KEGG   ENZYME: 1.14.13.209Help
Entry
EC 1.14.13.209              Enzyme                                 

Name
salicyloyl-CoA 5-hydroxylase;
sdgC (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
salicyloyl-CoA,NADH:oxygen oxidoreductase (5-hydroxylating)
Reaction(IUBMB)
2-hydroxybenzoyl-CoA + NADH + H+ + O2 = gentisyl-CoA + NAD+ + H2O [RN:R11056]
Reaction(KEGG)
Substrate
2-hydroxybenzoyl-CoA [CPD:C20394];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
gentisyl-CoA [CPD:C21081];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Comment
The enzyme, characterized from the bacterium Streptomyces sp. WA46, participates in a pathway for salicylate degradation. cf. EC 1.14.13.172, salicylate 5-hydroxylase.
History
EC 1.14.13.209 created 2015
Orthology
K21684  salicyloyl-CoA 5-hydroxylase
Genes
APN: Asphe3_39870
PSUL: AU252_00400
AMQ: AMETH_3628
PDX: Psed_5066
Taxonomy
Reference
1  [PMID:15006746]
  Authors
Ishiyama D, Vujaklija D, Davies J
  Title
Novel pathway of salicylate degradation by Streptomyces sp. strain WA46.
  Journal
Appl Environ Microbiol 70:1297-306 (2004)
DOI:10.1128/AEM.70.3.1297-1306.2004
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.209
IUBMB Enzyme Nomenclature: 1.14.13.209
ExPASy - ENZYME nomenclature database: 1.14.13.209
BRENDA, the Enzyme Database: 1.14.13.209

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