Entry
Name
farnesoate epoxidase;
CYP15C1
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
(2E,6E)-farnesoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase
Reaction(IUBMB)
(2E,6E)-farnesoate + [reduced NADPH---hemoprotein reductase] + O2 = juvenile-hormone-III carboxylate + [oxidized NADPH---hemoprotein reductase] + H2O [RN:
R10925 ]
Reaction(KEGG)
Substrate
(2E,6E)-farnesoate [CPD:
C16502 ];
[reduced NADPH---hemoprotein reductase] [CPD:
C03024 ];
O2 [CPD:
C00007 ]
Product
juvenile-hormone-III carboxylate [CPD:
C16504 ];
[oxidized NADPH---hemoprotein reductase] [CPD:
C03161 ];
H2O [CPD:
C00001 ]
Comment
A cytochrome P-450 (heme-thiolate) protein. The enzyme, found in Lepidoptera (moths and butterflies), is specific for farnesoate (cf. EC
1.14.14.127 , methyl farnesoate epoxidase) [1,2]. It is involved in the synthesis of juvenile hormone.
History
EC 1.14.14.128 created 2015 as EC 1.14.13.203, transferred 2018 to EC 1.14.14.128
Pathway
ec00981 Insect hormone biosynthesis
Orthology
K14937 methyl farnesoate epoxidase / farnesoate epoxidase
Genes
ASTE : 118512764 118516377
AALB : 109400580 109404918
BCOO : 119066619 119073268 119073855 119083868
ACER : 107999236 107999579
ALAB : 122719253 122721167
CCAL : 108622763 108626525 108628064
MGEN : 117222866 117228940
NMEA : 116430512 116432333
CGIG : 122395104 122402997
ACEP : 105617514 105626825
PBAR : 105428423 105432897
PFUC : 122515519 122517103
CSOL : 105360112 105365111
TPRE : 106655022 106660328
CGLO : 123266720 123266763 123271251
AGIF : 122855280 122856814
CCIN : 107269292 107273413
API : 100160402 100162751 100169165
DCI : 103505369 103519287 103523306
FOC : 113202002 113205309 113218014
TPAL : 117642593 117653881
CSEC : 111866554 111868805 111871464 111871465
DMK : 116924346 116931639 116932049 116932050 116932816 116932985 116932987 116933272 116933273 116933274 116933275 123476951
PCHN : 125030907 125030911
PCLA : 123751070 123755940 123767222
PPOI : 119089751 119091396 119095793 119095804 119101642 119102852 119104409 119104475 119104495 119104602 119104834 119104835 119104836 119104837 119104838 119104840 119107626 119108650 119109044 119109052 119110551 119110590
» show all
Taxonomy
Reference
Authors
Daimon T, Kozaki T, Niwa R, Kobayashi I, Furuta K, Namiki T, Uchino K, Banno Y, Katsuma S, Tamura T, Mita K, Sezutsu H, Nakayama M, Itoyama K, Shimada T, Shinoda T
Title
Precocious metamorphosis in the juvenile hormone-deficient mutant of the silkworm, Bombyx mori.
Journal
Sequence
Reference
Authors
Daimon T, Shinoda T
Title
Function, diversity, and application of insect juvenile hormone epoxidases (CYP15).
Journal
Other DBs