KEGG   ENZYME: 1.14.14.127Help
Entry
EC 1.14.14.127              Enzyme                                 

Name
methyl farnesoate epoxidase;
CYP15A1
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
methyl (2E,6E)-farnesoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase
Reaction(IUBMB)
methyl (2E,6E)-farnesoate + [reduced NADPH---hemoprotein reductase] + O2 = juvenile hormone III + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R08148]
Reaction(KEGG)
Substrate
methyl (2E,6E)-farnesoate [CPD:C16503];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
juvenile hormone III [CPD:C09694];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein. The enzyme, found in insects except for Lepidoptera (moths and butterflies) is specific for methyl farnesoate (cf. EC 1.14.14.128, farnesoate epoxidase) [1,2].
History
EC 1.14.14.127 created 2015 as EC 1.14.13.202, transferred 2018 to EC 1.14.14.127
Pathway
ec00981  Insect hormone biosynthesis
Orthology
K14937  methyl farnesoate epoxidase / farnesoate epoxidase
Genes
AGA: AgaP_AGAP005658
AAG: 5573424
CQU: CpipJ_CPIJ014944
AME: 551179
BIM: 100741407
BTER: 100642209
SOC: 105201474
MPHA: 105834547
AEC: 105147163 105149500
ACEP: 105626825
NVI: 100121983(Cyp15a1)
MDL: 103572873
TCA: 658858(CYP15A1)
DPA: 109538052
NVL: 108561482
BMOR: 100286798(P450)
PMAC: 106719118
PRAP: 110999807
HAW: 110370071
TNL: 113496128
PXY: 105393482
DNX: 107173974
CLEC: 106662678
 » show all
Taxonomy
Reference
1  [PMID:15024118]
  Authors
Helvig C, Koener JF, Unnithan GC, Feyereisen R.
  Title
CYP15A1, the cytochrome P450 that catalyzes epoxidation of methyl farnesoate to juvenile hormone III in cockroach corpora allata.
  Journal
Proc Natl Acad Sci U S A 101:4024-9 (2004)
DOI:10.1073/pnas.0306980101
  Sequence
Reference
2  [PMID:23586995]
  Authors
Daimon T, Shinoda T
  Title
Function, diversity, and application of insect juvenile hormone epoxidases (CYP15).
  Journal
Biotechnol Appl Biochem 60:82-91 (2013)
DOI:10.1002/bab.1058
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.127
IUBMB Enzyme Nomenclature: 1.14.14.127
ExPASy - ENZYME nomenclature database: 1.14.14.127
BRENDA, the Enzyme Database: 1.14.14.127

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