KEGG   ENZYME: 1.14.14.130
Entry
EC 1.14.14.130              Enzyme                                 
Name
laurate 7-monooxygenase;
CYP703A2 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
dodecanoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (7-hydroxylating)
Reaction(IUBMB)
dodecanoate + [reduced NADPH---hemoprotein reductase] + O2 = 7-hydroxydodecanoate + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R11054]
Reaction(KEGG)
R11054
Substrate
dodecanoate [CPD:C02679];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
7-hydroxydodecanoate [CPD:C21080];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein found in plants. The enzyme is involved in the synthesis of sporopollenin - a complex polymer found at the outer layer of spores and pollen. It can also act on decanoate (C10), myristate (C14), and palmitate (C16) with lower activity. The enzyme also produces a small amount of products that are hydroxylated at neighboring positions (C-6, C-8 and C-9).
History
EC 1.14.14.130 created 2015 as EC 1.14.13.206, transferred 2018 to EC 1.14.14.130
Orthology
K20496  laurate 7-monooxygenase
Genes
ATHAT1G01280(CYP703A2)
ALY9328138
CRB17896796
CSAT104738665 104754273 104778519
EUSEUTSA_v10007395mg
BRP103844638
BNA106370068 106400415 106400422
BOE106293335
RSZ108853661
THJ104825880
CPAP110811031
CIT102625867
CICCICLE_v10023470mg
PVY116121534 116121561
MINC123222697
TCC18613966
GRA105762440
GHI107947528 107949243
GAB108477801
DZI111305969
EGR104443225
GMX100789889
GSJ114378926
PVUPHAVU_011G159600g
VRA106752700
VAR108339159
VUN114170177 114170386
CCAJ109806212
APRC113865136
MTRMTR_7g087520
CAM101514759
LJALj3g3v0428480.1(Lj3g3v0428480.1)
ADU107478471
AIP107634316
AHF112737919 112790061
LANG109363395
FVE101293350
RCN112169376
PPER18787141
PMUM103332232
PAVI110757680
PDUL117618316
MDM114823871
PXB103929347
ZJU107423645
MNT21406259
CSV101205312
CMO103483180
BHJ120070266
MCHA111016260
CMAX111479555
CMOS111431947
CPEP111790097
RCU8282130
JCU105642840
HBR110653613
MESC110614660
POP7497255
PEU105124757
PALZ118063450
JRE108989252
QSU111989342
QLO115983998
TWL119981982
VVI100253484
VRI117932706
SLY101265072
SPEN107032022
SOT102601340
CANN107845939
NTA107788932 107814441
NSY104217226
NTO104085251
NAU109231543
INI109155042
ITR115995652
SIND105173745
OEU111411946 111411948
EGT105963913
SSPL121751700 121792397
HAN110863788
ECAD122590472
LSV111894621
CCAV112526455
DCR108208274
CSIN114323145
BVG104882800
SOE110785044
CQI110713969 110725131
NNU104610254
MING122065199
TSS122639703
PSOM113286310 113332658
NCOL116264350
OSA4344594
DOSAOs08t0131100-01(Os08g0131100)
OBR102704827
BDI112268508
TDC119331949 119340947
TAES123147446 123157915 123165638
TUA125521741
SBI8074081
ZMA100282873
SITA101785968
SVS117860598
PVIR120677639 120711322
PHAI112898024
PDA120107104
EGU105059962
MUS103995628
DCT110114706
PEQ110026608
AOF109844353
ATR18427181
SMOSELMODRAFT_144382(CYP703C2_v2) SELMODRAFT_168652(CYP703C1_v2) SELMODRAFT_229947(CYP703C1) SELMODRAFT_74166(CYP703C2)
PPP112284522
 » show all
Reference
1  [PMID:17496121]
  Authors
Morant M, Jorgensen K, Schaller H, Pinot F, Moller BL, Werck-Reichhart D, Bak S
  Title
CYP703 is an ancient cytochrome P450 in land plants catalyzing in-chain hydroxylation of lauric acid to provide building blocks for sporopollenin synthesis in pollen.
  Journal
Plant Cell 19:1473-87 (2007)
DOI:10.1105/tpc.106.045948
  Sequence
[ath:AT1G01280]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.130
IUBMB Enzyme Nomenclature: 1.14.14.130
ExPASy - ENZYME nomenclature database: 1.14.14.130
BRENDA, the Enzyme Database: 1.14.14.130

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