KEGG   ENZYME: 1.14.13.227Help
Entry
EC 1.14.13.227              Enzyme                                 

Name
propane 2-monooxygenase;
prmABCD (gene names)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
propane,NADH:oxygen oxidoreductase (2-hydroxylating)
Reaction(IUBMB)
propane + NADH + H+ + O2 = propan-2-ol + NAD+ + H2O [RN:R10702]
Reaction(KEGG)
Substrate
propane [CPD:C20783];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
propan-2-ol [CPD:C01845];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Comment
The enzyme, characterized from several bacterial strains, is a multicomponent dinuclear iron monooxygenase that includes a hydroxylase, an NADH-dependent reductase, and a coupling protein. The enzyme has several additional activities, including acetone monooxygenase (acetol-forming) and phenol 4-monooxygenase.
History
EC 1.14.13.227 created 2016
Pathway
ec00640  Propanoate metabolism
ec01100  Metabolic pathways
Orthology
K18223  propane 2-monooxygenase large subunit
K18224  propane 2-monooxygenase small subunit
Genes
GAI: IMCC3135_23930(mmoY) IMCC3135_23940(mmoX)
BCAI: K788_0003073 K788_0003075
PHS: C2L64_20505 C2L64_20515
VEI: Veis_4409 Veis_4411
MPT: Mpe_A0950(prmA) Mpe_A0952(ormC)
METP: C1M51_04490 C1M51_04500
AZO: azo1219 azo1221
AOA: dqs_1334 dqs_1336
AZR: CJ010_07485 CJ010_07495
MAMO: A6B35_24800 A6B35_24810
PLEO: OHA_1_03553(mmoY) OHA_1_03555(mmoX)
HDI: HDIA_3874(mmoY) HDIA_3876(mmoX)
AMV: ACMV_14260(prmC) ACMV_14280(prmA)
ALI: AZOLI_p10730(prmC) AZOLI_p10732(prmA)
MTER: 4434518_02253(mmoX) 4434518_02255(mmoY)
RFA: A3L23_02106(mmoY) A3L23_02108(mmoX)
RHS: A3Q41_01275(mmoX) A3Q41_01277(mmoY)
GRU: GCWB2_18380(mmoX) GCWB2_18390(mmoY)
GOM: D7316_05134(mmoY) D7316_05136(mmoX)
NDK: I601_2091(mmoX) I601_2093(mmoY)
 » show all
Taxonomy
Reference
1  [PMID:14645271]
  Authors
Kotani T, Yamamoto T, Yurimoto H, Sakai Y, Kato N.
  Title
Propane monooxygenase and NAD+-dependent secondary alcohol dehydrogenase in propane metabolism by Gordonia sp. strain TY-5.
  Journal
J Bacteriol 185:7120-8 (2003)
DOI:10.1128/JB.185.24.7120-7128.2003
Reference
2  [PMID:17873074]
  Authors
Sharp JO, Sales CM, LeBlanc JC, Liu J, Wood TK, Eltis LD, Mohn WW, Alvarez-Cohen L
  Title
An inducible propane monooxygenase is responsible for N-nitrosodimethylamine degradation by Rhodococcus sp. strain RHA1.
  Journal
Appl Environ Microbiol 73:6930-8 (2007)
DOI:10.1128/AEM.01697-07
Reference
3  [PMID:21183637]
  Authors
Furuya T, Hirose S, Osanai H, Semba H, Kino K
  Title
Identification of the monooxygenase gene clusters responsible for the regioselective oxidation of phenol to hydroquinone in mycobacteria.
  Journal
Appl Environ Microbiol 77:1214-20 (2011)
DOI:10.1128/AEM.02316-10
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.227
IUBMB Enzyme Nomenclature: 1.14.13.227
ExPASy - ENZYME nomenclature database: 1.14.13.227
BRENDA, the Enzyme Database: 1.14.13.227

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