Entry
Name
oryzalexin E synthase;
CYP76M6
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
ent-sandaracopimaradien-3beta-ol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (oryzalexin-E-forming)
Reaction(IUBMB)
ent-sandaracopimaradien-3beta-ol + [reduced NADPH---hemoprotein reductase] + O2 = oryzalexin E + [oxidized NADPH---hemoprotein reductase] + H2O [RN:
R11657 ]
Reaction(KEGG)
Substrate
ent-sandaracopimaradien-3beta-ol [CPD:
C21560 ];
[reduced NADPH---hemoprotein reductase] [CPD:
C03024 ];
O2 [CPD:
C00007 ]
Product
oryzalexin E [CPD:
C21561 ];
[oxidized NADPH---hemoprotein reductase] [CPD:
C03161 ];
H2O [CPD:
C00001 ]
Comment
A cytochrome P-450 (heme-thiolate) protein. Isolated from Oryza sativa (rice). Oryzalexin E is a phytoalexin.
History
EC 1.14.14.122 created 2014 as EC 1.14.13.192, transferred 2018 to EC 1.14.14.122
Pathway
ec01110 Biosynthesis of secondary metabolites
Orthology
Genes
Taxonomy
Reference
Authors
Wu Y, Wang Q, Hillwig ML, Peters RJ
Title
Picking sides: distinct roles for CYP76M6 and CYP76M8 in rice oryzalexin biosynthesis.
Journal
Sequence
Other DBs