KEGG   ENZYME: 1.14.12.7
Entry
EC 1.14.12.7                Enzyme                                 

Name
phthalate 4,5-dioxygenase;
PDO ;
phthalate dioxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
Sysname
phthalate,NADH:oxygen oxidoreductase (4,5-hydroxylating)
Reaction(IUBMB)
phthalate + NADH + H+ + O2 = cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+ [RN:R03630]
Reaction(KEGG)
R03630
Substrate
phthalate [CPD:C01606];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate [CPD:C04783];
NAD+ [CPD:C00003]
Comment
A system, containing a reductase which is an iron-sulfur flavoprotein (FMN), an iron-sulfur oxygenase, and no independent ferredoxin. Requires Fe2+.
History
EC 1.14.12.7 created 1990
Pathway
ec00624  Polycyclic aromatic hydrocarbon degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K18068  phthalate 4,5-dioxygenase
Genes
OTW: 112243036
PLUL: FOB45_02790
MBS: MRBBS_1311(cbaA)
HAM: HALO0380
HSR: HSBAA_48220
HMD: CTT34_16730
GBI: PG2T_14045
RPF: Rpic12D_2779 Rpic12D_4958
RPJ: N234_12835
CNC: CNE_2c21230(pht1)
RME: Rmet_5548
BCEN: DM39_1999
BMJ: BMULJ_03712(ophA2)
BMU: Bmul_4805
BMK: DM80_4020
BGO: BM43_4032
PPUL: RO07_06175
PSPU: NA29_21445
BPT: Bpet0252
BHZ: ACR54_04439(pht3)
PNA: Pnap_4627
VEI: Veis_2928
RTA: Rta_18000
LIM: L103DPR2_00195(pht3_1) L103DPR2_00198(pht3_2) L103DPR2_02573(pht3_3) L103DPR2_02721(pht3_4)
LIH: L63ED372_02473(pht3_1) L63ED372_03070(pht3_2)
HPSE: HPF_14820(pht3)
AOL: S58_21510
BRAD: BF49_7248
MMED: Mame_05096(pht3)
HDI: HDIA_4250(pht3)
RBM: TEF_13150
JAN: Jann_1445(cbaB)
LABT: FIU93_07195(pht1)
RID: RIdsm_00905(pht3)
AHT: ANTHELSMS3_04462(pht3)
ROT: FIV09_12260(pht5)
MALU: KU6B_35110
SPHP: LH20_19475
SMAZ: LH19_17785
SPHI: TS85_13270
SSAN: NX02_22625
SMIC: SmB9_09290
AAY: WYH_03341(pht3)
BFD: NCTC4823_00630(kshA_1)
PSAB: PSAB_03650
RRT: 4535765_03823(kshA_3)
GOR: KTR9_0709
SMAL: SMALA_7807
SAQ: Sare_0574
 » show all
Reference
1  [PMID:3805038]
  Authors
Batie CJ, LaHaie E, Ballou DP.
  Title
Purification and characterization of phthalate oxygenase and phthalate oxygenase reductase from Pseudomonas cepacia.
  Journal
J Biol Chem 262:1510-8 (1987)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.12.7
IUBMB Enzyme Nomenclature: 1.14.12.7
ExPASy - ENZYME nomenclature database: 1.14.12.7
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.12.7
BRENDA, the Enzyme Database: 1.14.12.7
CAS: 63626-44-8

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