KEGG   ENZYME: 1.14.14.118
Entry
EC 1.14.14.118              Enzyme                                 

Name
tryprostatin B 6-hydroxylase;
ftmC (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
tryprostatin B,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (6-hydroxytryprostatin B-forming)
Reaction(IUBMB)
tryprostatin B + [reduced NADPH---hemoprotein reductase] + O2 = 6-hydroxytryprostatin B + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R10321]
Reaction(KEGG)
R10321
Substrate
tryprostatin B [CPD:C20512];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
6-hydroxytryprostatin B [CPD:C20513];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein. Involved in the biosynthetic pathways of several indole alkaloids such as tryprostatins, fumitremorgins and verruculogen.
History
EC 1.14.14.118 created 2013 as EC 1.14.13.176, transferred 2018 to EC 1.14.14.118
Pathway
ec00404  Staurosporine biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K17475  tryprostatin B 6-hydroxylase
Genes
AFM: AFUA_8G00190
NFI: NFIA_093700
Reference
1  [PMID:19226505]
  Authors
Kato N, Suzuki H, Takagi H, Asami Y, Kakeya H, Uramoto M, Usui T, Takahashi S, Sugimoto Y, Osada H
  Title
Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus.
  Journal
Chembiochem 10:920-8 (2009)
DOI:10.1002/cbic.200800787
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.118
IUBMB Enzyme Nomenclature: 1.14.14.118
ExPASy - ENZYME nomenclature database: 1.14.14.118
BRENDA, the Enzyme Database: 1.14.14.118

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