Entry |
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Name |
rifampicin monooxygenase;
RIF-O
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Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
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Sysname |
rifampicin:NAD(P)H:oxygen oxidoreductase (2'-N-hydroxyrifampicin-forming)
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Reaction(IUBMB) |
rifampicin + NAD(P)H + O2 = 2'-N-hydroxyrifampicin + NAD(P)+ + H2O [RN: R11151 R11152]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
The enzyme has been found in the Corynebacteria Rhodococcus equi and Nocardia farcinica. It confers increased resistance to the antibiotic rifampicin by initiating its degradation.
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History |
EC 1.14.13.211 created 2016
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Orthology |
K21267 | rifampicin monooxygenase |
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Genes |
» show all
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Reference |
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Authors |
Andersen SJ, Quan S, Gowan B, Dabbs ER |
Title |
Monooxygenase-like sequence of a Rhodococcus equi gene conferring increased resistance to rifampin by inactivating this antibiotic. |
Journal |
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Sequence |
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Reference |
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Authors |
Hoshino Y, Fujii S, Shinonaga H, Arai K, Saito F, Fukai T, Satoh H, Miyazaki Y, Ishikawa J |
Title |
Monooxygenation of rifampicin catalyzed by the rox gene product of Nocardia farcinica: structure elucidation, gene identification and role in drug resistance. |
Journal |
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Other DBs |
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