KEGG   ENZYME: 1.14.13.114Help
Entry
EC 1.14.13.114              Enzyme                                 

Name
6-hydroxynicotinate 3-monooxygenase;
NicC;
6HNA monooxygenase;
HNA-3-monooxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
6-hydroxynicotinate,NADH:oxygen oxidoreductase (3-hydroxylating, decarboxylating)
Reaction(IUBMB)
6-hydroxynicotinate + NADH + H+ + O2 = 2,5-dihydroxypyridine + NAD+ + H2O + CO2 [RN:R08764]
Reaction(KEGG)
Substrate
6-hydroxynicotinate [CPD:C01020];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
2,5-dihydroxypyridine [CPD:C01059];
NAD+ [CPD:C00003];
H2O [CPD:C00001];
CO2 [CPD:C00011]
Comment
A flavoprotein (FAD) [1]. The reaction is involved in the aerobic catabolism of nicotinic acid.
History
EC 1.14.13.114 created 2010
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K14974  6-hydroxynicotinate 3-monooxygenase
Genes
GQU: AWC35_02980
SPE: Spro_2311
SRR: SerAS9_2268
SRL: SOD_c21410(nicC)
SRY: M621_11730
SPLY: Q5A_011865(nicC)
SRS: SerAS12_2268
SRA: SerAS13_2269
SMW: SMWW4_v1c23250
SMAR: SM39_1770
SERF: L085_17120
PPU: PP_3944(nicC)
PPF: Pput_1893
PPB: PPUBIRD1_1864(nahG)
PPI: YSA_08966
PPX: T1E_5123
PPUT: L483_21710
PPUN: PP4_17780
PFS: PFLU_2799
PFB: VO64_0126
PANR: A7J50_2716
PSIL: PMA3_12565
HAM: HALO0543
ADI: B5T_02296
REH: H16_A0922(h16_A0922)
CGD: CR3_3010(nicC)
BCN: Bcen_4324
BCJ: BCAM1146
BCEN: DM39_3876
BCEO: I35_4992
BMU: Bmul_4547
BMK: DM80_3717
BMUL: NP80_4072
BCED: DM42_3945
BCON: NL30_06905
BSEM: WJ12_25625
BPSL: WS57_08400
BMEC: WJ16_24255
BSTG: WT74_20840
BGU: KS03_3918
BGO: BM43_2602
BFN: OI25_6802
PSPU: NA29_11655
BPE: BP1954
BPC: BPTD_1926
BPER: BN118_0960
BPEU: Q425_15000
BPA: BPP2327
BBR: BB1778
BPT: Bpet1330
BAV: BAV1532
AMIM: MIM_c31140
AFQ: AFA_08350
ODI: ODI_R3895
AAV: Aave_3927
AAA: Acav_3824
DAC: Daci_1853
CTES: O987_23175
RLG: Rleg_6042
GXL: H845_1043
KSC: CD178_02882(nicC_2)
APK: APA386B_1213(nahG)
ALI: AZOLI_p20435(nahG)
 » show all
Taxonomy
Reference
1  [PMID:10091591]
  Authors
Nakano H, Wieser M, Hurh B, Kawai T, Yoshida T, Yamane T, Nagasawa T.
  Title
Purification, characterization and gene cloning of 6-hydroxynicotinate 3-monooxygenase from Pseudomonas fluorescens TN5.
  Journal
Eur J Biochem 260:120-6 (1999)
DOI:10.1046/j.1432-1327.1999.00124.x
Reference
2  [PMID:18678916]
  Authors
Jimenez JI, Canales A, Jimenez-Barbero J, Ginalski K, Rychlewski L, Garcia JL, Diaz E
  Title
Deciphering the genetic determinants for aerobic nicotinic acid degradation: the  nic cluster from Pseudomonas putida KT2440.
  Journal
Proc Natl Acad Sci U S A 105:11329-34 (2008)
DOI:10.1073/pnas.0802273105
  Sequence
[ppu:PP_3944]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.114
IUBMB Enzyme Nomenclature: 1.14.13.114
ExPASy - ENZYME nomenclature database: 1.14.13.114
BRENDA, the Enzyme Database: 1.14.13.114

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