KEGG   ENZYME: 1.14.13.219Help
Entry
EC 1.14.13.219              Enzyme                                 

Name
resorcinol 4-hydroxylase (NADPH)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
resorcinol,NADPH:oxygen oxidoreductase (4-hydroxylating)
Reaction(IUBMB)
resorcinol + NADPH + H+ + O2 = hydroxyquinol + NADP+ + H2O [RN:R05249]
Reaction(KEGG)
Substrate
resorcinol [CPD:C01751];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
hydroxyquinol [CPD:C02814];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
The enzyme, characterized from the bacterium Corynebacterium glutamicum, is a single-component hydroxylase. The enzyme has no activity with NADH. cf. EC 1.14.13.220, resorcinol 4-hydroxylase (NADH), and EC 1.14.14.27, resorcinol 4-hydroxylase (FADH2).
History
EC 1.14.13.219 created 2016
Pathway
ec00362  Benzoate degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K20943  resorcinol 4-hydroxylase (NADPH)
Genes
CGL: NCgl1111(mhpA)
CGB: cg1309
CGU: WA5_1111(MhpA)
CGT: cgR_1240
CGS: C624_06615(mhpA)
CGG: C629_06615(mhpA)
CGM: cgp_1309
ROP: ROP_42950
Taxonomy
Reference
1  [PMID:16963551]
  Authors
Huang Y, Zhao KX, Shen XH, Chaudhry MT, Jiang CY, Liu SJ
  Title
Genetic characterization of the resorcinol catabolic pathway in Corynebacterium glutamicum.
  Journal
Appl Environ Microbiol 72:7238-45 (2006)
DOI:10.1128/AEM.01494-06
  Sequence
[cgl:NCgl1111]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.219
IUBMB Enzyme Nomenclature: 1.14.13.219
ExPASy - ENZYME nomenclature database: 1.14.13.219
BRENDA, the Enzyme Database: 1.14.13.219

DBGET integrated database retrieval system