tetX (gene name)
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
tetracycline,NADPH:oxygen oxidoreductase (11a-hydroxylating)
tetracycline + NADPH + H+ + O2 = 11a-hydroxytetracycline + NADP+ + H2O [RN:
A flavoprotein (FAD). This bacterial enzyme confers resistance to all clinically relevant tetracyclines when expressed under aerobic conditions. The hydroxylated products are very unstable and lead to intramolecular cyclization and non-enzymic breakdown to undefined products.
EC 188.8.131.52 created 2016
ec01110 Biosynthesis of secondary metabolites
K18221 tetracycline 11a-monooxygenase, tetracycline resistance protein
MOD: AS202_10870 AS202_15215 AS202_20005
CSUP: MTP09_11285(tet(X)) MTP09_11315
EBV: F0358_17055(tet(X)) F0358_17090(tet(X)) F0358_17245(tet(X))
ESTE: HNV03_01140(tet(X)) HNV03_01225(tet(X)) HNV03_01240(tet(X)) » show all
Yang W, Moore IF, Koteva KP, Bareich DC, Hughes DW, Wright GD
TetX is a flavin-dependent monooxygenase conferring resistance to tetracycline antibiotics.
Moore IF, Hughes DW, Wright GD
Tigecycline is modified by the flavin-dependent monooxygenase TetX.
Volkers G, Palm GJ, Weiss MS, Wright GD, Hinrichs W
Structural basis for a new tetracycline resistance mechanism relying on the TetX monooxygenase.