KEGG   ENZYME: 1.14.14.127
Entry
EC 1.14.14.127              Enzyme                                 
Name
methyl farnesoate epoxidase;
CYP15A1
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
methyl (2E,6E)-farnesoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase
Reaction(IUBMB)
methyl (2E,6E)-farnesoate + [reduced NADPH---hemoprotein reductase] + O2 = juvenile hormone III + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R08148]
Reaction(KEGG)
R08148
Substrate
methyl (2E,6E)-farnesoate [CPD:C16503];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
juvenile hormone III [CPD:C09694];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein. The enzyme, found in insects except for Lepidoptera (moths and butterflies) is specific for methyl farnesoate (cf. EC 1.14.14.128, farnesoate epoxidase) [1,2].
History
EC 1.14.14.127 created 2015 as EC 1.14.13.202, transferred 2018 to EC 1.14.14.127
Pathway
ec00981  Insect hormone biosynthesis
Orthology
K14937  methyl farnesoate epoxidase / farnesoate epoxidase
Genes
AGA: AgaP_AGAP005658
AARA: 120898567
AAG: 5573424
AALB: 109400580 109404918
CQU: CpipJ_CPIJ014944
CPII: 120418041
CNS: 116337601
AME: 551179 551632
ACER: 107999236 107999579
ALAB: 122719253 122721167
BIM: 100741407
BBIF: 117211650
BVK: 117235254
BVAN: 117153463
BTER: 100642209
BPYO: 122569627
CCAL: 108622763 108626525 108628064
OBB: 114880426 114882699
MGEN: 117222866 117228940
NMEA: 116430512 116432333
CGIG: 122395104 122402997
SOC: 105193715 105201474
MPHA: 105834547
AEC: 105147163 105149500
ACEP: 105617514 105626825
PBAR: 105428423 105432897
VEM: 105558159 105558997
HST: 105182362 105187618
DQU: 106745424 106751299
CFO: 105250281 105252412
FEX: 115237489 115240245
LHU: 105675309 105675920
PGC: 109853606 109859696
OBO: 105278352 105280475
PCF: 106791257 106793595
PFUC: 122515519 122517103
VPS: 122628798 122635796
NVI: 100115268 100121983
CSOL: 105360112 105365111
TPRE: 106655022 106660328
MDL: 103570493 103572873
CGLO: 123266720 123266763 123271251
FAS: 105264223 105273313
DAM: 107039388 107046687
AGIF: 122855280 122856814
CCIN: 107269292 107273413
TCA: 658858(CYP15A1)
DPA: 109538052
SOY: 115885225 115888817
ATD: 109600030
CSET: 123314899
LDC: 111504976
NVL: 108561482
APLN: 108737126
OTU: 111425794
BMOR: 100286798(P450)
BMAN: 114249593
MSEX: 115449469
DPL: KGM_211658
BANY: 112044993
PMAC: 106719118
PPOT: 106104656
PXU: 106121159
PRAP: 110999807
ZCE: 119840891
HAW: 110370071
TNL: 113496128
SLIU: 111358892
OFU: 114359897
PXY: 105393482
API: 100160402 100162751 100169165
DNX: 107173974
AGS: 114123568 114131329
RMD: 113557298 113557424
BTAB: 109037742
DCI: 103505369 103519287 103523306
CLEC: 106662678
HHAL: 106685080
NLU: 111052581
PHU: Phum_PHUM035220
FOC: 113202002 113205309 113218014
ZNE: 110840507
CSEC: 111866554 111868805 111871464 111871465
DMK: 116924346 116931639 116932049 116932050 116932816 116932985 116932987 116933272 116933273 116933274 116933275 123476951
PJA: 122248669 122261841
PCHN: 125030907 125030911
HAME: 121857122
PCLA: 123751070 123755940 123767222
PTRU: 123510213
HAZT: 108676579
EAF: 111710422 111716236
LSM: 121119927
BGT: 106067243
 » show all
Reference
1  [PMID:15024118]
  Authors
Helvig C, Koener JF, Unnithan GC, Feyereisen R
  Title
CYP15A1, the cytochrome P450 that catalyzes epoxidation of methyl farnesoate to juvenile hormone III in cockroach corpora allata.
  Journal
Proc Natl Acad Sci U S A 101:4024-9 (2004)
DOI:10.1073/pnas.0306980101
  Sequence
[ag:AAS13464]
Reference
2  [PMID:23586995]
  Authors
Daimon T, Shinoda T
  Title
Function, diversity, and application of insect juvenile hormone epoxidases (CYP15).
  Journal
Biotechnol Appl Biochem 60:82-91 (2013)
DOI:10.1002/bab.1058
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.127
IUBMB Enzyme Nomenclature: 1.14.14.127
ExPASy - ENZYME nomenclature database: 1.14.14.127
BRENDA, the Enzyme Database: 1.14.14.127

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Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (158)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (157)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (4)   
   InterPro (4)   
All databases (174)   

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