KEGG   ENZYME: 1.14.14.130
Entry
EC 1.14.14.130              Enzyme                                 

Name
laurate 7-monooxygenase;
CYP703A2 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
dodecanoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (7-hydroxylating)
Reaction(IUBMB)
dodecanoate + [reduced NADPH---hemoprotein reductase] + O2 = 7-hydroxydodecanoate + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R11054]
Reaction(KEGG)
R11054
Substrate
dodecanoate [CPD:C02679];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
7-hydroxydodecanoate [CPD:C21080];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein found in plants. The enzyme is involved in the synthesis of sporopollenin - a complex polymer found at the outer layer of spores and pollen. It can also act on decanoate (C10), myristate (C14), and palmitate (C16) with lower activity. The enzyme also produces a small amount of products that are hydroxylated at neighboring positions (C-6, C-8 and C-9).
History
EC 1.14.14.130 created 2015 as EC 1.14.13.206, transferred 2018 to EC 1.14.14.130
Orthology
K20496  laurate 7-monooxygenase
Genes
ATH: AT1G01280(CYP703A2)
ALY: 9328138
CRB: 17896796
CSAT: 104738665 104754273 104778519
EUS: EUTSA_v10007395mg
BRP: 103844638
BNA: 106370068 106400415 106400422
BOE: 106293335
RSZ: 108853661
THJ: 104825880
CPAP: 110811031
CIT: 102625867
TCC: 18613966
GRA: 105762440
GAB: 108477801
DZI: 111305969
EGR: 104443225
GMX: 100789889
GSJ: 114378926
VRA: 106752700
VAR: 108339159
CCAJ: 109806212
CAM: 101514759
LJA: Lj3g3v0428480.1(Lj3g3v0428480.1)
ADU: 107478471
AIP: 107634316
LANG: 109363395
FVE: 101293350
RCN: 112169376
PPER: 18787141
PMUM: 103332232
PAVI: 110757680
MDM: 114823871
PXB: 103929347
ZJU: 107423645
CSV: 101205312
CMO: 103483180
MCHA: 111016260
CMAX: 111479555
CMOS: 111431947
CPEP: 111790097
RCU: 8282130
JCU: 105642840
HBR: 110653613
MESC: 110614660
POP: 7497255
PEU: 105124757
JRE: 108989252
QSU: 111989342
VVI: 100253484
SLY: 101265072
SPEN: 107032022
SOT: 102601340
CANN: 107845939
NSY: 104217226
NTO: 104085251
NAU: 109231543
INI: 109155042
SIND: 105173745
HAN: 110863788
LSV: 111894621
CCAV: 112526455
DCR: 108208274
BVG: 104882800
SOE: 110785044
NNU: 104610254
OSA: 4344594
DOSA: Os08t0131100-01(Os08g0131100)
OBR: 102704827
ATS: 109743246(LOC109743246)
SBI: 8074081
ZMA: 100282873
SITA: 101785968
EGU: 105059962
MUS: 103995628
DCT: 110114706
PEQ: 110026608
AOF: 109844353
ATR: 18427181
SMO: SELMODRAFT_108395 SELMODRAFT_144382(CYP703C2_v2) SELMODRAFT_155508(CYP703D2_v2) SELMODRAFT_168443(CYP703D1) SELMODRAFT_168652(CYP703C1_v2) SELMODRAFT_229947(CYP703C1) SELMODRAFT_230667(CYP703D2) SELMODRAFT_235879(CYP703E1) SELMODRAFT_427258(CYP797C4) SELMODRAFT_43356(CYP703E1_v2) SELMODRAFT_74166(CYP703C2)
 » show all
Reference
1  [PMID:17496121]
  Authors
Morant M, Jorgensen K, Schaller H, Pinot F, Moller BL, Werck-Reichhart D, Bak S
  Title
CYP703 is an ancient cytochrome P450 in land plants catalyzing in-chain hydroxylation of lauric acid to provide building blocks for sporopollenin synthesis in pollen.
  Journal
Plant Cell 19:1473-87 (2007)
DOI:10.1105/tpc.106.045948
  Sequence
[ath:AT1G01280]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.130
IUBMB Enzyme Nomenclature: 1.14.14.130
ExPASy - ENZYME nomenclature database: 1.14.14.130
BRENDA, the Enzyme Database: 1.14.14.130

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