KEGG   ENZYME: 1.14.13.24Help
Entry
EC 1.14.13.24               Enzyme                                 

Name
3-hydroxybenzoate 6-monooxygenase;
3-hydroxybenzoate 6-hydroxylase;
m-hydroxybenzoate 6-hydroxylase;
3-hydroxybenzoic acid-6-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
3-hydroxybenzoate,NADH:oxygen oxidoreductase (6-hydroxylating)
Reaction(IUBMB)
3-hydroxybenzoate + NADH + H+ + O2 = 2,5-dihydroxybenzoate + NAD+ + H2O [RN:R02589]
Reaction(KEGG)
Substrate
3-hydroxybenzoate [CPD:C00587];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
2,5-dihydroxybenzoate [CPD:C00628];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Comment
A flavoprotein (FAD). Acts also on a number of analogues of 3-hydroxybenzoate substituted in the 2, 4, 5 and 6 positions; NADPH can act instead of NADH, but more slowly.
History
EC 1.14.13.24 created 1984
Pathway
ec00362  Benzoate degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K22270  3-hydroxybenzoate 6-monooxygenase
Genes
ECE: Z3390
ECS: ECs3027
ECF: ECH74115_3267
ETW: ECSP_3013
ELX: CDCO157_2790
ECOO: ECRM13514_5372
ECOH: ECRM13516_3724
EOK: G2583_2678
ELR: ECO55CA74_13240
EAL: EAKF1_ch3857
STY: STY2405
STT: t0680
SEX: STBHUCCB_7280
SENT: TY21A_03470
STM: STM2175
SEO: STM14_2682
SEV: STMMW_22071
SEY: SL1344_2152
SEM: STMDT12_C21960
SEJ: STMUK_2205
SEB: STM474_2264
SEF: UMN798_2349
SETU: STU288_07260
SETC: CFSAN001921_05910
SENR: STMDT2_21521
SEND: DT104_22351
SENI: CY43_11700
SEEN: SE451236_17080
SPT: SPA0676
SEK: SSPA0635
SPQ: SPAB_00841
SEI: SPC_1527
SEC: SCH_2192(nhg)
SEH: SeHA_C2410
SHB: SU5_02767
SENH: CFSAN002069_20950
SEEH: SEEH1578_20150
SEE: SNSL254_A2365
SENN: SN31241_32870
SEW: SeSA_A2414
SEA: SeAg_B2321
SENS: Q786_10795
SED: SeD_A2522
SEG: SG2211
SEL: SPUL_0714
SEGA: SPUCDC_0714
SET: SEN2168
SENA: AU38_10960
SENO: AU37_10970
SENV: AU39_10970
SENQ: AU40_12270
SENL: IY59_11265
SENJ: CFSAN001992_00485
SEEC: CFSAN002050_17880
SEEB: SEEB0189_008635
SEEP: I137_03245
SENB: BN855_22640
SENE: IA1_10880
SENC: SEET0819_18050
SBG: SBG_1987
SBZ: A464_2299
SBV: N643_09685
KOX: KOX_25675
KOE: A225_4035
KOM: HR38_23810
KOK: KONIH1_19970
KOC: AB185_16310
EAE: EAE_23875
EAR: CCG29101
KQV: B8P98_08965
KLL: BJF97_19860
KLW: DA718_09145
CKO: CKO_00654
CRO: ROD_22631
CFD: CFNIH1_21965
CBRA: A6J81_00350
CYO: CD187_08425
CAMA: F384_11420
CAF: AL524_11385
CFAR: CI104_16805
CIR: C2U53_26655
CIE: AN232_13145
EBT: EBL_c13690
RON: TE10_19725
PGE: LG71_12560
EBF: D782_1486
SMAR: SM39_2826(mhbM)
SMAC: SMDB11_2639(mhbM)
XBV: XBW1_2121(mhbM)
PEN: PSEEN2596(mhbM)
PCZ: PCL1606_26180
PSEM: TO66_18335
ALC: OTEC02_09095
ACD: AOLE_09105
AEI: AOY20_07145
HAK: KO116_03925
MARS: A8C75_13630
OCE: GU3_03005
ZDF: AN401_12515
VFF: VITFI_CDS3374
VIT: ADP71_15240
PSE: NH8B_2047
RPJ: N234_25225 N234_25345
REU: Reut_B5805 Reut_B5861
REH: H16_B0876(h16_B0876)
CNC: CNE_2c08340(mhbM) CNE_BB2p00890(xlnD)
CUH: BJN34_30895
CBW: RR42_s0703 RR42_s2029
CCUP: BKK81_09165
CUP: BKK80_09450
CUU: BKK79_03670
BUR: Bcep18194_B1886
BCN: Bcen_4218
BCH: Bcen2424_4148
BCM: Bcenmc03_3371
BCJ: BCAM1274(mhbM)
BCEN: DM39_3727(mhbM)
BCEO: I35_5123(mhbM)
BMU: Bmul_4439
BMJ: BMULJ_04070(nahG)
BMK: DM80_3604(mhbM)
BMUL: NP80_4175(mhbM)
BCT: GEM_4469
BCED: DM42_3818(mhbM)
BCEP: APZ15_18310
BCON: NL30_06230
BDF: WI26_19460
BTEI: WS51_04055
BPSL: WS57_07660
BMEC: WJ16_24850
BSTL: BBJ41_19360
BGO: BM43_4139(nagX)
BYI: BYI23_C002800
BUE: BRPE67_CCDS09420
BUZ: AYM40_11940
PPK: U875_20465
PPNO: DA70_13155
PPNM: LV28_17545
PRB: X636_13710
PPUL: RO07_11650
PSPU: NA29_07575
PAPI: SG18_11980
PVE: UC34_03450
POX: MB84_06150 MB84_07885
PFG: AB870_14580
PNR: AT302_11600
BPT: Bpet0509 Bpet1428
BAV: BAV1787
BHZ: ACR54_02471(mhbM)
BPDZ: BBN53_09845
AXY: AXYL_05897(mhbM)
AXO: NH44784_016421
AXN: AX27061_0548
AXX: ERS451415_00540(mhbM)
ADT: APT56_02825
AIS: BUW96_28515
ASW: CVS48_09390
ACHR: C2U31_07410
ACHB: DVB37_25380
AMIM: MIM_24p00150
PIG: EGT29_07605 EGT29_26025
POL: Bpro_2128
PNA: Pnap_3144
POS: DT070_19585
ACK: C380_12540
DAC: Daci_3703
DEL: DelCs14_3111
DTS: BI380_04665
DHK: BO996_16830
VAP: Vapar_0355
VPE: Varpa_0370 Varpa_5098
VPD: VAPA_1c04210
VBO: CKY39_02010
VAM: C4F17_17010
RTA: Rta_17950
LIH: L63ED372_01176(nagX)
HYR: BSY239_3884(nagX)
HYC: E5678_18615
JSV: CNX70_17175
LCH: Lcho_3669
PBH: AAW51_2010
EBA: ebA1378(s5h)
AZO: azo2422(nahG)
AZI: AzCIB_1240
AOA: dqs_2566
ACOM: CEW83_02845
AZD: CDA09_08480
TCL: Tchl_1075
TAK: Tharo_1113
MES: Meso_0052
OCH: CES85_5237(xlnD)
BJU: BJ6T_69760
BRK: CWS35_03695 CWS35_17225
RHZ: RHPLAN_00130 RHPLAN_07540 RHPLAN_20830 RHPLAN_58370
MAAD: AZF01_02545
PSIN: CAK95_01775 CAK95_16830 CAK95_22270
RBM: TEF_07880
CBOT: ATE48_17610
SIL: SPO3692
JAN: Jann_2908
PGD: Gal_04153
CID: P73_1457
CEH: CEW89_18625
CON: TQ29_16425
PABY: Ga0080574_TMP3110
AHT: ANTHELSMS3_02406 ANTHELSMS3_04577
THAA: CFI11_22050
ABQ: ABAZ39_29180
ATI: AL072_21230
BACO: OXB_0838
BEO: BEH_11950
BSJ: UP17_05920
BKW: BkAM31D_03935(mhbM) BkAM31D_23545(xlnD_2)
BKO: CKF48_08415
BMUR: ABE28_008485
GYC: GYMC61_2253
GYA: GYMC52_1381
GJF: M493_07430
FAR: ABE41_018090
SEQO: SE1039_23060
PNP: IJ22_26140 IJ22_51690
SIV: SSIL_3714
SSIL: SOLI23_19490
SAY: TPY_1281
MSA: Mycsm_01819
MDX: BTO20_29025
MLL: B1R94_28765
MAB: MAB_0288
MMV: MYCMA_0154
MABB: MASS_0290
MABL: MMASJCM_0287
MCHE: BB28_01425
MIZ: BAB75_01975
MSAO: MYCSP_01255
CGL: NCgl2923(Cgl3026)
CGB: cg3354
CGU: WA5_2923
CGT: cgR_2913
CGS: C624_14855
CGG: C629_14865
CGM: cgp_3354
CGJ: AR0_14655
CGQ: CGLAR1_14510
CGX: SB89_14510
CEF: CE2863
CHN: A605_04735
CCN: H924_12685
CMD: B841_04345
CGY: CGLY_10980
CHM: B842_04175
CMQ: B840_03695
CDX: CDES_13725
CCJZ: ccrud_13660
BFV: C628_15275
NFR: ERS450000_00740 ERS450000_02621(nagX)
NTP: CRH09_24065
RHA: RHA1_ro01869
ROP: ROP_15470
ROA: Pd630_LPD06032
RAV: AAT18_09000
RRZ: CS378_23960
RRT: 4535765_00318(xlnD) 4535765_01432
GRU: GCWB2_11220(mhbM)
SALB: XNR_0599
SCB: SCAB_12141
SSX: SACTE_1745
SDV: BN159_7509
SGU: SGLAU_17245(xlnD1) SGLAU_17380(xlnD2)
STRM: M444_18400
SAMB: SAM23877_1103(mhbM)
SRW: TUE45_05046(xlnD)
SPLU: LK06_026300
STRD: NI25_24455
SALJ: SMD11_3540
KSK: KSE_58270
KIT: CFP65_3596
STRI: C7M71_014685
SALC: C2138_00735
ART: Arth_2055
ARE: AL755_09505
ARW: MB46_06810
ARH: AHiyo8_19200
ARZ: AUT26_01460
ARU: ASPU41_15325
ARQ: BWQ92_22040
ARN: CGK93_01920
ARX: ARZXY2_3573
AAU: AAur_0334
ACH: Achl_0762
CFI: Celf_3007
ICA: Intca_3430
NOA: BKM31_03435
FRE: Franean1_3612
SVI: Svir_20710
AMQ: AMETH_4245
AMYC: CU254_18630
APRE: CNX65_15965
KPHY: AOZ06_25110
LED: BBK82_23365
PMAD: BAY61_14405
MICB: MicB006_2939
AEY: CDG81_16840
 » show all
Taxonomy
Reference
1  [PMID:4357436]
  Authors
Groseclose EE, Ribbons DW, Hughes H.
  Title
3-Hydroxybenzoate 6-hydroxylase from Pseudomonas aeruginosa.
  Journal
Biochem Biophys Res Commun 55:897-903 (1973)
DOI:10.1016/0006-291X(73)91228-X
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.24
IUBMB Enzyme Nomenclature: 1.14.13.24
ExPASy - ENZYME nomenclature database: 1.14.13.24
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.24
BRENDA, the Enzyme Database: 1.14.13.24
CAS: 51570-26-4

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Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (1493)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (322)   
   KEGG MGENES (937)   
   RefGene (233)   
Protein sequence (2953)   
   UniProt (1224)   
   SWISS-PROT (5)   
   RefSeq(pep) (1719)   
   PDBSTR (5)   
DNA sequence (2531)   
   RefSeq(nuc) (1400)   
   GenBank (568)   
   EMBL (563)   
3D Structure (5)   
   PDB (5)   
Enzyme (1)   
   UMBBD-EC (1)   
All databases (6996)   

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