KEGG   ENZYME: 1.14.13.238
Entry
EC 1.14.13.238              Enzyme                                 
Name
dimethylamine monooxygenase;
dmmABC (gene names)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
dimethylamine,NADPH:oxygen oxidoreductase (formaldehyde-forming)
Reaction(IUBMB)
dimethylamine + NADPH + H+ + O2 = methylamine + formaldehyde + NADP+ + H2O [RN:R11805]
Reaction(KEGG)
R11805
Substrate
dimethylamine [CPD:C00543];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
methylamine [CPD:C00218];
formaldehyde [CPD:C00067];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
The enzyme, characterized from several bacterial species, is involved in a pathway for the degradation of methylated amines. It is composed of three subunits, one of which is a ferredoxin, and contains heme iron and an FMN cofactor.
History
EC 1.14.13.238 created 2017
Orthology
K22342  dimethylamine monooxygenase subunit A
K22343  dimethylamine monooxygenase subunit B
K22344  dimethylamine monooxygenase subunit C
Genes
EBTEBL_c15110 EBL_c15120 EBL_c15130
PMYPmen_3453 Pmen_3454 Pmen_3455
PREPCA10_14430 PCA10_14440 PCA10_14450 PCA10_19610 PCA10_19620 PCA10_19630
PFUWKF707C_42020 KF707C_42030 KF707C_42040
PCQPcP3B5_03590 PcP3B5_03600(ophA1_1) PcP3B5_03610 PcP3B5_34290 PcP3B5_34300(ophA1_3) PcP3B5_34310
PMUIG4G71_01650 G4G71_01655 G4G71_01660
PPIYSA_00714 YSA_00715 YSA_00717
PFEPSF113_3543 PSF113_3544 PSF113_3545
PFSPFLU_2334 PFLU_2335 PFLU_2336
PVRPverR02_12530 PverR02_12535 PverR02_12540
PMEDE3Z27_11135 E3Z27_11140 E3Z27_11145
PBAPSEBR_a2223 PSEBR_a2224 PSEBR_a2225
PSVPVLB_12400 PVLB_12405 PVLB_12410
PSKU771_12140 U771_12145 U771_12150
PKCPKB_0260 PKB_0261(yeax1) PKB_0262
PSETTHL1_1505 THL1_1506 THL1_1507 THL1_1959 THL1_1960 THL1_1961
PSILPMA3_11140 PMA3_11145 PMA3_11150
PUMHGP31_17890 HGP31_17895 HGP31_17900
PVKEPZ47_12045 EPZ47_12050 EPZ47_12055
PBZGN234_06115 GN234_06120 GN234_06125
PKHJLK41_14835 JLK41_14840 JLK41_14845
PMAOPMYSY11_0188 PMYSY11_0189(yeaX) PMYSY11_0190
PTRTHU722_0011575 HU722_0011580 HU722_0011585
PAZEKSS91_17200 KSS91_17205 KSS91_17210
PWZJ7655_05195 J7655_05200 J7655_05205
PZAHU749_012845 HU749_012850 HU749_012855
ACIUA3K93_14325 A3K93_14330
HTREPV75_09260 EPV75_09265 EPV75_09270
MPINLGT42_011235 LGT42_011240
HAFC8233_03660 C8233_03665 C8233_03670
CMAIBFX80_10290 BFX80_10295 BFX80_10300
MSECLN244_01155 LN244_01160 LN244_01165
NIKF5I99_18940 F5I99_18945 F5I99_18950
COXE0W60_31890 E0W60_31895 E0W60_31900
BPHBphy_5962 Bphy_5963 Bphy_5965
BUZAYM40_12335 AYM40_12340 AYM40_12345
BCAIK788_0001535 K788_0001537 K788_0001538
PHSC2L64_21895 C2L64_21900 C2L64_21910
PTERC2L65_26060 C2L65_26070 C2L65_26075
HTNKI616_05440 KI616_05450
LCHLcho_0170 Lcho_0171 Lcho_0172
AONDEH84_17395 DEH84_17405
METRBSY238_2319 BSY238_2320 BSY238_2321
MFAMfla_0440 Mfla_0441 Mfla_0442
MEHM301_1392 M301_1393 M301_1394
MEIMsip34_2468 Msip34_2469 Msip34_2470
MEPMPQ_2411 MPQ_2412 MPQ_2413
MEUACJ67_08500 ACJ67_08505 ACJ67_08510
ACOMCEW83_16690 CEW83_16695 CEW83_16700
MXAMXAN_7111
MYMA176_007424
MFBMFUL124B02_41055
MFULILAB_10835
MMASMYMAC_006812
AGEAA314_00292
AVMJQX13_15995
MBDMEBOL_003198
CFUSCYFUS_009781
MLOmlr7321 mlr7322 mlr7324
MLNA9174_29055 A9174_29060 A9174_29065
MCIMesci_5143 Mesci_5144 Mesci_5145
MOPMesop_5726 Mesop_5727 Mesop_5728
MAMMesau_05220 Mesau_05221 Mesau_05222
MAMOA6B35_11125 A6B35_11130 A6B35_11135
MESWA9K65_028200 A9K65_028205 A9K65_028210
MESMEJ066_15710 EJ066_15715 EJ066_15720
MESPC1M53_18695 C1M53_18700 C1M53_18705
MHUAMCHK_0839 MCHK_0840 MCHK_0841
MJREB229_29630 EB229_29635 EB229_29640
MERDEB233_25675 EB233_25680 EB233_25685
MOHIHQ72_30430 IHQ72_30435 IHQ72_30440
AAKAA2016_5262 AA2016_5263 AA2016_5264
AMIHCO731_04997 CO731_04998(ophA1_4) CO731_04999
PHTBLM14_24640 BLM14_24645 BLM14_24650
SMESMc04150 SMc04151 SMc04152
SMKSinme_3431 Sinme_3432 Sinme_3433
SMQSinmeB_3206 SinmeB_3207 SinmeB_3208
SMXSM11_chr3571 SM11_chr3572 SM11_chr3573
SMIBN406_03234 BN406_03235(yeaX) BN406_03236
SMEGC770_GR4Chr0107 C770_GR4Chr0108 C770_GR4Chr0109
SMELSM2011_c04150 SM2011_c04151 SM2011_c04152
SMERDU99_00540 DU99_00545 DU99_00550
SMDSmed_3312 Smed_3313 Smed_3314
SIXBSY16_5791 BSY16_5792 BSY16_5793
EAKEKH55_4289 EKH55_4290 EKH55_4291
ARAArad_8373 Arad_8374 Arad_8376
RETRHE_PE00412 RHE_PE00413 RHE_PE00414
RELREMIM1_PD00434 REMIM1_PD00435 REMIM1_PD00436
RLEpRL110549 pRL110550 pRL110551
RLTRleg2_5645 Rleg2_5646 Rleg2_5647
RLGRleg_6581 Rleg_6582 Rleg_6583
RLBRLEG3_05375 RLEG3_05380 RLEG3_05385
RLURLEG12_01980 RLEG12_01985 RLEG12_01990
RTRRTCIAT899_PC09265 RTCIAT899_PC09270 RTCIAT899_PC09275
RHLLPU83_pLPU83c0698 LPU83_pLPU83c0699(vanB) LPU83_pLPU83c0700
RJGCCGE525_22865 CCGE525_22870 CCGE525_22875
RHRCKA34_31860 CKA34_31865 CKA34_31870
RADCO657_28945 CO657_28950 CO657_28955
RIIFFM53_030580 FFM53_030585 FFM53_030590
RHIDFFM81_029925 FFM81_029930 FFM81_029935
RLNJ0663_26890 J0663_26895 J0663_26900
RBANJ2J98_25850 J2J98_25855 J2J98_25860
RRGJ3P73_30895 J3P73_30900 J3P73_30905
RLSHB780_09380 HB780_09385 HB780_09390
RAWNE851_05380 NE851_05385 NE851_05390
XAUXaut_3180 Xaut_3181 Xaut_3182
XDIEZH22_17035 EZH22_17040 EZH22_17045
AZCAZC_1371 AZC_1372 AZC_1373
LNEFZC33_26160 FZC33_26165 FZC33_26170
METDC0214_27055 C0214_27060 C0214_27065 C0214_27340 C0214_27345 C0214_27350
METXA3862_04310 A3862_04315
MOGMMB17_17410 MMB17_17415 MMB17_17420
MSLMsil_3607 Msil_3608 Msil_3609
MTUNMTUNDRAET4_3214 MTUNDRAET4_3215 MTUNDRAET4_3216
MLGCWB41_11295 CWB41_11300 CWB41_11305
BBARRHAL1_03798 RHAL1_03799(cntB) RHAL1_03800
HDNHden_0082 Hden_0083 Hden_0084
HDTHYPDE_22963 HYPDE_22968 HYPDE_22973 HYPDE_25248 HYPDE_25253 HYPDE_25258
HMCHYPMC_2731 HYPMC_2732(yeaX) HYPMC_2733
CMETK6K41_17895 K6K41_17905
AUZSa4125_10190 Sa4125_10200 Sa4125_10210
LIZLGH83_08120 LGH83_08125 LGH83_08130
SILSPO1580 SPO1581 SPO1582
RCONK3740_20060 K3740_20065 K3740_20070
RDERD1_0004 RD1_0005(vanB) RD1_0006
RLIRLO149_c005890 RLO149_c005900 RLO149_c005910
OAROA238_c26740 OA238_c26750 OA238_c26760
LMDMETH_18465 METH_18470
LEJETW24_17985 ETW24_17990 ETW24_17995
LAQUR2C4_19710 R2C4_19715 R2C4_19720
LEVETW23_00165 ETW23_00170 ETW23_00175
LCAEK3721_16255 K3721_16260 K3721_16265
REDroselon_03549 roselon_03550 roselon_03551
CIDP73_0120 P73_0121 P73_0122
CEHCEW89_17320 CEW89_17325 CEW89_17330
SULZC1J03_14610 C1J03_14615 C1J03_14620
RMMROSMUCSMR3_00037 ROSMUCSMR3_00038(pht2) ROSMUCSMR3_00039
ROKRAK1035_2888 RAK1035_2889 RAK1035_2890
MALUKU6B_39870 KU6B_39880 KU6B_39890
PALXGQA70_23295(dmmA) GQA70_23300 GQA70_23305
RHPLPB142_05585 LPB142_05590 LPB142_05595
PAMIJCM7686_pAMI6p071 JCM7686_pAMI6p072 JCM7686_pAMI6p073
PYEA6J80_01595 A6J80_01600 A6J80_01605
PZHCX676_01725 CX676_01730 CX676_01735
PAMNpAMV1p0116(dmmA) pAMV1p0117(dmmB) pAMV1p0118(dmmC)
DAAAKL17_0583 AKL17_0584 AKL17_0585
RBGBG454_03410 BG454_03415 BG454_03420
GEHHYN69_06790 HYN69_06795 HYN69_06800
GFUKM031_03400 KM031_03405 KM031_03410
TAWEI545_08470 EI545_08475 EI545_08480
SEDIEBB79_24070
FAPGR316_12800 GR316_12805 GR316_12810
SSANNX02_15670 NX02_15675 NX02_15680
GBEGbCGDNIH1_1827 GbCGDNIH1_1828 GbCGDNIH1_1829
GBHGbCGDNIH2_1827 GbCGDNIH2_1828 GbCGDNIH2_1829
GBCGbCGDNIH3_1827 GbCGDNIH3_1828 GbCGDNIH3_1829
GBSGbCGDNIH4_1827 GbCGDNIH4_1828 GbCGDNIH4_1829
GXLH845_62 H845_63
KEUS101446_00775(vanB) S101446_00776(alg9) S101446_00786
AACEA0U92_02475 A0U92_02480 A0U92_02485
ACEKFLP30_07315 FLP30_07320 FLP30_07325
TIIDY252_08065 DY252_08070 DY252_08075
THAIIT893_13185 IT893_13190 IT893_13195
APBSAR116_0236 SAR116_0237 SAR116_0238
BFDNCTC4823_00918 NCTC4823_00919 NCTC4823_00920(hmp_1)
BSHILGQ02_10745 LGQ02_10750
BBADK7T73_21040 K7T73_21045 K7T73_21050
BACIB1NLA3E_07675 B1NLA3E_07705 B1NLA3E_07710
BACOOXB_0420
BHKB4U37_20960 B4U37_20965 B4U37_20970
BCOHBC6307_22590 BC6307_22595 BC6307_22600
LYGC1N55_15855 C1N55_15860 C1N55_15865
FARABE41_001890 ABE41_001895 ABE41_001900
APAKAP3564_11175
BSJUP17_14805 UP17_14810 UP17_14815
BMURABE28_004425 ABE28_004430 ABE28_004435
PBUTDTO10_26625 DTO10_26630 DTO10_26635
NDTL1999_09925 L1999_09930 L1999_09935
GAJMY490_10750 MY490_10755 MY490_10760
MJOFOF60_24040
BCHSJNE38_06835 JNE38_06840
PBJVN24_01145 VN24_01150 VN24_01155
PNPIJ22_08080 IJ22_08090 IJ22_08100
ACURJZ785_18150 JZ785_18155
PGQFK545_11780 FK545_11785 FK545_11790
PABSJIR001_04420 JIR001_04440 JIR001_04450(yeaX)
MYEAB431_11625 AB431_11630 AB431_11635
MGOAFA91_17355 AFA91_17360 AFA91_27000 AFA91_27005 AFA91_27010
MDXBTO20_03305 BTO20_03310 BTO20_03315
MSHGMSG_02015 MSG_02016 MSG_02017 MSG_02018 MSG_02019 MSG_02020
MSTOMSTO_13650 MSTO_13660 MSTO_13670 MSTO_13680 MSTO_13690
MDFK0O62_19495 K0O62_19500 K0O62_19505
MPAEK0O64_11295 K0O64_11300 K0O64_11305
MPAAMKK62_18125 MKK62_18130 MKK62_18135 MKK62_18185 MKK62_18190
MCROMI149_12155 MI149_12160 MI149_12165
MSMMSMEG_1988 MSMEG_1989 MSMEG_1990 MSMEG_4637 MSMEG_4638 MSMEG_4639
MSGMSMEI_1944 MSMEI_1945 MSMEI_1946 MSMEI_4520 MSMEI_4521 MSMEI_4522
MSBLJ00_09920 LJ00_09925 LJ00_09930 LJ00_22940 LJ00_22945 LJ00_22950
MSNLI99_09920 LI99_09925 LI99_09930 LI99_22945 LI99_22950 LI99_22955
MSHLI98_09920 LI98_09925 LI98_09930 LI98_22950 LI98_22955 LI98_22960
MVAMvan_3957 Mvan_3958 Mvan_3959
MGIMflv_2622 Mflv_2623 Mflv_2624
MSPMspyr1_20570 Mspyr1_20580 Mspyr1_20590
MNED174_19215 D174_19220 D174_19225
MYNMyAD_18845 MyAD_18850 MyAD_18855
MPHLMPHLCCUG_03436 MPHLCCUG_03437(ophA1) MPHLCCUG_03438
MVQMYVA_3786 MYVA_3787 MYVA_3788
MLLB1R94_17530 B1R94_17535 B1R94_17540
MHASMHAS_01245 MHAS_01246(ophA1) MHAS_01247
MAUUNCTC10437_03738 NCTC10437_03739(ophA1_2) NCTC10437_03740
MMORMMOR_05190 MMOR_05200 MMOR_05210
MAICMAIC_20160 MAIC_20170 MAIC_20180
MTYMTOK_60030 MTOK_60040 MTOK_60050
MHEVMHEL_45160 MHEL_45170 MHEL_45180
MSARMSAR_32990 MSAR_33000 MSAR_33010
MANYMANY_06680 MANY_06690 MANY_06700
MAUBMAUB_31050 MAUB_31060 MAUB_31070
MPOFMPOR_41130 MPOR_41140 MPOR_41150
MMATMMAGJ_74180 MMAGJ_74190 MMAGJ_74200
CVACVAR_1017 CVAR_1018 CVAR_1019 CVAR_1021 CVAR_1022 CVAR_1023
CTERA606_03950 A606_03955 A606_03960 A606_03975 A606_03980 A606_03985
CPRECsp1_17860 Csp1_17870(pobB_2) Csp1_17880 Csp1_17910 Csp1_17920(ophA1) Csp1_17930
NFANFA_21070 NFA_21080 NFA_21090
NFRERS450000_01994 ERS450000_01995(ophA1_4) ERS450000_01996
NSLBOX37_13585 BOX37_13590 BOX37_13595
RHARHA1_ro00467 RHA1_ro00468 RHA1_ro00470 RHA1_ro02823 RHA1_ro02824 RHA1_ro02825
ROPROP_25460 ROP_25470 ROP_25480
ROAPd630_LPD03616 Pd630_LPD03617 Pd630_LPD03618 Pd630_LPD06983 Pd630_LPD06984 Pd630_LPD06985 Pd630_LPD06986
RPYY013_00720 Y013_00725 Y013_00730 Y013_00735 Y013_00740
RBYCEJ39_11315 CEJ39_11320 CEJ39_11325 CEJ39_11330 CEJ39_11335
RAVAAT18_11030 AAT18_11035 AAT18_11045 AAT18_11050
RRZCS378_00780 CS378_00785 CS378_00790 CS378_00795 CS378_00800
RHQIM25_14675 IM25_14680 IM25_14685 IM25_14690 IM25_14695
RRT4535765_01850 4535765_01851(ophA1_3) 4535765_01852
RCRNCTC10994_01054 NCTC10994_01055(ophA1_1) NCTC10994_01056
RKOJWS14_00070 JWS14_00075 JWS14_00080 JWS14_14865 JWS14_14870 JWS14_14875
RGOKYT97_17305 KYT97_17310 KYT97_17315 KYT97_17320 KYT97_17325
ROZCBI38_08780 CBI38_08785 CBI38_08790
RPSKJWS13_30015 JWS13_30020 JWS13_30025 JWS13_30360 JWS13_30365 JWS13_30370
GBRGbro_4809 Gbro_4810 Gbro_4811 Gbro_4812 Gbro_4813
GPOGPOL_c00400 GPOL_c00410 GPOL_c00420 GPOL_c00430 GPOL_c00440
GORKTR9_4677 KTR9_4678 KTR9_4679 KTR9_4680 KTR9_4681
GTABCM27_24825 BCM27_24830 BCM27_24835 BCM27_24840 BCM27_24845
GRUGCWB2_23600 GCWB2_23605(ophA1) GCWB2_23610 GCWB2_23615(ophA2) GCWB2_23620
GAVC5O27_04900 C5O27_04905 C5O27_04910 C5O27_04915 C5O27_04920
GODGKZ92_22500 GKZ92_22505 GKZ92_22510 GKZ92_22515 GKZ92_22520
GAMGII34_01295 GII34_01300 GII34_01305 GII34_01310 GII34_01315
GPDGII33_01075 GII33_01080 GII33_01085 GII33_01090 GII33_01095
GJIH1R19_22720 H1R19_22725 H1R19_22730 H1R19_22735 H1R19_22740
GOILK459_09085 LK459_09090 LK459_09095 LK459_09100 LK459_09105
GHNMVF96_23460 MVF96_23465 MVF96_23470 MVF96_23475 MVF96_23480
GAMIIHQ52_04465 IHQ52_04470 IHQ52_04475 IHQ52_04480 IHQ52_04485
GMGNWF22_12035 NWF22_12040 NWF22_12045 NWF22_12050
AREAL755_14045 AL755_14050 AL755_14055
ARUASPU41_05965 ASPU41_05970 ASPU41_05975
ARQBWQ92_09805 BWQ92_09810 BWQ92_09815
ACITHPK19_05195 HPK19_05200 HPK19_05205
PSULAU252_12825 AU252_12830
PSEYGU243_15510
RAINRai3103_10555 Rai3103_10560 Rai3103_10565 Rai3103_10570 Rai3103_10575
NAROCFH99_03845
AERAERYTH_00705 AERYTH_00710 AERYTH_00715
FRIFraEuI1c_6661 FraEuI1c_6662 FraEuI1c_6663
PSEAWY02_00870 WY02_00880
PSEEFRP1_12700 FRP1_12705
PSEHXF36_13300 XF36_13310
PSEQAD006_18280 AD006_18285
PECQAD017_26110 AD017_26115
PAUTPdca_36960 Pdca_36970 Pdca_36980
PMADBAY61_15245 BAY61_15250
CAUCaur_3088
CHLChy400_3336
CAGCagg_0865
SLISlin_1933
SRDSD10_11390
SMONAWR27_17355
SPIRCWM47_33900
SPIKEXU85_15580
SPIBG8759_18960
RUPDTQ70_17305
FAEFAES_2569
FIBA6C57_14275
HSINKDQ40_01085
 » show all
Reference
1  [PMID:4389011]
  Authors
Eady RR, Large PJ
  Title
Bacterial oxidation of dimethylamine, a new mono-oxygenase reaction.
  Journal
Biochem J 111:37P-38P (1969)
DOI:10.1042/bj1110037pb
Reference
2  [PMID:4401380]
  Authors
Eady RR, Jarman TR, Large PJ
  Title
Microbial oxidation of amines. Partial purification of a mixed-function secondary-amine oxidase system from Pseudomonas aminovorans that contains an enzymically active cytochrome-P-420-type haemoprotein.
  Journal
Biochem J 125:449-59 (1971)
DOI:10.1042/bj1250449
Reference
3  [PMID:3624236]
  Authors
Alberta JA, Dawson JH
  Title
Purification to homogeneity and initial physical characterization of secondary amine monooxygenase.
  Journal
J Biol Chem 262:11857-63 (1987)
Reference
4  [PMID:28304370]
  Authors
Lidbury I, Mausz MA, Scanlan DJ, Chen Y
  Title
Identification of dimethylamine monooxygenase in marine bacteria reveals a metabolic bottleneck in the methylated amine degradation pathway.
  Journal
ISME J 11:1592-1601 (2017)
DOI:10.1038/ismej.2017.31
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.238
IUBMB Enzyme Nomenclature: 1.14.13.238
ExPASy - ENZYME nomenclature database: 1.14.13.238
BRENDA, the Enzyme Database: 1.14.13.238

DBGET integrated database retrieval system