KEGG   ENZYME: 1.14.13.238
Entry
EC 1.14.13.238              Enzyme                                 

Name
dimethylamine monooxygenase;
dmmABC (gene names)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
dimethylamine,NADPH:oxygen oxidoreductase (formaldehyde-forming)
Reaction(IUBMB)
dimethylamine + NADPH + H+ + O2 = methylamine + formaldehyde + NADP+ + H2O [RN:R11805]
Reaction(KEGG)
R11805
Substrate
dimethylamine [CPD:C00543];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
methylamine [CPD:C00218];
formaldehyde [CPD:C00067];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
The enzyme, characterized from several bacterial species, is involved in a pathway for the degradation of methylated amines. It is composed of three subunits, one of which is a ferredoxin, and contains heme iron and an FMN cofactor.
History
EC 1.14.13.238 created 2017
Orthology
K22342  dimethylamine monooxygenase subunit A
K22343  dimethylamine monooxygenase subunit B
K22344  dimethylamine monooxygenase subunit C
Genes
DSR: 110180814
EBT: EBL_c15110 EBL_c15120 EBL_c15130
PMY: Pmen_3453 Pmen_3454 Pmen_3455
PRE: PCA10_14430 PCA10_14440 PCA10_14450 PCA10_19610 PCA10_19620 PCA10_19630
PCQ: PcP3B5_03590 PcP3B5_03600(ophA1_1) PcP3B5_03610 PcP3B5_34290 PcP3B5_34300(ophA1_3) PcP3B5_34310
PPI: YSA_00714 YSA_00715 YSA_00717
PFS: PFLU_2334 PFLU_2335 PFLU_2336
PFE: PSF113_3543 PSF113_3544 PSF113_3545
PVR: PverR02_12530 PverR02_12535 PverR02_12540
PBA: PSEBR_a2223 PSEBR_a2224 PSEBR_a2225
PSV: PVLB_12400 PVLB_12405 PVLB_12410
PSK: U771_12140 U771_12145 U771_12150
PKC: PKB_0260 PKB_0261(yeax1) PKB_0262
PSET: THL1_1505 THL1_1506 THL1_1507 THL1_1959 THL1_1960 THL1_1961
PSIL: PMA3_11140 PMA3_11145 PMA3_11150
MICC: AUP74_02228
MAGA: Mag101_06770
MHYD: GTQ55_07450
HALC: EY643_05860
HTR: EPV75_09260 EPV75_09265 EPV75_09270
HAF: C8233_03660 C8233_03665 C8233_03670
CMAI: BFX80_10290 BFX80_10295 BFX80_10300
NIK: F5I99_18940 F5I99_18945 F5I99_18950
PSPI: PS2015_605
COX: E0W60_31890 E0W60_31895 E0W60_31900
BUZ: AYM40_12335 AYM40_12340 AYM40_12345
BPH: Bphy_5962 Bphy_5963 Bphy_5965
BCAI: K788_0001535 K788_0001537 K788_0001538
PHS: C2L64_21895 C2L64_21900 C2L64_21910
PTER: C2L65_26060 C2L65_26070 C2L65_26075
VEI: Veis_1371
CTES: O987_18275
RTA: Rta_24540
HPSE: HPF_01260
MPT: Mpe_A1963
METP: C1M51_17805
LCH: Lcho_0170 Lcho_0171 Lcho_0172
RGE: RGE_16190
AON: DEH84_17395 DEH84_17405
METR: BSY238_2319 BSY238_2320 BSY238_2321
MFA: Mfla_0440 Mfla_0441 Mfla_0442
MEH: M301_1392 M301_1393 M301_1394
MEI: Msip34_2468 Msip34_2469 Msip34_2470
MEP: MPQ_2411 MPQ_2412 MPQ_2413
MEU: ACJ67_08500 ACJ67_08505 ACJ67_08510
ACOM: CEW83_16690 CEW83_16695 CEW83_16700
MXA: MXAN_7111
MYM: A176_007424
MFU: LILAB_10835
MMAS: MYMAC_006812
AGE: AA314_00292
MBD: MEBOL_003198
CFUS: CYFUS_009781
SAMY: DB32_008090
HOH: Hoch_2221
MLO: mlr7321 mlr7322 mlr7324
MLN: A9174_09805 A9174_29055 A9174_29060 A9174_29065
MCI: Mesci_1891 Mesci_5143 Mesci_5144 Mesci_5145
MOP: Mesop_1940 Mesop_5726 Mesop_5727 Mesop_5728
MAM: Mesau_01950 Mesau_05220 Mesau_05221 Mesau_05222
MAMO: A6B35_11125 A6B35_11130 A6B35_11135 A6B35_27875
MESO: BSQ44_21690
MESW: A9K65_009880 A9K65_028200 A9K65_028205 A9K65_028210
MESM: EJ066_15710 EJ066_15715 EJ066_15720
MESP: C1M53_18015 C1M53_18695 C1M53_18700 C1M53_18705
MHUA: MCHK_0839 MCHK_0840 MCHK_0841 MCHK_4527
AAK: AA2016_2037 AA2016_5262 AA2016_5263 AA2016_5264
AMIH: CO731_02154 CO731_04997 CO731_04998(ophA1_4) CO731_04999
PHT: BLM14_03015 BLM14_24640 BLM14_24645 BLM14_24650
RPOD: E0E05_14705
NIY: FQ775_21630
ORM: HTY61_18980
SME: SMc04150 SMc04151 SMc04152
SMK: Sinme_3431 Sinme_3432 Sinme_3433
SMQ: SinmeB_3206 SinmeB_3207 SinmeB_3208
SMX: SM11_chr3571 SM11_chr3572 SM11_chr3573
SMI: BN406_03234 BN406_03235(yeaX) BN406_03236
SMEG: C770_GR4Chr0107 C770_GR4Chr0108 C770_GR4Chr0109
SMEL: SM2011_c04150 SM2011_c04151 SM2011_c04152
SMER: DU99_00540 DU99_00545 DU99_00550
SMD: Smed_3312 Smed_3313 Smed_3314
RHI: NGR_c28460
SFH: SFHH103_02856
SFD: USDA257_c52680
SIX: BSY16_5791 BSY16_5792 BSY16_5793
SAME: SAMCFNEI73_Ch3222
SINO: SS05631_c32560
EAD: OV14_0296
EAH: FA04_15180
ESJ: SJ05684_c28220
EAK: EKH55_2760 EKH55_4289 EKH55_4290 EKH55_4291
ARA: Arad_3813 Arad_8373 Arad_8374 Arad_8376
AGC: BSY240_3984
RET: RHE_PE00412 RHE_PE00413 RHE_PE00414
REL: REMIM1_PD00434 REMIM1_PD00435 REMIM1_PD00436
RLE: pRL110549 pRL110550 pRL110551
RLT: Rleg2_5645 Rleg2_5646 Rleg2_5647
RLG: Rleg_6581 Rleg_6582 Rleg_6583
RLB: RLEG3_05375 RLEG3_05380 RLEG3_05385
RLU: RLEG12_01980 RLEG12_01985 RLEG12_01990
RTR: RTCIAT899_PC09265 RTCIAT899_PC09270 RTCIAT899_PC09275
RHL: LPU83_3540 LPU83_pLPU83c0698 LPU83_pLPU83c0699(vanB) LPU83_pLPU83c0700
RJG: CCGE525_17450 CCGE525_22865 CCGE525_22870 CCGE525_22875
RHR: CKA34_31860 CKA34_31865 CKA34_31870
RGR: FZ934_13335
RAD: CO657_28945 CO657_28950 CO657_28955
NEN: NCHU2750_27640
SHZ: shn_15285
ABAW: D5400_19565
BRO: BRAD285_5426
BRK: CWS35_13730
BOT: CIT37_00680
BRQ: CIT40_06460
BGQ: X265_29220
BGZ: XH91_27165
BSYM: CIT39_05230
BBET: F8237_07960
XAU: Xaut_3180 Xaut_3181 Xaut_3182
AZC: AZC_1371 AZC_1372 AZC_1373
SNO: Snov_2697
LNE: FZC33_26160 FZC33_26165 FZC33_26170
ANC: GBB76_08075
APRA: G3A50_05285
METD: C0214_27055 C0214_27060 C0214_27065 C0214_27340 C0214_27345 C0214_27350
METX: A3862_04310 A3862_04315
MSL: Msil_3607 Msil_3608 Msil_3609
MTUN: MTUNDRAET4_3214 MTUNDRAET4_3215 MTUNDRAET4_3216
MLG: CWB41_11295 CWB41_11300 CWB41_11305
BBAR: RHAL1_03798 RHAL1_03799(cntB) RHAL1_03800
HDN: Hden_0082 Hden_0083 Hden_0084
HDT: HYPDE_22963 HYPDE_22968 HYPDE_22973 HYPDE_25248 HYPDE_25253 HYPDE_25258
HMC: HYPMC_2731 HYPMC_2732(yeaX) HYPMC_2733
MEY: TM49_01035
MAAD: AZF01_18725
MMED: Mame_01225
BRN: D1F64_19855
HDI: HDIA_3678
RBM: TEF_09490 TEF_10625
PHB: HYN04_12160
AEX: Astex_1830
SIL: SPO1580 SPO1581 SPO1582 SPO2298
SIT: TM1040_1017
RUA: D1823_03250
RUT: FIU92_09670
RMB: K529_008290
RHP: LPB142_05585 LPB142_05590 LPB142_05595 LPB142_10480
RBL: B6K69_01670
JAN: Jann_1780
RDE: RD1_0004 RD1_0005(vanB) RD1_0006
RLI: RLO149_c005890 RLO149_c005900 RLO149_c005910 RLO149_c019870
RPON: G3256_10350
PAMI: JCM7686_0714 JCM7686_pAMI6p071 JCM7686_pAMI6p072 JCM7686_pAMI6p073
PYE: A6J80_01595 A6J80_01600 A6J80_01605
PZH: CX676_01725 CX676_01730 CX676_01735 CX676_09270
PARO: CUV01_11165
PAMN: pAMV1p0116(dmmA) pAMV1p0117(dmmB) pAMV1p0118(dmmC)
PSF: PSE_4749
PGA: PGA1_c18740
PGL: PGA2_c17830
PGD: Gal_01519
PHP: PhaeoP97_01910
PPIC: PhaeoP14_01723
PHQ: D1820_04970
OAT: OAN307_c20500
OAR: OA238_c10550 OA238_c26740 OA238_c26750 OA238_c26760
OCT: FTO60_09480
LMD: METH_18465 METH_18470
LEJ: ETW24_17985 ETW24_17990 ETW24_17995
LAQU: R2C4_09685 R2C4_19710 R2C4_19715 R2C4_19720
RED: roselon_02547 roselon_03549 roselon_03550 roselon_03551
PTP: RCA23_c18190
CID: P73_0120 P73_0121 P73_0122
CEH: CEW89_06660 CEW89_17320 CEW89_17325 CEW89_17330
PPHR: APZ00_09335
LAP: ACP90_04595
LAGG: B0E33_16145
LABR: CHH27_16270
LABP: FJ695_07390
LABT: FIU93_10225
DAA: AKL17_0583 AKL17_0584 AKL17_0585 AKL17_2650
YAN: AYJ57_13060
YPAC: CEW88_06075
SUAM: BOO69_11420
SPSE: SULPSESMR1_01060
SULZ: C1J03_14610 C1J03_14615 C1J03_14620 C1J03_15190
SULI: C1J05_08420
DON: BSK21_07855
TPRO: Ga0080559_TMP4291
TOM: BWR18_02245
PABY: Ga0080574_TMP4110
THW: BMG03_08480
RMM: ROSMUCSMR3_00037 ROSMUCSMR3_00038(pht2) ROSMUCSMR3_00039 ROSMUCSMR3_00623
ROK: RAK1035_2888 RAK1035_2889 RAK1035_2890 RAK1035_3458
RID: RIdsm_02248
AHT: ANTHELSMS3_03776
RBG: BG454_03410 BG454_03415 BG454_03420 BG454_09645
SAGU: CDO87_01420
THAA: CFI11_16005
GEH: HYN69_06790 HYN69_06795 HYN69_06800
TAW: EI545_08470 EI545_08475 EI545_08480 EI545_18155
SALO: EF888_20630
SEDI: EBB79_15130 EBB79_24070
HML: HmaOT1_05430
BOO: E2K80_08455
OCD: FHY55_11015
MARU: FIU81_06495
ROT: FIV09_07840
PPRU: FDP22_13810
SIW: GH266_10295
HDH: G5B40_05120
MON: G8E03_12030
MALU: KU6B_32410 KU6B_39870 KU6B_39880 KU6B_39890
TGL: HFZ77_00980
RBZ: B9057_05485
THAS: C6Y53_05930
HNE: HNE_0487
GAK: X907_0322
NPP: PP1Y_AT29703
NPN: JI59_01710
SSAN: NX02_15670 NX02_15675 NX02_15680
CIJ: WG74_11480
ELI: ELI_04930
ELQ: Ga0102493_112757
ERY: CP97_06335
EGN: BMF35_a1308
ERK: CD351_08775
ERF: FIU90_08860
AAY: WYH_03198
ANH: A6F65_01050
ALB: AEB_P1336
CNA: AB433_11250
CMAN: A9D14_02400
POT: E2E27_13165
GBE: GbCGDNIH1_1827 GbCGDNIH1_1828 GbCGDNIH1_1829
GBH: GbCGDNIH2_1827 GbCGDNIH2_1828 GbCGDNIH2_1829
GBC: GbCGDNIH3_1827 GbCGDNIH3_1828 GbCGDNIH3_1829
GBS: GbCGDNIH4_1827 GbCGDNIH4_1828 GbCGDNIH4_1829
ACR: Acry_2373
AMV: ACMV_26990
GXL: H845_62 H845_63
KEU: S101446_00775(vanB) S101446_00776(alg9) S101446_00786
AACE: A0U92_02475 A0U92_02480 A0U92_02485
RCE: RC1_3800
TII: DY252_08065 DY252_08070 DY252_08075
NAO: Y958_21825
NCB: C0V82_17820
APC: HIMB59_00000760
PGV: SL003B_0876
APB: SAR116_0236 SAR116_0237 SAR116_0238
HAX: BALOs_1381
BSTO: C0V70_09070
BACI: B1NLA3E_07675 B1NLA3E_07705 B1NLA3E_07710
BACO: OXB_0420
BSJ: UP17_14805 UP17_14810 UP17_14815
BHK: B4U37_20960 B4U37_20965 B4U37_20970
BMUR: ABE28_004425 ABE28_004430 ABE28_004435
LYG: C1N55_15865
FAR: ABE41_001890 ABE41_001895 ABE41_001900
APAK: AP3564_11175
PBJ: VN24_01145 VN24_01150 VN24_01155
PNP: IJ22_08080 IJ22_08090 IJ22_08100
PGQ: FK545_11780 FK545_11790
MYE: AB431_11625 AB431_11630 AB431_11635
MYN: MyAD_18845 MyAD_18850 MyAD_18855
MDX: BTO20_03305 BTO20_03310 BTO20_03315
MSHG: MSG_02015 MSG_02016 MSG_02017 MSG_02018 MSG_02019 MSG_02020
MSM: MSMEG_1990 MSMEG_4637 MSMEG_4638 MSMEG_4639
MSG: MSMEI_1945 MSMEI_1946 MSMEI_4520 MSMEI_4521 MSMEI_4522
MSB: LJ00_09925 LJ00_09930 LJ00_22940 LJ00_22945 LJ00_22950
MSN: LI99_09925 LI99_09930 LI99_22945 LI99_22950 LI99_22955
MSH: LI98_09925 LI98_09930 LI98_22950 LI98_22955 LI98_22960
MVA: Mvan_3957 Mvan_3958 Mvan_3959
MGI: Mflv_2622 Mflv_2623 Mflv_2624
MSP: Mspyr1_20570 Mspyr1_20580 Mspyr1_20590
MNE: D174_19215 D174_19220 D174_19225
MGO: AFA91_17355 AFA91_17360 AFA91_27000 AFA91_27005 AFA91_27010
MPHL: MPHLCCUG_03436 MPHLCCUG_03437(ophA1) MPHLCCUG_03438
MVQ: MYVA_3786 MYVA_3787 MYVA_3788
MLL: B1R94_17530 B1R94_17535 B1R94_17540
MHAS: MHAS_01245 MHAS_01246(ophA1) MHAS_01247
CVA: CVAR_1017 CVAR_1018 CVAR_1019 CVAR_1021 CVAR_1022 CVAR_1023
CTER: A606_03950 A606_03955 A606_03960 A606_03975 A606_03980 A606_03985
NFA: NFA_21070 NFA_21080 NFA_21090
NFR: ERS450000_01994 ERS450000_01995(ophA1_4) ERS450000_01996
NSL: BOX37_13585 BOX37_13590 BOX37_13595
RHA: RHA1_ro00467 RHA1_ro00470 RHA1_ro02823 RHA1_ro02824 RHA1_ro02825
ROP: ROP_25460 ROP_25470 ROP_25480
ROA: Pd630_LPD03616 Pd630_LPD03617 Pd630_LPD03618 Pd630_LPD06983 Pd630_LPD06984 Pd630_LPD06985 Pd630_LPD06986
RPY: Y013_00720 Y013_00725 Y013_00730 Y013_00735 Y013_00740
RAV: AAT18_11030 AAT18_11035 AAT18_11045 AAT18_11050
RRZ: CS378_00780 CS378_00785 CS378_00790 CS378_00795 CS378_00800
RHQ: IM25_14675 IM25_14680 IM25_14685 IM25_14690 IM25_14695
RRT: 4535765_01850 4535765_01851(ophA1_3) 4535765_01852
RBY: CEJ39_11315 CEJ39_11320 CEJ39_11325 CEJ39_11330 CEJ39_11335
GBR: Gbro_4809 Gbro_4810 Gbro_4811 Gbro_4812 Gbro_4813
GPO: GPOL_c00400 GPOL_c00410 GPOL_c00420 GPOL_c00430 GPOL_c00440
GOR: KTR9_4677 KTR9_4678 KTR9_4679 KTR9_4680 KTR9_4681
GTA: BCM27_24825 BCM27_24830 BCM27_24835 BCM27_24840 BCM27_24845
GRU: GCWB2_23600 GCWB2_23605(ophA1) GCWB2_23610 GCWB2_23615(ophA2) GCWB2_23620
GAV: C5O27_04900 C5O27_04905 C5O27_04910 C5O27_04915 C5O27_04920
GOD: GKZ92_22500 GKZ92_22505 GKZ92_22510 GKZ92_22515 GKZ92_22520
ARE: AL755_14045 AL755_14050 AL755_14055
ARU: ASPU41_05965 ASPU41_05970 ASPU41_05975
ARQ: BWQ92_09805 BWQ92_09810 BWQ92_09815
ACIT: HPK19_05195 HPK19_05200 HPK19_05205
PSUL: AU252_12825 AU252_12830
PSEY: GU243_15510
RAIN: Rai3103_10555 Rai3103_10560 Rai3103_10565 Rai3103_10570 Rai3103_10575
AER: AERYTH_00705 AERYTH_00710 AERYTH_00715
FRI: FraEuI1c_6661 FraEuI1c_6662 FraEuI1c_6663
PSEA: WY02_00870 WY02_00880
PSEE: FRP1_12700 FRP1_12705
PSEH: XF36_13300 XF36_13310
PSEQ: AD006_18280 AD006_18285
PECQ: AD017_26110 AD017_26115
PAUT: Pdca_36960 Pdca_36970 Pdca_36980
PMAD: BAY61_15245 BAY61_15250
NAB: B1sIIB91_02600
AYM: YM304_39030
LEN: LEP3755_56330
LET: O77CONTIG1_02593
LBO: LBWT_37180
GLP: Glo7428_3070
CYC: PCC7424_2574
CYN: Cyan7425_5139
GLJ: GKIL_3171
NOP: Nos7524_1966
NON: NOS3756_48700
NFL: COO91_03968
NOE: CLI64_09650
NSH: GXM_02658
RIV: Riv7116_2241
NSP: BMF81_02671
TOQ: HCG51_01315
NCN: BZZ01_10450
PLP: Ple7327_0018
CAU: Caur_3088
CHL: Chy400_3336
CAG: Cagg_0865
DDR: Deide_13150
DSW: QR90_10010
DCH: SY84_02410
DAB: AUC44_09520
DPU: SU48_04525
DEZ: DKM44_08935
DFC: DFI_07630
DEIN: DAAJ005_11600
DGA: DEGR_18190
FGI: OP10G_3046
OBG: Verru16b_01644
ROO: G5S37_19755
RUL: UC8_44060
PLS: VT03_08230
SLI: Slin_1933
SRD: SD10_11390
SMON: AWR27_17355
SPIR: CWM47_33900
SPIK: EXU85_15580
SPIB: G8759_18960
RUP: DTQ70_17305
FAE: FAES_2569
FIB: A6C57_14275
 » show all
Reference
1  [PMID:4389011]
  Authors
Eady RR, Large PJ
  Title
Bacterial oxidation of dimethylamine, a new mono-oxygenase reaction.
  Journal
Biochem J 111:37P-38P (1969)
DOI:10.1042/bj1110037pb
Reference
2  [PMID:4401380]
  Authors
Eady RR, Jarman TR, Large PJ
  Title
Microbial oxidation of amines. Partial purification of a mixed-function secondary-amine oxidase system from Pseudomonas aminovorans that contains an enzymically active cytochrome-P-420-type haemoprotein.
  Journal
Biochem J 125:449-59 (1971)
DOI:10.1042/bj1250449
Reference
3  [PMID:3624236]
  Authors
Alberta JA, Dawson JH
  Title
Purification to homogeneity and initial physical characterization of secondary amine monooxygenase.
  Journal
J Biol Chem 262:11857-63 (1987)
Reference
4  [PMID:28304370]
  Authors
Lidbury I, Mausz MA, Scanlan DJ, Chen Y
  Title
Identification of dimethylamine monooxygenase in marine bacteria reveals a metabolic bottleneck in the methylated amine degradation pathway.
  Journal
ISME J 11:1592-1601 (2017)
DOI:10.1038/ismej.2017.31
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.238
IUBMB Enzyme Nomenclature: 1.14.13.238
ExPASy - ENZYME nomenclature database: 1.14.13.238
BRENDA, the Enzyme Database: 1.14.13.238

  All links  
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (2238)   
   KEGG ORTHOLOGY (3)   
   KEGG GENES (803)   
   KEGG MGENES (1164)   
   RefGene (268)   
All databases (2248)   

Download RDF
DBGET integrated database retrieval system