KEGG   ENZYME: 1.14.14.128
Entry
EC 1.14.14.128              Enzyme                                 
Name
farnesoate epoxidase;
CYP15C1
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
(2E,6E)-farnesoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase
Reaction(IUBMB)
(2E,6E)-farnesoate + [reduced NADPH---hemoprotein reductase] + O2 = juvenile-hormone-III carboxylate + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R10925]
Reaction(KEGG)
R10925
Substrate
(2E,6E)-farnesoate [CPD:C16502];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
juvenile-hormone-III carboxylate [CPD:C16504];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein. The enzyme, found in Lepidoptera (moths and butterflies), is specific for farnesoate (cf. EC 1.14.14.127, methyl farnesoate epoxidase) [1,2]. It is involved in the synthesis of juvenile hormone.
History
EC 1.14.14.128 created 2015 as EC 1.14.13.203, transferred 2018 to EC 1.14.14.128
Pathway
ec00981  Insect hormone biosynthesis
Orthology
K14937  methyl farnesoate epoxidase / farnesoate epoxidase
Genes
CLON129614750
HIS119647701
AARA120898567
AMER121592490
ASTE118512764 118516377
AFUN125772139
AMOU128302416
AALI118466508
AAG5573424
AALB109400580 109404918
CQUCpipJ_CPIJ014944
CPII120418041
CNS116337601
BCOO119066619 119073268 119073855 119083868
AME551179 551632
ACER107999236 107999579
ALAB122719253 122721167
ADR102678213 102681974
AFLR100866566 100870838
BIM100741407
BBIF117211650
BVK117235254
BVAN117153463
BTER100642209
BPYO122569627
BPAS132916590
FVI122530826 122533892
CCAL108622763 108626525 108628064
OBB114880426 114882699
OLG117600197 117600899
MGEN117222866 117228940
NMEA116430512 116432333
CGIG122395104 122402997
SOC105193715 105201474
MPHA105834547
AEC105147163 105149500
ACEP105617514 105626825
PBAR105428423 105432897
VEM105558159 105558997
HST105182362 105187618
DQU106745424 106751299
CFO105250281 105252412
FEX115237489 115240245
LHU105675309 105675920
PGC109853606 109859696
OBO105278352 105280475
PCF106791257 106793595
PFUC122515519 122517103
VPS122628798 122635796
VCRB124424609 124428312
VVE124948965 124956299
NVI100115268 100121983
CSOL105360112 105365111
TPRE106655022 106660328
LHT122497829
LBD127288702
MDL103570493 103572873
CGLO123266720 123266763 123271251
FAS105264223 105273313
DAM107039388 107046687
AGIF122855280 122856814
CINS118068554 118074777
VCAN122405938 122417189
CCIN107269292 107273413
DSM124407243
NPT124211876 124213576
NFB124175547 124178747
NLO107222571 107224051
NVG124297681 124300018
AROA105684963 105685744
TCA658858(CYP15A1)
SOY115888817
ATD109600030
CSET123314899
LDC111504976
NVL108561482
APLN108737126
OTU111425794
BMOR100286798(P450)
BMAN114249593
MSEX115449469
DPLKGM_211658
BANY112044993
MJU123867953
NIQ126774551
VCD124536229
MCIX123659785
PMAC106719118
PPOT106104656
PXU106121159
PRAP110999807
PBX123710010
PNAP125048643
ZCE119840891
CCRC123694296
LSIN126970164
HAW110370071
HZE124634923
TNL113496128
SLIU111358892
OFU114359897
PXY105393482
PGW126372671
CFEL113375671
API100160402 100162751 100169165
DNX107173974
AGS114123568 114131329
RMD113557298 113557424
ACOO126838167
DVT126894530
BTAB109037742
DCI103505369 103523306
CLEC106662678
HHAL106685080
NLU111052581
HVI124354873 124354874 124354875 124354880 124355845 124363098
MQU128994102 128995641 129004845 129004882
PHUPhum_PHUM035220
FOC113202002 113205309 113218014
TPAL117642593 117653881
ZNE110840507
CSEC111866554 111868805 111871464 111871465
SGRE126267564 126272610 126272979 126272980 126273242
IEL124159398 124161931 124162168 124162206 124162214 124162282 124162320 124162352 124162462 124162472 124162501 124162633 124162844 124166645 124167510 124167769 124167830 124168163
DPXDAPPUDRAFT_301663 DAPPUDRAFT_315215
DMK116924346 116931639 116932049 116932050 116932816 116932985 116932987 116933272 116933273 116933274 116933275 123476951
DPZ124349645 124349655 124349661
PJA122248669 122261841
PCHN125030907 125030911
HAME121857122
PCLA123751070 123755940 123767222
CQD128700072 128700083 128703296 128703656
PTRU123510213
ESN126982377 126996066
HAZT108676579
EAF111710422 111716236
LSM121119927
TCF131885335 131888931 131892864
PPOI119089751 119091396 119101642 119102852 119104409 119104475 119104495 119104602 119104834 119104835 119104836 119104837 119104838 119104840 119107626 119108650 119109044 119109052 119110551 119110590
BGT106067243
 » show all
Reference
1  [PMID:22412378]
  Authors
Daimon T, Kozaki T, Niwa R, Kobayashi I, Furuta K, Namiki T, Uchino K, Banno Y, Katsuma S, Tamura T, Mita K, Sezutsu H, Nakayama M, Itoyama K, Shimada T, Shinoda T
  Title
Precocious metamorphosis in the juvenile hormone-deficient mutant of the silkworm, Bombyx mori.
  Journal
PLoS Genet 8:e1002486 (2012)
DOI:10.1371/journal.pgen.1002486
  Sequence
[bmor:100286798]
Reference
2  [PMID:23586995]
  Authors
Daimon T, Shinoda T
  Title
Function, diversity, and application of insect juvenile hormone epoxidases (CYP15).
  Journal
Biotechnol Appl Biochem 60:82-91 (2013)
DOI:10.1002/bab.1058
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.128
IUBMB Enzyme Nomenclature: 1.14.14.128
ExPASy - ENZYME nomenclature database: 1.14.14.128
BRENDA, the Enzyme Database: 1.14.14.128

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