KEGG   ENZYME: 1.14.13.1
Entry
EC 1.14.13.1                Enzyme                                 

Name
salicylate 1-monooxygenase;
salicylate hydroxylase;
salicylate 1-hydroxylase;
salicylate monooxygenase;
salicylate hydroxylase (decarboxylating)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
salicylate,NADH:oxygen oxidoreductase (1-hydroxylating, decarboxylating)
Reaction(IUBMB)
salicylate + NADH + 2 H+ + O2 = catechol + NAD+ + H2O + CO2 [RN:R00818]
Reaction(KEGG)
R00818;
(other) R05632 R06915 R06936 R06939
Substrate
salicylate [CPD:C00805];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
catechol [CPD:C00090];
NAD+ [CPD:C00003];
H2O [CPD:C00001];
CO2 [CPD:C00011]
Comment
A flavoprotein (FAD).
History
EC 1.14.13.1 created 1972
Pathway
ec00621  Dioxin degradation
ec00624  Polycyclic aromatic hydrocarbon degradation
ec00626  Naphthalene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00480  salicylate hydroxylase
Genes
QSU: 111995269 112020488
NCR: NCU11363
NTE: NEUTE1DRAFT120622(NEUTE1DRAFT_120622)
SMP: SMAC_07304
PAN: PODANSg276
TTT: THITE_2076116
MTM: MYCTH_2305618
CTHR: CTHT_0064630
MGR: MGG_08293
TMN: UCRPA7_4723
CMT: CCM_06214
MBE: MBM_02468
ANG: ANI_1_1410064(An07g00550) ANI_1_1448144(An16g01280) ANI_1_688094(An11g05130)
PNO: SNOG_15763(AY587541)
TASA: A1Q1_05812
ABP: AGABI1DRAFT107807(AGABI1DRAFT_107807) AGABI1DRAFT51593(AGABI1DRAFT_51593) AGABI1DRAFT54356(AGABI1DRAFT_54356)
ABV: AGABI2DRAFT177137(AGABI2DRAFT_177137) AGABI2DRAFT214062(AGABI2DRAFT_214062) AGABI2DRAFT222486(AGABI2DRAFT_222486)
IZH: FEM41_17505(salA)
PSD: DSC_14905
PRE: PCA10_41220(nahG)
PPI: ND016(nahG) ND091(nahG)
PPX: T1E_5510(nahG)
PSES: PSCI_4557(nahG)
PSIL: PMA3_14235
PALL: UYA_07000
PAZE: KSS91_14745(salA)
ACC: BDGL_001688(salR)
ACI: ACIAD1424(salA)
ADV: DJ533_02040(salA)
AGU: AS4_21780(salA)
HHH: CLM76_07000(salA)
HPIZ: GYM47_16310(salA)
 » show all
Reference
1  [PMID:4390441]
  Authors
Uzuki K, Takemori S, Katagiri M.
  Title
Mechanism of the salicylate hydroxylase reaction. IV. Fluorometric analysis of the complex formation.
  Journal
Biochim Biophys Acta 191:77-85 (1969)
DOI:10.1016/0005-2744(69)90316-7
Reference
2  [PMID:4898626]
  Authors
Takemori S, Yasuda H, Mihara K, Suzuki K, Katagiri M.
  Title
Mechanism of the salicylate hydroxylase reaction. II. The enzyme-substrate complex.
  Journal
Biochim Biophys Acta 191:58-68 (1969)
DOI:10.1016/0005-2744(69)90314-3
Reference
3  [PMID:4309912]
  Authors
Takemori S, Yasuda H, Mihara K, Suzuki K, Katagiri M.
  Title
Mechanism of the salicylate hydroxylase reaction. 3. Characterization and reactivity of chemically or photochemically reduced enzyme-flavin.
  Journal
Biochim Biophys Acta 191:69-76 (1969)
DOI:10.1016/0005-2744(69)90315-5
Reference
4  [PMID:14321380]
  Authors
YAMAMOTO S, KATAGIRI M, MAENO H, HAYAISHI O.
  Title
SALICYLATE HYDROXYLASE, A MONOOXYGENASE REQUIRING FLAVIN ADENINE DINUCLEOTIDE. I. PURIFICATION AND GENERAL PROPERTIES.
  Journal
J Biol Chem 240:3408-13 (1965)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.1
IUBMB Enzyme Nomenclature: 1.14.13.1
ExPASy - ENZYME nomenclature database: 1.14.13.1
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.1
BRENDA, the Enzyme Database: 1.14.13.1
CAS: 9059-28-3

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