KEGG ENZYME: 1.14.14.128

ENZYME: 1.14.14.128

Entry

EC 1.14.14.128 Enzyme

Name

farnesoate epoxidase;
CYP15C1

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

(2E,6E)-farnesoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase

Reaction(IUBMB)

(2E,6E)-farnesoate + [reduced NADPH---hemoprotein reductase] + O2 = juvenile-hormone-III carboxylate + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R10925]

Reaction(KEGG)

R10925

Substrate

(2E,6E)-farnesoate [CPD:C16502];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]

Product

juvenile-hormone-III carboxylate [CPD:C16504];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]

Comment

A cytochrome P-450 (heme-thiolate) protein. The enzyme, found in Lepidoptera (moths and butterflies), is specific for farnesoate (cf. EC 1.14.14.127, methyl farnesoate epoxidase) [1,2]. It is involved in the synthesis of juvenile hormone.

History

EC 1.14.14.128 created 2015 as EC 1.14.13.203, transferred 2018 to EC 1.14.14.128

Pathway

ec00981

Insect hormone biosynthesis

Orthology

K14937

methyl farnesoate epoxidase / farnesoate epoxidase

Genes

AGA:	AgaP_AGAP005658

AAG:

5573424

AALB:

109400580 109404918

CQU:	CpipJ_CPIJ014944

AME:	551179 551632

BIM:

100741407

BTER:

100642209

CCAL:

108622763 108626525 108628064

OBB:	114880426 114882699

SOC:	105193715 105201474

MPHA:

105834547

AEC:	105147163 105149500

ACEP:

105617514 105626825

PBAR:

105428423 105432897

VEM:	105558159 105558997

HST:	105182362 105187618

DQU:	106745424 106751299

CFO:	105250281 105252412

LHU:	105675309 105675920

PGC:	109853606 109859696

OBO:	105278352 105280475

PCF:	106791257 106793595

NVI:	100115268 100121983

CSOL:

105360112 105365111

MDL:	103570493 103572873

TCA:	658858(CYP15A1)

DPA:

109538052

ATD:

109600030

NVL:

108561482

BMOR:

100286798(P450)

BMAN:

114249593

DPL:	KGM_211658

PMAC:

PRAP:

HAW:

TNL:

PXY:

API:	100160402 100162751 100169165

DNX:

107173974

AGS:	114123568 114131329

RMD:	113557298 113557424

BTAB:

109037742

CLEC:

106662678

PHU:	Phum_PHUM035220

ZNE:

110840507

» show all

Reference

1 [PMID:22412378]

Authors

Daimon T, Kozaki T, Niwa R, Kobayashi I, Furuta K, Namiki T, Uchino K, Banno Y, Katsuma S, Tamura T, Mita K, Sezutsu H, Nakayama M, Itoyama K, Shimada T, Shinoda T

Title

Precocious metamorphosis in the juvenile hormone-deficient mutant of the silkworm, Bombyx mori.

Journal

PLoS Genet 8:e1002486 (2012)
DOI:10.1371/journal.pgen.1002486

Sequence

[bmor:100286798]

Reference

2 [PMID:23586995]

Authors

Daimon T, Shinoda T

Title

Function, diversity, and application of insect juvenile hormone epoxidases (CYP15).