KEGG   ENZYME: 1.14.14.119Help
Entry
EC 1.14.14.119              Enzyme                                 

Name
fumitremorgin C monooxygenase;
ftmG (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
fumitremorgin C,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (12alpha,13alpha-dihydroxyfumitremorgin C-forming)
Reaction(IUBMB)
fumitremorgin C + 2 [reduced NADPH---hemoprotein reductase] + 2 O2 = 12alpha,13alpha-dihydroxyfumitremorgin C + 2 [oxidized NADPH---hemoprotein reductase] + 2 H2O [RN:R10414]
Reaction(KEGG)
Substrate
fumitremorgin C [CPD:C20604];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
12alpha,13alpha-dihydroxyfumitremorgin C [CPD:C20605];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein. Involved in the biosynthetic pathway of the indole alkaloid verruculogen.
History
EC 1.14.14.119 created 2013 as EC 1.14.13.177, transferred 2018 to EC 1.14.14.119
Pathway
ec00404  Staurosporine biosynthesis
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K17826  fumitremorgin C monooxygenase
Genes
AFM: AFUA_8G00240
NFI: NFIA_093750
PCS: Pc21g15450
Taxonomy
Reference
1  [PMID:19226505]
  Authors
Kato N, Suzuki H, Takagi H, Asami Y, Kakeya H, Uramoto M, Usui T, Takahashi S, Sugimoto Y, Osada H
  Title
Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus.
  Journal
Chembiochem 10:920-8 (2009)
DOI:10.1002/cbic.200800787
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.119
IUBMB Enzyme Nomenclature: 1.14.14.119
ExPASy - ENZYME nomenclature database: 1.14.14.119
BRENDA, the Enzyme Database: 1.14.14.119

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