KEGG   ENZYME: 1.14.14.131
Entry
EC 1.14.14.131              Enzyme                                 

Name
bursehernin 5'-monooxygenase;
CYP71CU1 (gene name);
bursehernin 5'-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
(-)-bursehernin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (5'-hydroxylating)
Reaction(IUBMB)
(-)-bursehernin + [reduced NADPH---hemoprotein reductase] + O2 = (-)-5'-demethylyatein + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R11211]
Reaction(KEGG)
R11211
Substrate
(-)-bursehernin [CPD:C21183];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
(-)-5'-demethylyatein [CPD:C21184];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein characterized from the plant Sinopodophyllum hexandrum. The enzyme is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs.
History
EC 1.14.14.131 created 2016 as EC 1.14.13.213, transferred 2018 to EC 1.14.14.131
Pathway
ec00998  Biosynthesis of various secondary metabolites - part 2
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K21205  bursehernin 5'-monooxygenase
Reference
1  [PMID:26359402]
  Authors
Lau W, Sattely ES
  Title
Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone.
  Journal
Science 349:1224-8 (2015)
DOI:10.1126/science.aac7202
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.131
IUBMB Enzyme Nomenclature: 1.14.14.131
ExPASy - ENZYME nomenclature database: 1.14.14.131
BRENDA, the Enzyme Database: 1.14.14.131

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