Entry Name 6-hydroxy-3-succinoylpyridine 3-monooxygenase;
Class Oxidoreductases;BRITE hierarchy
Sysname 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate,NADH:oxygen oxidoreductase (3-hydroxylating, succinate semialdehyde releasing)
Reaction(IUBMB) 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 NADH + 2 H+ + O2 = 2,5-dihydroxypyridine + succinate semialdehyde + 2 NAD+ + H2O [RN:
R09472 ]
Reaction(KEGG) Substrate Product Comment The enzyme catalyses a reaction in the nicotine degradation pathway of Pseudomonas species. One of the enzymes from the soil bacterium Pseudomonas putida S16 contains an FAD cofactor [2].
History EC 1.14.13.163 created 2012
Pathway ec00760 Nicotinate and nicotinamide metabolism
ec01120 Microbial metabolism in diverse environments
Orthology K15359 6-hydroxy-3-succinoylpyridine 3-monooxygenase
K18276 6-hydroxy-3-succinoylpyridine 3-monooxygenase
Genes PMON : X969_00225 X969_19895
PMOT : X970_00225 X970_19530
GOI : LK459_20845 LK459_20935
» show all Taxonomy Reference Authors Tang H, Wang S, Ma L, Meng X, Deng Z, Zhang D, Ma C, Xu P
Title A novel gene, encoding 6-hydroxy-3-succinoylpyridine hydroxylase, involved in nicotine degradation by Pseudomonas putida strain S16.
Journal Sequence Reference Authors Tang H, Yao Y, Zhang D, Meng X, Wang L, Yu H, Ma L, Xu P
Title A novel NADH-dependent and FAD-containing hydroxylase is crucial for nicotine degradation by Pseudomonas putida.
Journal Sequence Other DBs
