KEGG   ENZYME: 1.14.14.129
Entry
EC 1.14.14.129              Enzyme                                 
Name
long-chain acyl-CoA omega-monooxygenase;
long-chain acyl-CoA omega-hydroxylase;
CYP86A22 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
long-chain acyl-CoA,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (omega-hydroxylating)
Reaction(IUBMB)
(1) oleoyl-CoA + [reduced NADPH---hemoprotein reductase] + O2 = 18-hydroxyoleoyl-CoA + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R10999];
(2) linoleoyl-CoA + [reduced NADPH---hemoprotein reductase] + O2 = 18-hydroxylinoleoyl-CoA + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R11000]
Reaction(KEGG)
R10999 R11000
Substrate
oleoyl-CoA [CPD:C00510];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007];
linoleoyl-CoA [CPD:C02050]
Product
18-hydroxyoleoyl-CoA [CPD:C21005];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001];
18-hydroxylinoleoyl-CoA [CPD:C21006]
Comment
A cytochrome P-450 (heme-thiolate) protein. The enzymes from solanaceous plants are involved in the biosynthesis of stigmatic estolide, a lipid-based polyester that forms a major component of the exudate.
History
EC 1.14.14.129 created 2015 as EC 1.14.13.204, transferred 2018 to EC 1.14.14.129
Orthology
K20544  long-chain acyl-CoA omega-monooxygenase
Genes
SLY: 101254719
SPEN: 107028839
SOT: 102594638
SSTN: 125841229
CANN: 107865299
LBB: 132634916
NTA: 107771909 107811390
NSY: 104243883
NTO: 104103878
NAU: 109220597
INI: 109147653
ITR: 116000278
SIND: 105157979
OEU: 111398498 111407574
EGT: 105956908 105973796
SSPL: 121768943 121772216 121789206
SMIL: 130994853
APAN: 127243158 127250219
RVL: 131333385
ATRI: 130798317 130799665
NCOL: 116253952
 » show all
Reference
1  [PMID:19940120]
  Authors
Han J, Clement JM, Li J, King A, Ng S, Jaworski JG
  Title
The cytochrome P450 CYP86A22 is a fatty acyl-CoA omega-hydroxylase essential for Estolide synthesis in the stigma of Petunia hybrida.
  Journal
J Biol Chem 285:3986-96 (2010)
DOI:10.1074/jbc.M109.050765
  Sequence
[ag:AAZ39642]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.129
IUBMB Enzyme Nomenclature: 1.14.14.129
ExPASy - ENZYME nomenclature database: 1.14.14.129
BRENDA, the Enzyme Database: 1.14.14.129

  All links  
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (3)   
   KEGG REACTION (2)   
   KEGG RCLASS (1)   
Gene (30)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (29)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
DNA sequence (2)   
   GenBank (2)   
Protein domain (4)   
   InterPro (4)   
All databases (49)   

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