KEGG   ENZYME: 1.14.13.228Help
Entry
EC 1.14.13.228              Enzyme                                 

Name
jasmonic acid 12-hydroxylase;
ABM (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
jasmonate,NADPH:oxygen oxidoreductase (12-hydroxylating)
Reaction(IUBMB)
(-)-jasmonate + NADPH + H+ + O2 = trans-12-hydroxyjasmonate + NADP+ + H2O [RN:R11446]
Reaction(KEGG)
Substrate
(-)-jasmonate [CPD:C08491];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
trans-12-hydroxyjasmonate [CPD:C21385];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
Although believed to occur in plants, the enzyme has so far been characterized only from the rice blast fungus, Magnaporthe oryzae. The fungus strategically deploys the enzyme to hydroxylate and inactivate endogenous jasmonate to evade the jasmonate-based innate immunity in rice plants.
History
EC 1.14.13.228 created 2016
Reference
1  [PMID:26258762]
  Authors
Patkar RN, Benke PI, Qu Z, Chen YY, Yang F, Swarup S, Naqvi NI
  Title
A fungal monooxygenase-derived jasmonate attenuates host innate immunity.
  Journal
Nat Chem Biol 11:733-40 (2015)
DOI:10.1038/nchembio.1885
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.228
IUBMB Enzyme Nomenclature: 1.14.13.228
ExPASy - ENZYME nomenclature database: 1.14.13.228
BRENDA, the Enzyme Database: 1.14.13.228

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