KEGG   ENZYME: 1.14.13.182Help
Entry
EC 1.14.13.182              Enzyme                                 

Name
2-heptyl-3-hydroxy-4(1H)-quinolone synthase;
PqsH;
2-heptyl-3,4-dihydroxyquinoline synthase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
2-heptyl-4(1H)-quinolone,NADH:oxygen oxidoreductase (3-hydroxylating)
Reaction(IUBMB)
2-heptyl-4(1H)-quinolone + NADH + H+ + O2 = 2-heptyl-3-hydroxy-4(1H)-quinolone + NAD+ + H2O [RN:R10467]
Reaction(KEGG)
Substrate
2-heptyl-4(1H)-quinolone [CPD:C20643];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
2-heptyl-3-hydroxy-4(1H)-quinolone [CPD:C11848];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Comment
The enzyme from the bacterium Pseudomonas aeruginosa catalyses the terminal step in biosynthesis of the signal molecule 2-heptyl-3,4-dihydroxyquinoline that plays a role in regulation of virulence genes.
History
EC 1.14.13.182 created 2013
Pathway
ec00405  Phenazine biosynthesis
ec01130  Biosynthesis of antibiotics
Orthology
K17940  2-heptyl-3-hydroxy-4(1H)-quinolone synthase
Genes
PAE: PA2587(pqsH)
PAEV: N297_2666
PAEI: N296_2666
PAU: PA14_30630(pqsH)
PAP: PSPA7_2611
PAG: PLES_26011(pqsH)
PAF: PAM18_2406(pqsH)
PNC: NCGM2_3602(pqsH)
PAEB: NCGM1900_3928(pqsH)
PDK: PADK2_11725
PAEP: PA1S_12675
PAEM: U769_12240
PAEL: T223_13295
PAEU: BN889_02851(pqsH)
PAEG: AI22_21235
PAEC: M802_2663
PAEO: M801_2532
 » show all
Taxonomy
Reference
1  [PMID:20662781]
  Authors
Schertzer JW, Brown SA, Whiteley M
  Title
Oxygen levels rapidly modulate Pseudomonas aeruginosa social behaviours via substrate limitation of PqsH.
  Journal
Mol Microbiol 77:1527-38 (2010)
DOI:10.1111/j.1365-2958.2010.07303.x
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.182
IUBMB Enzyme Nomenclature: 1.14.13.182
ExPASy - ENZYME nomenclature database: 1.14.13.182
BRENDA, the Enzyme Database: 1.14.13.182

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