KEGG   ENZYME: 1.14.12.7
Entry
EC 1.14.12.7                Enzyme                                 
Name
phthalate 4,5-dioxygenase;
PDO ;
phthalate dioxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
Sysname
phthalate,NADH:oxygen oxidoreductase (4,5-hydroxylating)
Reaction(IUBMB)
phthalate + NADH + H+ + O2 = cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+ [RN:R03630]
Reaction(KEGG)
R03630
Substrate
phthalate [CPD:C01606];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate [CPD:C04783];
NAD+ [CPD:C00003]
Comment
A system, containing a reductase which is an iron-sulfur flavoprotein (FMN), an iron-sulfur oxygenase, and no independent ferredoxin. Requires Fe2+.
History
EC 1.14.12.7 created 1990
Pathway
ec00624  Polycyclic aromatic hydrocarbon degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K18068  phthalate 4,5-dioxygenase
Genes
PLULFOB45_02790
MBSMRBBS_1311(cbaA)
HAMHALO0380
HSRHSBAA_48220
HMDCTT34_16730
HSXHNO51_14950
MPRFJ8N69_04550
MGEOCFI10_14950
GBIPG2T_14045
RPFRpic12D_2779 Rpic12D_4958
RPJN234_12835
CNCCNE_2c21230(pht1)
CUHBJN34_09610 BJN34_28850
REUReut_B5781
RMERmet_5548
CBWRR42_s1578
CCUPBKK81_29815
CUPBKK80_26540
CUUBKK79_32425
COXE0W60_20460
BVIBcep1808_4273
BCENDM39_1999
BMJBMULJ_03712(ophA2)
BMUBmul_4805
BMKDM80_4020
BUBBW23_5728 BW23_5729
BUGBC1001_4039
BGOBM43_4032
BYIBYI23_B001650 BYI23_C002440 BYI23_D003170 BYI23_D008300
BUEBRPE67_BCDS04040 BRPE67_CCDS09780 BRPE67_DCDS04970 BRPE67_DCDS10220
BPLAbpln_1p1370
BXBDR64_1235 DR64_4702
BPHBphy_3201 Bphy_4881 Bphy_4882 Bphy_6982
BGEBC1002_3595 BC1002_4693
BPXBUPH_00622 BUPH_02685
BPYBphyt_7254
BUZAYM40_12125 AYM40_32995 AYM40_33000
BCAIK788_0000443 K788_0005439
PSPWBJG93_04590
PARABTO02_23060
PHSC2L64_49415
PTERC2L65_19050 C2L65_44680
PCJCUJ87_29360
PEWKZJ38_26705
PPULRO07_06175
PSPUNA29_21445
POXMB84_08085
PTXABW99_00725
PFGAB870_18750
PNRAT302_05945 AT302_13310
PFIBPI93_011765 PI93_023915
BUOBRPE64_DCDS03430 BRPE64_DCDS07110
BBHBN112_3649
BBMBN115_4450
BBXBBS798_4550
BPTBpet0252
BHZACR54_04439(pht3)
BBROBAU06_03620 BAU06_03750 BAU06_03780
BFZBAU07_13845 BAU07_15835 BAU07_15865
BPDZBBN53_00955
BOHAKI39_21300 AKI39_21330
BGMCAL15_17820
BOJCBF45_02355
PUDG9Q38_00025 G9Q38_10670
PHNPAEH1_01175
PIGEGT29_10005 EGT29_10580 EGT29_22455 EGT29_23240 EGT29_23705 EGT29_25710 EGT29_27735 EGT29_27745
KGYEHF36_02745
RHYRD110_25740
POLBpro_1910 Bpro_5154
PNAPnap_4627
POSDT070_19560 DT070_20425
POOF7R28_10150 F7R28_11010
ACIDCBP33_05530
ACIPCBP36_05980 CBP36_20410
ACINCBP34_05365
ACISCBP35_12965 CBP35_20490
VEIVeis_2928
DELDelCs14_1655 DelCs14_1661
DLAI6G47_32030 I6G47_32085 I6G47_32165 I6G47_32230 I6G47_33695
VPEVarpa_0165
VPDVAPA_1c01740 VAPA_2c09710
VBOCKY39_00895 CKY39_21970
VAMC4F17_18170 C4F17_30665
CTTCtCNB1_1488
CTESO987_16325 O987_21865 O987_28200
RTARta_18000
OTKC6570_10585
LIML103DPR2_00195(pht3_1) L103DPR2_00198(pht3_2) L103DPR2_02573(pht3_3) L103DPR2_02721(pht3_4)
LIHL63ED372_02473(pht3_1) L63ED372_03070(pht3_2)
HYRBSY239_1474 BSY239_2699 BSY239_3345 BSY239_3465
HYBQ5W_00860 Q5W_13295 Q5W_24655
HYLLPB072_09690
HYCE5678_06755
HPSEHPF_14820(pht3)
HYNF9K07_00645 F9K07_00650 F9K07_00665 F9K07_06620 F9K07_07515 F9K07_11625 F9K07_11660 F9K07_11665 F9K07_11680 F9K07_13635 F9K07_22870 F9K07_27550 F9K07_30150 F9K07_30200 F9K07_30250 F9K07_30395 F9K07_30445
HTNKI616_03525 KI616_14275
MASWAM586_27410 AM586_27625 AM586_27690
RGUA4W93_01640
XYKGT347_06320
RBUPG1C_09135
AZRCJ010_07345
THKCCZ27_15665
MESOBSQ44_11250
RPODE0E05_06090
NIYFQ775_20935
EMXFKV68_30120
ABAWD5400_03680 D5400_20255
AOLS58_21510
BRADBF49_7248
BICLMTR13_01465
BRKCWS35_04530 CWS35_19800
BOTCIT37_09645
BGQX265_35300
BVZBRAD3257_6131
BELBE61_11040 BE61_64940 BE61_87020
BVVBHK69_01760
BOIBLM15_16160
MLGCWB41_10140
RHZRHPLAN_00120 RHPLAN_01370 RHPLAN_59330
DSALK1X15_01480
HDIHDIA_4250(pht3)
MMEDMame_05096(pht3)
PSINCAK95_02265 CAK95_05895
RBMTEF_13150
LABTFIU93_07195(pht1)
JANJann_1445(cbaB)
CIDP73_1053 P73_2875 P73_2968
CEHCEW89_13880
CONTQ29_05745
TPROGa0080559_TMP5103
PABYGa0080574_TMP2103
SUAMBOO69_02335
SULZC1J03_03940
RIDRIdsm_00905(pht3)
AHTANTHELSMS3_04462(pht3)
THAACFI11_17535
OCDFHY55_12625
ROTFIV09_12260(pht5)
RMHLVO79_19250
MALUKU6B_35110
TGLHFZ77_01120
SEDIEBB79_15935
PPRUFDP22_04970
PALWPSAL_037190(pht3)
HDHG5B40_16605
NORFA702_15515 FA702_19040
NDRHT578_08880
SPHPLH20_19475
SMAZLH19_17785
RDICMV14_06830 CMV14_06835
SPHITS85_13270
SSANNX02_22625
SSYSLG_07580 SLG_19120 SLG_34970
SBDATN00_07605
SPHRBSY17_2023 BSY17_4182
SHYDCJD35_19410 CJD35_19645
SPYGYGS_C1P1166
PALGHFP57_16190
SMICSmB9_09290
AAYWYH_03341(pht3)
CMANA9D14_14470
POTE2E27_18200
GTIFXF46_11610
RMTIAI58_16250
NAOY958_23895
FERFNB15_09005
BFDNCTC4823_00630(kshA_1)
AIAAWH56_017995
PSABPSAB_03650
PBJVN24_18685
PNPIJ22_14360
EFFskT53_12430 skT53_33890
SPOSDV702_11120
MGOAFA91_26505
MGAUMGALJ_59780
MPAEK0O64_27755
MRHMycrhN_3125
MGADMGAD_32490
NTPCRH09_08335
RRT4535765_03823(kshA_3)
RKOJWS14_40240
GORKTR9_0709
GOQACH46_18515
SMALSMALA_7807
SSOII1A49_42875
SGMGCM10017557_02470
SPADDVK44_00575
STUIGCM10017668_58100
SALCC2138_02790
ARZAUT26_02365 AUT26_19495
ACRYAC20117_22710
ASUFMNQ99_18620
PUEFV140_21245
AACDLWP59_23325 LWP59_25695
PDXPsed_1414 Psed_3698 Psed_3921 Psed_3923
PMADBAY61_17900
SAQSare_0574
PFLAPflav_042940 Pflav_042960
PSUUPsuf_003970 Psuf_021450 Psuf_075920
 » show all
Reference
1  [PMID:3805038]
  Authors
Batie CJ, LaHaie E, Ballou DP.
  Title
Purification and characterization of phthalate oxygenase and phthalate oxygenase reductase from Pseudomonas cepacia.
  Journal
J Biol Chem 262:1510-8 (1987)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.12.7
IUBMB Enzyme Nomenclature: 1.14.12.7
ExPASy - ENZYME nomenclature database: 1.14.12.7
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.12.7
BRENDA, the Enzyme Database: 1.14.12.7
CAS: 63626-44-8

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