KEGG   ENZYME: 1.14.14.100
Entry
EC 1.14.14.100              Enzyme                                 

Name
dihydrosanguinarine 10-monooxygenase;
dihydrosanguinarine 10-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
dihydrosanguinarine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (10-hydroxylating)
Reaction(IUBMB)
dihydrosanguinarine + [reduced NADPH---hemoprotein reductase] + O2 = 10-hydroxydihydrosanguinarine + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R04702]
Reaction(KEGG)
R04702
Substrate
dihydrosanguinarine [CPD:C05191];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
10-hydroxydihydrosanguinarine [CPD:C05247];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein involved in benzophenanthridine alkaloid synthesis in higher plants.
History
EC 1.14.14.100 created 1999 as EC 1.14.13.56, transferred 2018 to EC 1.14.14.100
Pathway
ec00950  Isoquinoline alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Reference
1
  Authors
De-Eknamkul, W., Tanahashi, T. and Zenk, M.H.
  Title
Enzymic 10-hydroxylation and 10-O-methylation of dihydrosanguinarine in dihydrochelirubine formation by Eschscholtzia.
  Journal
Phytochemistry 31:2713-2717 (1992)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.100
IUBMB Enzyme Nomenclature: 1.14.14.100
ExPASy - ENZYME nomenclature database: 1.14.14.100
BRENDA, the Enzyme Database: 1.14.14.100
CAS: 144388-41-0

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