KEGG   ENZYME: 1.14.14.127
Entry
EC 1.14.14.127              Enzyme                                 
Name
methyl farnesoate epoxidase;
CYP15A1
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
methyl (2E,6E)-farnesoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase
Reaction(IUBMB)
methyl (2E,6E)-farnesoate + [reduced NADPH---hemoprotein reductase] + O2 = juvenile hormone III + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R08148]
Reaction(KEGG)
R08148
Substrate
methyl (2E,6E)-farnesoate [CPD:C16503];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
juvenile hormone III [CPD:C09694];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein. The enzyme, found in insects except for Lepidoptera (moths and butterflies) is specific for methyl farnesoate (cf. EC 1.14.14.128, farnesoate epoxidase) [1,2].
History
EC 1.14.14.127 created 2015 as EC 1.14.13.202, transferred 2018 to EC 1.14.14.127
Pathway
ec00981  Insect hormone biosynthesis
Orthology
K14937  methyl farnesoate epoxidase / farnesoate epoxidase
Genes
AGAAgaP_AGAP005658
AARA120898567
AAG5573424
AALB109400580 109404918
CQUCpipJ_CPIJ014944
CPII120418041
CNS116337601
AME551179 551632
ACER107999236 107999579
ALAB122719253 122721167
BIM100741407
BBIF117211650
BVK117235254
BVAN117153463
BTER100642209
BPYO122569627
CCAL108622763 108626525 108628064
OBB114880426 114882699
MGEN117222866 117228940
NMEA116430512 116432333
CGIG122395104 122402997
SOC105193715 105201474
MPHA105834547
AEC105147163 105149500
ACEP105617514 105626825
PBAR105428423 105432897
VEM105558159 105558997
HST105182362 105187618
DQU106745424 106751299
CFO105250281 105252412
FEX115237489 115240245
LHU105675309 105675920
PGC109853606 109859696
OBO105278352 105280475
PCF106791257 106793595
PFUC122515519 122517103
VPS122628798 122635796
NVI100115268 100121983
CSOL105360112 105365111
TPRE106655022 106660328
MDL103570493 103572873
CGLO123266720 123266763 123271251
FAS105264223 105273313
DAM107039388 107046687
AGIF122855280 122856814
CCIN107269292 107273413
TCA658858(CYP15A1)
DPA109538052
SOY115885225 115888817
ATD109600030
CSET123314899
LDC111504976
NVL108561482
APLN108737126
OTU111425794
BMOR100286798(P450)
BMAN114249593
MSEX115449469
DPLKGM_211658
BANY112044993
PMAC106719118
PPOT106104656
PXU106121159
PRAP110999807
ZCE119840891
HAW110370071
TNL113496128
SLIU111358892
OFU114359897
PXY105393482
API100160402 100162751 100169165
DNX107173974
AGS114123568 114131329
RMD113557298 113557424
BTAB109037742
DCI103505369 103519287 103523306
CLEC106662678
HHAL106685080
NLU111052581
PHUPhum_PHUM035220
FOC113202002 113205309 113218014
ZNE110840507
CSEC111866554 111868805 111871464 111871465
DMK116924346 116931639 116932049 116932050 116932816 116932985 116932987 116933272 116933273 116933274 116933275 123476951
PJA122248669 122261841
PCHN125030907 125030911
HAME121857122
PCLA123751070 123755940 123767222
PTRU123510213
HAZT108676579
EAF111710422 111716236
LSM121119927
BGT106067243
 » show all
Reference
1  [PMID:15024118]
  Authors
Helvig C, Koener JF, Unnithan GC, Feyereisen R
  Title
CYP15A1, the cytochrome P450 that catalyzes epoxidation of methyl farnesoate to juvenile hormone III in cockroach corpora allata.
  Journal
Proc Natl Acad Sci U S A 101:4024-9 (2004)
DOI:10.1073/pnas.0306980101
  Sequence
Reference
2  [PMID:23586995]
  Authors
Daimon T, Shinoda T
  Title
Function, diversity, and application of insect juvenile hormone epoxidases (CYP15).
  Journal
Biotechnol Appl Biochem 60:82-91 (2013)
DOI:10.1002/bab.1058
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.127
IUBMB Enzyme Nomenclature: 1.14.14.127
ExPASy - ENZYME nomenclature database: 1.14.14.127
BRENDA, the Enzyme Database: 1.14.14.127

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