KEGG   ENZYME: 1.14.14.127Help
Entry
EC 1.14.14.127              Enzyme                                 

Name
methyl farnesoate epoxidase;
CYP15A1
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
methyl (2E,6E)-farnesoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase
Reaction(IUBMB)
methyl (2E,6E)-farnesoate + [reduced NADPH---hemoprotein reductase] + O2 = juvenile hormone III + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R08148]
Reaction(KEGG)
Substrate
methyl (2E,6E)-farnesoate [CPD:C16503];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
juvenile hormone III [CPD:C09694];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein. The enzyme, found in insects except for Lepidoptera (moths and butterflies) is specific for methyl farnesoate (cf. EC 1.14.14.128, farnesoate epoxidase) [1,2].
History
EC 1.14.14.127 created 2015 as EC 1.14.13.202, transferred 2018 to EC 1.14.14.127
Pathway
ec00981  Insect hormone biosynthesis
Orthology
K14937  methyl farnesoate epoxidase / farnesoate epoxidase
Genes
AGA: AgaP_AGAP005658
AAG: 5573424
CQU: CpipJ_CPIJ014944
AME: 551179
BIM: 100741407
BTER: 100642209
SOC: 105201474
MPHA: 105834547
AEC: 105147163 105149500
ACEP: 105626825
PBAR: 105428423 105432897
HST: 105182362 105187618
DQU: 106745424 106751299
CFO: 105250281 105252412
LHU: 105675309 105675920
PGC: 109853606 109859696
OBO: 105278352 105280475
PCF: 106791257 106793595
NVI: 100121983(Cyp15a1)
MDL: 103572873
TCA: 658858(CYP15A1)
DPA: 109538052
NVL: 108561482
BMOR: 100286798(P450)
DPL: KGM_211658
PMAC: 106719118
PRAP: 110999807
HAW: 110370071
TNL: 113496128
PXY: 105393482
API: 100160402 100162751 100169165
DNX: 107173974
AGS: 114123568 114131329
CLEC: 106662678
PHU: Phum_PHUM035220 Phum_PHUM084900
ZNE: 110826700 110829837 110829838 110829839 110840507
FCD: 110841974 110842161 110843433 110843631 110845535 110849912 110850040 110852132 110852433 110853359 110856389 110856390 110857178 110857181 110857213 110857228 110857382 110857745 110861344 110862062
DPX: DAPPUDRAFT_209641 DAPPUDRAFT_239125 DAPPUDRAFT_301662 DAPPUDRAFT_310332 DAPPUDRAFT_315215 DAPPUDRAFT_47245 DAPPUDRAFT_47261
 » show all
Taxonomy
Reference
1  [PMID:15024118]
  Authors
Helvig C, Koener JF, Unnithan GC, Feyereisen R.
  Title
CYP15A1, the cytochrome P450 that catalyzes epoxidation of methyl farnesoate to juvenile hormone III in cockroach corpora allata.
  Journal
Proc Natl Acad Sci U S A 101:4024-9 (2004)
DOI:10.1073/pnas.0306980101
  Sequence
Reference
2  [PMID:23586995]
  Authors
Daimon T, Shinoda T
  Title
Function, diversity, and application of insect juvenile hormone epoxidases (CYP15).
  Journal
Biotechnol Appl Biochem 60:82-91 (2013)
DOI:10.1002/bab.1058
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.127
IUBMB Enzyme Nomenclature: 1.14.14.127
ExPASy - ENZYME nomenclature database: 1.14.14.127
BRENDA, the Enzyme Database: 1.14.14.127

  All links  
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (82)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (81)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
All databases (94)   

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