KEGG   ENZYME: 1.14.13.170
Entry
EC 1.14.13.170              Enzyme                                 

Name
pentalenolactone D synthase;
penE (gene name);
pntE (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
1-deoxy-11-oxopentalenate,NADH:oxygen oxidoreductase (pentalenolactone-D-forming)
Reaction(IUBMB)
1-deoxy-11-oxopentalenate + NADPH + H+ + O2 = pentalenolactone D + NADP+ + H2O [RN:R10154]
Reaction(KEGG)
R10154
Substrate
1-deoxy-11-oxopentalenate [CPD:C20400];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
pentalenolactone D [CPD:C20399];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A FAD-dependent oxygenase. Isolated from the bacteria Streptomyces exfoliatus and Streptomyces arenae. The ketone undergoes a biological Baeyer-Villiger reaction. Part of the pathway of pentalenolactone biosynthesis.
History
EC 1.14.13.170 created 2012
Pathway
ec00998  Biosynthesis of various antibiotics
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K18091  pentalenolactone D synthase
Genes
MHOL: K3U96_25175
MHER: K3U94_10700
SMA: SAVERM_2994(ptlE)
SBH: SBI_09676
SCI: B446_29680
SCW: TU94_27390
SLE: sle_13190(sle_13190)
SSIA: A7J05_09255
Reference
1  [PMID:21250661]
  Authors
Seo MJ, Zhu D, Endo S, Ikeda H, Cane DE
  Title
Genome mining in Streptomyces. Elucidation of the role of Baeyer-Villiger monooxygenases and non-heme iron-dependent dehydrogenase/oxygenases in the final steps of the biosynthesis of pentalenolactone and neopentalenolactone.
  Journal
Biochemistry 50:1739-54 (2011)
DOI:10.1021/bi1019786
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.170
IUBMB Enzyme Nomenclature: 1.14.13.170
ExPASy - ENZYME nomenclature database: 1.14.13.170
BRENDA, the Enzyme Database: 1.14.13.170

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