KEGG ENZYME: 1.14.13.182

ENZYME: 1.14.13.182

Entry

EC 1.14.13.182              Enzyme

Name

2-heptyl-3-hydroxy-4(1H)-quinolone synthase;
PqsH;
2-heptyl-3,4-dihydroxyquinoline synthase

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

2-heptyl-4(1H)-quinolone,NADH:oxygen oxidoreductase (3-hydroxylating)

Reaction(IUBMB)

2-heptyl-4(1H)-quinolone + NADH + H+ + O2 = 2-heptyl-3-hydroxy-4(1H)-quinolone + NAD+ + H2O [RN:R10467]

Reaction(KEGG)

R10467

Substrate

2-heptyl-4(1H)-quinolone [CPD:C20643];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]

Product

2-heptyl-3-hydroxy-4(1H)-quinolone [CPD:C11848];
NAD+ [CPD:C00003];
H2O [CPD:C00001]

Comment

The enzyme from the bacterium Pseudomonas aeruginosa catalyses the terminal step in biosynthesis of the signal molecule 2-heptyl-3,4-dihydroxyquinoline that plays a role in regulation of virulence genes.

History

EC 1.14.13.182 created 2013

Pathway

ec00405

Phenazine biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K17940

2-heptyl-3-hydroxy-4(1H)-quinolone synthase

Genes