KEGG   ENZYME: 1.14.13.20
Entry
EC 1.14.13.20               Enzyme                                 
Name
2,4-dichlorophenol 6-monooxygenase;
2,4-dichlorophenol hydroxylase;
2,4-dichlorophenol monooxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
2,4-dichlorophenol,NADPH:oxygen oxidoreductase (6-hydroxylating)
Reaction(IUBMB)
2,4-dichlorophenol + NADPH + H+ + O2 = 3,5-dichlorocatechol + NADP+ + H2O [RN:R03997]
Reaction(KEGG)
R03997;
(other) R05441
Substrate
2,4-dichlorophenol [CPD:C02625];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
3,5-dichlorocatechol [CPD:C02933];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A flavoprotein (FAD). Also acts, more slowly, on 4-chlorophenol and 4-chloro-2-methylphenol; NADH can act instead of NADPH, but more slowly.
History
EC 1.14.13.20 created 1983
Pathway
ec00361  Chlorocyclohexane and chlorobenzene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K10676  2,4-dichlorophenol 6-monooxygenase
Genes
PAKHB0X70_03075
PLUICE143_03060
PCQPcP3B5_21640(tfdB)
PNTG5B91_07365(hbpA)
PPUHB479_25850
PDRH681_09635
PSVPVLB_26087
MSHEMAALD49_03580
MANPEHN06_06635 EHN06_06685
ACBA1S_1079
ACALBUM88_05190
ASEII8T81_13610
ACDAOLE_13995
AEIAOY20_13805
ACUMC9E88_009150
ALWFOB21_04930
ACHICDG60_06750
ASHAG8E00_06060
ABOUACBO_09460
ACIUA3K93_08085
APOTMZO21_08345
OSGBST96_10705
MGEOCFI10_06255
CKSH9L41_22945
CNCCNE_BB2p00380(tfdB)
REUReut_B4679 Reut_D6462 Reut_D6470
COXE0W60_36470 E0W60_36560 E0W60_36900
BCENDM39_5592(tfdB)
BMJBMULJ_00773
BMUBmul_2460
BCTGEM_2096
BPSLWS57_14635
BANNJFN94_06885
BYIBYI23_F000530(mhqA) BYI23_F000610(mhqA)
BUZAYM40_28715
PHSC2L64_52635
PCAFDSC91_003624
PACPFAZ97_19160
PPULRO07_24965
TVLFAZ95_22945
BPTBpet1331
AXYAXYL_03121
AISBUW96_12410
APESFOC84_29900
AALNQ3V95_01245
PIGEGT29_10725
ADNAlide_3930
ADKAlide2_4275
DRGH9K76_13735
PAQAK9V56_003680
DARDaro_0899
THKCCZ27_15525
MLNA9174_15455
MCIMesci_5342
MCICA4R28_00400
MAMOA6B35_10195
MESWA9K65_029190
MJREB229_15655
MESOBSQ44_19310
RPODE0E05_06010
NIYFQ775_05325
PLAPlav_0131
RBSRHODOSMS8_01308(tfdB) RHODOSMS8_02317(tfdB) RHODOSMS8_03465(tfdB)
SIXBSY16_5886(tfdB)
EAKEKH55_4641
STEGQA637_22765
AGCBSY240_3583(tfdB)
AVVRvVAT039_pl00630
AVFRvVAR031_pl02700
AVIAvi_7439
RLEpRL120094(tfdB)
RLGRleg_5534
RHLLPU83_3293(tfdB)
RGRFZ934_22095
RLNJ0663_26265
RRGJ3P73_27975
RROSD4A92_03065
RAWNE851_01970
RBWRLCC275e_25950
SHZshn_17085
SOJK6301_14535
SSUMQ9314_11240
ABAWD5400_18555
BRABRADO2271(tfdB)
BROBRAD285_6478(tfdB)
BRKCWS35_17625
BVZBRAD3257_2215(tfdB)
BSEPHAP48_0030295
BQBJ4P68_0031560
BBANJ4G43_002830
BCANBcanWSM471_04095 BcanWSM471_18225
RBKE0H22_14530
LNEFZC33_07665
MSLMsil_1463
PHLKKY_3150
DEAFPZ08_02915
PLEOOHA_1_04031(tfdB)
MAADAZF01_21740
MMEDMame_00353(tfdB_1)
MLUTJET14_22390
BRND1F64_20720
RPONG3256_03730
PPICPhaeoP14_02543
OATOAN307_c31200
LEJETW24_15985
CEHCEW89_05510
SULZC1J03_12300
PZHCX676_20335
PPANESD82_09880
PSTLJHW45_15635
PFEOE3U26_16715
RBGBG454_13025
TAWEI545_03210 EI545_15125
CACTHZ995_11470
NSMJO391_15080
AMYLQBD29_07650
NREBES08_18240
SINAKNJ79_21045
SPHUSPPYR_1422
SWISwit_2298 Swit_3045
SPHDHY78_10325 HY78_14035
RDICMV14_05145
SPHFDM480_04910 DM480_13535
SJPSJA_C1-21170(tfdB)
SINBSIDU_04775
SPPHKFK14_07125 KFK14_10980 KFK14_23090
SCLsce6695(cadA)
EUZDVS28_a4350
MMIMMAR_3384
MMAEMMARE11_32850
MDXBTO20_24030
MSIMMSIM_49230
MSAKMSAS_18810 MSAS_43450
MKUI2456_26965
MLJMLAC_15310
MSPGF6B93_10655
MPAAMKK62_25015
MVAMvan_4406
MYNMyAD_07550
MTHN4412656_01070(tfdB) 4412656_02644(tcmG)
MCHTMCHIJ_49160
MMAGMMAD_32310
MIJMINS_17270
MARZMARA_34500
MHEVMHEL_50940
MMUCC1S78_006365 C1S78_014655
MSEIMSEDJ_41060
MGROFZ046_12670
CEFCE2219
CHNA605_00660 A605_12305
CMDB841_02870
CHMB842_00260 B842_11315
CDXCDES_03630(tfdB)
CCOECETAM_00270(tfdB)
COKCOCCU_00115(tfdB1) COCCU_00185(tfdB2)
CCYCSCMU_34840
CGFCGUA_01850(tfdB)
CSUEQP029_02345 QP029_06365
CBREQP027_01750 QP027_10725
NSLBOX37_13460
NTPCRH09_29765
NWLNWFMUON74_39440 NWFMUON74_45630
NTCKHQ06_23985
RHARHA1_ro00520(ohpB) RHA1_ro00538 RHA1_ro10313
REBXU06_29335
RQIC1M55_30810
ROPROP_46190
ROAPd630_LPD12046
RPYY013_12685
RHBNY08_3120
RAVAAT18_09060 AAT18_09315
RFAA3L23_01332(tfdB)
RHSA3Q41_02037(tfdB)
RRZCS378_24130
RHUA3Q40_02898(tfdB)
RHODAOT96_34420
RKOJWS14_14265 JWS14_20530 JWS14_46965 JWS14_47000 JWS14_47920
ROZCBI38_01165 CBI38_32790
RPSKJWS13_03800 JWS13_05395 JWS13_45120
GOCCXX93_14715
GAMGII34_02375
GOILK459_00990
GSIP5P27_07205 P5P27_08345
TSDMTP03_45030
SRTSrot_2422
DIZCT688_00820
SGRFSGFS_022110 SGFS_022650 SGFS_026090 SGFS_100090
SCBSCAB_12351 SCAB_14111 SCAB_23631
SVLStrvi_3710 Strvi_4586
SHYSHJG_8539
SHOSHJGH_8299
SDVBN159_1741
SCWTU94_32215
SXISXIM_06260 SXIM_35670
STRCAA958_24210
SCXAS200_01245 AS200_38910
SLEsle_04010(sle_04010)
SGSAVL59_28985
STSIA4E84_33880
SGMGCM10017557_34850
SCADDN051_01855 DN051_35330 DN051_39765 DN051_43520
SLSSLINC_1036
SNWBBN63_05670
SGEDWG14_00198(tfdB_1) DWG14_01104(tfdB_2)
SDXC4B68_17110
SCYAEJ357_04120 EJ357_37240
SFYGFH48_10085
SAQUEJC51_07500 EJC51_44160
SBYH7H31_31070
SPHVF9278_41170
SPACB1H29_00665 B1H29_36395
SCHACP983_03980
SCOECP976_36295
STUIGCM10017668_59540
SCHFIPT68_02060
SHARHUT13_00410
SFEUIM697_19750
SMOBJ7W19_03210 J7W19_27645
SROIIAG44_02080 IAG44_37690
SMAOCAG99_11020 CAG99_26330
SINEKI385_36970
SLFJEQ17_02155 JEQ17_08035
SDECL3078_39450
SAKBK1J60_04890
SCAEIHE65_05265
SANTQR300_06020
SARGHKX69_01025
SJNRI060_06610
SCYNN8I84_06530 N8I84_40540
SKGKJK29_04965
SCOAQU709_40790
KISHUT16_21995
STRHGXP74_28295
ABRYNYE86_28185
AGLAOIE69_08690
MCAWF6J84_00360
MAZANFX31_14545
MELYL2X98_27600 L2X98_30500
MVDAWU67_12435 AWU67_12440
FRPAX769_00705
AARCG127AT_14245
MDBOVN18_09695
SALDFVA74_01625
LRPMUN76_11660
SUBTKPL76_07445
ARTArth_1929
ACRYAC20117_12520
ARTPE5206_04650 E5206_13920
AJGKKR91_07500
ASUNKG104_03755
ASUFMNQ99_07130
AGEGMUG94_07235
ACHAchl_4564
PSEYGU243_16740
KPLKPaMU14_06545
NAEBHE16_06590
CIGE7744_15345
PAEYKUF55_08570
BCAUI6G59_06830 I6G59_09640 I6G59_09900
NANOG5V58_19740
NAROCFH99_24180
NAQUENKNEFLB_03878(tfdB)
NROK8W59_17650 K8W59_18520
NMARHPC71_03210 HPC71_13685
PSIMKR76_25500
AERAERYTH_12990
AEFGEV26_15515
AWNNQV15_13620
KSLOG809_09400
NGVCDO52_16685
FREFranean1_2986
NMLNamu_0227
NAKAH7F38_04265
AMDAMED_5991
AMNRAM_30725
AMMAMES_5907
AMZB737_5907
AMQAMETH_1296
AMYCCU254_22230 CU254_25580
AACDLWP59_06385
APRTMUY14_05945
ARHDVSH64_17320 VSH64_18835
PSEAWY02_07855
PSEHXF36_06625
PHHAFB00_24145
PAUTPdca_45420
PBROHOP40_17930
PPELH6H00_04965 H6H00_25965
KUTJJ691_01250 JJ691_13930
KBUQ4V64_48910
KPHYAOZ06_37215
AHMTL08_18505
STPStrop_2185
MCRAID554_06970
AFSAFR_25335
ACTLL3i22_033060
ASICQ0Z83_037310
DVCDvina_24335 Dvina_29130
DMATDmats_19960 Dmats_24370
EKEEK0264_03995 EK0264_08060 EK0264_11535
RMARGBA65_09710
SBAEDSM104329_02808(tfdB)
ABASACPOL_6348 ACPOL_6587
 » show all
Reference
1  [PMID:7075592]
  Authors
Beadle CA, Smith AR.
  Title
The purification and properties of 2,4-dichlorophenol hydroxylase from a strain of Acinetobacter species.
  Journal
Eur J Biochem 123:323-32 (1982)
DOI:10.1111/j.1432-1033.1982.tb19771.x
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.20
IUBMB Enzyme Nomenclature: 1.14.13.20
ExPASy - ENZYME nomenclature database: 1.14.13.20
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.20
BRENDA, the Enzyme Database: 1.14.13.20
CAS: 82047-82-3

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