KEGG   ENZYME: 1.14.13.245Help
Entry
EC 1.14.13.245              Enzyme                                 

Name
assimilatory dimethylsulfide S-monooxygenase;
dsoBCDEF (gene names)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
dimethyl sulfide,NADH:oxygen oxidoreductase (S-oxidizing)
Reaction(IUBMB)
(1) dimethyl sulfide + NADH + H+ + O2 = dimethyl sulfoxide + NAD+ + H2O [RN:R12319];
(2) dimethyl sulfoxide + NADH + H+ + O2 = dimethyl sulfone + NAD+ + H2O [RN:R12320]
Reaction(KEGG)
Substrate
dimethyl sulfide [CPD:C00580];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007];
dimethyl sulfoxide [CPD:C11143]
Product
dimethyl sulfoxide [CPD:C11143];
NAD+ [CPD:C00003];
H2O [CPD:C00001];
dimethyl sulfone [CPD:C11142]
Comment
The enzyme, studied from the bacterium Acinetobacter sp. strain 20B, is very similar to EC 1.14.13.244, phenol 2-monooxygenase (NADH). It consists of a multisubunit oxygenease component that contains the active site and a dinuclear iron center, a reductase component that contains FAD and one iron-sulfur cluster, and a regulatory component. The three components comprise five different polypeptides. The enzyme catalyses the first two steps of a dimethyl sulfide oxidation pathway in this organism.
History
EC 1.14.13.245 created 2019
Reference
1  [PMID:9345770]
  Authors
Horinouchi M, Kasuga K, Nojiri H, Yamane H, Omori T
  Title
Cloning and characterization of genes encoding an enzyme which oxidizes dimethyl  sulfide in Acinetobacter sp. strain 20B.
  Journal
FEMS Microbiol Lett 155:99-105 (1997)
DOI:10.1111/j.1574-6968.1997.tb12692.x
  Sequence
Reference
2  [PMID:26300166]
  Authors
Horinouchi M, Yoshida T, Nojiri H, Yamane H, Omori T
  Title
Polypeptide Requirement of Multicomponent Monooxygenase DsoABCDEF for Dimethyl Sulfide Oxidizing Activity.
  Journal
Biosci Biotechnol Biochem 63:1765-71 (1999)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.245
IUBMB Enzyme Nomenclature: 1.14.13.245
ExPASy - ENZYME nomenclature database: 1.14.13.245
BRENDA, the Enzyme Database: 1.14.13.245

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