KEGG   ENZYME: 1.14.13.225
Entry
EC 1.14.13.225              Enzyme                                 
Name
F-actin monooxygenase;
MICAL (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
[F-actin]-L-methionine,NADPH:O2 S-oxidoreductase
Reaction(IUBMB)
[F-actin]-L-methionine + NADPH + O2 + H+ = [F-actin]-L-methionine-(R)-S-oxide + NADP+ + H2O [RN:R11425]
Reaction(KEGG)
R11425
Substrate
[F-actin]-L-methionine [CPD:C21377];
NADPH [CPD:C00005];
O2 [CPD:C00007];
H+ [CPD:C00080]
Product
[F-actin]-L-methionine-(R)-S-oxide [CPD:C21378];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
The enzyme, characterized from the fruit fly Drosophila melanogaster, is a multi-domain oxidoreductase that acts as an F-actin disassembly factor. The enzyme selectively reduces two L-Met residues of F-actin, causing fragmentation of the filaments and preventing repolymerization [1]. Free methionine is not a substrate [2]. The reaction is stereospecific and generates the (R)-sulfoxide [3]. In the absence of substrate, the enzyme can act as an NAD(P)H oxidase (EC 1.6.3.1) [4,5].
History
EC 1.14.13.225 created 2016
Orthology
K19947  F-actin monooxygenase
Genes
HSA57553(MICAL3) 64780(MICAL1) 9645(MICAL2)
PTR451031(MICAL2) 463145(MICAL1) 745678(MICAL3)
PPS100969548(MICAL1) 100987179(MICAL3) 100994154(MICAL2)
GGO101127991(MICAL1) 101139251(MICAL2) 101149053(MICAL3)
PON100173765(MICAL1) 100438047(MICAL2) 100444220(MICAL3)
PPYG129007149(MICAL2) 129023720(MICAL3) 129037839(MICAL1)
NLE100581557(MICAL3) 100599627(MICAL2) 100604034(MICAL1)
HMH116459454(MICAL3) 116470763(MICAL1) 116476503(MICAL2)
SSYN129468309(MICAL3) 129471766(MICAL1) 129484402(MICAL2)
MCC698737(MICAL1) 701439 710292(MICAL3)
MCF102124064(MICAL2) 102135771(MICAL3) 102139619(MICAL1)
MTHB126929587 126935643 126953624
MNI105480748(MICAL3) 105486894 105492054(MICAL1)
CSAB103222878(MICAL3) 103240067(MICAL2) 103240597(MICAL1)
CATY105581354(MICAL1) 105591254(MICAL3) 105595703(MICAL2)
PANU100999634(MICAL2) 101008997(MICAL3) 101016773(MICAL1)
TGE112606066(MICAL2) 112622882(MICAL1) 112632620(MICAL3)
MLEU105533147(MICAL2) 105536563(MICAL1) 105542931(MICAL3)
RRO104668570 104668827(MICAL1) 104676297(MICAL3)
RBB108533801(MICAL1) 108535533(MICAL2) 108541715(MICAL3)
TFN117080870 117096064(MICAL3) 117097193(MICAL1)
PTEH111538558(MICAL1) 111555030
CANG105514347(MICAL3) 105519453(MICAL1) 105520515(MICAL2)
CJC100394528(MICAL2) 100395442(MICAL1) 100400227(MICAL3)
SBQ101027900(MICAL2) 101040006(MICAL3) 101042616(MICAL1)
CIMI108281729(MICAL1) 108294852(MICAL3) 108302227(MICAL2)
ANAN105707444(MICAL1) 105718510(MICAL3) 105720249(MICAL2)
CSYR103252673(MICAL2) 103263619(MICAL3) 103274988(MICAL1)
MMUR105859950(MICAL2) 105861853(MICAL3) 105864963(MICAL1)
LCAT123633149(MICAL1) 123640173(MICAL3) 123642453(MICAL2)
PCOQ105815809(MICAL3) 105815925(MICAL1) 105818412(MICAL2)
OGA100941168(MICAL3) 100954750 100956324(MICAL1)
MMU171580(Mical1) 194401(Mical3) 320878(Mical2)
MCAL110295772(Mical3) 110299452(Mical2) 110303515(Mical1)
MPAH110314399(Mical3) 110318852(Mical2) 110326332(Mical1)
RNO294520(Mical1) 362427(Mical3) 365352(Mical2)
MCOC116074518(Mical1) 116099519(Mical3) 116102810(Mical2)
ANU117710358(Mical2) 117714636(Mical3) 117724952(Mical1)
MUN110541039(Mical2) 110546057(Mical3) 110555442(Mical1)
CGE100752579(Mical1) 100754319(Mical3) 100763886(Mical2)
MAUA101829614(Mical1) 101839304(Mical2) 101844880(Mical3)
PROB127215168(Mical1) 127228206(Mical2) 127236162(Mical3)
PLEU114697590(Mical2) 114700733(Mical3) 114707525(Mical1)
MORG121440143(Mical3) 121449337(Mical1) 121457859(Mical2)
MFOT126487629 126490748 126514919
AAMP119808170(Mical3) 119820673(Mical1) 119827053(Mical2)
NGI103745899(Mical3) 103749557(Mical1) 103750410(Mical2)
HGL101701740(Mical1) 101709910(Mical3) 101712859(Mical2)
CPOC100715118(Mical1) 100726239(Mical3) 100735168(Mical2)
CCAN109684398 109684399 109688102(Mical2) 109694751(Mical1)
DORD105990107(Mical1) 105991117(Mical3) 105995126(Mical2)
DSP122101655(Mical3) 122103969(Mical1) 122117730(Mical2)
PLOP125342866(Mical3) 125357062(Mical1) 125361187(Mical2)
NCAR124958484 124982602 124988883
MMMA107135657(Mical2) 107154429(Mical1) 107155038(Mical3)
OCU100347412 100353897 100354238
OPI101516967(MICAL3) 101520406(MICAL1) 101525940(MICAL2)
TUP102480907(MICAL3) 102486503(MICAL1) 102494378(MICAL2)
GVR103591690(MICAL2) 103594224(MICAL1)
CFA476858(MICAL2) 481958(MICAL1) 486761(MICAL3)
CLUD112658393(MICAL1) 112667644(MICAL2) 112668955(MICAL3)
VVP112917441(MICAL3) 112925126(MICAL1) 112927059(MICAL2)
VLG121473673(MICAL1) 121476354 121479938(MICAL3)
NPO129503359(MICAL3) 129504759(MICAL2) 129512648(MICAL1)
AML100465187(MICAL3) 100465934(MICAL2) 100478759(MICAL1)
UMR103675754(MICAL3) 103677024(MICAL1) 103682359
UAH113246261 113258066(MICAL3) 113264746(MICAL1)
UAR123778075(MICAL3) 123791651(MICAL2) 123792939(MICAL1)
ELK111158225 111159507 111159745
LLV125078235 125102461 125107032
MPUF101684119 101687316(MICAL3) 101691585(MICAL1)
MNP132018350(MICAL1) 132019999(MICAL3) 132022995(MICAL2)
MLK131809358(MICAL2) 131833519(MICAL1) 131838339(MICAL3)
NVS122892231(MICAL3) 122903673(MICAL1) 122912732(MICAL2)
ORO101366928(MICAL2) 101371709(MICAL3) 101380122(MICAL1)
EJU114209988(MICAL1) 114219307 114222543(MICAL3)
ZCA113913852 113922520(MICAL3) 113927204(MICAL1)
MLX118001582(MICAL1) 118004247(MICAL2) 118025826(MICAL3)
NSU110576240(MICAL2) 110583013(MICAL1)
LWW102733303(MICAL3) 102734026(MICAL1) 102742847
FCA101081558(MICAL3) 101091046(MICAL2) 101100722(MICAL1)
PYU121018204 121022012(MICAL3) 121029882(MICAL1)
PCOO112861982(MICAL1) 112864889(MICAL2) 112867182(MICAL3)
PBG122473998(MICAL3) 122483572(MICAL2) 122489850(MICAL1)
PVIV125146955(MICAL2) 125166179(MICAL1) 125169684(MICAL3)
LRUF124502356 124504691 124528602
PTG102951530(MICAL3) 102962220(MICAL1) 102962641(MICAL2)
PPAD109263525(MICAL1) 109271148 109276281(MICAL3)
PUC125918696 125936014 125938783
AJU106968456 106968890 106971840
HHV120235204(MICAL1) 120237523(MICAL2) 120243763(MICAL3)
BTA508306(MICAL1) 532244(MICAL3) 534041(MICAL2)
BOM102266509(MICAL2) 102273179(MICAL1) 102286656(MICAL3)
BIU109559784(MICAL3) 109563835(MICAL1) 109569548(MICAL2)
BBUB102391634(MICAL1) 102395599(MICAL3) 102401601(MICAL2)
BBIS104981466(MICAL2) 104992259(MICAL3) 105000704(MICAL1)
CHX102172084 102178522(MICAL3) 102185000(MICAL1)
OAS101113940(MICAL1) 101118097(MICAL3) 101121880(MICAL2)
BTAX128047574(MICAL3) 128053091(MICAL1) 128061027(MICAL2)
ODA120857828(MICAL3) 120862517(MICAL1) 120876445(MICAL2)
CCAD122422634(MICAL1) 122423031(MICAL3) 122450612(MICAL2)
MREE136150777(MICAL1) 136173628(MICAL3) 136174021(MICAL2)
MBEZ129536990(MICAL3) 129554503(MICAL2) 129561122(MICAL1)
SSC100153346(MICAL1) 100157721(MICAL3) 100519075(MICAL2)
CFR102507940 102511399(MICAL1) 102522111(MICAL3)
CBAI105076002(MICAL3) 105076623(MICAL2) 105077112(MICAL1)
CDK105086699 105097110(MICAL1) 105100736(MICAL3)
VPC102532262 102533183(MICAL1) 102536845(MICAL3)
BACU103000884(MICAL1) 103012504(MICAL3) 103012861(MICAL2)
BMUS118899967 118901890(MICAL3) 118905172(MICAL1)
LVE103069359(MICAL2) 103087508(MICAL1) 103088697(MICAL3)
OOR101275370(MICAL2) 101275745(MICAL3) 101285142(MICAL1)
DLE111164423(MICAL1) 111165227(MICAL2) 111176586(MICAL3)
PCAD102977044(MICAL1) 102988858(MICAL2) 102991718(MICAL3)
PSIU116758806 116760249(MICAL3) 116763523(MICAL1)
NASI112391716(MICAL3) 112406597(MICAL1) 112407716
ECB100054807(MICAL3) 100055978 100066627(MICAL1)
EPZ103551111(MICAL1) 103565092(MICAL3) 103566075
EAI106829758(MICAL1) 106833091(MICAL2) 106839442(MICAL3)
MYB102248958(MICAL2) 102251692(MICAL1) 102258499(MICAL3)
MYD102751644(MICAL3) 102759552(MICAL1) 102769793(MICAL2)
MMYO118651865(MICAL3) 118660499(MICAL1) 118664835(MICAL2)
MLF102416812(MICAL1) 102427093(MICAL3) 102434288(MICAL2)
MDT132228224(MICAL3) 132237008(MICAL1) 132240971(MICAL2)
PKL118705608(MICAL1) 118713387 118728785(MICAL3)
EFUS103294616(MICAL2) 103300624(MICAL1) 103303804(MICAL3)
MNA107535318(MICAL2) 107537711(MICAL3) 107540706(MICAL1)
DRO112297007(MICAL1) 112303258 112311619(MICAL3)
SHON118989745(MICAL2) 118995136(MICAL3) 119000160(MICAL1)
AJM119044370(MICAL3) 119050526(MICAL2) 119059422(MICAL1)
PDIC114494320(MICAL1) 114499263 114508579(MICAL3)
PHAS123810068(MICAL2) 123818862(MICAL3) 123822103(MICAL1)
MMF118621017(MICAL1) 118624452(MICAL3) 118628128(MICAL2)
PPAM129067694(MICAL1) 129080552(MICAL2) 129080991(MICAL3)
HAI109373294(MICAL3) 109388271 109391423(MICAL1)
RFQ117016704(MICAL1) 117029356(MICAL3) 117031043
PALE102887125(MICAL3) 102889705(MICAL2) 102892071(MICAL1)
PGIG120603214(MICAL2) 120607363(MICAL3) 120608311(MICAL1)
PVP105295244(MICAL1) 105297236(MICAL3) 105301471(MICAL2)
RAY107500353(MICAL3) 107505345(MICAL2) 107518492(MICAL1)
MJV108395279(MICAL2) 108406778(MICAL3)
TOD119247867(MICAL3) 119252765(MICAL1) 119255478(MICAL2)
SARA101551779(MICAL3) 101558616(MICAL2)
SETR126005911(MICAL1) 126018890(MICAL2) 126022450(MICAL3)
LAV100661909(MICAL3) 100663700 100665365(MICAL1)
TMU101340914 101352495 101356859
ETF101650782(MICAL2) 101658014(MICAL1) 101658909(MICAL3)
DNM101414165(MICAL2) 101440708(MICAL3) 101446608(MICAL1)
MDO100022040(MICAL3) 100029104(MICAL1) 100030142(MICAL2) 107649961
GAS123247707(MICAL1) 123250329(MICAL3) 123252537(MICAL2)
SHR100920737(MICAL1) 100922670(MICAL2) 100929940(MICAL3)
AFZ127538158 127540361 127562074
PCW110218729(MICAL3) 110218891(MICAL2) 110222901(MICAL1)
TVP118851713(MICAL3) 118852756(MICAL2) 118858600(MICAL1)
OAA100073551(MICAL2) 100085361(MICAL1) 100086054(MICAL3)
GGA418164(MICAL3) 423031(MICAL2) 429474(MICAL1)
PCOC116226876(MICAL3) 116238782(MICAL1) 116242975(MICAL2)
MGP100541969 100545712(MICAL1) 100548226 104911003(MICAL2) 104912086
CJO107314574(MICAL2) 107314988(MICAL3) 107324612(MICAL1)
TPAI128085607(MICAL2) 128090232(MICAL1)
LMUT125684000(MICAL1) 125688304(MICAL3) 125694918(MICAL2)
NMEL110388263(MICAL1) 110395577(MICAL3) 110400782(MICAL2)
APLA101794484(MICAL2) 101803780(MICAL1) 101805047(MICAL3)
ACYG106030921(MICAL3) 106040898(MICAL2) 106046127(MICAL1)
CATA118249852(MICAL2) 118259514(MICAL1)
AFUL116489487(MICAL2) 116490301(MICAL3) 116498739(MICAL1)
TGU100219168(MICAL3) 100227450(MICAL2) 100232670(MICAL1)
LSR110469104(MICAL2) 110473459(MICAL1) 110482582(MICAL3)
SCAN103820469(MICAL3) 103823343(MICAL1) 103824313(MICAL2)
PMOA120495838(MICAL1) 120501683(MICAL3) 120509914(MICAL2)
OTC121332813(MICAL3) 121345942(MICAL2) 121347968(MICAL1)
PRUF121353947(MICAL1) 121362696(MICAL3) 121363394(MICAL2)
GFR102032677(MICAL3) 102033849(MICAL2) 102043330(MICAL1)
FAB101811190(MICAL2) 101819614(MICAL3) 101820098(MICAL1)
OMA130254406(MICAL2) 130261838(MICAL3) 130263673(MICAL1)
PHI102107564(MICAL3) 102107919(MICAL2) 102108714(MICAL1)
PMAJ107204329(MICAL3) 107205792(MICAL2) 107214787(MICAL1)
CCAE111928083(MICAL3) 111930849(MICAL2) 111939748(MICAL1)
CCW104692251(MICAL3) 104692546 104692969(MICAL2)
CBRC103624698(MICAL3) 103624782(MICAL2) 103625350(MICAL1)
ETL114056527(MICAL2) 114065769(MICAL1) 114068977(MICAL3)
ZAB102066089(MICAL1) 102069145(MICAL3) 102073024(MICAL2)
ZLE135449136(MICAL2) 135458264(MICAL1) 135459486(MICAL3)
ACHL103799117(MICAL3) 103803541(MICAL2) 103803943(MICAL1)
SVG106849426(MICAL3) 106851044(MICAL1) 106856830(MICAL2)
MMEA130582643(MICAL1) 130582975(MICAL2) 130588977(MICAL3)
HRT120751378(MICAL3) 120754488(MICAL2) 120762690(MICAL1)
SATI136361483(MICAL3) 136362220(MICAL2) 136371658(MICAL1)
FPG101914505(MICAL3) 101922313(MICAL1) 101924713(MICAL2)
FCH102047357(MICAL3) 102052557(MICAL2) 102060220(MICAL1)
CCRI104168442(MICAL2)
NNT104407793(MICAL3) 104408471(MICAL2)
SHAB115602218(MICAL1) 115605748(MICAL3) 115607663(MICAL2)
ACUN113481325(MICAL2) 113489033(MICAL1) 113491284(MICAL3)
TALA104358733(MICAL3) 104363867(MICAL2) 116965567(MICAL1)
ACHC115334805(MICAL1) 115351903(MICAL2) 115352746(MICAL3)
HALD104315494(MICAL3) 104322975(MICAL2)
HLE104829498(MICAL2) 104830922(MICAL3) 104842358(MICAL1)
AGEN126046917 126047644 126052449
GCL127016493 127026248 127029786
CSTI104556584(MICAL2) 104559846
LDI104342824(MICAL2) 104351505(MICAL3)
MNB103771765 103777665(MICAL3)
DPUB104296675(MICAL2) 104304696(MICAL3) 104305365(MICAL1)
AVIT104271002(MICAL2) 104274576
BRHI104496879(MICAL2) 104498836(MICAL3) 104500163(MICAL1)
EGZ104123406(MICAL2) 104125757(MICAL1) 104134379(MICAL3)
NNI104009445(MICAL2) 104013230(MICAL1) 104020203(MICAL3)
PCRI104027094(MICAL3) 104039063
PCAO104043696 104045830(MICAL2) 104049401
PADL103919887 103924360(MICAL3) 103925723(MICAL2)
AFOR103893727 103898655(MICAL3) 103906781(MICAL2)
FGA104078996(MICAL3)
GSTE104263774(MICAL3) 104264509(MICAL2)
CLV102085132(MICAL2) 102093478(MICAL3) 102096460(MICAL1)
MUI104536761 104544834(MICAL2)
PGUU104471230(MICAL2)
PLET104624437
EHS104505964(MICAL2) 104515632
CMAC104477093(MICAL3)
CUCA104055894(MICAL3) 104061836(MICAL2) 104064949(MICAL1)
TEO104379206 104383290
BREG104634439(MICAL3) 104638606(MICAL2) 104640800(MICAL1)
OHA104326374(MICAL2) 104337124(MICAL3)
ACAR104526452
CPEA104385768(MICAL2) 104393432(MICAL3) 104397186(MICAL1)
CVF104281611(MICAL3) 104293172(MICAL2)
RTD128900240(MICAL1) 128904769(MICAL3) 128908600(MICAL2)
AAM106487711(MICAL1) 106488631(MICAL3) 106497117(MICAL2)
AROW112961422(MICAL1) 112968271(MICAL3) 112974004(MICAL2)
NPD112943517(MICAL2) 112958345(MICAL3) 112959154(MICAL1)
TGT104578880(MICAL2) 104579060(MICAL1)
DNE112985684(MICAL2) 112990247(MICAL1) 112993396(MICAL3)
SCAM104147378(MICAL3) 104152068(MICAL2)
ASN102371980 102375438(MICAL3) 102377820(MICAL2)
AMJ102565781(MICAL1) 102574107(MICALCL) 106737063(MICAL3)
CPOO109316446(MICAL3) 109317837 109321193
GGN109295337(MICAL1) 109296245(MICAL3) 109299071(MICAL2)
PSS102443943(MICAL3) 102447311 102462749(MICAL2)
CMY102932362(MICAL2) 102935764(MICAL1) 102942117(MICAL3)
CCAY125625245 125625709(MICAL3) 125639091(MICAL2)
DCC119846398(MICAL1) 119856585(MICAL2)
CPIC101936236(MICAL1) 101936780(MICAL3) 101946730(MICAL2)
TST117875899(MICAL1) 117876498 117882738(MICAL3)
CABI116829948(MICAL1) 116830089(MICAL3) 116831648(MICAL2)
MRV120403291(MICAL2) 120404395(MICAL1) 120408712(MICAL3)
ACS100552986(mical1) 100554427(mical3) 100564862(mical2)
ASAO132769938(MICAL2) 132773750(MICAL1) 132775760(MICAL3)
PVT110076703(MICAL3) 110079674(MICAL1) 110080915(MICAL2)
SUND121926475(MICAL2) 121928893(MICAL1) 121931170(MICAL3)
PBI103048923 103058605(MICAL1) 103058722(MICAL2) 103064154
PMUR107289040(MICAL1) 107292277(MICAL3) 107293552
CTIG120298967(MICAL1) 120306686(MICAL2) 120317642(MICAL3)
TSR106540548 106543098 106546022 106554910 106555040
PGUT117655329(MICAL3) 117664022(MICAL1) 117665343(MICAL2)
APRI131187432(MICAL2) 131194414 131202107(MICAL3)
PTEX113439683(MICAL2) 113446449(MICAL3) 113446968 113447781
NSS113410315(MICAL2) 113418788 113418967 113419348(MICAL3)
VKO123021138(MICAL2) 123030031 123036086(MICAL3)
PMUA114597808(MICAL2) 114599198 114604933(MICAL3)
PRAF128415097(MICAL2) 128415977(MICAL1) 128421898(MICAL3)
ZVI118086880(MICAL2) 118088166(MICAL1) 118090781(MICAL3)
HCG128322372(MICAL1) 128322878(MICAL2) 128326284(MICAL3)
GJA107108023 107110968 107114958 107116309(MICAL2)
STOW125426590(MICAL2) 125432619(MICAL1) 125435915(MICAL3)
EMC129325275(MICAL2) 129329963(MICAL1) 129335282(MICAL3)
XLA108704384(mical3.L) 108712569(mical3.S) 108713737 108715283
XTR100486205(mical3) 100487018(mical2)
NPR108786140(MICAL2) 108791576(MICAL3)
RTEM120916987 120932722(MICAL3)
BBUF120980982(MICAL2) 121004621(MICAL3)
BGAR122920224(MICAL2) 122928479(MICAL3)
MUO115468873(MICAL2) 115477148(MICAL3) 115481756(MICAL1)
GSH117347228(MICAL1) 117352145(MICAL2) 117363346(MICAL3)
DRE402881(mical3a) 566850(mical3b) 568573(mical1) 569564(mical2b) 569607(mical2a)
SRX107707484 107722450 107726023 107727100 107730085 107738397 107738415 107743961 107745933 107754885
SANH107654348 107656292 107658814 107664200 107672585 107673136 107686639 107686850 107697883 107701044
SGH107558750 107559327 107562792 107572458 107581280 107584726 107587046 107589188 107590487 107592209
CCAR109054397 109057386 109057463 109057741 109069974 109079851 109082941 109109594 109109600 109109904
CAUA113041277 113043106 113048312 113051769 113059278 113060030 113061528 113065630 113065666 113066852 113068816 113097201 113106480 113118209
CGIB127933893 127944930 127947215 127956889 127961987 127976741 127977121 128011560 128014201 128016518
PTET122323016(mical3a) 122330750(mical2b) 122332809(mical1) 122343293 122348596(mical2a)
LROH127154808(mical1) 127156688(mical2b) 127163903(mical3b) 127168070(mical2a) 127180997(mical3a)
OMC131524333(mical3a) 131531941(mical1) 131534938(mical2b) 131543645(mical2a)
PPRM120460225(mical2b) 120462996(mical1) 120474291(mical3a) 120476785(mical3b) 120492652(mical2a)
RKG130069527(mical3b) 130076247(mical1) 130085265(mical2b) 130094854(mical3a) 130100373(mical2a)
MAMB125245110(mical3b) 125247010(mical2b) 125253909(mical3a) 125260083(mical1) 125265779(mical2a)
CIDE127500023 127504652 127507335 127510441 127515751
CERY137008909(mical1) 137014513(mical2b) 137023250(mical3a) 137024309(mical3b) 137030090(mical2a)
MASI127412613 127417058 127418738 127419975 127435298 127435886 127437354 127440450 127456203
TROS130545209(mical1) 130548227(mical3b) 130551716(mical2b) 130554990(mical2a) 130562598(mical3a)
TDW130409271(mical1) 130413881(mical2b) 130418520(mical2a) 130421382(mical3b) 130435342(mical3a)
MANU129419749(mical3a) 129430980(mical1) 129432576(mical3b) 129433434(mical2b) 129450903(mical2a)
IPU108264267(mical3a) 108269164(mical2b) 108271050(mical2a) 108276121(mical1) 108279684(mical3b)
IFU128606578(mical3a) 128611684(mical2b) 128613866(mical2a) 128619588(mical1) 128623139(mical3b)
PHYP113530650 113531879 113534442 113536712 113546575
SMEO124385840(mical2b) 124390950(mical2a) 124396235(mical3a) 124398989(mical1) 124401046(mical3b)
TFD113636039(mical2b) 113641886(mical1) 113645760(mical3b) 113646713(mical2a) 113652390(mical3a)
TVC132851331(mical3a) 132855644(mical2b) 132856386(mical2a) 132858665(mical3b) 132861841(mical1)
TRN134314213(mical3b) 134319552(mical2b) 134322857(mical3a) 134331798(mical2a) 134333100(mical1)
AMEX103027313(mical3b) 103033073(mical3a) 103035944(mical2b) 103039549(mical1) 103041185(mical2a)
CMAO118803226(mical3b) 118806635(mical2b) 118817937(mical3a) 118818826(mical2a) 118822153(mical1)
EEE113576304 113579066(mical2) 113582500 113584408 113589628 113589629
CHAR105905150(mical3a) 105906362(mical1) 105906548(mical2a) 105910422(mical2b)
TRU101067707(mical2) 101068062 101075455 101078087(mical3)
TFS130519786 130520993(mical2a) 130530518(mical1) 130536351(mical3a) 130536936(mical2b)
TNGGSTEN00005241G001 GSTEN00016838G001 GSTEN00017771G001 GSTEN00035663G001
LCO104923864 104930096(mical2) 104934557 104935406 104940257
NCC104947440 104962979(mical2) 104963695
TBEN117471847(mical2a) 117483563(mical1) 117491373(mical2b) 117491784(mical3a)
CGOB115009280 115009542(mical3) 115010592 115027260(mical2)
PGEO117443733 117447687(mical2b) 117447881(mical3a) 117449461(mical1) 117467669(mical2a)
GACU117532902(mical2b) 117533313(mical2a) 117537116 117537388(mical1) 117550841(mical3a)
EMAC134863043(mical2a) 134866876(mical1) 134879534 134880401(mical2b) 134881674(mical3a)
ELY117249600 117253746(mical3a) 117255597(mical2a) 117258420(mical1) 117261847(mical2b)
EFO125883078 125887082(mical2b) 125888125(mical3a) 125891817(mical1) 125905856(mical2a)
PLEP121944379(mical2a) 121946665(mical1) 121949689(mical2b) 121949913(mical3a) 121961649
SLUC116038671(mical3a) 116043692(mical1) 116048679(mical2b) 116067719(mical2a)
ECRA117944361(mical2a) 117947226(mical1) 117948581(mical3a) 117948584(mical2b)
ESP116686714 116688308(mical2) 116692730 116694327
PFLV114550471 114553052(mical2) 114558963 114559964 114560232
GAT120809051(mical2b) 120809321 120812478 120817926(mical3b) 120829288(mical1) 120831698(mical2a)
PPUG119195544(mical3a) 119196034(mical2b) 119210297 119223768(mical1) 119229535(mical2a)
AFB129099268(mical2a) 129099737(mical1) 129107688(mical3a) 129107792(mical2b) 129112798
CLUM117726540 117732014(mical2b) 117732865(mical3a) 117733090(mical1) 117750323(mical2a)
PSWI130192965(mical2a) 130195212(mical2b) 130195945(mical3a) 130199506(mical1)
CANA137798955(mical2a) 137800450(mical1) 137801732 137803928(mical3a) 137804751
CVE137880951(mical2b) 137881069(mical3a) 137887937(mical2a) 137889176(mical1) 137889960
MSAM119884220 119890609(mical2a) 119893282 119894420 119895533 119905126(mical1) 119917843
SCHU122871423 122874389(mical3a) 122874552(mical2b) 122876097(mical2a) 122882518(mical1)
CUD121505383 121506861 121514570(mical3a) 121515399(mical2b) 121517766(mical1)
ALAT119017827(mical2a) 119022329(mical1) 119024271(mical2b) 119024855(mical3a) 119032346
ASTR137589630 137593448(mical2a) 137594032(mical3a) 137594591 137610020(mical1)
MZE101468163 101468834 101479267 101482484(mical2) 101483062(mical3)
ONL100692605(mical2) 100695036 100701520 100703176 100709311
OAU116309401(mical3a) 116313773(mical3b) 116319135(mical2b) 116320228(mical2a) 116321981(mical1)
OLA101158080 101161940 101162445(mical3) 101162914(mical2) 101171492
OML112141146(mical2b) 112152148(mical3a) 112155189 112158704(mical1) 112160807(mical2a)
CSAI133424009 133443877(mical2b) 133443982(mical3a) 133456660(mical1) 133462051(mical2a)
XMA102223100 102226853(mical2) 102228008 102231712 102232140
XCO114140356 114142885(mical2) 114156092 114160608 114160769
XHE116717436 116718551(mical2) 116730706(mical3) 116734966 116736451
PRET103459833 103462477 103466250 103467967 103481203(mical3)
PFOR103129565 103138857 103139480(mical2) 103142522 103152499
PLAI106947923 106950419 106954104 106954617 106958858
PMEI106917099 106918113 106926054 106927665 106928687
GAF122821586(mical2a) 122826769 122834946(mical1) 122835001(mical3a) 122835003(mical2b)
PPRL129351936 129363126(mical3a) 129364203(mical2a) 129377075(mical1) 129379678(mical2b)
CVG107084740(mical3) 107090202(mical2) 107092972 107101150 107103849
CTUL119777218(mical1) 119787214(mical3a) 119790614 119792185(mical2a) 119799029(mical2b)
GMU124867358(mical2a) 124873768(mical1) 124881960(mical3a) 124883380 124884873(mical2b)
NFU107374222 107381406(mical2) 107389084 107389209 107390458 107397376
KMR108228914(mical2a) 108229591 108237501(mical3a) 108237661(mical1) 108243470(mical2b)
ALIM106523178 106530300 106530301 106531251 106534701 106535855
NWH119416172(mical2b) 119416240(mical3a) 119428429
AOCE111566215 111568429 111570486 111570864 111575931
MCEP125000285 125005632(mical2a) 125014760(mical2b) 125014803(mical3a) 125019903(mical1)
CSEM103379765 103380424(mical3) 103382487 103385235 103398410(mical2)
POV109636865(mical2) 109639898(mical3) 109640267 109640338 109641646 109645222
SSEN122766977(mical3b) 122772082(mical2a) 122775703(mical2b) 122775999(mical3a) 122777163(mical1)
HHIP117754926(mical2a) 117757289(mical3b) 117763306(mical3a) 117763753(mical2b) 117764345(mical1)
HSP118101956(mical3b) 118106389(mical2a) 118109572(mical3a) 118109893(mical2b) 118110746(mical1)
PPLT128429072 128442411(mical1) 128444608(mical2b) 128444884(mical2a) 128445158(mical3a)
SMAU118301881(mical2a) 118315072(mical3a) 118315972(mical2b) 118316539(mical1)
LCF108875448 108879907 108890621(mical2a) 108892103 108895333(mical1) 108902312(mical2b)
SDU111222517 111228358 111229482 111234946 111236549(mical2)
SLAL111644253 111647664 111653081 111653403 111658348(mical2) 111661808
XGL120793122(mical2b) 120793404(mical3a) 120795547(mical2a) 120803748(mical1) 120804093
HCQ109512974 109520720 109525935(mical2) 109530374(mical3) 109532568
SSCV125967643(mical2a) 125970504 125971324(mical3a) 125989204(mical1) 125992450
SBIA133493219 133497787(mical2a) 133501632(mical3a) 133501783(mical2b) 133505272(mical1)
PEE133397471 133399270(mical2a) 133402749(mical3a) 133402980(mical2b) 133411700(mical1)
PTAO133468212(mical2a) 133472168 133477074(mical1) 133477612(mical2b) 133478766(mical3a)
BPEC110154008 110161532 110169287 110175060(mical3) 110175382(mical2)
MALB109961790 109962503 109962892(mical2) 109971000
BSPL114851857(mical2a) 114857632(mical2b) 114857663(mical3a) 114858577(mical1) 114862396
SJO128353185 128357217(mical1) 128358432(mical3a) 128359489(mical2b) 128363569(mical2a)
SASA106561386 106561462 106561477 106562102 106567111 106572625 106573174 106573205 106576093 106587193 106609145
STRU115152209 115152261 115165585 115167288 115167933 115180187 115197409 115197473 115198686 115203060
OTW112215051 112216307 112216812 112218753 112218807(mical2b) 112221779(mical1) 112249569 112252562 112252603 112263679(mical2a)
OMY110490203 110492051 110498015 110498817(mical2b) 110501065 110506499 110523110 110523755 110526379 110532622
OGO123994686 124002854(mical3a) 124003378 124014359 124032208 124033779(mical2a) 124034241 124034659 124035756 124046025
ONE115102495 115106901 115109580 115109617 115112216 115113638 115132454 115133828 115134075
OKI109864354 109867080 109867196 109869171 109887421 109889545 109889585 109895259 109896324 109908262
OKE118360706 118362387 118372023 118392775 118393841(mical2a) 118396043(mical2b) 118401019 118401065(mical3a)
SALP111951310 111952514 111952935(mical3) 111956125 111962602 111962638 111966756 111969353 111976617 112068647
SNH120024955 120031783 120046701 120049864 120053289 120054092(mical3a) 120059155 120061078 120065864(mical2b) 120066430
CCLU121532284 121532340(mical2b) 121537960 121543978 121545785 121546615 121556336 121559486 121576922 121576970(mical3a)
ELS105013576 105016835(mical2) 105018133 105018257 105020163
SFM108923275 108931534 108934626 108935978 108942170
PKI111832973 111833245 111834363 111834693 111857398
AANG118208582(mical1) 118215474(mical2b) 118218793(mical3a) 118228296(mical2a) 118231531(mical3b)
LOC102682516(mical3) 102685438 102698794
PSPA121294400 121299647 121300159 121318088(mical3a) 121320007 121329865
ARUT117397166 117419817 117431940 117432252 117434979
PSEX120525937 120526805 120533808
LCM102345089 102360081(MICAL3) 102366021(MICAL2)
CMK103175113(mical2a) 103189720 103190352(mical3a)
RTP109918782 109935358
CPLA122557729 122562959 122563302(mical1)
HOC132824465(mical2a) 132825026 132828447(mical1)
LERI129705655
PMRN116939898 116945575
LRJ133350324(MICAL3) 133351535
BFO118406631
BBEL109463367
CIN100175527
SCLV120331928
SPU582210
APLC110989175
ARUN117291708
SKO100378899
DMEDmel_CG33208(Mical)
DER6552049
DSE6607011
DSIDsimw501_GD20744(Dsim_GD20744)
DYADyak_GE24713
DAN6499929
DSR110188462
DPE6598648
DMN108155526
DWI6647152
DGR6567609
DAZ108615232
DNV108658541
DHE111595671
DVI6630093
CCAT101461727
BOD106615184
BDR105225857
RZE108372393
AOQ129235652
TDA119678548
MDE101887289
SCAC106080531
LCQ111690633
LSQ119612091
GFS119640090
ECOE129938805
HIS119650882
ACOZ120957678
AARA120905537
ASTE118506709
AAG5568484
AALB109622444 115260102
ASUA134205905
CQUCpipJ_CPIJ013401 CpipJ_CPIJ013403
CPII120426071
CNS116343176
BCOO119081069
LLL129786396
PPAP129807545
AME413310
ACER107998540
ALAB122710683
ADR102679655
AFLR100869779
BIM100744389
BBIF117210322
BVK117242074
BVAN117159486
BHUN126871446
BTER100650962
BAFF126915669
BPYO122569298
BPAS132916255
FVI122533470
CCAL108628034
OBB114878658
OLG117607963
MGEN117218581
NMEA116433105
CGIG122399978
SOC105204672
MPHA105832633 105837906
AEC105145217
ACEP105617147
PBAR105423576
VEM105565851
HST105181424 105187813
DQU106741595
CFO105257878
FEX115244410
LHU105675006(Mical)
PGC109854698
OBO105283811
PCF106785377
PFUC122524970
VPS122631229
VCRB124425837
VVE124951875
NVI100120752
CSOL105360342
TPRE106657087
MDL103579831
CGLO123267013
FAS105273333
DAM107048514
AGIF122856900
CCIN107274519
TCA100141546
DPA109542110
CSET123312276
AGB108917939
LDC111505921
NVL108557182
APLN108735517
PPYR116173363 116173364
OTU111416895
BMOR101742566
BMAN114246423
MSEX115440545
DPLKGM_203372
MCIX123668387
PMAC106717230
PPOT106110241
PXU106126107
BPHI137921634(Mical)
PRAP111003396
ZCE119835875
CCRC123705053
LSIN126978528
AAGE121738444
HAW110382349
HZE124644745
TNL113503945
SLIU111360670
OFU114362758
ATRA106142306
GMW113512763
LGLY125240661
CCRN123296568
API100168266
DNX107162729
AGS114132361 114132377
RMD113550115
BTAB109029643
DCI103513125
CLEC106674386
HHAL106689369(Mical)
NLU111047126
PHUPhum_PHUM131590
FOC113215085
TPAL117640578
ZNE110827699
CSEC111868080
BROR134538857
FCD110843113 110851562
DPXDAPPUDRAFT_605
DMK116923296
DPZ124342234 124344495
PVM113802897 113810462
PJA122249514
PCHN125030332
PMOO119572369
HAME121867957
PCLA123755898
PTRU123519450
MRJ136849673(Mical)
HAZT108667277
EAF111696410 111696437 111701615 111702890 111708683
LSM121124341
TCF131883336
PPOI119097135 119108074
DSV119464482
RSAN119403408
RMP119163869
VDE111252253
VJA111264794
TUT107372243
DPTE113794869
DFR124493261
CSCU111623901
CVS136984306(Mical)
PTEP107453849
ABRU129964304
UDV129229339
SDM118183661
NAINECAME_14230
BMYBM_BM10060(Bm10060)
LOALOAG_18362
TSPTsp_08092
LGILOTGIDRAFT_106467 LOTGIDRAFT_51710
PVUL126811481
PCAN112565533 112565534
BGT106078791
GAE121370621
HRF124122405
HRJ124260930
HASI137286924
CRG105346067
CANU128183102
CVN111104401
OED125673352
MYI110457951
PMAX117327417
RPHI132759086
OBI106870794
OSN115220265
LJP135480584
LAK106178150
SMMSmp_130440
SHXMS3_00010476(MICAL3_1)
OVIT265_04365
EGLEGR_02335
NVE5504232 5509851
EPA110233073 110252769
ATEN116293795 116294133
ADF107332908
AMIL114961133 114968231
PDAM113668834 113676994
SPIS111321254 111326638
DGT114530260 114531751
XEN124438597 124439271
HMG100203435 101241235
HSY130654219
RES135685253
TADTRIADDRAFT_451
AQU100633984 100634111 105311991
PIFPITG_13712 PITG_13713 PITG_14532 PITG_14547
PSOJPHYSODRAFT_253756 PHYSODRAFT_324211 PHYSODRAFT_545333 PHYSODRAFT_546706
EHXEMIHUDRAFT_465693
 » show all
Reference
1  [PMID:20148037]
  Authors
Hung RJ, Yazdani U, Yoon J, Wu H, Yang T, Gupta N, Huang Z, van Berkel WJ, Terman JR
  Title
Mical links semaphorins to F-actin disassembly.
  Journal
Nature 463:823-7 (2010)
DOI:10.1038/nature08724
  Sequence
Reference
2  [PMID:22116028]
  Authors
Hung RJ, Pak CW, Terman JR
  Title
Direct redox regulation of F-actin assembly and disassembly by Mical.
  Journal
Science 334:1710-3 (2011)
DOI:10.1126/science.1211956
  Sequence
Reference
3  [PMID:24212093]
  Authors
Hung RJ, Spaeth CS, Yesilyurt HG, Terman JR
  Title
SelR reverses Mical-mediated oxidation of actin to regulate F-actin dynamics.
  Journal
Nat Cell Biol 15:1445-54 (2013)
DOI:10.1038/ncb2871
  Sequence
Reference
4  [PMID:21864500]
  Authors
Zucchini D, Caprini G, Pasterkamp RJ, Tedeschi G, Vanoni MA
  Title
Kinetic and spectroscopic characterization of the putative monooxygenase domain of human MICAL-1.
  Journal
Arch Biochem Biophys 515:1-13 (2011)
DOI:10.1016/j.abb.2011.08.004
  Sequence
[hsa:64780]
Reference
5  [PMID:26845023]
  Authors
Vitali T, Maffioli E, Tedeschi G, Vanoni MA
  Title
Properties and catalytic activities of MICAL1, the flavoenzyme involved in cytoskeleton dynamics, and modulation by its CH, LIM and C-terminal domains.
  Journal
Arch Biochem Biophys 593:24-37 (2016)
DOI:10.1016/j.abb.2016.01.016
  Sequence
[hsa:64780]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.225
IUBMB Enzyme Nomenclature: 1.14.13.225
ExPASy - ENZYME nomenclature database: 1.14.13.225
BRENDA, the Enzyme Database: 1.14.13.225

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