KEGG ENZYME: 1.14.13.253

ENZYME: 1.14.13.253

Entry

EC 1.14.13.253              Enzyme

Name

3-demethoxyubiquinone 3-hydroxylase (NADH);
COQ7

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzoquinone,NADH:oxygen oxidoreductase (5-hydroxylating)

Reaction(IUBMB)

5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzoquinone + NADH + O2 = 3-demethylubiquinone-n + NAD+ + H2O [RN:R13408]

Reaction(KEGG)

R13408

Substrate

5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzoquinone [CPD:C17561];
NADH [CPD:C00004];
O2 [CPD:C00007]

Product

3-demethylubiquinone-n [CPD:C17562];
NAD+ [CPD:C00003];
H2O [CPD:C00001]

Comment

The enzyme, found in eukaryotes, is involved in the biosynthesis of ubiquinone. The vertebrate enzyme has no activity with 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol (cf. EC 1.14.99.60, 3-demethoxyubiquinol 3-hydroxylase). The number of isoprenoid subunits in the side chain varies in different species. The enzyme does not have any specificity concerning the length of the polyprenyl tail, and accepts tails of various lengths with similar efficiency.

History

EC 1.14.13.253 created 2024

Pathway

ec00130

Ubiquinone and other terpenoid-quinone biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K28034

3-demethoxyubiquinone 3-hydroxylase (NADH)

Genes

HSA:	10229(COQ7)

PTR:	740917(COQ7)

PPS:	100984081(COQ7)

GGO:	101139785(COQ7)

PON:	100437081(COQ7)

PPYG:

129015538(COQ7)

NLE:	100603314(COQ7)

HMH:	116462375(COQ7)

SSYN:

129468365(COQ7)

MCC:	693931(COQ7)

MCF:	102138856(COQ7)

MTHB:

126945070 126949153

MNI:	105464274(COQ7)

CSAB:

103229039(COQ7)

CATY:

105586784(COQ7)

PANU:

101007203(COQ7)

TGE:	112614185(COQ7)

MLEU:

105536674(COQ7)

RRO:	104665345(COQ7)

RBB:	108531125(COQ7)

TFN:	117080010 117097596(COQ7)

PTEH:

111524542(COQ7)

CANG:

105526551(COQ7)

CJC:	100411103(COQ7)

SBQ:	101041653(COQ7)

CIMI:

108308457(COQ7)

ANAN:

105725556(COQ7)

CSYR:

103249301(COQ7)

MMUR:

105855207(COQ7)

LCAT:

123632432(COQ7)

ERUF:

138394243(COQ7)

PCOQ:

105812990(COQ7)

OGA:	100956176(COQ7)

MMU:	12850(Coq7)

MCAL:

110298631(Coq7)

MPAH:

110329695(Coq7)

RNO:	25249(Coq7)

MCOC:

116100878(Coq7)

ANU:	117701449(Coq7)

ASYL:

127697386(Coq7)

MUN:	110554338(Coq7)

CGE:	100762279(Coq7)

MAUA:

101826192(Coq7)

PROB:

127228238(Coq7)

PLEU:

114692143(Coq7)

PMAV:

102914868(Coq7)

MORG:

121457834(Coq7)

MFOT:

126502397

AAMP:

119820040(Coq7)

CNL:	130879709(Coq7)

NGI:	103742780(Coq7)

HGL:	101700328(Coq7)

CPOC:

100735871(Coq7)

CCAN:

109684162(Coq7)

DORD:

105982039(Coq7)

DSP:	122096245(Coq7)

DMER:

138814914 138825592

PLOP:

125340639(Coq7)

NCAR:

124962460 124970408

MMMA:

107146835(Coq7)

ITI:	101966703(Coq7)

OCU:

100354177

OPI:	101535287(COQ7)

OCZ:	121152020(COQ7)

TUP:	102489453(COQ7)

GVR:	103584555 103594412(COQ7)

CFA:	479828(COQ7)

CLUD:

112640315(COQ7)

VVP:	112923363(COQ7)

VLG:	121486153(COQ7)

NPO:	129519085(COQ7)

AML:	100476648(COQ7)

UMR:	103668644(COQ7)

UAR:	123775583(COQ7)

ELK:

111156102

LLV:

125091099

MPUF:

101671618(COQ7)

MNP:	132027205(COQ7)

MLK:	131819721(COQ7)

NVS:	122895673(COQ7)

ORO:	101373671(COQ7)

EJU:	114199680(COQ7)

ZCA:	113925306 113932807(COQ7)

MLX:	118021877(COQ7)

MANO:

123844504(COQ7)

NSU:	110587979(COQ7)

LWW:	102751062(COQ7)

FCA:	101085941(COQ7)

PYU:	121019454(COQ7)

PCOO:

112853327(COQ7)

PBG:	122471612(COQ7)

PVIV:

125154583(COQ7)

LRUF:

124517941

LGF:	123588926(COQ7)

AJU:

106970545

PTG:	102960078(COQ7)

PPAD:

109278399(COQ7)

PUC:

125927928

PLEZ:

122210059(COQ7)

HHV:	120247846(COQ7)

CCRU:

144239257(COQ7)

BTA:	504771(COQ7)

BOM:	102287123(COQ7)

BIU:	109578782(COQ7)

BJV:	133238325(COQ7)

BBUB:

102391516(COQ7)

BKE:	129637791(COQ7)

BBIS:

104986522(COQ7)

CHX:	102175353(COQ7)

OAS:	101116112(COQ7)

OCAN:

138429756(COQ7)

BTAX:

128071494(COQ7)

CSUM:

138076455(COQ7)

ODA:	120875282(COQ7)

CCAD:

122433414(COQ7)

MREE:

136158500(COQ7)

OVR:	110128322(COQ7)

MBEZ:

129545413(COQ7)

SSC:	110259917(COQ7)

CFR:	102522271(COQ7)

CBAI:

105073723(COQ7)

CDK:	105091144(COQ7)

VPC:	102532466(COQ7)

BACU:

103005485(COQ7)

BMUS:

118881929(COQ7)

LVE:	103091245(COQ7)

OOR:	101269450(COQ7)

LALB:

132505872(COQ7)

GMF:	115847370(COQ7)

DDP:	132438781(COQ7)

DLE:	111163528(COQ7)

PCAD:

102994297(COQ7)

PSIU:

116740598(COQ7)

PPHC:

136134776(COQ7)

NASI:

112399161(COQ7)

ECB:	100050077(COQ7)

EPZ:	103541870(COQ7)

EAI:	106839023(COQ7)

MYB:	102250037(COQ7)

MYD:	102757865(COQ7)

MMYO:

118655651(COQ7)

MLF:	102418745(COQ7)

MDT:	132233131(COQ7)

MYUM:

139009018(COQ7)

PKL:	118702821(COQ7)

EFUS:

103286077(COQ7)

MNA:	107524366(COQ7)

DRO:	112314982(COQ7)

SHON:

119002023(COQ7)

AJM:	119055044(COQ7)

PDIC:

114512033(COQ7)

PHAS:

123806395(COQ7)

MMF:	118641864(COQ7)

PPAM:

129083722(COQ7)

HAI:	109395682(COQ7)

RFQ:	117019767(COQ7)

PALE:

102886648(COQ7)

PGIG:

120620450(COQ7)

PVP:	105303732(COQ7)

RAY:	107516842(COQ7)

MJV:	108393705(COQ7)

TOD:	119241884(COQ7)

SARA:

101549351(COQ7)

SFUM:

130045984(COQ7)

SETR:

126030943(COQ7)

LAV:	100666009(COQ7)

TMU:

101345780

ETF:	101640490(COQ7) 101654257

DNM:	101439343(COQ7)

MDO:	100025859(COQ7)

GAS:	123231215(COQ7)

SHR:	100926370(COQ7)

AFZ:

127564934

PCW:	110193527(COQ7)

TVP:	118833842 118856925(COQ7)

PBRV:

138167331(COQ7)

MLAO:

141498226(COQ7)

OAA:	100078169(COQ7)

TACU:

119942898(COQ7)

GGA:	416609(COQ7)

PCOC:

116237386(COQ7)

MGP:	100545230(COQ7)

CJO:	107320852(COQ7)

TPAI:

128079075(COQ7)

LMUT:

125700906(COQ7)

NMEL:

110405711(COQ7)

APLA:

101803000(COQ7)

AACU:

137864634(COQ7)

OJA:	118174105(COQ7)

ACYG:

106033330(COQ7)

CATA:

118249118(COQ7)

AFUL:

116495470(COQ7)

TGU:	100225057 116808957

LSR:	110475592(COQ7)

VMC:	128815318(COQ7)

VCHA:

128796141(COQ7)

AIB:	137483628(COQ7)

SCAN:

103817892(COQ7)

PMOA:

120513256(COQ7)

OTC:	121334663(COQ7)

PRUF:

121350946(COQ7)

ATRC:

139598149(COQ7)

GFR:	102038156(COQ7)

FAB:	101807270(COQ7)

OMA:	130259370(COQ7)

PHI:	102102074(COQ7)

PMAJ:

107210930(COQ7)

CCAE:

111935987(COQ7)

CCW:	104685067(COQ7)

CBRC:

103615470(COQ7)

ACOE:

138118596(COQ7)

ETL:	114058271(COQ7)

ZAB:	102069414(COQ7)

ZLE:	135454063(COQ7)

ACHL:

103800424(COQ7)

SVG:	106848739(COQ7)

MMEA:

130584279(COQ7)

HRT:	120759634(COQ7)

SATI:

136367818(COQ7)

CCIC:

134050478(COQ7)

FPG:	101923723(COQ7)

FCH:	102046043(COQ7)

FRS:	119146290(COQ7)

CCRI:

104156227(COQ7)

NNT:	104400246(COQ7)

SHAB:

115607377(COQ7)

ACUN:

113485848(COQ7)

SURA:

141950672(COQ7)

TALA:

104364209(COQ7)

ACHC:

115335959(COQ7)

HALD:

104311645(COQ7)

HLE:	104833687(COQ7)

AGEN:

126034250

HHAR:

128134944(COQ7)

BBUT:

142045108(COQ7)

GCL:

127022438

CSTI:

104549714(COQ7)

LDI:	104340867(COQ7)

MNB:	103772429(COQ7)

DPUB:

104299004(COQ7)

PPUS:

135180960(COQ7)

AVIT:

104268060(COQ7)

BRHI:

104488257(COQ7)

EGZ:	104135875(COQ7)

NNI:	104015175(COQ7)

PCRI:

104033848(COQ7)

PARX:

142062575(COQ7)

PADL:

103917639(COQ7)

AFOR:

103900902(COQ7)

FGA:	104071341(COQ7)

CBOR:

142089090(COQ7)

GSTE:

104251392(COQ7)

CBOY:

140659177(COQ7)

MAME:

142416090(COQ7)

CLV:	102085869(COQ7)

CNIC:

135994376(COQ7)

MUI:	104534500(COQ7)

PGUU:

104458800(COQ7)

PLET:

104619883(COQ7)

EHS:	104504544(COQ7)

CMAC:

104483928(COQ7)

CUCA:

104054236(COQ7)

TEO:	104373002(COQ7)

BREG:

104640761(COQ7)

GAME:

129213088(COQ7)

OHA:	104333695(COQ7)

ACAR:

104518865(COQ7)

CPEA:

104393779(COQ7)

CVF:	104287870(COQ7)

RTD:	128914267(COQ7)

CRID:

134520085(COQ7)

LMIC:

141747718(COQ7)

NARQ:

141471705(COQ7)

AAM:	106491283 106491318

AROW:

112974321(COQ7)

NPD:	112960060(COQ7)

TGT:	104569468(COQ7)

DNE:	112990408(COQ7)

SCAM:

104149756(COQ7)

ASN:	102385439(COQ7)

AMJ:	102569098(COQ7)

CPOO:

109314562(COQ7)

GGN:	109294460(COQ7)

PSS:	102449841(COQ7)

CIZ:	142021564(COQ7)

CMY:	102943213(COQ7)

CCAY:

125643509(COQ7)

LKP:	140918284(COQ7)

NDS:	141994892(COQ7)

DCC:	119863087(COQ7)

CPIC:

101946060(COQ7)

TST:	117883533(COQ7)

CABI:

116836520(COQ7)

MRV:	120373977(COQ7)

ASAO:

132781825(COQ7)

PVT:	110084008(COQ7)

SUND:

121937452(COQ7)

PBI:	103061387(COQ7)

PMUR:

107297133(COQ7)

CTIG:

120315623(COQ7)

PGUT:

117670800(COQ7)

PCAE:

139325208(COQ7)

APRI:

131185108(COQ7)

PTEX:

113438730(COQ7)

NSS:	113421888(COQ7)

VKO:	123025119(COQ7)

PMUA:

114584433(COQ7)

PRAF:

128401379(COQ7)

ZVI:	118093149(COQ7)

HCG:	128336439(COQ7)

GJA:	107114587(COQ7)

STOW:

125430758(COQ7)

EMC:	129338805(COQ7)

XLA:	447783(coq7.L)

XTR:	548822(coq7)

NPR:	108788652(COQ7)

RTEM:

120943534(COQ7)

ACAT:

141101784(COQ7)

PADS:

140335943(COQ7)

BBUF:

121008552(COQ7)

BGAR:

122945039(COQ7)

DTC:	141047713(COQ7)

PWL:	138261363(COQ7)

MUO:	115476092 115476715

GSH:	117368833(COQ7)

DRE:	559504(coq7)

SRX:	107705527 107729533 107740598

SANH:

107658455 107677563

SGH:	107581445 107583049

CCAR:

122144265(coq7)

CAUA:

113047060 113088284

CGIB:

127953679 127959884

PTET:

122341818 122346557(coq7)

LROH:

127156825 127166384(coq7)

GRF:	141347076(coq7)

OMC:	131537718 131542598(coq7)

PPRM:

120489352 120491296(coq7)

RKG:	130097230 130101345(coq7)

MAMB:

125274365(coq7)

CIDE:

127507438 127514917

CERY:

137011281(coq7)

MASI:

127446484 127450753

TROS:

130556821(coq7)

TDW:	130424724(coq7)

MANU:

129451003(coq7)

PDAB:

135717913(coq7)

IPU:

108273351

IFU:	128616196(coq7)

PHYP:

113538406(coq7)

SMEO:

124388357(coq7)

TFD:	113651161(coq7)

TVC:	132844052(coq7)

CGAR:

128526040(coq7)

NGRA:

132884776(coq7)

TRN:	134316497(coq7)

AMEX:

103039596(coq7)

CMAO:

118807810(coq7)

EEE:	113582755(coq7)

CHAR:

105899925 105903454(coq7)

SPIL:

134077220 134094756

ASAD:

121704660 121718769(coq7)

TRU:	101061366(coq7)

TFS:	130527669(coq7)

TNG:	GSTEN00022667G001

LCO:	104927353(coq7)

NCC:	104941205(coq7)

TBEN:

117483270(coq7)

CGOB:

115010405(coq7)

PGEO:

117453457(coq7)

GACU:

117537227(coq7)

EMAC:

134864171(coq7)

ELY:	117254655(coq7)

EFO:	125886086(coq7)

PLEP:

121942639(coq7)

SLUC:

116057238(coq7)

ECRA:

117961458(coq7)

ESP:	116705387(coq7)

PFLV:

114571693(coq7)

GAT:	120824825(coq7)

PPUG:

119217751(coq7)

AFB:	129096154(coq7)

CLUM:

117731721(coq7)

PSWI:

130190657(coq7)

CANA:

137793134(coq7)

CVE:	137886456(coq7)

MSAM:

119899615(coq7)

SCHU:

122873761(coq7)

EARM:

139299965(coq7)

CUD:	121507961(coq7)

SPUL:

138594997(coq7)

LMIX:

132984466(coq7)

HTC:	141807204(coq7)

ALAT:

119005622(coq7)

ASTR:

137600452(coq7)

PKLU:

139198993(coq7)

MZE:	101464636(coq7)

ONL:	100699055(coq7)

OAU:	116331258(coq7)

OLA:	101164460(coq7)

OML:	112137626(coq7)

CSAI:

133445388(coq7)

XMA:	102233310(coq7)

XCO:	114145644(coq7)

XHE:	116720819(coq7)

PRET:

103464803(coq7)

PFOR:

103131731 103131737

PLAI:

106942734 106943024(coq7)

PMEI:

106926716(coq7)

GAF:	122829255(coq7)

PPRL:

129367010(coq7)

CVG:	107089089(coq7)

CTUL:

119787116(coq7)

GMU:	124867923(coq7)

NFU:	107392846(coq7)

KMR:	108236310(coq7)

ALIM:

106524630(coq7)

NWH:	119422865(coq7)

AOCE:

111581302(coq7)

EJA:	138208153(coq7)

BFRE:

138624691(coq7)

MCEP:

125004176(coq7)

CSEM:

103384063(coq7)

POV:	109627406(coq7)

SSEN:

122770441(coq7)

SSOE:

131466347(coq7)

HHIP:

117767343(coq7)

HSP:	118121568(coq7)

PPLT:

128436668(coq7)

SMAU:

118313019(coq7)

LCF:

108875589

SDU:	111229352(coq7)

SLAL:

111666627(coq7)

XGL:	120800802(coq7)

HCQ:	109527229(coq7)

SSCV:

125969099(coq7)

SBIA:

133506588(coq7)

PEE:	133404196(coq7)

PTAO:

133476400(coq7)

BPEC:

110175712(coq7)

ENY:	140377972(coq7)

MALB:

109957908(coq7)

BSPL:

114860978(coq7)

SJO:	128375736(coq7)

SSCO:

134002044(coq7)

TTY:	137178719(coq7)

GMH:	115540897(coq7)

SASA:

100195871(coq7) 106564609

STRU:

115147278 115178313

OTW:	112263695(coq7)

OMY:	100301840(coq7) 110493493

OGO:	124003084 124015897

ONE:	115122305 115142409

OKI:	109885029 109885804

OKE:	118378985 127925690

OMM:	135524520 135536540

OCLA:

139370279 139423791

SALP:

112078131(coq7)

SNH:	120027839 120036278

SFON:

129839296(coq7)

CCLU:

121533127(coq7)

ELS:	105012220(coq7)

OEP:	134008636(coq7) 134036665

SFM:	108926746(coq7)

PKI:	111850855(coq7)

AANG:

118216174(coq7)

AROT:

135243652(coq7)

CCOG:

133114807(coq7)

LOC:	102689688(coq7)

PSPA:

121330505(coq7)

ARUT:

117418018(coq7)

PSEX:

120542801(coq7)

LCM:	102359634(COQ7)

CMK:	103178803(coq7)

RTP:	109919302(coq7)

CPLA:

122560910(coq7)

CPUN:

140464729(coq7)

HOC:	132825106(coq7)

SCAU:

119978491(coq7)

LERI:

129706604(coq7)

HAKA:

140735451(coq7)

PMRN:

116951532(COQ7)

LRJ:	133340644(COQ7)

BFO:

118425775

BBEL:

109463625

CIN:

100177404

SCLV:

120341378

CLEP:

143445950

SPU:

582622

LPIC:

129269520

LVG:

121423303

AJJ:

139960537

APLC:

110979681

ARUN:

117292731

AAMU:

139943702

AFIL:

140136341

AJC:

117118087

SKO:

100377736

PFLL:

139151736

DME:	Dmel_CG14437(Coq7)

DER:

6551686

DSE:

6612211

DSI:	Dsimw501_GD16815(Dsim_GD16815)

DYA:	Dyak_GE16772

DAN:

116655267

DSR:

110179526

DPO:

4815772

DPE:

6599934

DMN:

108153817

DWI:

6648952

DGR:

6566265

DMO:	Dmoj_GI21648

DAZ:

108618547

DNV:

108656430

DHE:

111598879

DVI:	6633575(Coq7)

CCAT:

101459590

BOD:	106626614(Coq7)

BDR:

105228853

RZE:

108363922

AOQ:

129237200

ALUD:

128857997

TDA:

119671885

MDE:

101898525

SCAC:

106095503

LCQ:

111690835

LSQ:

119603724

CVJ:	135948656(Coq7)

GFS:

119635470

ECOE:

129946605

CLON:

129618657

HIS:

119656664

AGA:	1272149 1277156

ACOZ:

120947975 120952927

AARA:

120894938 120906643

AMER:

121589595 121593168

ASTE:

118505416 118514401

AMAP:

126560789 126563096

AFUN:

125766624

AMOU:

128305883 128307004

AMRS:

128707655

ANIL:

128729247

AALI:

118458227

ADAR:

125949946

ACOS:

131269413

AAG:

5574741

AALB:

109431071 115255655

ASUA:

134207979

CQU:	CpipJ_CPIJ003762

CPII:

120422045

CBRI:

134827519

CNS:

116339408

BCOO:

119069514

LLL:

129788794

PPAP:

129807893

AME:	409224(Coq7)

ACER:

107994346

ALAB:

122715290

ADR:

102681499

AFLR:

100864727

BIM:

100746879

BBIF:

117210928

BVK:

117232906

BVAN:

117164176

BHUN:

126871814

BTER:

100652312

BAFF:

126921678

BPYO:

122567333

BPAS:

132912667

FVI:

122528519

CCAL:

108630996

OBB:

114872900

OLG:

117610031

MGEN:

117221262

APUR:

144469250(Coq7)

NMEA:

116427537

CGIG:

122398790

SOC:

105194778

MPHA:

105828708

AEC:

105151511

ACEP:

105627736

ACOC:

108694343

MZT:	108731129(Coq7)

CCOA:

108773136

TSEP:

108753187

PBAR:

105423389

VEM:

105569359

COBS:

139103555(Coq7)

TLN:	139809571(Coq7)

TAME:

143900184(Coq7)

TNY:	139768356(Coq7)

HST:

105191691

DQU:

106743714

CFO:

105250914

FEX:

115243530

PMEC:

138936407(Coq7)

LHU:	105677465(Coq7)

PGC:

109854137

OBO:

105286846

PCF:

106793329

PFUC:

122524708

VPS:

122631247

VCRB:

124426300

VVE:

124951447

NVI:

103317748

CSOL:

105362904

TPRE:

106660534

LHT:

122508586

LBD:

127281149

MDL:

103573145

CGLO:

123266599

CTYP:

141531269(Coq7)

DAM:

107045461

AGIF:

122855955

CINS:

118066480

VCAN:

122409836

CCIN:

107264013

DSM:

124415028

NPT:	124221172(Coq7)

NFB:

124183511

NLO:

107224863

NVG:

124306220

AROA:

105687513

TCA:

663384

TMOL:

138131651(Coq7)

DPA:

109540376

ESIM:

136408804

EFOR:

136345774(Coq7)

SOY:

115886729

RFG:	143190015(Coq7)

AGRG:

126742671

ATD:

109605649

CSET:

123311356

HAXR:

123678313

AGB:

108906882

LDC:

111516070

DVV:

114345681

NVL:

108569391

DCOR:

135796602(Coq7)

APLN:

108745076

PPYR:

116167236 116167784 116170929

OTU:

111424727

BMOR:

100101152

BMAN:

114250681

MSEX:

115448859

DPL:	KGM_206394

BANY:

112048374

MJU:

123873553

NIQ:

126770518

VCD:

124537594

MCIX:

123658289

PMAC:

106716070

PPOT:

106099261

PXU:

106124313

BPHI:

137927128(Coq7)

PRAP:

110993668

PBX:

123714738

PNAP:

125060049

ZCE:

119838792

CCRC:

123695651

LSIN:

126968751

AAGE:

121730185

HAW:

110381223

HZE:

124632613

TNL:

113502156

SLIU:

111353533

OFU:

114352879

ONU:

135074475

ATRA:

106132997

GMW:

113513089

ECLR:

140749732(Coq7)

PXY:

119692356

PGW:

126378902

LGLY:

125225846

CSTB:

134755685

CFUM:

141438099(Coq7)

CFEL:

113365911

CCRN:

123302782

API:	100161974(Coq7)

DNX:

107161278

RMD:

113557904

ACOO:

126836148

DVT:

126897031

BTAB:

109042464

DCI:	103510079 103522043 103522045

CLEC:

106672432

HHAL:

106680890(Coq7)

NLU:

111046073

LDA:	142322023(Coq7)

HVI:

124354561

MQU:

128997688

PHU:	Phum_PHUM477240

FOC:

113202226

TPAL:

117643205

ZNE:

110826480

CSEC:

111863586

PAME:

138712419(Coq7)

SGRE:

126271929

BROR:

134542457

IEL:

124157908

HAMR:

139691327(Coq7)

FCD:

110859823

DPX:	DAPPUDRAFT_230290

DMK:	116917707 123470270

DPZ:

124329202

AFRA:

136035429

PVM:	113810944(Coq7)

PJA:

122262998

PCHN:

125032680

PMOO:

119599466

HAME:

121855738

PCLA:

123747401(Coq7)

CQD:	128700357(Coq7)

PTRU:

123507437

SPRM:

135091882

ESN:

126995224

MNZ:

135212999

MRJ:	136826304(Coq7)

HAZT:

108664803

OOT:	143040665(Coq7)

EAF:

111696115

LSM:	121132356(Coq7)

TCF:

131880787

PPOI:

119089412 119089606 119090360

ISC:

120850197

DSV:	119431000 119434992

RMP:	119163023(Coq7)

VDE:

111243970

VJA:

111259303

GOE:

100905021

TUT:

107364149

DPTE:

113789009

DFR:	124490843(Coq7)

CSCU:

111633980

CVS:	136975793(Coq7)

PTEP:

107437621

ABRU:

129989143

UDV:

129229243

SDM:

118200937

LPOL:

106474909

PMEO:

129580970

CEL:	CELE_ZC395.2(clk-1)

CBR:	CBG_21190(Cbr-clk-1)

CRQ:	GCK72_008444

BMY:	BM_BM7374(Bma-clk-1)

LOA:	LOAG_17300

TSP:

Tsp_01363

HRO:	HELRODRAFT_114997

LGI:	LOTGIDRAFT_154620

PVUL:

126810138

PCAN:

112574402

LSAX:

138959479

BARL:

143283330

BGT:

106057461

GAE:

121378977

HRF:

124137219

HRJ:

124263798

HASI:

137284652

HCRA:

139468812

CRG:

105319133

CANU:

128166156

CVN:

111121226

OED:

125668131

MYI:

110451231

PMAX:

117331302

AIRR:

138324127

YBA:

132558099

MCAF:

127709306

MMER:

123564526

RPHI:

132715031 132722324 132741251

DPOL:

127866334

MAEA:

128211291 128211767

OBI:

106883686

OSN:

115220907

LJP:

135466379

LAK:	106152769 106156250

SMM:	Smp_180060

SHX:	MS3_00010358(COQ7_1)

OVI:	T265_15259

LLON:

135486949

NVE:

5516938

EPA:

110251795

ATEN:

116302180

AMIL:

114947374 122947718

MCAZ:

138060018

MFOO:

137972182

PDAM:

113683870

SPIS:

111325580

DGT:

114519264

XEN:

124448390

HMG:

105845958

HSY:

130649460

RES:

135692184

TAD:	TRIADDRAFT_24662

AQU:	100633914 100636897

CCLM:

134178284 134185036

CME:	CYME_CMH107C

SCE:	YOR125C(CAT5)

SEUB:

DI49_4960

SPAO:

SPAR_O02570

AGO:	AGOS_ACL162C

ERC:

Ecym_4516

KLA:	KLLA0_E02421g

KMX:	KLMA_20608(COQ7)

LTH:	KLTH0F15774g

VPO:	Kpol_1062p21

ZRO:	ZYRO0G01650g

CGR:	2890116(GVI51_K10109)

NCS:	NCAS_0H02110(NCAS0H02110)

NDI:	NDAI_0C01540(NDAI0C01540)

TPF:	TPHA_0E01690(TPHA0E01690) TPHA_0J02630(TPHA0J02630)

TBL:	TBLA_0A02760(TBLA0A02760)

TGB:	HG536_0F02700

TDL:	TDEL_0D02560(TDEL0D02560)

KAF:	KAFR_0D05080(KAFR0D05080)

KNG:	KNAG_0B04180(KNAG0B04180)

ZMK:	HG535_0C04280

SLUD:

SCDLUD_003227

DHA:	DEHA2E15114g

PIC:	PICST_73817(CAT5)

PGU:	PGUG_00842

SPAA:

SPAPADRAFT_61134

LEL:	PVL30_004614(CAT5)

CAL:	CAALFM_C501290CA(CaO19.1940)

CTP:	CTRG_05382

COT:	CORT_0E05470

CDU:	CD36_51040

CTEN:

18249471(NUF2)

CLU:	CLUG_04794

CLUS:

A9F13_27g00154

CAUR:

CJI96_0002737

ASAU:

88174694(PUMCH_003631)

PPA:	PAS_chr1-1_0169

PKZ:	C5L36_0A07340

BNN:	FOA43_002058

BBRX:

BRETT_003952

OPA:	HPODL_00180

YLI:	2911989(YALI2_E01456g)

SLB:	AWJ20_149(CAT5)

NCR:

NCU03957

NTE:	NEUTE1DRAFT87974(NEUTE1DRAFT_87974)

SMP:	10802162(SMAC4_06128)

PAN:	PODANSg955

PBEL:

QC761_402850(COQ7)

PPSD:

QC762_402850(COQ7)

PPSP:

QC763_402850(COQ7)

PPSA:

QC764_402850(COQ7)

TTT:	THITE_2110789

MTM:	MYCTH_2307394

CTHR:

CTHT_0045990

RTHE:

98128924(VTJ83DRAFT_7456)

MGR:

MGG_00959

PPEI:

PpBr36_08180

PGRI:

PgNI_08291

TMN:	UCRPA7_1018

SSCK:

SPSK_09652

FGR:	FGSG_09918

FPU:	FPSE_03096

FPOA:

FPOAC1_002996

FVN:	FVRRES_03319

FVR:	FVEG_02636

FOX:	FOXG_05505

NHE:	NECHADRAFT_69339

FFC:	NCS54_00689600

FKR:	NCS57_00729600

FMU:	J7337_005553

TRE:	TRIREDRAFT_63742

TRR:	M419DRAFT_81590

TATV:

25781522(TrAtP1_003429)

TASP:

36608915(TrAFT101_007104)

MAW:	19245463(COQ7_1)

MAJ:

MAA_05582

MBRN:

26238858(CAT5)

PCHM:

VFPPC_13403

UVI:	66065383(UV8b_04605)

CMT:

CCM_00523

AMUS:

LMH87_000848

PLJ:	28891501(PLICBS_010431)

PTKZ:

JDV02_002321(COQ7)

DCON:

63718007(DCS_05364)

VDA:	VDAG_01825

CFJ:	CFIO01_04473

CLUP:

CLUP02_10502

CHIG:

CH63R_09138

CDET:

87950330(CDEST_13830)

SAPO:

SAPIO_CDS10847

PFY:	PFICI_06651

SSL:	SS1G_04965

BFU:	BCIN_09g01250(Bccat5)

MBE:

MBM_07927

PSCO:

LY89DRAFT_653218

GLZ:	GLAREA_09708

ANI:	ANIA_04569

AFM:	AFUA_2G01890

ACT:	ACLA_092970

NFI:	NFIA_034260

AOR:	AO090011000456

ANG:	An07g05610

AFV:	AFLA_007841

ALUC:

AKAW2_11674S

ACHE:

ACHE_40488S

APUU:

APUU_70773A

PCS:	N7525_008936

PDP:	PDIP_07680

POU:	POX_g08782

PPSF:

300791119(PFLUO_LOCUS520)

TMF:	EYB26_005011

TRG:	TRUGW13939_01537

CIM:	CIMG_05595

CPW:	9693245(D8B26_000066)

URE:	UREG_06138

ABE:

ARB_02484

TVE:

TRV_07348

PBL:	PAAG_03346

PBN:	PADG_06476

AJE:	HCAG_08844

BGH:	BDBG_05133

PNO:	SNOG_06117

PTE:

PTT_06766

PTRR:

6340651(PtrM4_059500)

BZE:	COCCADRAFT_33258

BSC:	COCSADRAFT_32970

BOR:	COCMIDRAFT_36469

AALT:

CC77DRAFT_1024600

ADAC:

96082069(ACET3X_001747)

ARAB:

EKO05_0005625

ZTR:	MYCGRDRAFT_102191

PFJ:	MYCFIDRAFT_45964

FFU:	CLAFUR5_12018

CBET:

CB0940_07699

BCOM:

BAUCODRAFT_53584

NPA:	UCRNP2_1777

TML:	GSTUM_00011833001

SPO:	2541024(coq7)

SOM:	SOMG_01398(coq7)

CNE:

CND01210

CNB:

CNBD5090

CNG:	CNAG_00993

CGI:	CGB_D3440C

CDEU:

CNBG_0573

CDEC:

89987317(IAS62_000541)

CTEG:

91987165(I308_100307)

CBAS:

91980593(I312_100545)

CDEP:

91088104(L203_103894)

KMG:	30162027(I203_107461)

KNE:	92183146(IAR55_005888)

KDJ:	28965792(I303_101771)

KBI:	30208428(I302_100654)

KPIN:

30174754(I206_101645)

KSH:	87954059(IL334_001928)

KER:	91104802(V865_006001)

KEP:	91092661(L201_001989)

TMS:	TREMEDRAFT_17977

TASA:

A1Q1_00940

CCAC:

CcaHIS019_0702960(COQ7)

TVS:	TRAVEDRAFT_36352

DSQ:	DICSQDRAFT_84351

PCO:	PHACADRAFT_121888

SHS:	STEHIDRAFT_108986

HIR:	HETIRDRAFT_432275

PSQ:	PUNSTDRAFT_70311

ADL:	AURDEDRAFT_111019

FME:	FOMMEDRAFT_87899

GTR:	GLOTRDRAFT_35734

RSX:	RhiXN_02239

CCI:	CC1G_03799

PCUB:

JR316_0003261

MRR:	Moror_14717

E1B28_008584

SCM:	SCHCO_02614858(SCHCODRAFT_02614858)

CPUT:

CONPUDRAFT_79938

SLA:	SERLADRAFT_474608

WSE:	WALSEDRAFT_12608

WIC:	J056_000892

UMA:	UMAG_11797

PFP:	PFL1_02464

SGRA:

EX895_003302

MGL:

MGL_0767

MRT:

MRET_0051

MSYM:

MSY001_2122

RIE:	OCT59_003835

MBR:	MONBRDRAFT_11685

DDI:	DDB_G0280475(coq7)

DPP:	DICPUDRAFT_92759

DFA:	DFA_03563(coq7)

TBR:	Tb927.3.4890

TBG:	TbgDal_III5480

TCR:	508153.170 508183.10

LMA:	LMJF_29_2350

LIF:	LINJ_29_2460

LDO:	LDBPK_292460

LMI:	LMXM_08_29_2350

LMAT:

92514538(LSCM1_04522)

LBZ:	LBRM_29_2320

LPAN:

LPMP_292370

LOI:	92359610(LSCM4_03680)

LEIS:

94179267(GH5_03806)

LENR:

94171512(CUR178_04293)

LEIN:

94187581(JIQ42_03912)

PHET:

94286567(JKF63_00439)

NGR:	NAEGRDRAFT_61151

EHX:	EMIHUDRAFT_197688

» show all

Reference

1 [PMID:23445365]

Authors

Lu TT, Lee SJ, Apfel UP, Lippard SJ.

Title

Aging-associated enzyme human clock-1: substrate-mediated reduction of the diiron center for 5-demethoxyubiquinone hydroxylation.

Journal

Biochemistry 52:2236-44 (2013)
DOI:10.1021/bi301674p

Sequence

[hsa:10229]

Reference

2 [PMID:38425362]

Authors

Nicoll CR, Alvigini L, Gottinger A, Cecchini D, Mannucci B, Corana F, Mascotti ML, Mattevi A.

Title

In vitro construction of the COQ metabolon unveils the molecular determinants of coenzyme Q biosynthesis.

Journal

Nat Catal 7:148-160 (2024)
DOI:10.1038/s41929-023-01087-z

Other DBs

ExplorEnz - The Enzyme Database:

1.14.13.253

IUBMB Enzyme Nomenclature:

1.14.13.253

ExPASy - ENZYME nomenclature database:

1.14.13.253

BRENDA, the Enzyme Database:

1.14.13.253

All links

Protein sequence (33)   
   UniProt (8)   
   SWISS-PROT (8)   
   RefSeq(pep) (17)   
DNA sequence (20)   
   RefSeq(nuc) (19)   
   EMBL (1)   
All databases (53)   

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