KEGG   ENZYME: 1.14.14.120Help
Entry
EC 1.14.14.120              Enzyme                                 

Name
dammarenediol 12-hydroxylase;
protopanaxadiol synthase;
CYP716A47
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
dammarenediol-II,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (12beta-hydroxylating)
Reaction(IUBMB)
dammarenediol-II + [reduced NADPH---hemoprotein reductase] + O2 = protopanaxadiol + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R10540]
Reaction(KEGG)
Substrate
dammarenediol II [CPD:C19829];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
protopanaxadiol [CPD:C20715];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein isolated from ginseng (Panax ginseng). Involved in the biosynthetic pathway of ginsenosides.
History
EC 1.14.14.120 created 2013 as EC 1.14.13.183, transferred 2018 to EC 1.14.14.120
Orthology
K20545  dammarenediol 12-hydroxylase
Reference
1  [PMID:22039120]
  Authors
Han JY, Kim HJ, Kwon YS, Choi YE
  Title
The Cyt P450 enzyme CYP716A47 catalyzes the formation of protopanaxadiol from dammarenediol-II during ginsenoside biosynthesis in Panax ginseng.
  Journal
Plant Cell Physiol 52:2062-73 (2011)
DOI:10.1093/pcp/pcr150
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.120
IUBMB Enzyme Nomenclature: 1.14.14.120
ExPASy - ENZYME nomenclature database: 1.14.14.120
BRENDA, the Enzyme Database: 1.14.14.120

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