KEGG ENZYME: 1.14.14.127

ENZYME: 1.14.14.127

Entry

EC 1.14.14.127              Enzyme

Name

methyl farnesoate epoxidase;
CYP15A1

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

methyl (2E,6E)-farnesoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase

Reaction(IUBMB)

methyl (2E,6E)-farnesoate + [reduced NADPH---hemoprotein reductase] + O2 = juvenile hormone III + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R08148]

Reaction(KEGG)

R08148

Substrate

methyl (2E,6E)-farnesoate [CPD:C16503];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]

Product

juvenile hormone III [CPD:C09694];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]

Comment

A cytochrome P-450 (heme-thiolate) protein. The enzyme, found in insects except for Lepidoptera (moths and butterflies) is specific for methyl farnesoate (cf. EC 1.14.14.128, farnesoate epoxidase) [1,2].

History

EC 1.14.14.127 created 2015 as EC 1.14.13.202, transferred 2018 to EC 1.14.14.127

Pathway

ec00981

Insect hormone biosynthesis

Orthology

K14937

methyl farnesoate epoxidase / farnesoate epoxidase

Genes

CLON:

129614750

HIS:

119647701

AARA:

120898567

AMER:

121592490

ASTE:

118512764 118516377

AMAP:

126562128

AFUN:

125772139

AMOU:

128302416

AMRS:

128712866

AALI:

118466508

ACOS:

131264673

AAG:

5573424

AALB:

109400580 109404918

ASUA:

134214994

CQU:	CpipJ_CPIJ014944

CPII:

120418041

CBRI:

134831957

CNS:

116337601

BCOO:

119073268 119073855

LLL:

129791890

PPAP:

129800621

AME:	551179 551632

ACER:

107999236 107999579

ALAB:

122719253 122721167

ADR:	102678213 102681974

AFLR:

100866566 100870838

BIM:

100741407

BBIF:

117211650

BVK:

117235254

BVAN:

117153463

BHUN:

126867614

BTER:

100642209

BPYO:

122569627

BPAS:

132916590

FVI:	122530826 122533892

CCAL:

108622763 108626525 108628064

OBB:	114880426 114882699

OLG:	117600197 117600899

MGEN:

117222866 117228940

NMEA:

116430512 116432333

CGIG:

122395104 122402997

SOC:	105193715 105201474

MPHA:

105834547 105836293

AEC:	105147163 105149500

ACEP:

105617514 105626825

PBAR:

105428423 105432897

VEM:	105558159 105558997

COBS:

139103425 139112249

TLN:	139812166 139813290

HST:	105182362 105187618

DQU:	106745424 106751299

CFO:	105250281 105252412

FEX:	115237489 115240245

PMEC:

138932416 138933190

LHU:	105675309 105675920

PGC:	109853606 109859696

OBO:	105278352 105280475

PCF:	106791257 106793595

PFUC:

122515519 122517103

VPS:	122628798 122635796

VCRB:

124424609 124428312

VVE:	124948965 124956299

NVI:	100115268 100121983

CSOL:

105360112 105365111

TPRE:

106655022 106660328

LHT:

122497829

LBD:

127288702

MDL:	103570493 103572873

CGLO:

123266720 123266763 123271251

FAS:	105264223 105273313

DAM:	107039388 107046687

AGIF:

122855280 122856814

CINS:

118068554 118074777

VCAN:

122405938 122417189

CCIN:

107269292 107273413

DSM:

124407243

NPT:	124211876 124213576

NFB:	124175547 124178747

NLO:	107222571 107224051

NVG:	124297681 124300018

AROA:

105684963 105685744

TCA:	658858(CYP15A1)

TMOL:

138125021

SOY:

115888817

ATD:

109600030

CSET:

123314899

HAXR:

123673635

LDC:

111504976

DVV:

114334611

NVL:

108561482

DCOR:

135795053

APLN:

108737126

OTU:

111425794

BMOR:

100286798(P450)

BMAN:

114249593

MSEX:

115449469

DPL:	KGM_211658

BANY:

112044993

MJU:

123867953

NIQ:

126774551

VCD:

124536229

MCIX:

123659785

PMAC:

106719118

PPOT:

106104656

PXU:

106121159

BPHI:

137919564

PRAP:

110999807

PBX:

123710010

PNAP:

125048643

ZCE:

119840891

CCRC:

123694296

LSIN:

126970164

AAGE:

121738984

HAW:

110370071

HZE:

124634923

TNL:

113496128

SLIU:

111358892

OFU:

114359897

ONU:

135077543

ATRA:

106134953

GMW:

113521454

PXY:

105393482

PGW:

126372671

LGLY:

125232236

CSTB:

134745137

CFUM:

141430505

CFEL:

113375671

API:	100160402 100162751 100169165

DNX:

107173974

AGS:	114123568 114131329

RMD:	113557298 113557424

ACOO:

126838167

DVT:

126894530

BTAB:

109037742

DCI:	103505369 103523306

CLEC:

106662678

HHAL:

106685080

NLU:

111052581

HVI:	124354873 124354874 124354875 124354880 124355845 124363098

MQU:	128994102 128995641 128997231 129004845 129004882

PHU:	Phum_PHUM035220 Phum_PHUM084900

FOC:	113202002 113205309 113218014

TPAL:

117642593 117653881

ZNE:	110826700 110829837 110829838 110829839 110840507

CSEC:

111866554 111868805 111871464 111871465

PAME:

138692873 138692874 138692875 138692880 138704537 138704538 138709375 138709376 138709377 138713168

SGRE:

126267564 126272610 126272979 126272980 126273242

BROR:

134527535 134528134 134536071 134538589 134538919 134541542 134541570

IEL:	124159398 124161931 124162168 124162206 124162214 124162282 124162320 124162352 124162462 124162472 124162501 124162633 124162844 124166645 124167510 124167769 124167830 124168163

HAMR:

139692489 139695233 139697662 139697734 139697736 139697743 139697823 139697864 139697891 139698009 139698988 139700723

FCD:	110843631 110853333

DPX:	DAPPUDRAFT_194538 DAPPUDRAFT_301662 DAPPUDRAFT_301663 DAPPUDRAFT_309471 DAPPUDRAFT_310332 DAPPUDRAFT_315215 DAPPUDRAFT_43213 DAPPUDRAFT_47245 DAPPUDRAFT_47355

DMK:	116924346 116931639 116932049 116932050 116932816 116932985 116932987 116933272 116933273 116933274 116933275 123476951

DPZ:	124334806 124348507 124349633 124349645 124349655 124349657 124349659 124349661 124349667 124349701 124350998

AFRA:

136036275 136036504 136041967

PVM:	113822977 113828909

PJA:	122248669 122261841

PCHN:

125030907 125030911

PMOO:

119572207 119572209 119572210

HAME:

121857122

PCLA:

123751070 123755940 123767222

CQD:	128700061 128700072 128700083 128703296 138851768

PTRU:

123510213

ESN:	126982377 126996066

MNZ:

135201612

MRJ:	136849924 136849925

PORN:

139747950

HAZT:

108676579

EAF:	111710422 111716236

LSM:

121119927

TCF:	131885335 131888931 131892864

PPOI:

119089751 119091396 119101642 119102852 119104409 119104475 119104495 119104602 119104834 119104835 119104836 119104837 119104838 119104840 119107626 119108650 119109044 119109052 119110551 119110590

LSAX:

138946881

» show all

Reference

1 [PMID:15024118]

Authors

Helvig C, Koener JF, Unnithan GC, Feyereisen R

Title

CYP15A1, the cytochrome P450 that catalyzes epoxidation of methyl farnesoate to juvenile hormone III in cockroach corpora allata.

Journal

Proc Natl Acad Sci U S A 101:4024-9 (2004)
DOI:10.1073/pnas.0306980101

Sequence

[ag:AAS13464]

Reference

2 [PMID:23586995]

Authors

Daimon T, Shinoda T

Title

Function, diversity, and application of insect juvenile hormone epoxidases (CYP15).

Journal

Biotechnol Appl Biochem 60:82-91 (2013)
DOI:10.1002/bab.1058

Other DBs

ExplorEnz - The Enzyme Database:

1.14.14.127

IUBMB Enzyme Nomenclature:

1.14.14.127

ExPASy - ENZYME nomenclature database:

1.14.14.127

BRENDA, the Enzyme Database:

1.14.14.127

All links

Gene (1)   
   RefGene (1)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (5)   
   InterPro (5)   
All databases (8)   

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