2+.
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History |
EC 1.14.12.3 created 1972
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Pathway |
ec00361 | Chlorocyclohexane and chlorobenzene degradation |
ec01120 | Microbial metabolism in diverse environments |
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Orthology |
K03268 | benzene/toluene/chlorobenzene dioxygenase subunit alpha |
K16268 | benzene/toluene/chlorobenzene dioxygenase subunit beta |
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Genes |
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Reference |
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Authors |
Gibson DT, Koch JR, Kallio RE. |
Title |
Oxidative degradation of aromatic hydrocarbons by microorganisms. I. Enzymatic formation of catechol from benzene. |
Journal |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 1.14.12.3 |
UM-BBD (Biocatalysis/Biodegradation Database): | 1.14.12.3 |
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