KEGG ENZYME: 1.14.14.128

ENZYME: 1.14.14.128

Entry

EC 1.14.14.128              Enzyme

Name

farnesoate epoxidase;
CYP15C1

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

(2E,6E)-farnesoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase

Reaction(IUBMB)

(2E,6E)-farnesoate + [reduced NADPH---hemoprotein reductase] + O2 = juvenile-hormone-III carboxylate + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R10925]

Reaction(KEGG)

R10925

Substrate

(2E,6E)-farnesoate [CPD:C16502];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]

Product

juvenile-hormone-III carboxylate [CPD:C16504];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]

Comment

A cytochrome P-450 (heme-thiolate) protein. The enzyme, found in Lepidoptera (moths and butterflies), is specific for farnesoate (cf. EC 1.14.14.127, methyl farnesoate epoxidase) [1,2]. It is involved in the synthesis of juvenile hormone.

History

EC 1.14.14.128 created 2015 as EC 1.14.13.203, transferred 2018 to EC 1.14.14.128

Pathway

ec00981

Insect hormone biosynthesis

Orthology

K14937

methyl farnesoate epoxidase / farnesoate epoxidase

Genes

HIS:

119647701

AGA:	AgaP_AGAP005658

AARA:

120898567

ASTE:

118512764 118516377

AAG:

5573424

AALB:

109400580 109404918

CQU:	CpipJ_CPIJ014944

CPII:

120418041

CNS:

116337601

BCOO:

119066619 119073268 119073855 119083868

AME:	551179 551632

ACER:

107999236 107999579

ALAB:

122719253 122721167

BIM:

100741407

BBIF:

117211650

BVK:

117235254

BVAN:

117153463

BTER:

100642209

BPYO:

122569627

CCAL:

108622763 108626525 108628064

OBB:	114880426 114882699

MGEN:

117222866 117228940

NMEA:

116430512 116432333

CGIG:

122395104 122402997

SOC:	105193715 105201474

MPHA:

105834547

AEC:	105147163 105149500

ACEP:

105617514 105626825

PBAR:

105428423 105432897

VEM:	105558159 105558997

HST:	105182362 105187618

DQU:	106745424 106751299

CFO:	105250281 105252412

FEX:	115237489 115240245

LHU:	105675309 105675920

PGC:	109853606 109859696

OBO:	105278352 105280475

PCF:	106791257 106793595

PFUC:

122515519 122517103

VPS:	122628798 122635796

NVI:	100115268 100121983

CSOL:

105360112 105365111

TPRE:

106655022 106660328

MDL:	103570493 103572873

CGLO:

123266720 123266763 123271251

FAS:	105264223 105273313

DAM:	107039388 107046687

AGIF:

122855280 122856814

CCIN:

107269292 107273413

TCA:	658858(CYP15A1)

DPA:

109538052

SOY:	115885225 115888817

ATD:

109600030

CSET:

123314899

LDC:

111504976

NVL:

108561482

APLN:

108737126

OTU:

111425794

BMOR:

100286798(P450)

BMAN:

114249593

MSEX:

115449469

DPL:	KGM_211658

BANY:

112044993

PMAC:

106719118

PPOT:

106104656

PXU:

106121159

PRAP:

110999807

ZCE:

119840891

HAW:

110370071

TNL:

113496128

SLIU:

111358892

OFU:

114359897

PXY:

105393482

API:	100160402 100162751 100169165

DNX:

107173974

AGS:	114123568 114131329

RMD:	113557298 113557424

BTAB:

109037742

DCI:	103505369 103519287 103523306

CLEC:

106662678

HHAL:

106685080

NLU:

111052581

PHU:	Phum_PHUM035220

FOC:	113202002 113205309 113218014

TPAL:

117642593 117653881

ZNE:

110840507

CSEC:

111866554 111868805 111871464 111871465

DMK:	116924346 116931639 116932049 116932050 116932816 116932985 116932987 116933272 116933273 116933274 116933275 123476951

PJA:	122248669 122261841

PCHN:

125030907 125030911

HAME:

121857122

PCLA:

123751070 123755940 123767222

PTRU:

123510213

HAZT:

108676579

EAF:	111710422 111716236

LSM:

121119927

PPOI:

119089751 119091396 119095793 119095804 119101642 119102852 119104409 119104475 119104495 119104602 119104834 119104835 119104836 119104837 119104838 119104840 119107626 119108650 119109044 119109052 119110551 119110590

BGT:

106067243

» show all

Reference

1 [PMID:22412378]

Authors

Daimon T, Kozaki T, Niwa R, Kobayashi I, Furuta K, Namiki T, Uchino K, Banno Y, Katsuma S, Tamura T, Mita K, Sezutsu H, Nakayama M, Itoyama K, Shimada T, Shinoda T

Title

Precocious metamorphosis in the juvenile hormone-deficient mutant of the silkworm, Bombyx mori.

Journal

PLoS Genet 8:e1002486 (2012)
DOI:10.1371/journal.pgen.1002486

Sequence

[bmor:100286798]

Reference

2 [PMID:23586995]

Authors

Daimon T, Shinoda T

Title

Function, diversity, and application of insect juvenile hormone epoxidases (CYP15).