KEGG   ENZYME: 1.14.13.24Help
Entry
EC 1.14.13.24               Enzyme                                 

Name
3-hydroxybenzoate 6-monooxygenase;
3-hydroxybenzoate 6-hydroxylase;
m-hydroxybenzoate 6-hydroxylase;
3-hydroxybenzoic acid-6-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
3-hydroxybenzoate,NADH:oxygen oxidoreductase (6-hydroxylating)
Reaction(IUBMB)
3-hydroxybenzoate + NADH + H+ + O2 = 2,5-dihydroxybenzoate + NAD+ + H2O [RN:R02589]
Reaction(KEGG)
Substrate
3-hydroxybenzoate [CPD:C00587];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
2,5-dihydroxybenzoate [CPD:C00628];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Comment
A flavoprotein (FAD). Acts also on a number of analogues of 3-hydroxybenzoate substituted in the 2, 4, 5 and 6 positions; NADPH can act instead of NADH, but more slowly.
History
EC 1.14.13.24 created 1984
Pathway
ec00362  Benzoate degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K22270  3-hydroxybenzoate 6-monooxygenase
Genes
ECE: Z3390
ECS: ECs3027
ECF: ECH74115_3267
ETW: ECSP_3013
ELX: CDCO157_2790
ECOO: ECRM13514_5372
ECOH: ECRM13516_3724
EOK: G2583_2678
ELR: ECO55CA74_13240
EAL: EAKF1_ch3857
STY: STY2405
STT: t0680
SEX: STBHUCCB_7280
SENT: TY21A_03470
STM: STM2175
SEO: STM14_2682
SEV: STMMW_22071
SEY: SL1344_2152
SEM: STMDT12_C21960
SEJ: STMUK_2205
SEB: STM474_2264
SEF: UMN798_2349
SETU: STU288_07260
SETC: CFSAN001921_05910
SENR: STMDT2_21521
SEND: DT104_22351
SENI: CY43_11700
SEEN: SE451236_17080
SPT: SPA0676
SEK: SSPA0635
SPQ: SPAB_00841
SEI: SPC_1527
SEC: SCH_2192(nhg)
SEH: SeHA_C2410
SHB: SU5_02767
SENH: CFSAN002069_20950
SEEH: SEEH1578_20150
SEE: SNSL254_A2365
SENN: SN31241_32870
SEW: SeSA_A2414
SEA: SeAg_B2321
SENS: Q786_10795
SED: SeD_A2522
SEG: SG2211
SEL: SPUL_0714
SEGA: SPUCDC_0714
SET: SEN2168
SENA: AU38_10960
SENO: AU37_10970
SENV: AU39_10970
SENQ: AU40_12270
SENL: IY59_11265
SENJ: CFSAN001992_00485
SEEC: CFSAN002050_17880
SEEB: SEEB0189_008635
SEEP: I137_03245
SENB: BN855_22640
SENE: IA1_10880
SENC: SEET0819_18050
SBG: SBG_1987
SBZ: A464_2299
SBV: N643_09685
KOX: KOX_25675
KOE: A225_4035
KOM: HR38_23810
KOK: KONIH1_19970
KOC: AB185_16310
EAE: EAE_23875
EAR: CCG29101
KQV: B8P98_08965
CKO: CKO_00654
CRO: ROD_22631
CFD: CFNIH1_21965
CBRA: A6J81_00350
CYO: CD187_08425
CAMA: F384_11420
CAF: AL524_11385
CFAR: CI104_16805
CIR: C2U53_26655
CIE: AN232_13145
EBT: EBL_c13690
RON: TE10_19725
PGE: LG71_12560
EBF: D782_1486
SMAR: SM39_2826(mhbM)
SMAC: SMDB11_2639(mhbM)
XBV: XBW1_2121(mhbM)
PEN: PSEEN2596(mhbM)
PCZ: PCL1606_26180
PSEM: TO66_18335
ALC: OTEC02_09095
ACD: AOLE_09105
AEI: AOY20_07145
HAK: KO116_03925
MARS: A8C75_13630
OCE: GU3_03005
ZDF: AN401_12515
VFF: VITFI_CDS3374
VIT: ADP71_15240
PSE: NH8B_2047
RPJ: N234_25225 N234_25345
REU: Reut_B5805 Reut_B5861
REH: H16_B0876(h16_B0876)
CNC: CNE_2c08340(mhbM) CNE_BB2p00890(xlnD)
CUH: BJN34_30895
CBW: RR42_s0703 RR42_s2029
CCUP: BKK81_09165
CUP: BKK80_09450
CUU: BKK79_03670
BUR: Bcep18194_B1886
BCN: Bcen_4218
BCH: Bcen2424_4148
BCM: Bcenmc03_3371
BCJ: BCAM1274(mhbM)
BCEN: DM39_3727(mhbM)
BCEO: I35_5123(mhbM)
BMU: Bmul_4439
BMJ: BMULJ_04070(nahG)
BMK: DM80_3604(mhbM)
BMUL: NP80_4175(mhbM)
BCT: GEM_4469
BCED: DM42_3818(mhbM)
BCEP: APZ15_18310
BCON: NL30_06230
BDF: WI26_19460
BTEI: WS51_04055
BPSL: WS57_07660
BMEC: WJ16_24850
BSTL: BBJ41_19360
BGO: BM43_4139(nagX)
BYI: BYI23_C002800
BUE: BRPE67_CCDS09420
BUZ: AYM40_11940
PPK: U875_20465
PPNO: DA70_13155
PPNM: LV28_17545
PRB: X636_13710
PPUL: RO07_11650
PSPU: NA29_07575
PAPI: SG18_11980
PVE: UC34_03450
POX: MB84_06150 MB84_07885
PFG: AB870_14580
PNR: AT302_11600
BPT: Bpet0509 Bpet1428
BAV: BAV1787
BHZ: ACR54_02471(mhbM)
BPDZ: BBN53_09845
AXY: AXYL_05897(mhbM)
AXO: NH44784_016421
AXN: AX27061_0548
AXX: ERS451415_00540(mhbM)
ADT: APT56_02825
AIS: BUW96_28515
ASW: CVS48_09390
ACHR: C2U31_07410
ACHB: DVB37_25380
AMIM: MIM_24p00150
PIG: EGT29_07605 EGT29_26025
POL: Bpro_2128
PNA: Pnap_3144
POS: DT070_19585
ACK: C380_12540
DAC: Daci_3703
DEL: DelCs14_3111
DTS: BI380_04665
DHK: BO996_16830
VAP: Vapar_0355
VPE: Varpa_0370 Varpa_5098
VPD: VAPA_1c04210
VBO: CKY39_02010
VAM: C4F17_17010
RTA: Rta_17950
LIH: L63ED372_01176(nagX)
HYR: BSY239_3884(nagX)
JSV: CNX70_17175
LCH: Lcho_3669
PBH: AAW51_2010
EBA: ebA1378(s5h)
AZO: azo2422(nahG)
AZI: AzCIB_1240
AOA: dqs_2566
ACOM: CEW83_02845
AZD: CDA09_08480
TCL: Tchl_1075
TAK: Tharo_1113
MES: Meso_0052
OCH: CES85_5237(xlnD)
BJU: BJ6T_69760
BRK: CWS35_03695 CWS35_17225
RHZ: RHPLAN_00130 RHPLAN_07540 RHPLAN_20830 RHPLAN_58370
MAAD: AZF01_02545
PSIN: CAK95_01775 CAK95_16830 CAK95_22270
RBM: TEF_07880
CBOT: ATE48_17610
SIL: SPO3692
JAN: Jann_2908
PGD: Gal_04153
CID: P73_1457
CEH: CEW89_18625
CON: TQ29_16425
PABY: Ga0080574_TMP3110
AHT: ANTHELSMS3_02406 ANTHELSMS3_04577
ABQ: ABAZ39_29180
ATI: AL072_21230
BACO: OXB_0838
BEO: BEH_11950
BSJ: UP17_05920
BKW: BkAM31D_03935(mhbM) BkAM31D_23545(xlnD_2)
BKO: CKF48_08415
BMUR: ABE28_008485
GYC: GYMC61_2253
GYA: GYMC52_1381
GJF: M493_07430
FAR: ABE41_018090
SEQO: SE1039_23060
PNP: IJ22_26140 IJ22_51690
SIV: SSIL_3714
SSIL: SOLI23_19490
SAY: TPY_1281
MSA: Mycsm_01819
MDX: BTO20_29025
MLL: B1R94_28765
MAB: MAB_0288
MMV: MYCMA_0154
MABB: MASS_0290
MABL: MMASJCM_0287
MCHE: BB28_01425
MIZ: BAB75_01975
MSAO: MYCSP_01255
CGL: NCgl2923(Cgl3026)
CGB: cg3354
CGU: WA5_2923
CGT: cgR_2913
CGS: C624_14855
CGG: C629_14865
CGM: cgp_3354
CGJ: AR0_14655
CGQ: CGLAR1_14510
CGX: SB89_14510
CEF: CE2863
CHN: A605_04735
CCN: H924_12685
CMD: B841_04345
CGY: CGLY_10980
CHM: B842_04175
CMQ: B840_03695
CDX: CDES_13725
CCJZ: ccrud_13660
BFV: C628_15275
NFR: ERS450000_00740 ERS450000_02621(nagX)
NTP: CRH09_24065
RHA: RHA1_ro01869
ROP: ROP_15470
ROA: Pd630_LPD06032
RAV: AAT18_09000
RRZ: CS378_23960
RRT: 4535765_00318(xlnD) 4535765_01432
GRU: GCWB2_11220(mhbM)
SALB: XNR_0599
SCB: SCAB_12141
SSX: SACTE_1745
SDV: BN159_7509
SGU: SGLAU_17245(xlnD1) SGLAU_17380(xlnD2)
STRM: M444_18400
SAMB: SAM23877_1103(mhbM)
SRW: TUE45_05046(xlnD)
SPLU: LK06_026300
STRD: NI25_24455
SALJ: SMD11_3540
KSK: KSE_58270
KIT: CFP65_3596
STRI: C7M71_014685
SALC: C2138_00735
ART: Arth_2055
ARE: AL755_09505
ARW: MB46_06810
ARH: AHiyo8_19200
ARZ: AUT26_01460
ARU: ASPU41_15325
ARQ: BWQ92_22040
ARN: CGK93_01920
ARX: ARZXY2_3573
AAU: AAur_0334
ACH: Achl_0762
CFI: Celf_3007
ICA: Intca_3430
NOA: BKM31_03435
FRE: Franean1_3612
SVI: Svir_20710
AMQ: AMETH_4245
AMYC: CU254_18630
APRE: CNX65_15965
KPHY: AOZ06_25110
LED: BBK82_23365
PMAD: BAY61_14405
MICB: MicB006_2939
AEY: CDG81_16840
 » show all
Taxonomy
Reference
1  [PMID:4357436]
  Authors
Groseclose EE, Ribbons DW, Hughes H.
  Title
3-Hydroxybenzoate 6-hydroxylase from Pseudomonas aeruginosa.
  Journal
Biochem Biophys Res Commun 55:897-903 (1973)
DOI:10.1016/0006-291X(73)91228-X
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.24
IUBMB Enzyme Nomenclature: 1.14.13.24
ExPASy - ENZYME nomenclature database: 1.14.13.24
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.24
BRENDA, the Enzyme Database: 1.14.13.24
CAS: 51570-26-4

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Pathway (4)   
   KEGG PATHWAY (4)   
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Gene (1492)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (318)   
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   RefGene (233)   
Protein sequence (1092)   
   UniProt (816)   
   SWISS-PROT (5)   
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DNA sequence (1189)   
   RefSeq(nuc) (387)   
   GenBank (404)   
   EMBL (398)   
3D Structure (5)   
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   UMBBD-EC (1)   
All databases (3792)   

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