KEGG   ENZYME: 1.14.13.30Help
Entry
EC 1.14.13.30               Enzyme                                 

Name
leukotriene-B4 20-monooxygenase;
leukotriene-B4 20-hydroxylase;
leucotriene-B4 omega-hydroxylase;
LTB4 20-hydroxylase;
LTB4 omega-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)
Reaction(IUBMB)
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + H+ + O2 = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP+ + H2O [RN:R03866]
Reaction(KEGG)
Substrate
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate [CPD:C02165];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
(6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate [CPD:C04853];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A heme-thiolate protein (P-450). Not identical with EC 1.14.13.34, leukotriene-E4 20-monooxygenase.
History
EC 1.14.13.30 created 1989
Pathway
ec00590  Arachidonic acid metabolism
ec01100  Metabolic pathways
Orthology
K17726  leukotriene-B4 20-monooxygenase / phylloquinone omega-hydroxylase
Genes
HSA: 4051(CYP4F3) 8529(CYP4F2)
PTR: 748117(CYP4F3) 748531(CYP4F2)
PPS: 100967411 100969141 100969847 100982619
GGO: 101125692 101135418 101136503 101151919 101152881
PON: 100434096
NLE: 100579320 100588006 100592938
MCC: 718349 719246
MCF: 102120579 102130440(CYP4F3v2) 102134301(CYP4F45)
CSAB: 103234077 103234079 103234089
RRO: 104661012 104661014 104661137
CJC: 100411160 100412575(CYP4F2)
MMU: 170716(Cyp4f13) 64385(Cyp4f14) 72054(Cyp4f18)
RNO: 266689(Cyp4f6) 290623(Cyp4f18) 56266(Cyp4f1)
CFA: 484867
FCA: 105259722
AJU: 106987569
BTA: 100295883 507016(CYP4F2) 507615(CYP4F2) 509506 534967
SSC: 100113470(CYP4F2) 100620559(CYP4F55) 110259329
LVE: 103089103
MYB: 102257438
PALE: 102889043
PHI: 102108727
DRE: 100037390(cyp4f3)
SRX: 107715173
SANH: 107688049
SGH: 107597750
CCAR: 109105400
IPU: 108274321(CYP4F66)
TRU: 101071805
LCO: 104935050(CYP4F7)
NCC: 104952154
OLA: 101170499
XMA: 102221417
PRET: 103474609
NFU: 107380885
LCF: 108892835
HCQ: 109528684
BPEC: 110153255
SASA: 106577419 106592262(CP4F3)
ELS: 105009756
SFM: 108930167
 » show all
Taxonomy
Reference
1  [PMID:3027095]
  Authors
Romano MC, Eckardt RD, Bender PE, Leonard TB, Straub KM, Newton JF.
  Title
Biochemical characterization of hepatic microsomal leukotriene B4 hydroxylases.
  Journal
J Biol Chem 262:1590-5 (1987)
Reference
2  [PMID:4044832]
  Authors
Shak S, Goldstein IM.
  Title
Leukotriene B4 omega-hydroxylase in human polymorphonuclear leukocytes. Partial purification and identification as a cytochrome P-450.
  Journal
J Clin Invest 76:1218-28 (1985)
DOI:10.1172/JCI112077
Reference
3  [PMID:2986111]
  Authors
Soberman RJ, Harper TW, Murphy RC, Austen KF.
  Title
Identification and functional characterization of leukotriene B4 20-hydroxylase of human polymorphonuclear leukocytes.
  Journal
Proc Natl Acad Sci U S A 82:2292-5 (1985)
DOI:10.1073/pnas.82.8.2292
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.30
IUBMB Enzyme Nomenclature: 1.14.13.30
ExPASy - ENZYME nomenclature database: 1.14.13.30
BRENDA, the Enzyme Database: 1.14.13.30
CAS: 90119-11-2

DBGET integrated database retrieval system