KEGG   ENZYME: 1.14.13.216Help
Entry
EC 1.14.13.216              Enzyme                                 

Name
asperlicin C monooxygenase;
AspB
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
asperlicin C,NAD(P)H:oxygen oxidoreductase
Reaction(IUBMB)
asperlicin C + NAD(P)H + H+ + O2 = asperlicin E + NAD(P)+ + H2O [RN:R11156 R11157]
Reaction(KEGG)
Substrate
asperlicin C [CPD:C21147];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
asperlicin E [CPD:C21148];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
The enzyme, characterized from the fungus Aspergillus alliaceus, contains an FAD cofactor. The enzyme inserts a hydroxyl group, leading to formation of a N-C bond that creates an additional cycle between the bicyclic indole and the tetracyclic core moieties, resulting in the heptacyclic asperlicin E.
History
EC 1.14.13.216 created 2016
Reference
1  [PMID:23030663]
  Authors
Haynes SW, Gao X, Tang Y, Walsh CT
  Title
Assembly of asperlicin peptidyl alkaloids from anthranilate and tryptophan: a two-enzyme pathway generates heptacyclic scaffold complexity in asperlicin E.
  Journal
J Am Chem Soc 134:17444-7 (2012)
DOI:10.1021/ja308371z
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.216
IUBMB Enzyme Nomenclature: 1.14.13.216
ExPASy - ENZYME nomenclature database: 1.14.13.216
BRENDA, the Enzyme Database: 1.14.13.216

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