KEGG   ENZYME: 1.14.13.1Help
Entry
EC 1.14.13.1                Enzyme                                 

Name
salicylate 1-monooxygenase;
salicylate hydroxylase;
salicylate 1-hydroxylase;
salicylate monooxygenase;
salicylate hydroxylase (decarboxylating)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
salicylate,NADH:oxygen oxidoreductase (1-hydroxylating, decarboxylating)
Reaction(IUBMB)
salicylate + NADH + 2 H+ + O2 = catechol + NAD+ + H2O + CO2 [RN:R00818]
Reaction(KEGG)
Substrate
salicylate [CPD:C00805];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
catechol [CPD:C00090];
NAD+ [CPD:C00003];
H2O [CPD:C00001];
CO2 [CPD:C00011]
Comment
A flavoprotein (FAD).
History
EC 1.14.13.1 created 1972
Pathway
ec00621  Dioxin degradation
ec00624  Polycyclic aromatic hydrocarbon degradation
ec00626  Naphthalene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00480  salicylate hydroxylase
Genes
PXB: 103939772 103939786
QSU: 111987977 111987979 111991307 111995269 112002650 112002724 112002824 112011552 112013348 112013352 112013482 112020297 112020488 112026368 112030261 112030322
CRE: CHLREDRAFT_205738
PPA: PAS_chr3_0010
DHA: DEHA2F17820g
PIC: PICST_28907(NHG4) PICST_31033(NHG3) PICST_31126(NHG1.1) PICST_50409(NHG2) PICST_56402(NHG1.2)
PGU: PGUG_01664 PGUG_02350
SPAA: SPAPADRAFT_154467 SPAPADRAFT_64670
LEL: LELG_02068
CTP: CTRG_03917
NTE: NEUTE1DRAFT120622(NEUTE1DRAFT_120622) NEUTE1DRAFT123698(NEUTE1DRAFT_123698) NEUTE1DRAFT49030(NEUTE1DRAFT_49030) NEUTE1DRAFT58990(NEUTE1DRAFT_58990) NEUTE1DRAFT78852(NEUTE1DRAFT_78852)
ANG: ANI_1_1034164(An18g01030) ANI_1_1128084(An09g01840) ANI_1_1332144(An16g00390) ANI_1_1352144(An16g00520) ANI_1_1364034(An03g04750) ANI_1_1404084(An09g04390) ANI_1_1410064(An07g00550) ANI_1_1448144(An16g01280) ANI_1_1470104(An12g02020) ANI_1_1590034(An03g06690) ANI_1_1640104(An12g03180) ANI_1_1718094 ANI_1_1792094(An11g03150) ANI_1_182034(An03g01540) ANI_1_1832064(An07g05650) ANI_1_1874094(An11g03800) ANI_1_1936104(An12g05970) ANI_1_2034144(An16g08140) ANI_1_2218024(An02g01050) ANI_1_242034(An03g02130) ANI_1_2550094(An11g10310) ANI_1_2696014(An01g07130) ANI_1_454044(An05g01200) ANI_1_688094(An11g05130)
ABP: AGABI1DRAFT107807(AGABI1DRAFT_107807) AGABI1DRAFT107973(AGABI1DRAFT_107973) AGABI1DRAFT114820(AGABI1DRAFT_114820) AGABI1DRAFT115067(AGABI1DRAFT_115067) AGABI1DRAFT115070(AGABI1DRAFT_115070) AGABI1DRAFT130099(AGABI1DRAFT_130099) AGABI1DRAFT42753(AGABI1DRAFT_42753) AGABI1DRAFT51593(AGABI1DRAFT_51593) AGABI1DRAFT54356(AGABI1DRAFT_54356) AGABI1DRAFT62273(AGABI1DRAFT_62273) AGABI1DRAFT70584(AGABI1DRAFT_70584)
ABV: AGABI2DRAFT177137(AGABI2DRAFT_177137) AGABI2DRAFT191047(AGABI2DRAFT_191047) AGABI2DRAFT195451(AGABI2DRAFT_195451) AGABI2DRAFT195454(AGABI2DRAFT_195454) AGABI2DRAFT206335(AGABI2DRAFT_206335) AGABI2DRAFT211127(AGABI2DRAFT_211127) AGABI2DRAFT212377(AGABI2DRAFT_212377) AGABI2DRAFT214062(AGABI2DRAFT_214062) AGABI2DRAFT222486(AGABI2DRAFT_222486) AGABI2DRAFT239563(AGABI2DRAFT_239563) AGABI2DRAFT239564(AGABI2DRAFT_239564)
IZH: FEM41_17505(salA)
SERF: L085_11765
SGL: SG0076
SOD: Sant_0203
PSD: DSC_14905
PCQ: PcP3B5_07970(nicC)
PPI: ND016(nahG) ND091(nahG)
PPX: T1E_5510(nahG)
PSES: PSCI_4557(nahG)
PSIL: PMA3_14235
ACC: BDGL_001688(salR)
ACI: ACIAD0984 ACIAD1424(salA)
ADV: DJ533_02040(salA)
AGU: AS4_21780(salA)
CPS: CPS_3257
PAT: Patl_3662
GNI: GNIT_3007
GPS: C427_0816
TMC: LMI_1626
HHH: CLM76_07000(salA)
HBE: BEI_0074
REH: H16_B0750(h16_B0750)
BOK: DM82_4145
BOC: BG90_3881
BCEW: DM40_4611
BAM: Bamb_4040
BMJ: BMULJ_04471(nahG)
BMU: Bmul_4033
BMK: DM80_5340
BMUL: NP80_4576
BCT: GEM_3843
BCON: NL30_03165
BLAT: WK25_25485
BSEM: WJ12_28930
BGU: KS03_4244
BPH: Bphy_6277
PPNO: DA70_10595
PPNM: LV28_20465
PSPU: NA29_22380
PAPI: SG18_14640
BPER: BN118_2186
BHZ: ACR54_00878(xlnD_1) ACR54_02370(xlnD_2)
AMIM: MIM_c02030
AFQ: AFA_18575(hpaM)
RFR: Rfer_3311
POL: Bpro_3591
PNA: Pnap_3023
AAV: Aave_1154
AJS: Ajs_1146
AAA: Acav_1164
ACRA: BSY15_481
VEI: Veis_1345
RTA: Rta_27950
LIM: L103DPR2_00963(xlnD_1) L103DPR2_02392(xlnD_3)
LIH: L63ED372_01904(xlnD)
HYB: Q5W_14520
HPSE: HPF_07025(mhbM)
CBAA: SRAA_1140
CBAB: SMCB_1165
CARE: LT85_0541
EBA: ebA5612(s5h)
MLO: mll8158
MHUA: MCHK_1489
AMIH: CO731_04143(xlnD)
RBS: RHODOSMS8_03638(xlnD)
SME: SMc02116
SMX: SM11_chr2088(nah)
SMER: DU99_07765
SMD: Smed_1110
SFH: SFHH103_01203(nah)
SFD: USDA257_c35200(xlnD)
SAME: SAMCFNEI73_Ch1611(xlnD)
EAD: OV14_2560
ATU: Atu1574(nah)
ARA: Arad_2202(nah)
ATF: Ach5_15140(nah)
AVI: Avi_2548(nah) Avi_9233
AGR: AGROH133_06363(nah)
RET: RHE_CH01900(nah)
RLE: RL2206
RHL: LPU83_2598(nah)
RHT: NT26_2050
NEN: NCHU2750_20330(nah)
LAA: WSI_00165
LSO: CKC_04620
LAR: lam_977(ubiH)
SHZ: shn_09455
BME: BMEI1207
BMEL: DK63_203
BMEE: DK62_658
BMF: BAB1_0770
BABO: DK55_767
BABR: DO74_1122
BABT: DK49_525
BABB: DK48_1351
BABU: DK53_751
BABS: DK51_706
BABC: DO78_672
BMS: BR0746
BSZ: DK67_1658
BOV: BOV_0740
BCAR: DK60_813
BCAS: DA85_03555
BMR: BMI_I744
BPP: BPI_I783
BPV: DK65_616
OAN: Oant_2546
OAH: DR92_2004
BJA: blr5591(nah)
BRA: BRADO2935
BBT: BBta_5237
BRS: S23_26640(nah)
AOL: S58_46830
RPA: RPA3433
RPB: RPB_2131
RPC: RPC_3149
RPD: RPD_3292
RPE: RPE_2307
RPT: Rpal_3920
NWI: Nwi_2182
NHA: Nham_2584
OCA: OCAR_5514
VGO: GJW-30_1_02680(xlnD_2)
BHE: BH09840
BQU: BQ07610
BQR: RM11_0721
BTR: BT_1363
BGR: Bgr_12120
BANC: PU02_0917
BEZ: NCTC12898_00597(mhbM)
XAU: Xaut_3231
AZC: AZC_3543
SNO: Snov_2030
MDI: METDI2976
MEX: Mext_2203
MCH: Mchl_2480
MPO: Mpop_2160
MET: M446_6758
MOR: MOC_0751
META: Y590_10595
MAQU: Maq22A_c24835(ubiH)
BID: Bind_0923
MSL: Msil_0982
HDN: Hden_0061
RVA: Rvan_1936
BVR: BVIR_1342
MSC: BN69_0805
PLEO: OHA_1_01152(xlnD)
MMED: Mame_03488(xlnD_2)
HDI: HDIA_2049(nagX)
SIL: SPO2510(nahG) SPO3153
RUT: FIU92_09115(mhbM)
RSP: RSP_2656(nahG)
RCP: RCAP_rcc02430(nahG)
JAN: Jann_2680
RDE: RD1_2791
PDE: Pden_0546
DSH: Dshi_1885
KVL: KVU_1493(nahG)
KVU: EIO_0198
PSF: PSE_3987
PGD: Gal_02384
OTM: OSB_18830(xlnD)
LAQU: R2C4_07035
MALG: MALG_01968
RSU: NHU_01945
RHC: RGUI_0772
LABT: FIU93_17935(xlnD)
SPSE: SULPSESMR1_01269(nagX)
RMM: ROSMUCSMR3_00407(nicC)
RID: RIdsm_03040(nicC)
ROH: FIU89_10645(nagX)
LVS: LOKVESSMR4R_01657(xlnD)
MARU: FIU81_08075(xlnD)
ROT: FIV09_05150(xlnD1)
HNE: HNE_1879
HBA: Hbal_1542
STAX: MC45_11940
SPHI: TS85_14975
SSY: SLG_11260
ANH: A6F65_01086(xlnD)
PUB: SAR11_0110(nah)
PGV: SL003B_1624(nah)
PMW: B2K_38935
MVQ: MYVA_3798
MAB: MAB_3330
MABB: MASS_3268
MCHE: BB28_16790
MSTE: MSTE_03298
CEF: CE0117
CUR: cu0195
ROP: ROP_38510
RFA: A3L23_03313(xlnD)
RHS: A3Q41_00019(xlnD_1)
TPR: Tpau_0310
SRT: Srot_0537
SCO: SCO3245(SCE29.14c)
SVE: SVEN_5141
SALU: DC74_1450
SALL: SAZ_07785
STRE: GZL_07762
SPRI: SPRI_1912
SMAL: SMALA_0614
ACH: Achl_0771
BCV: Bcav_2779
SRO: Sros_5419
MMAR: MODMU_2992
AOI: AORI_4774
AMYY: YIM_03665(hpxO1) YIM_29120(xlnD2)
PDX: Psed_4437
PSEA: WY02_22165
SESP: BN6_46870
KAL: KALB_4383
ACTN: L083_5373
CWO: Cwoe_4129
AMR: AM1_2165
CYT: cce_2733
TER: Tery_2172
CALH: IJ00_22130
PNL: PNK_0674
ACA: ACP_1941
FBA: FIC_01729
 » show all
Taxonomy
Reference
1  [PMID:4390441]
  Authors
Uzuki K, Takemori S, Katagiri M.
  Title
Mechanism of the salicylate hydroxylase reaction. IV. Fluorometric analysis of the complex formation.
  Journal
Biochim Biophys Acta 191:77-85 (1969)
DOI:10.1016/0005-2744(69)90316-7
Reference
2  [PMID:4898626]
  Authors
Takemori S, Yasuda H, Mihara K, Suzuki K, Katagiri M.
  Title
Mechanism of the salicylate hydroxylase reaction. II. The enzyme-substrate complex.
  Journal
Biochim Biophys Acta 191:58-68 (1969)
DOI:10.1016/0005-2744(69)90314-3
Reference
3  [PMID:4309912]
  Authors
Takemori S, Yasuda H, Mihara K, Suzuki K, Katagiri M.
  Title
Mechanism of the salicylate hydroxylase reaction. 3. Characterization and reactivity of chemically or photochemically reduced enzyme-flavin.
  Journal
Biochim Biophys Acta 191:69-76 (1969)
DOI:10.1016/0005-2744(69)90315-5
Reference
4  [PMID:14321380]
  Authors
YAMAMOTO S, KATAGIRI M, MAENO H, HAYAISHI O.
  Title
SALICYLATE HYDROXYLASE, A MONOOXYGENASE REQUIRING FLAVIN ADENINE DINUCLEOTIDE. I. PURIFICATION AND GENERAL PROPERTIES.
  Journal
J Biol Chem 240:3408-13 (1965)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.1
IUBMB Enzyme Nomenclature: 1.14.13.1
ExPASy - ENZYME nomenclature database: 1.14.13.1
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.1
BRENDA, the Enzyme Database: 1.14.13.1
CAS: 9059-28-3

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