KEGG   ENZYME: 1.14.14.123Help
Entry
EC 1.14.14.123              Enzyme                                 

Name
oryzalexin D synthase;
CYP76M8
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
ent-sandaracopimaradien-3beta-ol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (oryzalexin D forming)
Reaction(IUBMB)
ent-sandaracopimaradien-3beta-ol + [reduced NADPH---hemoprotein reductase] + O2 = oryzalexin D + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R11658]
Reaction(KEGG)
Substrate
ent-sandaracopimaradien-3beta-ol [CPD:C21560];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
oryzalexin D [CPD:C21562];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein. Isolated from Oryza sativa (rice). Oryzalexin D is a phytoalexin.
History
EC 1.14.14.123 created 2014 as EC 1.14.13.193, transferred 2018 to EC 1.14.14.123
Pathway
ec00904  Diterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K16084  ent-cassa-12,15-diene 11-hydroxylase / oryzalexin D synthase
Genes
OSA: 4329722 4329723 4341447
DOSA: Os02t0569400-01(Os02g0569400) Os02t0569900-01(Os02g0569900) Os06t0599200-01(Os06g0599200)
Taxonomy
Reference
1  [PMID:23795884]
  Authors
Wu Y, Wang Q, Hillwig ML, Peters RJ
  Title
Picking sides: distinct roles for CYP76M6 and CYP76M8 in rice oryzalexin biosynthesis.
  Journal
Biochem J 454:209-16 (2013)
DOI:10.1042/BJ20130574
  Sequence
[osa:4329722]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.123
IUBMB Enzyme Nomenclature: 1.14.14.123
ExPASy - ENZYME nomenclature database: 1.14.14.123
BRENDA, the Enzyme Database: 1.14.14.123

DBGET integrated database retrieval system