KEGG   ENZYME: 1.14.13.239
Entry
EC 1.14.13.239              Enzyme                                 
Name
carnitine monooxygenase;
cntAB (gene names);
yeaWX (gene names)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
L-carnitine,NAD(P)H:oxygen oxidoreductase (trimethylamine-forming)
Reaction(IUBMB)
L-carnitine + NAD(P)H + H+ + O2 = (3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD(P)+ + H2O [RN:R11875 R11911]
Reaction(KEGG)
R11875 R11911
Substrate
L-carnitine [CPD:C00318];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
(3R)-3-hydroxy-4-oxobutanoate [CPD:C21761];
trimethylamine [CPD:C00565];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
The bacterial enzyme is a complex consisting of a reductase and an oxygenase components. The reductase subunit contains a flavin and a plant-type ferredoxin [2Fe-2S] cluster, while the oxygenase subunit is a Rieske-type protein in which a [2Fe-2S] cluster is coordinated by two histidine and two cysteine residues.
History
EC 1.14.13.239 created 2017
Orthology
K22443  carnitine monooxygenase subunit
K22444  carnitine monooxygenase subunit
Genes
ECOb1802(yeaW) b1803(yeaX)
ECJJW1792(yeaX) JW5294(yeaW)
ECDECDH10B_1940(yeaW) ECDH10B_1941(yeaX)
EBWBWG_1615(yeaW) BWG_1616(yeaX)
ECOKECMDS42_1476(yeaW) ECMDS42_1477(yeaX)
ECEZ2845(yeaW) Z2846(yeaX)
ECSECs_2511(yeaW) ECs_2512(yeaX)
ECFECH74115_2528 ECH74115_2529
ETWECSP_2374(yeaW) ECSP_2375(yeaX)
ELXCDCO157_2345 CDCO157_2346
EOIECO111_2308(yeaW) ECO111_2309(yeaX)
EOJECO26_2571(yeaW) ECO26_2572(yeaX)
EOHECO103_1991(yeaW) ECO103_1992(yeaX)
ECOOECRM13514_2305(yeaW) ECRM13514_2306(yeaX)
ECOHECRM13516_2207(yeaW) ECRM13516_2208(yeaX)
ESLO3K_10935 O3K_10940
ESOO3O_14685 O3O_14690
ESMO3M_10905 O3M_10910
ECKEC55989_1975(yeaW) EC55989_1976(yeaX)
EOKG2583_2249(yeaW) G2583_2250(yeaX)
ELRECO55CA74_10820 ECO55CA74_10825
ELHETEC_1834 ETEC_1835
ECWEcE24377A_2028 EcE24377A_2029
EUNUMNK88_2272 UMNK88_2273
ECOAAPECO78_12810 APECO78_12815
ECXEcHS_A1890 EcHS_A1891
ECMEcSMS35_1385 EcSMS35_1386
ECYECSE_1976 ECSE_1977
ECRECIAI1_1871(yeaW) ECIAI1_1872(yeaX)
EUMECUMN_2094(yeaW) ECUMN_2095(yeaX)
ECTECIAI39_1250(yeaX) ECIAI39_1251(yeaW)
EOCCE10_2084(yeaW) CE10_2085(yeaX)
EBRECB_01772(yeaW) ECB_01773(yeaX)
EBLECD_01772(yeaW) ECD_01773(yeaX)
EBEB21_01760(yeaW) B21_01761(yeaX)
EBDECBD_1839 ECBD_1840
ELOEC042_1967 EC042_1968
ECLEcolC_1830 EcolC_1831
EKOEKO11_1970 EKO11_1971
EKFKO11_13700(yeaX) KO11_13705(yeaW)
EDHEcDH1_1840 EcDH1_1841
EDJECDH1ME8569_1746(yeaW) ECDH1ME8569_1747(yeaX)
ELWECW_m1971(yeaW) ECW_m1972(yeaX)
ELLWFL_09685(yeaW) WFL_09690(yeaX)
ELPP12B_c1278(yeaX) P12B_c1279(yeaW)
ECOLLY180_09385 LY180_09390
EALEAKF1_ch4248c EAKF1_ch4249c
ESZFEM44_23900(yeaW) FEM44_23905(yeaX)
SFLSF1425(yeaX)
SFXS1540(yeaX)
SFVSFV_1426(yeaX) SFV_1427
SFESFxv_1613(yeaX) SFxv_1614(yeaW)
SFNSFy_2039 SFy_2041
SFSSFyv_2091 SFyv_2093
SFTNCTC1_01526(ophA1) NCTC1_01527(yeaW)
SSNSSON_1358(yeaX) SSON_1359(yeaW)
SBOSBO_1285(yeaX) SBO_1286(yeaW)
SBCSbBS512_E2062 SbBS512_E2063
SDYSDY_1706(yeaW) SDY_1707(yeaX)
SHQA0259_13095 A0259_13100
KPNKPN_01011 KPN_01013
KPUKP1_1994 KP1_1996
KPMKPHS_18840 KPHS_18860
KPPA79E_3220 A79E_3222
KPHKPNIH24_19070 KPNIH24_19080
KPZKPNIH27_08905 KPNIH27_08915
KPVKPNIH29_09435 KPNIH29_09445
KPWKPNIH30_09950 KPNIH30_09960
KPYKPNIH31_09325 KPNIH31_09335
KPGKPNIH32_09790 KPNIH32_09800
KPCKPNIH10_09445 KPNIH10_09455
KPQKPR0928_09615 KPR0928_09625
KPTVK055_1464 VK055_1466
KPOKPN2242_08115 KPN2242_08125
KPRKPR_3509(yeaW) KPR_3512(xeaX)
KPJN559_3274 N559_3276
KPID364_05260 D364_05270
KPAKPNJ1_03516 KPNJ1_03518
KPSKPNJ2_03505 KPNJ2_03507
KPXPMK1_03351(ophA1) PMK1_03353(cbdA_1)
KPBFH42_00910 FH42_00920
KPNEKU54_016700 KU54_016710
KPNULI86_17010 LI86_17020
KPNKBN49_2098(xeaX) BN49_2100(yeaW)
KVAKvar_3366 Kvar_3368
KPEKPK_3547 KPK_3549
KPKA593_19555
KVDKR75_17225 KR75_17235
KVQSP68_23605 SP68_23615
KQUAVR78_13880 AVR78_13890
EAEEAE_15875 EAE_15885
EARCCG30729 CCG30731
KARLGL98_16160 LGL98_16170
CBRAA6J81_06350 A6J81_06355
CYOCD187_10200 CD187_10205
CPOTFOB25_21780 FOB25_21785
CFQC2U38_10320 C2U38_10325
CIFAL515_13735 AL515_13745
CPARCUC49_09460 CUC49_09470
CARSE1B03_15695 E1B03_15700
EBTEBL_c14120(yeaW) EBL_c14130(yeaxA)
ESCEntcl_2809 Entcl_2811
KLEAO703_08135 AO703_08145
EBUCUC76_06225 CUC76_06235
YPEYPO2492 YPO2493
YPKy1695
YPHYPC_1634
YPAYPA_1988 YPA_1989
YPNYPN_2086 YPN_2088
YPMYP_2307(hmp1) YP_2308(hcaA11)
YPPYPDSF_1904 YPDSF_1905
YPGYpAngola_A1752 YpAngola_A1753
YPZYPZ3_2135 YPZ3_2136
YPTA1122_13670 A1122_13675
YPDYPD4_2178 YPD4_2179
YPXYPD8_2208 YPD8_2209
YPWCH59_30 CH59_31
YPJCH55_116 CH55_118
YPVBZ15_1039 BZ15_1040
YPLCH46_2619 CH46_2620
YPSYPTB2529 YPTB2530
YPOBZ17_4107 BZ17_4108
YPIYpsIP31758_1516 YpsIP31758_1517
YPYYPK_1619 YPK_1620
YPBYPTS_2623 YPTS_2624
YPQDJ40_4012 DJ40_4013
YPUBZ21_1826 BZ21_1827
YPRBZ20_3678 BZ20_3679
YPCBZ23_2110 BZ23_2111
YPFBZ19_1891 BZ19_1892
YSIBF17_22110 BF17_22115
SMARSM39_3539 SM39_3541
SMACSMDB11_3351 SMDB11_3353
SMWSMWW4_v1c40530(yeaW) SMWW4_v1c40550(yeaX)
SLQM495_20620 M495_20630
SERFL085_08225 L085_08235
SERSSERRSCBI_19715 SERRSCBI_19725
SSURATE40_016980 ATE40_016990
SURIJ0X03_03620 J0X03_03630
XNEXNC1_0564(yeaW) XNC1_0567(yeaX)
XNMXNC2_0552(yeaW) XNC2_0555(yeaX)
XHOA9255_13410 A9255_13420
XBUHGO23_00085 HGO23_00090
PSIS70_07470 S70_07480
PSXDR96_1688 DR96_1690
PSTABGK56_10525 BGK56_10535
PRGRB151_006210(antA) RB151_006230(pobB)
PHEINCTC12003_00623(antA) NCTC12003_00625(ophA1)
PRQCYG50_12980 CYG50_12990
PVCG3341_02920 G3341_02930
PMAGJI723_03315 JI723_03325
VEJVEJY3_06970 VEJY3_06980
VTAA3368(yeaW) A3370(yeaX)
SKSFCN78_12235
PREPCA10_47180 PCA10_47190
PFUWKF707C_22480
PCQPcP3B5_28790(antA_2) PcP3B5_38790(pobB_4) PcP3B5_38810(antA_4)
PMUIG4G71_17985 G4G71_25695 G4G71_25700
PPGPputGB1_2193 PputGB1_2194 PputGB1_3019
PPUTL483_19325 L483_19330
PPUNPP4_21080(yeaX) PP4_21090(yeaW)
PMOSO165_007130 O165_007135
PMOLCLJ08_01940 CLJ08_01945
PAZOAYR47_20415 AYR47_20420
PENPSEEN2129 PSEEN2130
PKCPKB_3451(yeax3) PKB_3452(yeaW)
PALKPSAKL28_33290 PSAKL28_33310
PRHLT40_18970
PSECCCOS191_3070(yeaW) CCOS191_3071(yeaX)
PSETTHL1_4425
PKEDLD99_18940
PLALFXN65_16235 FXN65_16245 FXN65_21225
PQIKH389_11840 KH389_11850
PMAMKSS90_10595 KSS90_10600
PORYEJA05_15695 EJA05_15700
PCAVD3880_16575 D3880_16585
ACBA1S_0852 A1S_0855
ABMABSDF2579
ABYABAYE2957
ABCACICU_00805 ACICU_00807
ABNAB57_0900 AB57_0903
ABBABBFA_02735(pobB_2) ABBFA_02737(antA_3)
ABXABK1_0843 ABK1_0845
ABZABZJ_00846 ABZJ_00848
ABRABTJ_02957 ABTJ_02959
ABDABTW07_0836 ABTW07_0838
ABHM3Q_1051 M3Q_1053
ABADABD1_08020 ABD1_08040
ABJBJAB07104_00856 BJAB07104_00858
ABABBJAB0715_00841 BJAB0715_00843
ABAJBJAB0868_00865 BJAB0868_00867
ABKLX00_04265 LX00_04275
ABAUIX87_01885 IX87_01895
ABAAIX88_06250 IX88_06260
ABWBL01_07960 BL01_07970
ABALABLAC_30010 ABLAC_30030
ACCBDGL_000119(yeaW) BDGL_000121(yeaX)
ANORR32_13925 RR32_13935
ALCOTEC02_14660 OTEC02_14670
ASEII8T81_14745 I8T81_14755
ACDAOLE_15420 AOLE_15430
ACWA0J50_13230 A0J50_13240
ADVDJ533_02965 DJ533_02975
AGUAS4_16360 AS4_16380
AUGURS_2186 URS_2188
ADSFPL17_02690 FPL17_02700
ABERBSR55_16260 BSR55_16270
ACHICDG60_06700 CDG60_12925 CDG60_12935
AGYLFPL18_19170 FPL18_19180
CSACsal_2455
HBEBEI_2126
MSECLN244_09910 LN244_09920
VMSLVJ82_12445 LVJ82_12455
CRZD1345_05780 D1345_05785
CHAECH06BL_12570(yeaX) CH06BL_12580
AMAHDLM_3014 DLM_3015
AQSDKK66_11975 DKK66_11980
RPJN234_32220 N234_32250
REHH16_B2129(h16_B2129) H16_B2135(h16_B2135)
CNCCNE_2c20930 CNE_2c20990(vanB)
CUHBJN34_33200 BJN34_33230
REUReut_B5830 Reut_B5836
CTIRALTA_B1830 RALTA_B1836
CCUPBKK81_31870 BKK81_31880
CUPBKK80_24470 BKK80_24480
CUUBKK79_29745 BKK79_29755
COXE0W60_04285 E0W60_04315
BURBcep18194_B0529 Bcep18194_C7702
BCENDM39_6553 DM39_6555
BMJBMULJ_05505 BMULJ_05507
BMUBmul_6020 Bmul_6022
BMKDM80_6470 DM80_6472
BMULNP80_5234 NP80_5236
BPSLWS57_17685 WS57_17695
BANNJFN94_29655
PACSFAZ98_33730 FAZ98_33740
CABASBC2_60630(yeaW_3)
ASWCVS48_20825 CVS48_20830
ACHBDVB37_11460 DVB37_11465
VEIVeis_3584
HTNKI616_05445
MCIMesci_5764
MOPMesop_6341
MAMMesau_05813
MAMOA6B35_29595
LABRCHH27_14540
LABPFJ695_25375
CAULKCG34_17905
SILSPO1590
RUAD1823_09020 D1823_12800
RUTFIU92_00680(bedC1) FIU92_18595(antA)
OAROA238_c45000
LMDMETH_03745
LEJETW24_04600
LEVETW23_15600
SULZC1J03_06785 C1J03_24860
SULIC1J05_17375
RIDRIdsm_04325(antA_2) RIdsm_04442(antA_3)
ROMEI983_04510 EI983_11235 EI983_11745
ROHFIU89_04735(hcaE) FIU89_14340(antA4)
THAACFI11_19180
SEDIEBB79_03445
PAEDG5B38_01485
CACTHZ995_06905
HDHG5B40_19265
HTQFRZ44_08600(yeaW) FRZ44_35700(yeaW) FRZ44_43610 FRZ44_47310(yeaW) FRZ44_48050
HADHFRZ61_34840 FRZ61_41530(yeaW) FRZ61_43790 FRZ61_45160 FRZ61_45770
APCHIMB59_00013350
BCYBcer98_0763
BFDNCTC4823_03637(cbdA_2) NCTC4823_03640(cbdA_3)
BSHILGQ02_10755
BBADK7T73_16350 K7T73_16395
BACOOXB_3176
BKWBkAM31D_21665(bedC1)
BONA361_03025 A361_14510
CFIRNAF01_03055
CSOALIS82_03000
LAGRFJQ98_13530
VNECFK40_04990
PBUTDTO10_01915 DTO10_16030
PFRIL8956_15640
NMKCHR53_02140 CHR53_02265
NDTL1999_01780
MSEMGMB29_06775 GMB29_10200
BAGRBA6348_08160
BCOPJD108_07945
ANXACH33_04680
ATHEK3F53_14230
ACURJZ785_18145
SPOPSporoP37_10360
SPAEE2C16_10170
ACITHPK19_11355 HPK19_13185
NCXNocox_19550(antA1)
UAMUABAM_02282
ADINH7849_04440
 » show all
Reference
1  [PMID:8000862]
  Authors
Ditullio D, Anderson D, Chen CS, Sih CJ
  Title
L-carnitine via enzyme-catalyzed oxidative kinetic resolution.
  Journal
Bioorg Med Chem 2:415-20 (1994)
DOI:10.1016/0968-0896(94)80009-X
Reference
2  [PMID:24591617]
  Authors
Zhu Y, Jameson E, Crosatti M, Schafer H, Rajakumar K, Bugg TD, Chen Y
  Title
Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota.
  Journal
Proc Natl Acad Sci U S A 111:4268-73 (2014)
DOI:10.1073/pnas.1316569111
  Sequence
Reference
3  [PMID:25440057]
  Authors
Koeth RA, Levison BS, Culley MK, Buffa JA, Wang Z, Gregory JC, Org E, Wu Y, Li L, Smith JD, Tang WH, DiDonato JA, Lusis AJ, Hazen SL
  Title
gamma-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO.
  Journal
Cell Metab 20:799-812 (2014)
DOI:10.1016/j.cmet.2014.10.006
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.239
IUBMB Enzyme Nomenclature: 1.14.13.239
ExPASy - ENZYME nomenclature database: 1.14.13.239
BRENDA, the Enzyme Database: 1.14.13.239

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