KEGG   ENZYME: 1.14.14.135Help
Entry
EC 1.14.14.135              Enzyme                                 

Name
glyceollin synthase;
dimethylallyl-3,6a,9-trihydroxypterocarpan cyclase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
2-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (cyclizing)
Reaction(IUBMB)
(1) 2-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + [reduced NADPH---hemoprotein reductase] + O2 = glyceollin II + [oxidized NADPH---hemoprotein reductase] + 2 H2O [RN:R07195];
(2) 2-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + [reduced NADPH---hemoprotein reductase] + O2 = glyceollin III + [oxidized NADPH---hemoprotein reductase] + 2 H2O [RN:R07196];
(3) 4-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + [reduced NADPH---hemoprotein reductase] + O2 = glyceollin I + [oxidized NADPH---hemoprotein reductase] + 2 H2O [RN:R07197]
Reaction(KEGG)
Substrate
2-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan [CPD:C15509];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007];
4-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan [CPD:C15510]
Product
glyceollin II;
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001];
glyceollin III [CPD:C15511];
glyceollin I
Comment
A cytochrome P-450 (heme-thiolate) protein purified from soybean.
History
EC 1.14.14.135 created 2004 as EC 1.14.13.85, transferred 2018 to EC 1.14.14.135
Pathway
ec00943  Isoflavonoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Reference
1  [PMID:3369863]
  Authors
Welle R, Grisebach H.
  Title
Induction of phytoalexin synthesis in soybean: enzymatic cyclization of prenylated pterocarpans to glyceollin isomers.
  Journal
Arch Biochem Biophys 263:191-8 (1988)
DOI:10.1016/0003-9861(88)90627-3
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.135
IUBMB Enzyme Nomenclature: 1.14.14.135
ExPASy - ENZYME nomenclature database: 1.14.14.135
BRENDA, the Enzyme Database: 1.14.14.135

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (10)   
   KEGG COMPOUND (10)   
Chemical reaction (7)   
   KEGG REACTION (5)   
   KEGG RCLASS (2)   
All databases (21)   

Download RDF
DBGET integrated database retrieval system