KEGG   ENZYME: 1.14.13.148
Entry
EC 1.14.13.148              Enzyme                                 
Name
trimethylamine monooxygenase;
flavin-containing monooxygenase 3;
FMO3;
tmm (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
N,N,N-trimethylamine,NADPH:oxygen oxidoreductase (N-oxide-forming)
Reaction(IUBMB)
N,N,N-trimethylamine + NADPH + H+ + O2 = N,N,N-trimethylamine N-oxide + NADP+ + H2O [RN:R05623]
Reaction(KEGG)
R05623
Substrate
N,N,N-trimethylamine;
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
N,N,N-trimethylamine N-oxide;
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A flavoprotein. The bacterial enzyme enables bacteria to use trimethylamine as the sole source of carbon and energy [1,4]. The mammalian enzyme is involved in detoxification of trimethylamine. Mutations in the human enzyme cause the inheritable disease known as trimethylaminuria (fish odor syndrome) [2,3].
History
EC 1.14.13.148 created 2012
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K18277  trimethylamine monooxygenase
Genes
STEKAXG53_01325
LCICINQ41_07870
LAVIINQ42_07335
LUGFPZ22_13350
PMYPmen_3459
PREPCA10_14390
PFUWKF707C_42090
PCQPcP3B5_34340(hapE_3)
PPGPputGB1_2270
PPUTL483_19090
PPUNPP4_21860
PFEPSF113_3540
PFSPFLU_2331
PMANOU5_0413
PVRPverR02_12515
PBAPSEBR_a2220
PSVPVLB_12380
PSKU771_12125
PFZAV641_09420
PLQAA042_19100
PPSYAOC04_06155
PSETTHL1_1501
PSILPMA3_11125
PVKEPZ47_12030
PBZGN234_06140
PKHJLK41_14790
PMAOPMYSY11_2269
PTRTHU722_0011560
PQIKH389_01330
PZAHU749_012830
PWYHU734_002510
PTAENCTC10697_02640(hapE)
PBBAKN87_04520
HPEGEAO82_09950
MBSMRBBS_3053
MPQABA45_14390
PSPGAK823_03630
PSYGAK825_03560
PSYCDABAL43B_0718
ALABFG52_13560
ADVDJ533_05170
AWUBEN71_16350
ACHICDG60_10635
ATGJ4G44_11830
ACIUA3K93_14315
PHAPSHAa1699
PTNPTRA_a2101(tmm)
PNGPNIG_a2218(tmm)
HTREPV75_09255
MPINLGT42_007885
HAFC8233_03960 C8233_04000
CMAIBFX80_07300 BFX80_07330
CAMHLCW13_07380 LCW13_07455
PAURFGL86_11390
OAIOLEAN_C17270
MSECLN244_01210
NIKF5I99_18960
OCEGU3_01635
OCMCBP12_10665
OPFCBP31_06935
TSNW908_02175
THINCRN91_07935
IGNMMG00_06200
BUZAYM40_12365
BAVBAV1821
BTRMSAMEA390648701700(hapE_2)
BOJCBF45_10040
OURCEQ07_03955
OUEI6G29_03005
KGYEHF36_10445
SIMPC6571_15265
HARHEAR2456
LCHLcho_0154
AONDEH84_17435
METRBSY238_2316
MEUACJ67_08495
MXAMXAN_0506
MLOmlr7328
MLNA9174_29045
MCIMesci_5141
MOPMesop_5723
MAMMesau_05218
MAMOA6B35_11145
MESWA9K65_028190
MESMEJ066_15735
MESPC1M53_18785
MHUAMCHK_0843
MJREB229_29620
MERDEB233_25665
AAKAA2016_5256
AMIHCO731_04990(hapE_2)
PHTBLM14_24635
SMESMc04149
SMKSinme_3434
SMQSinmeB_3209
SMXSM11_chr3574
SMIBN406_03237
SMEGC770_GR4Chr0110
SMELSM2011_c04149
SMERDU99_00555
SMDSmed_3315
SIXBSY16_5790
EAKEKH55_4287
ARAArad_8377
RETRHE_PE00411
RELREMIM1_PD00433
RLEpRL110548
RLTRleg2_5648
RLGRleg_6584
RLBRLEG3_05370
RLURLEG12_01995
RTRRTCIAT899_PC09260
RHLLPU83_pLPU83c0701
RJGCCGE525_22880
RHRCKA34_31875
RADCO657_28960
RIIFFM53_030575
RHIDFFM81_029920
RLNJ0663_26905
RBANJ2J98_25845
RRGJ3P73_30890
RLSHB780_09375
AZCAZC_1374
LNEFZC33_22020
MOGMMB17_17390
MSLMsil_3604
MTUNMTUNDRAET4_3218
BBARRHAL1_03796
HMCHYPMC_2735
METGHT051_12810
CMETK6K41_17915
NOHG5V57_22945
LIZLGH83_08190
BNEDA69_09200
BDMEQG53_06870
SILSPO1551(tmm)
RDERD1_0632
RLIRLO149_c005810
OAROA238_c26840
LMDMETH_18525
LEJETW24_18045
LAQUR2C4_19660
REDroselon_03573
CIDP73_0139
CEHCEW89_17235
TPROGa0080559_TMP4888
PABYGa0080574_TMP1125
SULZC1J03_14655
RMMROSMUCSMR3_00018
ROKRAK1035_2867
RIDRIdsm_02096(hapE_4)
ROMEI983_08850
ROHFIU89_06135(hapE)
MALUKU6B_39800
PALXGQA70_23315
RHPLPB142_05620
PAMIJCM7686_pAMI6p076 JCM7686_pAMI6p102
PYEA6J80_01575
PZHCX676_01820
PAMNpAMV1p0112(tmm)
DAAAKL17_0587
RBGBG454_03475
GEHHYN69_06775
GFUKM031_03475
TAWEI545_08500
PSEBEOK75_16655
HDHG5B40_19235
FAPGR316_12235
SSANNX02_15600
GBEGbCGDNIH1_1825
GBHGbCGDNIH2_1825
GBCGbCGDNIH3_1825
GBSGbCGDNIH4_1825
GXLH845_65
KEUS101446_00773
AACEA0U92_02465
ACEKFLP30_07305
TIIDY252_08080
PUBSAR11_1296
PEGE5R92_06770
APCHIMB59_00013340
APMHIMB5_00009280
MDXBTO20_34855
MDFK0O62_10910
MVAMvan_1201
MGIMflv_5135
MSPMspyr1_45550
MPHLMPHLCCUG_02553(pamO_2)
MVQMYVA_1579
MHASMHAS_01947(pamO_2)
MAUUNCTC10437_00993(hapE_2)
MMORMMOR_34870
MTYMTOK_34480
MAUBMAUB_30960
MPOFMPOR_14890
MMATMMAGJ_74100
CGLCgl1141(Cgl1141)
CGBcg1292
CGUWA5_1096
CGTcgR_1225
CGSC624_06545
CGGC629_06545
CGMcgp_1292
CGJAR0_06205
CGQCGLAR1_06070
CGXSB89_05950
CEFCE1213
CMDB841_04830
CHMB842_05140
CMQB840_04730
CCJZccrud_05510
CSURN24_1258
CCOECETAM_05160
BFVC628_06180
REQREQ_34750
RPYY013_00300
RBYCEJ39_10890
RHQIM25_14250
RRT4535765_01758(hapE_3)
DPCA6048_14945
TOYFO059_01870
SVDCP969_24485
SPRACP972_27535
MIPAXH82_07385
MWAE4K62_12875
MOYCVS54_00105(hapE)
MCAWF6J84_14810
MLZF6J85_12255
MVDAWU67_07760
MSPOKXZ72_13180
SALCC2138_08735
GSDM3M28_07820
ARMART_3120
ARLAFL94_13965
AREAL755_14080
AAQAOC05_17140
ARWMB46_17795
ARYATC04_03995
ARUASPU41_06140
ARQBWQ92_06315
ACRYAC20117_12870
ARTPE5206_06715
ASUFMNQ99_14805
PSULAU252_13030
PSEYGU243_21735
AAIAARI_10490
GCRGcLGCM259_1571
GPRJQN66_13930
NOIFCL41_10090
NALB005_2927
SVISvir_30590
DSLDacsa_3562
THEUHPC62_19245
TERTery_0516
PSNPedsa_0537
SHTKO02_08030
SMIZ4412673_01531(hapE)
SPSCE2P86_10340
AEVEI546_10020
POACW731_04875
MYRMYRA21_0771
MPWMPR_3295
MODAS202_03260
MYZBK054_03370
MOAI6I89_00305
BIAGMA17_14435
WVIWeevi_1215
CSALNBC122_01708(hapE)
CJGNCTC13459_01237(hapE)
CCASEIB73_03325
CANTNCTC13489_02194(pamO)
KFAQ73A0000_12550
ESTEHNV03_09870
 » show all
Reference
1  [PMID:4404764]
  Authors
Large PJ, Boulton CA, Crabbe MJ
  Title
The reduced nicotinamide-adenine dinucleotide phosphate- and oxygen-dependent N-oxygenation of trimethylamine by Pseudomonas aminovorans.
  Journal
Biochem J 128:137P-138P (1972)
DOI:10.1042/bj1280137pb
Reference
2  [PMID:9417913]
  Authors
Dolphin CT, Riley JH, Smith RL, Shephard EA, Phillips IR
  Title
Structural organization of the human flavin-containing monooxygenase 3 gene (FMO3), the favored candidate for fish-odor syndrome, determined directly from genomic DNA.
  Journal
Genomics 46:260-7 (1997)
DOI:10.1006/geno.1997.5031
  Sequence
[hsa:2328]
Reference
3  [PMID:9536088]
  Authors
Treacy EP, Akerman BR, Chow LM, Youil R, Bibeau C, Lin J, Bruce AG, Knight M, Danks DM, Cashman JR, Forrest SM
  Title
Mutations of the flavin-containing monooxygenase gene (FMO3) cause trimethylaminuria, a defect in detoxication.
  Journal
Hum Mol Genet 7:839-45 (1998)
DOI:10.1093/hmg/7.5.839
  Sequence
[rno:84493]
Reference
4  [PMID:22006322]
  Authors
Chen Y, Patel NA, Crombie A, Scrivens JH, Murrell JC
  Title
Bacterial flavin-containing monooxygenase is trimethylamine monooxygenase.
  Journal
Proc Natl Acad Sci U S A 108:17791-6 (2011)
DOI:10.1073/pnas.1112928108
  Sequence
[msl:Msil_3604]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.148
IUBMB Enzyme Nomenclature: 1.14.13.148
ExPASy - ENZYME nomenclature database: 1.14.13.148
BRENDA, the Enzyme Database: 1.14.13.148

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