KEGG   ENZYME: 1.14.14.127
Entry
EC 1.14.14.127              Enzyme                                 

Name
methyl farnesoate epoxidase;
CYP15A1
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
methyl (2E,6E)-farnesoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase
Reaction(IUBMB)
methyl (2E,6E)-farnesoate + [reduced NADPH---hemoprotein reductase] + O2 = juvenile hormone III + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R08148]
Reaction(KEGG)
R08148
Substrate
methyl (2E,6E)-farnesoate [CPD:C16503];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
juvenile hormone III [CPD:C09694];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein. The enzyme, found in insects except for Lepidoptera (moths and butterflies) is specific for methyl farnesoate (cf. EC 1.14.14.128, farnesoate epoxidase) [1,2].
History
EC 1.14.14.127 created 2015 as EC 1.14.13.202, transferred 2018 to EC 1.14.14.127
Pathway
ec00981  Insect hormone biosynthesis
Orthology
K14937  methyl farnesoate epoxidase / farnesoate epoxidase
Genes
AGA: AgaP_AGAP005658
AAG: 5573424
AALB: 109400580 109404918
CQU: CpipJ_CPIJ014944
AME: 551179 551632
BIM: 100741407
BTER: 100642209
CCAL: 108622763 108626525 108628064
OBB: 114880426 114882699
SOC: 105193715 105201474
MPHA: 105834547
AEC: 105147163 105149500
ACEP: 105617514 105626825
PBAR: 105428423 105432897
VEM: 105558159 105558997
HST: 105182362 105187618
DQU: 106745424 106751299
CFO: 105250281 105252412
LHU: 105675309 105675920
PGC: 109853606 109859696
OBO: 105278352 105280475
PCF: 106791257 106793595
NVI: 100115268 100121983
CSOL: 105360112 105365111
MDL: 103570493 103572873
TCA: 658858(CYP15A1)
DPA: 109538052
ATD: 109600030
NVL: 108561482
BMOR: 100286798(P450)
BMAN: 114249593
DPL: KGM_211658
PMAC: 106719118
PRAP: 110999807
HAW: 110370071
TNL: 113496128
PXY: 105393482
API: 100160402 100162751 100169165
DNX: 107173974
AGS: 114123568 114131329
RMD: 113557298 113557424
BTAB: 109037742
CLEC: 106662678
PHU: Phum_PHUM035220
ZNE: 110840507
 » show all
Reference
1  [PMID:15024118]
  Authors
Helvig C, Koener JF, Unnithan GC, Feyereisen R
  Title
CYP15A1, the cytochrome P450 that catalyzes epoxidation of methyl farnesoate to juvenile hormone III in cockroach corpora allata.
  Journal
Proc Natl Acad Sci U S A 101:4024-9 (2004)
DOI:10.1073/pnas.0306980101
  Sequence
Reference
2  [PMID:23586995]
  Authors
Daimon T, Shinoda T
  Title
Function, diversity, and application of insect juvenile hormone epoxidases (CYP15).
  Journal
Biotechnol Appl Biochem 60:82-91 (2013)
DOI:10.1002/bab.1058
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.127
IUBMB Enzyme Nomenclature: 1.14.14.127
ExPASy - ENZYME nomenclature database: 1.14.14.127
BRENDA, the Enzyme Database: 1.14.14.127

  All links  
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (71)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (70)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (4)   
   InterPro (4)   
All databases (87)   

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