Entry
Name
phenol 2-monooxygenase (NADPH);
phenol hydroxylase;
phenol o-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
phenol,NADPH:oxygen oxidoreductase (2-hydroxylating)
Reaction(IUBMB)
phenol + NADPH + H+ + O2 = catechol + NADP+ + H2O [RN:
R00815 ]
Reaction(KEGG)
Substrate
Product
Comment
A flavoprotein (FAD). The enzyme from the fungus Trichosporon cutaneum has a broad substrate specificity, and has been reported to catalyse the hydroxylation of a variety of substituted phenols, such as fluoro-, chloro-, amino- and methyl-phenols and also dihydroxybenzenes. cf. EC
1.14.14.20 , phenol 2-monooxygenase (FADH2).
History
EC 1.14.13.7 created 1972, modified 2011, modified 2016
Pathway
ec01120 Microbial metabolism in diverse environments
Orthology
K03380 phenol 2-monooxygenase (NADPH)
Genes
CAL : CAALFM_CR07820WA(CaO19.3711) CAALFM_CR07940WA(CaO19.604)
CTP : CTRG_00423 CTRG_03102
CDU : CD36_33480 CD36_33600
NCR : NCU05188 NCU05708 NCU07916
NTE : NEUTE1DRAFT121791(NEUTE1DRAFT_121791) NEUTE1DRAFT61928(NEUTE1DRAFT_61928) NEUTE1DRAFT78296(NEUTE1DRAFT_78296)
SMP : SMAC_02070 SMAC_03046 SMAC_07153
PAN : PODANSg2532 PODANSg3801 PODANSg603 PODANSg7748
MTM : MYCTH_2119794 MYCTH_2303163
SSCK : SPSK_00425 SPSK_04049
FGR : FGSG_03199 FGSG_08228 FGSG_09110 FGSG_13839 FGSG_13983
FPU : FPSE_02824 FPSE_05978 FPSE_06369
FVR : FVEG_07692 FVEG_09986 FVEG_11003 FVEG_12251 FVEG_13906
FOX : FOXG_04525 FOXG_11855 FOXG_13286 FOXG_13497 FOXG_17384
NHE : NECHADRAFT_41156 NECHADRAFT_44538 NECHADRAFT_56594 NECHADRAFT_64650 NECHADRAFT_87341 NECHADRAFT_89551 NECHADRAFT_97987
FFC : NCS54_00493300 NCS54_00887700 NCS54_00893900 NCS54_01408300
MAW : MAC_02939 MAC_03791 MAC_05453 MAC_08552
MAJ : MAA_04220 MAA_06132 MAA_07739
CMT : CCM_03625 CCM_05662 CCM_09091
PLJ : VFPFJ_05073 VFPFJ_11745
CFJ : CFIO01_01350 CFIO01_02839 CFIO01_06230 CFIO01_07088 CFIO01_07927
CLUP : CLUP02_04436 CLUP02_09750
CHIG : CH63R_01255 CH63R_03295 CH63R_13194
SAPO : SAPIO_CDS0590 SAPIO_CDS6138 SAPIO_CDS6325 SAPIO_CDS6851 SAPIO_CDS8718
ELA : UCREL1_2808 UCREL1_2985 UCREL1_4251 UCREL1_6609 UCREL1_7737 UCREL1_9068 UCREL1_9311
PFY : PFICI_02524 PFICI_02860 PFICI_08061 PFICI_12581 PFICI_13333 PFICI_14690 PFICI_15196
SSL : SS1G_08429 SS1G_13313
BFU : BCIN_03g08120 BCIN_12g02320
PSCO : LY89DRAFT_603506 LY89DRAFT_622223 LY89DRAFT_636654 LY89DRAFT_657322 LY89DRAFT_692336
GLZ : GLAREA_03287 GLAREA_04112 GLAREA_08867 GLAREA_09785
ANI : AN0503.2 AN2075.2 AN3536.2 AN7418.2 AN8370.2 AN8592.2
AFM : AFUA_1G13660 AFUA_2G00140 AFUA_2G01580 AFUA_3G02620 AFUA_6G03490 AFUA_6G11480
ACT : ACLA_008430 ACLA_021780 ACLA_059660 ACLA_085150 ACLA_093360
NFI : NFIA_007570 NFIA_011840 NFIA_028000 NFIA_032310 NFIA_033860 NFIA_045600 NFIA_057170
AOR : AO090001000010 AO090005000923 AO090010000367 AO090012000460 AO090012000510 AO090023000432 AO090026000121 AO090026000771
ANG : ANI_1_1148034(An03g02320) ANI_1_1858184(An04g04680) ANI_1_2070074(An08g06720) ANI_1_2320104(An12g10250) ANI_1_3124014(An01g11800) ANI_1_966134(An15g07050)
AFV : AFLA_002180 AFLA_002233 AFLA_003744 AFLA_005514 AFLA_006183 AFLA_006777 AFLA_008359 AFLA_013857
ALUC : AKAW2_10434S AKAW2_30409S AKAW2_40205S AKAW2_51457A AKAW2_61332A
ACHE : ACHE_10075A ACHE_41120A ACHE_60018A ACHE_60032S ACHE_80119A
APUU : APUU_11540S APUU_50019S APUU_51273A APUU_60078A APUU_61355S
PCS : Pc13g05120 Pc13g12480 Pc16g06090 Pc20g01980
TMF : EYB26_003213 EYB26_005121 EYB26_007438
TRG : TRUGW13939_00901 TRUGW13939_01402 TRUGW13939_02567 TRUGW13939_03669 TRUGW13939_05966 TRUGW13939_06779 TRUGW13939_07862 TRUGW13939_09955
URE : UREG_04222 UREG_05983
PBL : PAAG_01548 PAAG_03627 PAAG_04128
PBN : PADG_00229 PADG_06199 PADG_07391
AJE : HCAG_00662 HCAG_06866 HCAG_07587
BGH : BDBG_01218 BDBG_08668 BDBG_09395
PNO : SNOG_01149 SNOG_04185 SNOG_10050 SNOG_13970
PTE : PTT_06930 PTT_08788 PTT_10340 PTT_19842
BZE : COCCADRAFT_110329 COCCADRAFT_111505 COCCADRAFT_32392 COCCADRAFT_88943 COCCADRAFT_97222
BSC : COCSADRAFT_115498 COCSADRAFT_169033 COCSADRAFT_180960 COCSADRAFT_203669 COCSADRAFT_93339
BOR : COCMIDRAFT_23298 COCMIDRAFT_35149 COCMIDRAFT_6415 COCMIDRAFT_8539
AALT : CC77DRAFT_1025846 CC77DRAFT_404506 CC77DRAFT_984487
PFJ : MYCFIDRAFT_135650 MYCFIDRAFT_32111
BCOM : BAUCODRAFT_124812 BAUCODRAFT_126186
NPA : UCRNP2_10125 UCRNP2_3806 UCRNP2_5277 UCRNP2_554 UCRNP2_7680 UCRNP2_8569
TML : GSTUM_00003434001 GSTUM_00005736001 GSTUM_00007918001
TASA : A1Q1_03969 A1Q1_06764 A1Q1_07864
PPL : POSPLDRAFT_101011 POSPLDRAFT_90902
TVS : TRAVEDRAFT_123403 TRAVEDRAFT_47634 TRAVEDRAFT_47635 TRAVEDRAFT_47636 TRAVEDRAFT_58730
DSQ : DICSQDRAFT_113295 DICSQDRAFT_175071 DICSQDRAFT_65759
PCO : PHACADRAFT_149799 PHACADRAFT_202149 PHACADRAFT_246963 PHACADRAFT_264124
SHS : STEHIDRAFT_103548 STEHIDRAFT_153772 STEHIDRAFT_166249 STEHIDRAFT_49341 STEHIDRAFT_53821 STEHIDRAFT_56448 STEHIDRAFT_68295 STEHIDRAFT_99702
HIR : HETIRDRAFT_152543 HETIRDRAFT_320909 HETIRDRAFT_386175 HETIRDRAFT_443851 HETIRDRAFT_459911 HETIRDRAFT_475911
ADL : AURDEDRAFT_136648 AURDEDRAFT_183516 AURDEDRAFT_75981
FME : FOMMEDRAFT_22425 FOMMEDRAFT_92013
GTR : GLOTRDRAFT_104589 GLOTRDRAFT_137955 GLOTRDRAFT_40546 GLOTRDRAFT_76869
RSX : RhiXN_04732 RhiXN_07697 RhiXN_11742
CCI : CC1G_14808 CC1G_14809
ABP : AGABI1DRAFT118718(AGABI1DRAFT_118718) AGABI1DRAFT129336(AGABI1DRAFT_129336)
ABV : AGABI2DRAFT180260(AGABI2DRAFT_180260) AGABI2DRAFT185850(AGABI2DRAFT_185850)
MRR : Moror_1977 Moror_3210 Moror_6832
SCM : SCHCO_02573393(SCHCODRAFT_02573393) SCHCO_02573396(SCHCODRAFT_02573396) SCHCO_02619840(SCHCODRAFT_02619840) SCHCO_02636849(SCHCODRAFT_02636849) SCHCO_02687836(SCHCODRAFT_02687836)
CPUT : CONPUDRAFT_164379 CONPUDRAFT_164380 CONPUDRAFT_59955 CONPUDRAFT_83128 CONPUDRAFT_85427 CONPUDRAFT_89327
SLA : SERLADRAFT_351441 SERLADRAFT_357363 SERLADRAFT_362748 SERLADRAFT_362787 SERLADRAFT_418880 SERLADRAFT_480556
UMA : UMAG_04107 UMAG_04348
MGL : MGL_4150 MGL_4156 MGL_4162
MLR : MELLADRAFT_109827 MELLADRAFT_113368 MELLADRAFT_36236 MELLADRAFT_38407
MGEO : CFI10_06160 CFI10_14990
MARL : HH196_03985 HH196_04645
CDN : BN940_06106 BN940_10251 BN940_12096
LIM : L103DPR2_02688(pcpB)
NPM : QEO92_22545 QEO92_32345
MNO : Mnod_0822 Mnod_3235 Mnod_8211
SPSE : SULPSESMR1_02017(mobA)
LALG : LentiSH36_00532(mhpA_1)
CGL : Cgl0050(Cgl0050) Cgl2681(Cgl2681)
CAMG : CAMM_01760 CAMM_12580
CMIN : NCTC10288_00046(pcpB_1)
CCYC : SCMU_34750 SCMU_39810
BFV : C628_00390 C628_13280
NFR : ERS450000_01314(pcpB_3)
MOO : BWL13_01222(mobA_2) BWL13_02299(mobA_3)
MPRT : ET475_02095 ET475_04430
MCAW : F6J84_11770 F6J84_14345
MVD : AWU67_07895 AWU67_12480
AMAU : DSM26151_30000(mobA_2)
LALL : MUN78_09535 MUN78_09615
PSEV : USB125703_00554(mobA)
GSD : M3M28_11635 M3M28_12225
GMN : GMOLON4_1800(pcpB) GMOLON4_866(mobA)
ARL : AFL94_05640 AFL94_15085
ARW : MB46_07100 MB46_18300
ARY : ATC04_02860 ATC04_12245
AAGI : NCTC2676_1_02846(pcpB_3)
ASUF : MNQ99_02535 MNQ99_17020 MNQ99_17465
ACAO : NF551_03620 NF551_07805
AAU : AAur_2032 AAur_pTC20088
AAI : AARI_11920 AARI_30840(1.14.13.-)
GAR : AOZ07_06265 AOZ07_15420
GLU : F0M17_05910 F0M17_13870 F0M17_14710 F0M17_15605
GPR : JQN66_06100 JQN66_15145
GMY : XH9_02770 XH9_10580 XH9_11585
GNC : QQS42_05945 QQS42_14285 QQS42_15135
RSA : RSal33209_1826 RSal33209_1827
KII : KocCE7_02545 KocCE7_11985
KOD : HBK84_02765 HBK84_11870
KVR : CIB50_0000835(mobA_1)
SATK : SA2016_3430 SA2016_3900
CMUA : P8192_06795 P8192_13245
PAEY : KUF55_01215 KUF55_17420
OCP : NF557_05490 NF557_12975
BLIN : BLSMQ_0802 BLSMQ_3182
DCO : SAMEA4475696_1574(pcpB)
MMAR : MODMU_2957 MODMU_2979
PHH : AFB00_24075 AFB00_30345
TBW : NCTC13354_01150(pcpB)
ASLA : NCTC11923_02459(pcpB)
MICA : P0L94_08480 P0L94_09420
» show all
Taxonomy
Reference
Authors
NAKAGAWA H, TAKEDA Y.
Title
Phenol hydroxylase.
Journal
Reference
Authors
Neujahr HY, Gaal A
Title
Phenol hydroxylase from yeast. Purification and properties of the enzyme from Trichosporon cutaneum.
Journal
Sequence
Reference
Authors
Neujahr HY, Gaal A.
Title
Phenol hydroxylase from yeast. Sulfhydryl groups in phenol hydroxylase from Trichosporon cutaneum.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 1.14.13.7
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.7