KEGG   ENZYME: 1.14.14.113
Entry
EC 1.14.14.113              Enzyme                                 

Name
alpha-humulene 10-hydroxylase;
CYP71BA1
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
alpha-humulene,[reduced NADPH---hemoprotein reductase]:oxygen 10-oxidoreductase
Reaction(IUBMB)
alpha-humulene + O2 + [reduced NADPH---hemoprotein reductase] = 10-hydroxy-alpha-humulene + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R09934]
Reaction(KEGG)
R09934
Substrate
alpha-humulene [CPD:C09684];
O2 [CPD:C00007];
[reduced NADPH---hemoprotein reductase] [CPD:C03024]
Product
10-hydroxy-alpha-humulene [CPD:C20229];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein. The recommended numbering of humulene gives 10-hydroxy-alpha-humulene as the product rather than 8-hydroxy-alpha-humulene as used by the reference. See {iupac/sectionF/index::Section F: Natural Product Nomenclature}.
History
EC 1.14.14.113 created 2012 as EC 1.14.13.150, transferred 2018 to EC 1.14.14.113
Orthology
K21717  alpha-humulene 10-hydroxylase
Reference
1  [PMID:20730551]
  Authors
Yu F, Okamoto S, Harada H, Yamasaki K, Misawa N, Utsumi R
  Title
Zingiber zerumbet CYP71BA1 catalyzes the conversion of alpha-humulene to 8-hydroxy-alpha-humulene in zerumbone biosynthesis.
  Journal
Cell Mol Life Sci 68:1033-40 (2011)
DOI:10.1007/s00018-010-0506-4
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.113
IUBMB Enzyme Nomenclature: 1.14.14.113
ExPASy - ENZYME nomenclature database: 1.14.14.113
BRENDA, the Enzyme Database: 1.14.14.113

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