KEGG ENZYME: 1.14.13.114

ENZYME: 1.14.13.114

Entry

EC 1.14.13.114              Enzyme

Name

6-hydroxynicotinate 3-monooxygenase;
NicC;
6HNA monooxygenase;
HNA-3-monooxygenase

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

6-hydroxynicotinate,NADH:oxygen oxidoreductase (3-hydroxylating, decarboxylating)

Reaction(IUBMB)

6-hydroxynicotinate + NADH + H+ + O2 = 2,5-dihydroxypyridine + NAD+ + H2O + CO2 [RN:R08764]

Reaction(KEGG)

R08764

Substrate

6-hydroxynicotinate [CPD:C01020];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]

Product

2,5-dihydroxypyridine [CPD:C01059];
NAD+ [CPD:C00003];
H2O [CPD:C00001];
CO2 [CPD:C00011]

Comment

A flavoprotein (FAD) [1]. The reaction is involved in the aerobic catabolism of nicotinic acid.

History

EC 1.14.13.114 created 2010

Pathway

ec00760

Nicotinate and nicotinamide metabolism

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K14974

6-hydroxynicotinate 3-monooxygenase

Genes

SMAR:

SM39_1770

SMAC:

SMDB11_1583

SMW:	SMWW4_v1c23250

SPE:

Spro_2311

SRR:	SerAS9_2268

SRL:	SOD_c21410(nicC)

SRY:	M621_11730

SPLY:

Q5A_011865(nicC)

SRS:	SerAS12_2268

SRA:	SerAS13_2269

SLQ:	M495_11500

SERF:

L085_17120

SQU:	E4343_04635

SFJ:	SAMEA4384070_2380

SOF:	NCTC11214_04489

SURI:

J0X03_12370

SNEM:

NLX84_11775

GQU:	AWC35_02980

PAO:	Pat9b_5176

TCI:	A7K98_12090

TPTY:

NCTC11468_02201

PPU:	PP_3944(nicC)

PPF:

Pput_1893

PPG:	PputGB1_3579

PPW:	PputW619_2140

PPB:	PPUBIRD1_1864(nahG)

PPI:

YSA_08966

PPX:

T1E_5123

PPUT:

L483_21710

PPUN:

PP4_17780

PFS:

PFLU_2799

PFB:

VO64_0126

PAZO:

AYR47_21615

PFW:	PF1751_v1c24700

PFF:	PFLUOLIPICF724380

PFX:	A7318_11830

PSK:	U771_14855

PFZ:	AV641_08725

PANR:

A7J50_2716

PSIL:

PMA3_12565

PYM:	AK972_2674

PGG:	FX982_03128

PEZ:	HWQ56_12830

PWY:	HU734_022655(nicC)

PTAE:

NCTC10697_01683

PPEG:

KUA23_13465

AWU:	BEN71_18355

AGU:

AS4_40070

HAM:

HALO0543

HVN:	EI420_01980

HAXI:

HAALTHF_14260n

HTT:	HZS52_07555

HSV:	HNO53_05755

HTX:	EKK97_06040

HPRO:

LMS44_20675

ADI:

B5T_02296

MARS:

A8C75_16300

RPJ:	N234_04315

REH:	H16_A0922(h16_A0922)

CNC:	CNE_1c08720

CUH:	BJN34_04895

REU:	Reut_A2515

CTI:	RALTA_A0867

CBW:	RR42_s0168

CGD:	CR3_3010(nicC)

CCUP:

BKK81_07355

CUP:	BKK80_06655

CUU:	BKK79_05495

CPAU:

EHF44_27000

COX:	E0W60_14755

CCAM:

M5D45_06890

CCAX:

KZ686_20190

BSAV:

WS86_30265

BCM:	Bcenmc03_3483

BCH:	Bcen2424_4042

BCJ:

BCAM1146

BCEN:

DM39_3876

BCEO:

I35_4992

BMJ:	BMULJ_03963(nahG)

BMU:

Bmul_4547

BMK:

DM80_3717

BMUL:

NP80_4072

BCED:

DM42_3945

BCEP:

APZ15_32845

BCON:

NL30_06905

BSEM:

WJ12_25625

BPSL:

WS57_08400

BMEC:

WJ16_24255

BSTG:

WT74_20840

BANN:

JFN94_22970

BARI:

NLX30_32970

BGL:	bglu_2g20070

BGU:

KS03_3918

BGD:	bgla_1g12700

BGO:

BM43_2602

BGP:	BGL_1c11630

BPLA:

bpln_1g11150

BUM:	AXG89_36980

BUI:	AX768_15610

BURK:

DM992_20090

BFN:

OI25_6802

BCAI:

K788_0007378

PTER:

C2L65_30600

PMEG:

FNZ07_29050

PTRO:

G5S35_31870

PSPU:

NA29_11655

PVE:	UC34_12655

PNR:	AT302_20380

CABA:

SBC2_37460(nicC_1)

BUO:	BRPE64_DCDS10960

BPE:

BP1954

BPC:

BPTD_1926

BPER:

BN118_0960

BPEU:

Q425_15000

BPA:

BPP2327

BBH:	BN112_1737

BBR:

BB1778

BBM:	BN115_1680

BBX:	BBS798_1679

BPT:

Bpet1330

BAV:

BAV1532

BFZ:	BAU07_16150

BGM:	CAL15_11485

AXO:	NH44784_051881

AXN:	AX27061_3325

AXX:	ERS451415_03305

ADT:	APT56_16390

AIS:	BUW96_28760

ASW:	CVS48_09660

ACHB:

DVB37_25095

PUD:	G9Q38_13515

AMIM:

MIM_c31140

AFA:	UZ73_17625

AFQ:

AFA_08350

AAQU:

D3M96_09555

AAMM:

FE795_07540

ODI:

ODI_R3895

PIG:	EGT29_04520

PACR:

FXN63_06610

AAV:

Aave_3927

AAA:

Acav_3824

DAC:

Daci_1853

DEL:	DelCs14_4785

DTS:	BI380_15385

DHK:	BO996_08775

DLA:	I6G47_15015

CTES:

O987_23175

HSE:	Hsero_1333

HSZ:	ACP92_06675

HEE:	hmeg3_19250

HFR:	G5S34_06890

MTIM:

DIR46_21185

XYK:	GT347_16855

AZR:	CJ010_22095

MLN:	A9174_33985

RLG:	Rleg_5073 Rleg_6042

RTR:	RTCIAT899_PC08600

RJG:	CCGE525_26735

RAD:	CO657_35845

RII:	FFM53_026860 FFM53_028495

RRG:	J3P73_36835

RAW:	NE851_01780

RSUL:

N2599_21380

BJU:	BJ6T_75310

BJP:	RN69_36540

BGZ:	XH91_28015

BBET:

F8237_08375

BARH:

WN72_11515

BBAN:

J4G43_012690

RBK:	E0H22_02830 E0H22_17990

TRB:	HB776_13840

XDI:	EZH22_19720

APRA:

G3A50_11390

HMC:	HYPMC_0199

RHZ:	RHPLAN_26580 RHPLAN_36190 RHPLAN_38050

DEA:	FPZ08_21690

AUB:	LXB15_07215

PSIN:

CAK95_14010 CAK95_28725

PPHR:

APZ00_25395

SAGU:

CDO87_22405

MALU:

KU6B_06580

PYE:	A6J80_23230

FAP:	GR316_11020

NRE:	BES08_14200

SNAP:

PQ455_05905

GOY:	GLS_c14190

GAL:	A0U94_10335

GTI:	FXF46_02595

GSP:	IGS75_12390

GXL:

H845_1043

KEU:	S101446_01671

KSC:	CD178_02882(nicC_2)

APT:	APA01_23790

APW:	APA42C_23790

APF:	APA03_23790

APU:	APA07_23790

APG:	APA12_23790

APQ:	APA22_23790

APX:	APA26_23790

APZ:	APA32_23790

APK:	APA386B_1213(nahG)

ASV:	WG31_11920

APOM:

CPF11_08760

ATO:	CIW82_09410

ACET:

DS739_11650

ROS:	CTJ15_00285

RMUC:

FOB66_01430

KHA:	IFJ82_11100

SRF:	LHU95_08710

ALI:	AZOLI_p20435(nahG)

AZM:	DM194_20095

AOZ:	HUE56_08295

HTQ:	FRZ44_10610

HADH:

FRZ61_10290

PARH:

I5S86_12075

KIS:	HUT16_21990

» show all

Reference

1 [PMID:10091591]

Authors

Nakano H, Wieser M, Hurh B, Kawai T, Yoshida T, Yamane T, Nagasawa T

Title

Purification, characterization and gene cloning of 6-hydroxynicotinate 3-monooxygenase from Pseudomonas fluorescens TN5.

Journal

Eur J Biochem 260:120-6 (1999)
DOI:10.1046/j.1432-1327.1999.00124.x

Reference

2 [PMID:18678916]

Authors

Jimenez JI, Canales A, Jimenez-Barbero J, Ginalski K, Rychlewski L, Garcia JL, Diaz E

Title

Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440.

Journal

Proc Natl Acad Sci U S A 105:11329-34 (2008)
DOI:10.1073/pnas.0802273105

Sequence

[ppu:PP_3944]

Other DBs

ExplorEnz - The Enzyme Database:

1.14.13.114

IUBMB Enzyme Nomenclature:

1.14.13.114

ExPASy - ENZYME nomenclature database:

1.14.13.114

BRENDA, the Enzyme Database:

1.14.13.114

DBGET integrated database retrieval system