KEGG   ENZYME: 1.14.13.238
Entry
EC 1.14.13.238              Enzyme                                 
Name
dimethylamine monooxygenase;
dmmABC (gene names)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
dimethylamine,NADPH:oxygen oxidoreductase (formaldehyde-forming)
Reaction(IUBMB)
dimethylamine + NADPH + H+ + O2 = methylamine + formaldehyde + NADP+ + H2O [RN:R11805]
Reaction(KEGG)
R11805
Substrate
dimethylamine [CPD:C00543];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
methylamine [CPD:C00218];
formaldehyde [CPD:C00067];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
The enzyme, characterized from several bacterial species, is involved in a pathway for the degradation of methylated amines. It is composed of three subunits, one of which is a ferredoxin, and contains heme iron and an FMN cofactor.
History
EC 1.14.13.238 created 2017
Orthology
K22342  dimethylamine monooxygenase subunit A
K22343  dimethylamine monooxygenase subunit B
K22344  dimethylamine monooxygenase subunit C
Genes
EBT: EBL_c15110 EBL_c15120 EBL_c15130
PMY: Pmen_3453 Pmen_3454 Pmen_3455
PRE: PCA10_14430 PCA10_14440 PCA10_14450 PCA10_19610 PCA10_19620 PCA10_19630
PFUW: KF707C_42020 KF707C_42030 KF707C_42040
PCQ: PcP3B5_03590 PcP3B5_03600(ophA1_1) PcP3B5_03610 PcP3B5_34290 PcP3B5_34300(ophA1_3) PcP3B5_34310
PMUI: G4G71_01650 G4G71_01655 G4G71_01660
PPI: YSA_00714 YSA_00715 YSA_00717
PFE: PSF113_3543 PSF113_3544 PSF113_3545
PFS: PFLU_2334 PFLU_2335 PFLU_2336
PVR: PverR02_12530 PverR02_12535 PverR02_12540
PMED: E3Z27_11135 E3Z27_11140 E3Z27_11145
PBA: PSEBR_a2223 PSEBR_a2224 PSEBR_a2225
PSV: PVLB_12400 PVLB_12405 PVLB_12410
PSK: U771_12140 U771_12145 U771_12150
PKC: PKB_0260 PKB_0261(yeax1) PKB_0262
PSET: THL1_1505 THL1_1506 THL1_1507 THL1_1959 THL1_1960 THL1_1961
PSIL: PMA3_11140 PMA3_11145 PMA3_11150
PUM: HGP31_17890 HGP31_17895 HGP31_17900
PVK: EPZ47_12045 EPZ47_12050 EPZ47_12055
PBZ: GN234_06115 GN234_06120 GN234_06125
PKH: JLK41_14835 JLK41_14840 JLK41_14845
PMAO: PMYSY11_0188 PMYSY11_0189(yeaX) PMYSY11_0190
PTRT: HU722_0011575 HU722_0011580 HU722_0011585
PAZE: KSS91_17200 KSS91_17205 KSS91_17210
PWZ: J7655_05195 J7655_05200 J7655_05205
PZA: HU749_012845 HU749_012850 HU749_012855
ACIU: A3K93_14325 A3K93_14330
HTR: EPV75_09260 EPV75_09265 EPV75_09270
MPIN: LGT42_011235 LGT42_011240
HAF: C8233_03660 C8233_03665 C8233_03670
CMAI: BFX80_10290 BFX80_10295 BFX80_10300
MSEC: LN244_01155 LN244_01160 LN244_01165
NIK: F5I99_18940 F5I99_18945 F5I99_18950
COX: E0W60_31890 E0W60_31895 E0W60_31900
BPH: Bphy_5962 Bphy_5963 Bphy_5965
BUZ: AYM40_12335 AYM40_12340 AYM40_12345
BCAI: K788_0001535 K788_0001537 K788_0001538
PHS: C2L64_21895 C2L64_21900 C2L64_21910
PTER: C2L65_26060 C2L65_26070 C2L65_26075
HTN: KI616_05440 KI616_05450
LCH: Lcho_0170 Lcho_0171 Lcho_0172
AON: DEH84_17395 DEH84_17405
METR: BSY238_2319 BSY238_2320 BSY238_2321
MFA: Mfla_0440 Mfla_0441 Mfla_0442
MEH: M301_1392 M301_1393 M301_1394
MEI: Msip34_2468 Msip34_2469 Msip34_2470
MEP: MPQ_2411 MPQ_2412 MPQ_2413
MEU: ACJ67_08500 ACJ67_08505 ACJ67_08510
ACOM: CEW83_16690 CEW83_16695 CEW83_16700
MXA: MXAN_7111
MYM: A176_007424
MFB: MFUL124B02_41055
MFU: LILAB_10835
MMAS: MYMAC_006812
AGE: AA314_00292
AVM: JQX13_15995
MBD: MEBOL_003198
CFUS: CYFUS_009781
MLO: mlr7321 mlr7322 mlr7324
MLN: A9174_29055 A9174_29060 A9174_29065
MCI: Mesci_5143 Mesci_5144 Mesci_5145
MOP: Mesop_5726 Mesop_5727 Mesop_5728
MAM: Mesau_05220 Mesau_05221 Mesau_05222
MAMO: A6B35_11125 A6B35_11130 A6B35_11135
MESW: A9K65_028200 A9K65_028205 A9K65_028210
MESM: EJ066_15710 EJ066_15715 EJ066_15720
MESP: C1M53_18695 C1M53_18700 C1M53_18705
MHUA: MCHK_0839 MCHK_0840 MCHK_0841
MJR: EB229_29630 EB229_29635 EB229_29640
MERD: EB233_25675 EB233_25680 EB233_25685
MOH: IHQ72_30430 IHQ72_30435 IHQ72_30440
AAK: AA2016_5262 AA2016_5263 AA2016_5264
AMIH: CO731_04997 CO731_04998(ophA1_4) CO731_04999
PHT: BLM14_24640 BLM14_24645 BLM14_24650
SME: SMc04150 SMc04151 SMc04152
SMK: Sinme_3431 Sinme_3432 Sinme_3433
SMQ: SinmeB_3206 SinmeB_3207 SinmeB_3208
SMX: SM11_chr3571 SM11_chr3572 SM11_chr3573
SMI: BN406_03234 BN406_03235(yeaX) BN406_03236
SMEG: C770_GR4Chr0107 C770_GR4Chr0108 C770_GR4Chr0109
SMEL: SM2011_c04150 SM2011_c04151 SM2011_c04152
SMER: DU99_00540 DU99_00545 DU99_00550
SMD: Smed_3312 Smed_3313 Smed_3314
SIX: BSY16_5791 BSY16_5792 BSY16_5793
EAK: EKH55_4289 EKH55_4290 EKH55_4291
ARA: Arad_8373 Arad_8374 Arad_8376
RET: RHE_PE00412 RHE_PE00413 RHE_PE00414
REL: REMIM1_PD00434 REMIM1_PD00435 REMIM1_PD00436
RLE: pRL110549 pRL110550 pRL110551
RLT: Rleg2_5645 Rleg2_5646 Rleg2_5647
RLG: Rleg_6581 Rleg_6582 Rleg_6583
RLB: RLEG3_05375 RLEG3_05380 RLEG3_05385
RLU: RLEG12_01980 RLEG12_01985 RLEG12_01990
RTR: RTCIAT899_PC09265 RTCIAT899_PC09270 RTCIAT899_PC09275
RHL: LPU83_pLPU83c0698 LPU83_pLPU83c0699(vanB) LPU83_pLPU83c0700
RJG: CCGE525_22865 CCGE525_22870 CCGE525_22875
RHR: CKA34_31860 CKA34_31865 CKA34_31870
RAD: CO657_28945 CO657_28950 CO657_28955
RII: FFM53_030580 FFM53_030585 FFM53_030590
RHID: FFM81_029925 FFM81_029930 FFM81_029935
RLN: J0663_26890 J0663_26895 J0663_26900
RBAN: J2J98_25850 J2J98_25855 J2J98_25860
RRG: J3P73_30895 J3P73_30900 J3P73_30905
RLS: HB780_09380 HB780_09385 HB780_09390
RAW: NE851_05380 NE851_05385 NE851_05390
XAU: Xaut_3180 Xaut_3181 Xaut_3182
XDI: EZH22_17035 EZH22_17040 EZH22_17045
AZC: AZC_1371 AZC_1372 AZC_1373
LNE: FZC33_26160 FZC33_26165 FZC33_26170
METD: C0214_27055 C0214_27060 C0214_27065 C0214_27340 C0214_27345 C0214_27350
METX: A3862_04310 A3862_04315
MOG: MMB17_17410 MMB17_17415 MMB17_17420
MSL: Msil_3607 Msil_3608 Msil_3609
MTUN: MTUNDRAET4_3214 MTUNDRAET4_3215 MTUNDRAET4_3216
MLG: CWB41_11295 CWB41_11300 CWB41_11305
BBAR: RHAL1_03798 RHAL1_03799(cntB) RHAL1_03800
HDN: Hden_0082 Hden_0083 Hden_0084
HDT: HYPDE_22963 HYPDE_22968 HYPDE_22973 HYPDE_25248 HYPDE_25253 HYPDE_25258
HMC: HYPMC_2731 HYPMC_2732(yeaX) HYPMC_2733
CMET: K6K41_17895 K6K41_17905
AUZ: Sa4125_10190 Sa4125_10200 Sa4125_10210
LIZ: LGH83_08120 LGH83_08125 LGH83_08130
SIL: SPO1580 SPO1581 SPO1582
RCON: K3740_20060 K3740_20065 K3740_20070
RDE: RD1_0004 RD1_0005(vanB) RD1_0006
RLI: RLO149_c005890 RLO149_c005900 RLO149_c005910
OAR: OA238_c26740 OA238_c26750 OA238_c26760
LMD: METH_18465 METH_18470
LEJ: ETW24_17985 ETW24_17990 ETW24_17995
LAQU: R2C4_19710 R2C4_19715 R2C4_19720
LEV: ETW23_00165 ETW23_00170 ETW23_00175
LCAE: K3721_16255 K3721_16260 K3721_16265
RED: roselon_03549 roselon_03550 roselon_03551
CID: P73_0120 P73_0121 P73_0122
CEH: CEW89_17320 CEW89_17325 CEW89_17330
SULZ: C1J03_14610 C1J03_14615 C1J03_14620
RMM: ROSMUCSMR3_00037 ROSMUCSMR3_00038(pht2) ROSMUCSMR3_00039
ROK: RAK1035_2888 RAK1035_2889 RAK1035_2890
MALU: KU6B_39870 KU6B_39880 KU6B_39890
PALX: GQA70_23295(dmmA) GQA70_23300 GQA70_23305
RHP: LPB142_05585 LPB142_05590 LPB142_05595
PAMI: JCM7686_pAMI6p071 JCM7686_pAMI6p072 JCM7686_pAMI6p073
PYE: A6J80_01595 A6J80_01600 A6J80_01605
PZH: CX676_01725 CX676_01730 CX676_01735
PAMN: pAMV1p0116(dmmA) pAMV1p0117(dmmB) pAMV1p0118(dmmC)
DAA: AKL17_0583 AKL17_0584 AKL17_0585
RBG: BG454_03410 BG454_03415 BG454_03420
GEH: HYN69_06790 HYN69_06795 HYN69_06800
GFU: KM031_03400 KM031_03405 KM031_03410
TAW: EI545_08470 EI545_08475 EI545_08480
SEDI: EBB79_24070
FAP: GR316_12800 GR316_12805 GR316_12810
SSAN: NX02_15670 NX02_15675 NX02_15680
GBE: GbCGDNIH1_1827 GbCGDNIH1_1828 GbCGDNIH1_1829
GBH: GbCGDNIH2_1827 GbCGDNIH2_1828 GbCGDNIH2_1829
GBC: GbCGDNIH3_1827 GbCGDNIH3_1828 GbCGDNIH3_1829
GBS: GbCGDNIH4_1827 GbCGDNIH4_1828 GbCGDNIH4_1829
GXL: H845_62 H845_63
KEU: S101446_00775(vanB) S101446_00776(alg9) S101446_00786
AACE: A0U92_02475 A0U92_02480 A0U92_02485
ACEK: FLP30_07315 FLP30_07320 FLP30_07325
TII: DY252_08065 DY252_08070 DY252_08075
THAI: IT893_13185 IT893_13190 IT893_13195
APB: SAR116_0236 SAR116_0237 SAR116_0238
BFD: NCTC4823_00918 NCTC4823_00919 NCTC4823_00920(hmp_1)
BSHI: LGQ02_10745 LGQ02_10750
BBAD: K7T73_21040 K7T73_21045 K7T73_21050
BACI: B1NLA3E_07675 B1NLA3E_07705 B1NLA3E_07710
BACO: OXB_0420
BHK: B4U37_20960 B4U37_20965 B4U37_20970
BCOH: BC6307_22590 BC6307_22595 BC6307_22600
LYG: C1N55_15855 C1N55_15860 C1N55_15865
FAR: ABE41_001890 ABE41_001895 ABE41_001900
APAK: AP3564_11175
BSJ: UP17_14805 UP17_14810 UP17_14815
BMUR: ABE28_004425 ABE28_004430 ABE28_004435
PBUT: DTO10_26625 DTO10_26630 DTO10_26635
NDT: L1999_09925 L1999_09930 L1999_09935
GAJ: MY490_10750 MY490_10755 MY490_10760
MJO: FOF60_24040
BCHS: JNE38_06835 JNE38_06840
PBJ: VN24_01145 VN24_01150 VN24_01155
PNP: IJ22_08080 IJ22_08090 IJ22_08100
ACUR: JZ785_18150 JZ785_18155
PGQ: FK545_11780 FK545_11785 FK545_11790
PABS: JIR001_04420 JIR001_04440 JIR001_04450(yeaX)
MYE: AB431_11625 AB431_11630 AB431_11635
MGO: AFA91_17355 AFA91_17360 AFA91_27000 AFA91_27005 AFA91_27010
MDX: BTO20_03305 BTO20_03310 BTO20_03315
MSHG: MSG_02015 MSG_02016 MSG_02017 MSG_02018 MSG_02019 MSG_02020
MSTO: MSTO_13650 MSTO_13660 MSTO_13670 MSTO_13680 MSTO_13690
MDF: K0O62_19495 K0O62_19500 K0O62_19505
MPAE: K0O64_11295 K0O64_11300 K0O64_11305
MPAA: MKK62_18125 MKK62_18130 MKK62_18135 MKK62_18185 MKK62_18190
MCRO: MI149_12155 MI149_12160 MI149_12165
MSM: MSMEG_1988 MSMEG_1989 MSMEG_1990 MSMEG_4637 MSMEG_4638 MSMEG_4639
MSG: MSMEI_1944 MSMEI_1945 MSMEI_1946 MSMEI_4520 MSMEI_4521 MSMEI_4522
MSB: LJ00_09920 LJ00_09925 LJ00_09930 LJ00_22940 LJ00_22945 LJ00_22950
MSN: LI99_09920 LI99_09925 LI99_09930 LI99_22945 LI99_22950 LI99_22955
MSH: LI98_09920 LI98_09925 LI98_09930 LI98_22950 LI98_22955 LI98_22960
MVA: Mvan_3957 Mvan_3958 Mvan_3959
MGI: Mflv_2622 Mflv_2623 Mflv_2624
MSP: Mspyr1_20570 Mspyr1_20580 Mspyr1_20590
MNE: D174_19215 D174_19220 D174_19225
MYN: MyAD_18845 MyAD_18850 MyAD_18855
MPHL: MPHLCCUG_03436 MPHLCCUG_03437(ophA1) MPHLCCUG_03438
MVQ: MYVA_3786 MYVA_3787 MYVA_3788
MLL: B1R94_17530 B1R94_17535 B1R94_17540
MHAS: MHAS_01245 MHAS_01246(ophA1) MHAS_01247
MAUU: NCTC10437_03738 NCTC10437_03739(ophA1_2) NCTC10437_03740
MMOR: MMOR_05190 MMOR_05200 MMOR_05210
MAIC: MAIC_20160 MAIC_20170 MAIC_20180
MTY: MTOK_60030 MTOK_60040 MTOK_60050
MHEV: MHEL_45160 MHEL_45170 MHEL_45180
MSAR: MSAR_32990 MSAR_33000 MSAR_33010
MANY: MANY_06680 MANY_06690 MANY_06700
MAUB: MAUB_31050 MAUB_31060 MAUB_31070
MPOF: MPOR_41130 MPOR_41140 MPOR_41150
MMAT: MMAGJ_74180 MMAGJ_74190 MMAGJ_74200
CVA: CVAR_1017 CVAR_1018 CVAR_1019 CVAR_1021 CVAR_1022 CVAR_1023
CTER: A606_03950 A606_03955 A606_03960 A606_03975 A606_03980 A606_03985
CPRE: Csp1_17860 Csp1_17870(pobB_2) Csp1_17880 Csp1_17910 Csp1_17920(ophA1) Csp1_17930
NFA: NFA_21070 NFA_21080 NFA_21090
NFR: ERS450000_01994 ERS450000_01995(ophA1_4) ERS450000_01996
NSL: BOX37_13585 BOX37_13590 BOX37_13595
RHA: RHA1_ro00467 RHA1_ro00468 RHA1_ro00470 RHA1_ro02823 RHA1_ro02824 RHA1_ro02825
ROP: ROP_25460 ROP_25470 ROP_25480
ROA: Pd630_LPD03616 Pd630_LPD03617 Pd630_LPD03618 Pd630_LPD06983 Pd630_LPD06984 Pd630_LPD06985 Pd630_LPD06986
RPY: Y013_00720 Y013_00725 Y013_00730 Y013_00735 Y013_00740
RBY: CEJ39_11315 CEJ39_11320 CEJ39_11325 CEJ39_11330 CEJ39_11335
RAV: AAT18_11030 AAT18_11035 AAT18_11045 AAT18_11050
RRZ: CS378_00780 CS378_00785 CS378_00790 CS378_00795 CS378_00800
RHQ: IM25_14675 IM25_14680 IM25_14685 IM25_14690 IM25_14695
RRT: 4535765_01850 4535765_01851(ophA1_3) 4535765_01852
RCR: NCTC10994_01054 NCTC10994_01055(ophA1_1) NCTC10994_01056
RKO: JWS14_00070 JWS14_00075 JWS14_00080 JWS14_14865 JWS14_14870 JWS14_14875
RGO: KYT97_17305 KYT97_17310 KYT97_17315 KYT97_17320 KYT97_17325
ROZ: CBI38_08780 CBI38_08785 CBI38_08790
RPSK: JWS13_30015 JWS13_30020 JWS13_30025 JWS13_30360 JWS13_30365 JWS13_30370
GBR: Gbro_4809 Gbro_4810 Gbro_4811 Gbro_4812 Gbro_4813
GPO: GPOL_c00400 GPOL_c00410 GPOL_c00420 GPOL_c00430 GPOL_c00440
GOR: KTR9_4677 KTR9_4678 KTR9_4679 KTR9_4680 KTR9_4681
GTA: BCM27_24825 BCM27_24830 BCM27_24835 BCM27_24840 BCM27_24845
GRU: GCWB2_23600 GCWB2_23605(ophA1) GCWB2_23610 GCWB2_23615(ophA2) GCWB2_23620
GAV: C5O27_04900 C5O27_04905 C5O27_04910 C5O27_04915 C5O27_04920
GOD: GKZ92_22500 GKZ92_22505 GKZ92_22510 GKZ92_22515 GKZ92_22520
GAM: GII34_01295 GII34_01300 GII34_01305 GII34_01310 GII34_01315
GPD: GII33_01075 GII33_01080 GII33_01085 GII33_01090 GII33_01095
GJI: H1R19_22720 H1R19_22725 H1R19_22730 H1R19_22735 H1R19_22740
GOI: LK459_09085 LK459_09090 LK459_09095 LK459_09100 LK459_09105
GHN: MVF96_23460 MVF96_23465 MVF96_23470 MVF96_23475 MVF96_23480
GAMI: IHQ52_04465 IHQ52_04470 IHQ52_04475 IHQ52_04480 IHQ52_04485
GMG: NWF22_12035 NWF22_12040 NWF22_12045 NWF22_12050
ARE: AL755_14045 AL755_14050 AL755_14055
ARU: ASPU41_05965 ASPU41_05970 ASPU41_05975
ARQ: BWQ92_09805 BWQ92_09810 BWQ92_09815
ACIT: HPK19_05195 HPK19_05200 HPK19_05205
PSUL: AU252_12825 AU252_12830
PSEY: GU243_15510
RAIN: Rai3103_10555 Rai3103_10560 Rai3103_10565 Rai3103_10570 Rai3103_10575
NARO: CFH99_03845
AER: AERYTH_00705 AERYTH_00710 AERYTH_00715
FRI: FraEuI1c_6661 FraEuI1c_6662 FraEuI1c_6663
PSEA: WY02_00870 WY02_00880
PSEE: FRP1_12700 FRP1_12705
PSEH: XF36_13300 XF36_13310
PSEQ: AD006_18280 AD006_18285
PECQ: AD017_26110 AD017_26115
PAUT: Pdca_36960 Pdca_36970 Pdca_36980
PMAD: BAY61_15245 BAY61_15250
CAU: Caur_3088
CHL: Chy400_3336
CAG: Cagg_0865
SLI: Slin_1933
SRD: SD10_11390
SMON: AWR27_17355
SPIR: CWM47_33900
SPIK: EXU85_15580
SPIB: G8759_18960
RUP: DTQ70_17305
FAE: FAES_2569
FIB: A6C57_14275
HSIN: KDQ40_01085
 » show all
Reference
1  [PMID:4389011]
  Authors
Eady RR, Large PJ
  Title
Bacterial oxidation of dimethylamine, a new mono-oxygenase reaction.
  Journal
Biochem J 111:37P-38P (1969)
DOI:10.1042/bj1110037pb
Reference
2  [PMID:4401380]
  Authors
Eady RR, Jarman TR, Large PJ
  Title
Microbial oxidation of amines. Partial purification of a mixed-function secondary-amine oxidase system from Pseudomonas aminovorans that contains an enzymically active cytochrome-P-420-type haemoprotein.
  Journal
Biochem J 125:449-59 (1971)
DOI:10.1042/bj1250449
Reference
3  [PMID:3624236]
  Authors
Alberta JA, Dawson JH
  Title
Purification to homogeneity and initial physical characterization of secondary amine monooxygenase.
  Journal
J Biol Chem 262:11857-63 (1987)
Reference
4  [PMID:28304370]
  Authors
Lidbury I, Mausz MA, Scanlan DJ, Chen Y
  Title
Identification of dimethylamine monooxygenase in marine bacteria reveals a metabolic bottleneck in the methylated amine degradation pathway.
  Journal
ISME J 11:1592-1601 (2017)
DOI:10.1038/ismej.2017.31
  Sequence
[sil:SPO1580 SPO1581 SPO1582]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.238
IUBMB Enzyme Nomenclature: 1.14.13.238
ExPASy - ENZYME nomenclature database: 1.14.13.238
BRENDA, the Enzyme Database: 1.14.13.238

  All links  
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (5427)   
   KEGG ORTHOLOGY (3)   
   KEGG GENES (876)   
   KEGG MGENES (4280)   
   RefGene (268)   
DNA sequence (6)   
   GenBank (3)   
   EMBL (3)   
All databases (5443)   

Download RDF
DBGET integrated database retrieval system